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World Journal of Gastroenterology 2007年第7期13卷 1141-1143页

作者： Güldeniz Karadeniz Cakmak Ali ugur Emre Oge Tascilar Sibel Bekta■ bulent hamdi uan Oktay Irkorucu Kemal Karakaya Yucel ustundag Mustafa Comert Department of Surgery Zonguldak Karaelmas Uni-versity School of Medicine Kozlu-Zonguldak Turkey Department of Pathology Zonguldak Karaelmas University School of Medicine Kozlu-Zonguldak Turkey Department of Gastroenterology Zonguldak Karaelmas University School of Medicine Kozlu-Zonguldak Turkey

Lipoma within an inverted Meckel's diverticulum presen- ting with hemorrhage and partial intestinal obstruction is an exceptional clinical entity. We report a case of 47-year-old male with a history of recurrent episodes of partial intestinal obstruction and melena due to a subserosal lipoma located in the base of an inverted Meckel's diverticulum. According to our knowledge, this is the first case of a lipoma within a Meckel's diverticulum giving rise to this clinical scenario without the existence of heterotrophic gastric or pancreatic tissues.

关键词： Meckel's diverticulum Lipoma Inversion Intestinal obstruction Hemorrhage

Appendiceal mucocele: Case reports and review of current literature

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World Journal of Gastroenterology 2008年第14期14卷 2280-2283页

作者： Kemal Karakaya Figen Barut Ali ugur Emre hamdi bulent ucan Guldeniz Karadeniz Cakmak Oktay Irkorucu Oge Tascilar Yucel ustundag Mustafa Comert Department of General Surgery Zonguldak Karaelmas University Zonguldak 67600 Turkey Department of Pathology Zonguldak Karaelmas University Zonguldak 67600 Turkey Department of Gastroenterology Zonguldak Karaelmas University Zonguldak 67600 Turkey

The mucocele of the appendix is an uncommon disorder which is often asymptomatic but sometimes causes acute appendicitis-like symptoms. Sometimes, patients with mucocele can present with confusing symptoms. Preoperative suspicion and diagnosis of appendiceal mucocele are important. ultrasonography and computed tomography are useful tools for the diagnosis of appendiceal mucocele. It may be also recognised by colonoscopy as a smooth submucosal lesion of the cecum. Optima management of the mucocele could be achieved through accurate preoperative diagnosis. Preoperative diagnosis is a major component for minimizing intra-operative and post-operative complications. We herein report five cases and discuss the diagnostic methods and surgical treatment.

关键词： Appendix Mucocele Diagnosis Surgical treatment

Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma:Feasible or not?

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World Journal of Gastroenterology 2007年第41期13卷 5476-5480页

作者： Oge Tascilar Gldeniz Karadeniz Cakmak Ishak Ozel Tekin Ali ugur Emre bulent hamdi ucan Oktay Irkorucu Kemal Karakaya Mesut Gl Hseyin Blent Engin Mustafa Comert Department of Surgery Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of Immunology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of Medical Oncology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey

AIM： To evaluate the frequency of neural cell adhesion molecule （NCAM）-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice.METHODS： Twenty-six patients （16 men, 10 women） with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression.RESuLTS： Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case （3.84%） with well-differentiated Stage Ⅱ disease who experienced no active disease at 30 months follow-up. CONCLuSION： As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

关键词： Neural cell adhesion molecule-180 Colorectal cancer Prognosis Flow-cytometry

Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis

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World Journal of Gastroenterology 2007年第46期13卷 6172-6182页

作者： Oge Tascilar Güldeniz Karadeniz Cakmak Ishak Ozel Tekin Ali ugur Emre bulent hamdi ucan Burak Bahadir Serefden Acikgoz Oktay Irkorucu Kemal Karakaya Hakan Balbaloglu Gürkan Kertis Handan Ankarali Mustafa Comert Department of Surgery Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of Immunology Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of Pathology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of Biochemistry Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of Biostatistics Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey

AIM： TO investigate the effect of exogenous erythro- poietin （EPO） administration on acute lung injury （ALI） in an experimental model of sodium taurodeoxycholate- induced acute necrotizing pancreatitis （ANP）. METHODS： Forty-seven male Wistar albino rats were randomly divided into 7 groups： sham group （n = 5）, 3 ANP groups （n = 7 each） and 3 EPO groups （n = 7 each）. ANP was induced by retrograde infusion of 5% sodium taurodeoxycholate into the common bile duct. Rats in EPO groups received 1000 u/kg intramuscular EPO immediately after induction of ANP. Rats in ANP groups were given 1 mL normal saline instead. All animals were sacrificed at postoperative 24 h, 48 h and 72 h. Serum arnilase, IL-2, IL-6 and lung tissue malondialdehyde （MDA） were measured. Pleural effusion volume and lung/body weight （LW/BW） ratios were calculated. Tissue levels of TNF-a, IL-2 and IL-6 were screened immunohistochemically. Additionally, ox-LDL accumulation was assessed with immune-fluorescent staining. Histopathological alterations in the lungs were also ***： The mean pleural effusion volume, calculated LW/BW ratio, serum IL-6 and lung tissue MDA levels were significantly lower in EPO groups than in ANP groups. No statistically significant difference was observed in either serum or tissue values of IL-2 among the groups. The level of tumor necrosis factor-（~ （TNF-（~） and IL-6 and accumulation of ox-LDL were evident in the lung tissues of ANP groups when compared to EPO groups, particularly at 72 h. Histopathological evaluation confirmed the improvement in lung injury parameters a^er exogenous EPO administration, particularly at 48 h and 72 h. CONCLuSION： EPO administration leads to a significant decrease in ALI parameters by inhibiting polymorphonuclear leukocyte （PMNL） accumulation, decreasing the levels of proinflammatory cytokines in circulation, preserving microvascular endothelial cell integrity and reducing oxidative stress-associated lipid peroxidation and therefore, can

关键词： Erythropoietin Acute pancreatitis Acute lunginjury Acute respiratory distress syndrome Cytokine