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Inflammatory responses in esophageal mucosa before and after laparoscopic antireflux surgery

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 871-881页

作者： Pelin Ergun Sezgi Kipcak Nur Selvi Gunel eser Yildirim Sozmen Serhat Bor Department of Otolaryngology Medical College of WisconsinMilwaukeeWI 53226United States Division of Gastroenterology Ege UniversityFaculty of MedicineEge Reflux GroupIzmir 35100Turkiye Department of Medical Biology Ege UniversityFaculty of MedicineIzmir 35100Turkiye Department of Medical Biochemistry Ege UniversityFaculty of MedicineIzmir 35100Turkiye

BACKGROUND Currently,the primary treatment for gastroesophageal reflux is acid suppression with proton pump inhibitors,but they are not a cure,and some patients don’t respond well or refuse long-term ***,alternative therapies are needed to understand the disease and develop better *** anti-reflux surgery(LARS)can resolve symptoms of these patients and plays a significant role in evaluating esophageal healing after preventing harmful *** LARS improves typical gastroesophageal reflux symptoms in most patients,main-ly by reducing the exposure time to gastric contents in the ***-ration of the inflammatory response and a recovery response in the esophageal epithelium is expected following the cessation of the noxious *** To explore the role of inflammatory biomolecules in LARS and assess the time required for esophageal epithelial *** Of 22 patients with LARS(pre-and post/5.8±3.8 months after LARS)and 25 healthy controls(HCs)were *** subjects underwent 24-h multichannel intraluminal impedance-pH monitoring and upper gastrointestinal endoscopy,during which esophageal biopsy samples were collected using endoscopic *** molecules in esophageal biopsies were investigated by reverse transcription-polymerase chain reaction and multiplex-enzyme-linked immunosorbent *** Post-LARS samples showed significant increases in proinflammatory cytokines[interleukin(IL)-1β,interferon-γ,C-X-C chemokine ligand 2(CXCL2)],anti-inflammatory cytokines[CC chemokine ligand(CCL)11,CCL13,CCL17,CCL26,CCL1,CCL7,CCL8,CCL24,IL-4,IL-10],and homeostatic cytokines(CCL27,CCL20,CCL19,CCL23,C-CL25,CXCL12,migration inhibitory factor)compared to both HCs and pre-LARS ***17 and CCL21 levels were higher in pre-LARS than in HCs(P<0.05).The mRNA expression levels of AKT1,fibroblast growth factor 2,HRAS,and mitogen-activated protein kinase 4 were significantly decreased post-LARS vs pre-LARS.

关键词： Anti-reflux surgery Gastroesophageal reflux disease Cytokine Inflammatory response Esophagus

An Alternative Method for Calculating Bound-State of Energy Eigenvalues of Klein-Gordon for Quasi-exactly Solvable Potentials

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Chinese Physics Letters 2009年第2期26卷 13-16页

作者： eser Olgar Department of Physics and Engineering University of Gaziantep Gaziantep Turkey

We obtain the bound-state energy of the Klein-Gordon equation for some examples of quasi-exactly solvable potentials within the framework of asymptotic iteration method （AIM）. The eigenvalues are calculated for type- 1 solutions. The whole quasi-exactly solvable potentials are generated from the defined relation between the vector and scalar potentials.

关键词： No English Keywords

Exact Solution of Klein-Gordon Equation by Asymptotic Iteration Method

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Chinese Physics Letters 2008年第6期25卷 1939-1942页

作者： eser Olgar University of Gaziantep Engineering of Physics Department Gaziantep Turkey

Using the asymptotic iteration method （AIM） we obtain the spectrum of the Klein-Gordon equation for some choices of scalar and vector potentials. In particular, it is shown that the AIM exactly reproduces the spectr... 详细信息

关键词： BOUND-STATES EIGENVALUE PROBLEMS VECTOR POTENTIALS DIRAC-EQUATION SCALAR OSCILLATORS SPECTRUM MODEL

Relationship between retinopathy and cirrhosis

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World Journal of Gastroenterology 2005年第14期11卷 2193-2196页

作者： Colakoglu Onder Taskiran Bengur Dayi Selcuk Sozmen bulent Unsal Belkis Maden Ahmet Pasa eser Aslan S. Leyla Clinics of Gastroenterology Izmir Ataturk Teaching and Research Hospital IzmirTurkey 3rd Clinics of Internal Medicine Izmir Ataturk Teaching and Research Hospital Izmir Turkey Clinics of Ophthalmology Izmir Ataturk Teaching and Research Hospital IzmirTurkey 3rd Clinics of Internal Medicine Izmir Ataturk Teaching and Research Hospital IzmirTurkey Clinics of Ophthalmology 9th September University Hospital IzmirTurkey

AIM: To evaluate ophthalmic disorders with special attention to retinopathy in cirrhotic patients. Vitamin A deficiency-related ophthalmopathy, xerophthalmia, and color blindness may be documented in cirrhosis due to various etiologies. Retinopathy is an obscure feature of cirrhosis. METHODS: Thirty-two cirrhotic patients, who were followed up by Clinics of Gastroenterology, Izmir Ataturk Teaching and Research Hospital, were enrolled to the study. Associated systemic diseases such as diabetes mellitus and hypertension were excluded. Thirty-two healthy volunteers took part as the control subjects. All participants had ophthalmologic examination in the same hospital. RESULTS: Five (15.6%) of the cirrhotic subjects had soft exudate in the retina. None of the control subjects had retinopathy (P＜0.05). Intraocular pressure (IOP) measured for both eyes were also significantly lower in the cirrhotics (P＜0.05 vs P = 0.01). There were no statistically significant differences between the two groups in terms of other ophthalmic pathologies. The ophthalmic findings did not show up any differences according to the etiology of cirrhosis. CONCLUSION: Soft exudates may develop in cirrhotic patients probably due to loss of synthetic function of liver and hemodynamic effects of portal hypertension. Retinopathy must be sought in cirrhosis because of its severe morbidity.

关键词： Cirrhosis Portal hypertension Retinopathy

Clinical,Biochemical,and Radiological Retrospective Analysis in Patients with Adrenal Incidentaloma-A Secondary Publication

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Proceedings of Anticancer Research 2024年第1期8卷 129-139页

作者： Zeynep Ebru eser Ramazan Gen Kadir eser Kerem Sezer Esen Akbay Department of Nephrology Mersin University HospitalMersinTurkey Mersin University Hospital Department of EndocrinologyMersinMersinTurkey Mersin University Hospital Department of Medical OncologyMersinMersinTurkey

Objective:To evaluate the epidemiological,demographic,clinical features,treatment approaches,and survival of patients followed up for adrenal ***:Data from 46 patients who were treated and followed up due to adrenal incidentaloma in the Endocrinology Department of Mersin University Health Research and Application Hospital between 2010 and 2014 were retrospectively ***:Of the cases included in the study,13 were male,33 were female,and the mean age was 54.09±10.7 *** most common reason for admission was abdominal pain in 34.78%of the patients,the most commonly diagnosed radiological method was dynamic adrenal CT in 60.87%,and the most common location was the left adrenal *** mean lesion diameter was between 26.8±16.5 *** frequency of hypertension was 50%,obesity 47.8%,type 2 diabetes 21.7%,osteoporosis 42.8%,and metabolic syndrome 41.3%.According to hormonal evaluation results,non-functional adrenal adenoma(NFAA)was found in 82.61%,subclinical Cushing’s syndrome(SCS)in 15.21%,and aldosteronoma in 2.1%.Myelolipoma,pheochromocytoma,and adrenocortical adenoma were diagnosed in 8 cases undergoing *** patient died due to liver *** hormonal activation or growth in lesion size was detected during the follow-up of the ***:Due to the very different pathological and radiological appearances of adrenal incidentaloma,it is important to evaluate demographic,etiological,clinical,laboratory,and radiological data as a whole in the treatment and follow-up.

关键词： Adrenal incidentaloma Subclinical Cushing’s syndrome Non-functional adrenal adenoma Diagnosis Treatment

Mangafodipir trisodium-enhanced magnetic resonance imaging for evaluation of pancreatic mass and mass-like lesions

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World Journal of Gastroenterology 2006年第10期12卷 1603-1606页

作者： Gul eser Aydin Karabacakoglu Serdar Karakose Cengiz eser Ertugrul Kayacetin Department of Radiology Selcuk University Meram Medical Faculty KonyaTurkey Department of Internal Medicine Numune Hospital KonyaTurkey Department of Gastroenterology Selcuk University Meram Medical Faculty KonyaTurkey Co-first-authors:Gul Eser

AIM： To investigate the role of mangafodipir trisodium （MnDPDP） in focal pancreatic masses and mass-like lesions by evaluating contrast uptake features of the lesions and pancreatic parenchyma after contrast medium injection. METHODS： A total of 37 patients with pancreatic mass or mass-like lesions were examined by unenhanced and MnDPDP-enhanced magnetic resonance imaging （MRI）. RESULTS： MRI was obtained 20-40 min after infusion of MnDPDP and homogeneous contrast enhancement was observed in normal pancreas parenchyma. In patients with atrophic pancreas there was no enhancement in pancreatic parenchyma on MnDPDP-enhanced MRI. In 37 patients with 41 pancreatic masses and mass-like lesions, contrast enhancement was observed at 5 lesions on MnDPDP enhanced MRI. Three of these 5 lesions were focal pancreatitis and the other 2 were adenocarcinoma. No contrast enhancement was determined in 36 pancreatic masses and mass-like lesions in 32 patients. CONCLUSION： MnDPDP contrast-enhanced MRI, especially in cases with no parenchyma atrophy, can distinguish focal pancreatic lesion margins. Information about the function of pancreatic parenchyma can be obtained out of tumor. MnDPDP facilitates staging of pancreatic tumors by detection of metastatic lesions in the liver. In addition, diminished heteregenous uptake of MnDPDP in patients with pancreatitis may be helpful in differential diagnosis.

关键词： MnDPDP Pancreas MRI

Asymptotic Iteration Method for Energies of Inversely Linear Potential with Spatially Dependent Mass

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Communications in Theoretical Physics 2010年第6期53卷 1043-1045页

作者： eser Olgar Haydar Mutaf University of Gaziantep Engineering of Physics Department

The bound-state solution of the position dependent mass Klein-Gordon equation including inversely linear potential is obtained within the framework of the asymptotic iteration method. The relation between the scalar and vector potentials is considered to S（x） = V（x）（β - 1）. In particular, it is shown that the corresponding method exactly reproduces the spectrum of linearly inversely potentials with spatially dependent mass.

关键词： Klein Gordon equation asymptotic iteration method position dependent mass

Bound States of the S-Wave Equation with Equal Scalar and Vector Standard Eckart Potential

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Chinese Physics Letters 2006年第3期23卷 539-541页

作者： eser Olgar Ramazan Koc Hayriye Tutunculer Department of Physics Faculty of Engineering University of Gaziantep 27310 Gaziantep Turkey

A supersymmetric technique for the bound-state solutions of the s-wave Klein-Gordon equation with equal scalar and vector standard Eckart-type potential is proposed. Its exact solutions are obtained. Possible generali... 详细信息

关键词： KLEIN-GORDON EQUATION

Self-sufficient Cytochrome P450s and their potential applications in biotechnology

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Chinese Journal of Chemical Engineering 2021年第2期34卷 121-135页

作者： Bekir Engin eser Yan Zhang Li Zong Zheng Guo Department of Engineering Faculty of Technical SciencesAarhus UniversityDenmark Key Laboratory for Molecular Enzymology and Engineering The Ministry of EducationSchool of Life ScienceJilin UniversityChangchun 130021China

Cytochrome P450s(CYPs)are ubiquitously found in all kingdoms of life,playing important role in various biosynthetic pathways as well as degradative pathways;accordingly find applications in a vast variety of areas from organic synthesis and drug metabolite production to modification of biomaterials and ***,CYPs catalyze chemically challenging CAH and CAC activation reactions using a reactive high-valent iron-oxo intermediate generated upon dioxygen activation at their heme center,while the other oxygen atom is reduced to the level of water by electrons provided through a reductase partner ***-sufficient CYPs,encoding their heme domain and reductase protein in a single polypeptide,facilitate increased catalytic efficiency and render a less complicated system to work *** self-sufficient CYP enzyme from CYP102A family(CYP102A1,BM3)is among the earliest and most-investigated model enzymes for mechanistic and structural studies as well as for biotechnological *** increasing number of self-sufficient CYPs from the same CYP102 family and from other families have also been reported in last *** this review,we introduce chemistry and biology of CYPs,followed by an overview of the characteristics of self-sufficient CYPs and representative *** engineering efforts leading to novel self-sufficient CYP variants that can catalyze synthetically useful natural and non-natural(nature-mimicking)reactions are ***,the strategy and efforts that aim to circumvent the challenges for improved thermostability,regio-and enantioselectivity,and total turnover number;associated with practical use of self-sufficient CYPs are reviewed.

关键词： Biocatalysis Heme enzymes CAH activation Cytochrome P450s Self-sufficient P450s P450 BM3