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Estimation of the density of neural,glial,and endothelial lineage cells in the adult mouse dentate gyrus

Neural Regeneration Research 2022年第6期17卷 1286-1292页

作者： Joshua D.Rieskamp Patricia Sarchet bryon m.smith Elizabeth D.Kirby Neuroscience Graduate Program The Ohio State UniversityColumbusOHUSA Department of Psychology The Ohio State UniversityColumbusOHUSA Department of Neuroscience The Ohio State UniversityColumbusOHUSA Chronic Brain Injury Program The Ohio State UniversityColumbusOHUSA

The dentate gyrus subregion of the mammalian hippocampus is an adult neural stem cell niche and site of lifelong *** regarding the role of adult-born neuron synaptic integration in hippocampal circuit function are framed by robust estimations of adultborn versus pre/perinatally-born neuron *** contrast,the non-neurogenic functions of adult neural stem cells and their immediate progeny,such as secretion of bioactive growth factors and expression of extracellular matrix-modifying proteins,lack similar framing due to few estimates of their number versus other prominent secretory ***,we apply immunohistochemical methods to estimate cell density of neural stem/progenitor cells versus other major classes of glial and endothelial cell types that are potentially secretory in the dentate gyrus of adult *** the cell types quantified,we found that GFAP^(+)SOX2^(+)stellate astrocytes were the most numerous,followed by CD31^(+)endothelia,GFAP-SOX2^(+)intermediate progenitors,Olig2^(+)oligodendrocytes,Iba1+microglia,and GFAP^(+)SOX2^(+)radial glia-like neural stem *** did not observe any significant sex differences in density of any cell ***,neural stem/progenitor cells were present at a similar density as several cell types known to have potent functional roles via their *** findings may be useful for refining hypotheses regarding the contributions of these cell types to regulating hippocampal function and their potential therapeutic *** experimental protocols were approved by the Ohio State University Institutional Animal Care and Use Committee(protocol#2016A00000068)on July 14,2016.

关键词： adult neurogenesis dentate gyrus endothelia glia hippocampus neural stem cell secretome stereology

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microstructure segmentation with deep learning encoders pre-trained on a large microscopy dataset

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npj Computational materials 2022年第1期8卷 1905-1916页

作者： Joshua Stuckner Bryan Harder Timothy m.smith materials and Structures Division NASA Glenn Research Center21000 Brookpark RdClevelandOH44135USA

This study examined the improvement of microscopy segmentation intersection over union accuracy by transfer learning from a large dataset of microscopy images called *** neural network encoder architectures were trained on over 100,000 labeled microscopy images from 54 material *** pre-trained encoders were then embedded into multiple segmentation architectures including UNet and DeepLabV3+to evaluate segmentation performance on created benchmark microscopy *** to ImageNet pre-training,models pre-trained on microNet generalized better to out-of-distribution micrographs taken under different imaging and sample conditions and were more accurate with less training *** training with only a single Ni-superalloy image,pre-training on microNet produced a 72.2%reduction in relative intersection over union *** results suggest that transfer learning from large in-domain datasets generate models with learned feature representations that are more useful for downstream tasks and will likely improve any microscopy image analysis technique that can leverage pre-trained encoders.

关键词： union intersection image

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Detailed characterization of kHz-rate laser-driven fusion at a thin liquid sheet with a neutron detection suite

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High Power Laser Science and Engineering 2024年第1期12卷 13-23页

作者： Benjamin m.Knight Connor m.Gautam Colton R.Stoner Bryan V.Egner Joseph R.smith Chris m.Orban Juan J.manfredi Kyle D.Frische michael L.Dexter Enam A.Chowdhury Anil K.Patnaik Department of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics Department Marietta CollegeMariettaOHUSA Department of Physics The Ohio State UniversityColumbusOHUSA Department of materials Science and Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Solutions LLCPlain CityOHUSA

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(<1 μm) D_2O liquid sheet employing a measurement suite. At relativistic inte... 详细信息

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(m) D_2O liquid sheet employing a measurement suite. At relativistic intensity(~ 5 × 10^(18)W/cm^(2))and high repetition rate(1 kHz), the system produces deuterium±deuterium(D-D) fusion, allowing for consistent neutron generation. Evidence of D-D fusion neutron production is verified by a measurement suite with three independent detection systems: an EJ-309 organic scintillator with pulse-shape discrimination, a ~3He proportional counter and a set of 36 bubble detectors. Time-of-flight analysis of the scintillator data shows the energy of the produced neutrons to be consistent with 2.45 meV. Particle-in-cell simulations using the WarpX code support significant neutron production from D-D fusion events in the laser±target interaction region. This high-repetition-rate laser-driven neutron source could provide a low-cost, on-demand test bed for radiation hardening and imaging applications.

关键词： high-repetition-rate laser-driven fusion laser-plasma interaction liquid target neutron detectors

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A stability evaluation method for deep-seated toppling in the upper Lancang river,Southwestern China

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Journal of Rock mechanics and Geotechnical Engineering 2024年第7期16卷 2388-2410页

作者： Yibing Ning Huiming Tang Jianbing Peng Yanjun Shen John V.smith Bocheng Zhang College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China Academy of Yellow River Sciences of Shaanxi Province Chang’an UniversityXi’an710054China Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan430074China School of Engineering RMIT UniversityMelbourne3001Australia

Deep-seated toppling in the upper reaches of the Lancang River,southwest China involves deformations exceeding 100 m in *** slope deformation is initiated by river downcutting and evolves distinctive characteristics with a depth of river *** this study,we propose a system for evaluating the stability of deep-seated toppled slopes in different evolutionary *** system contains identification criteria for each evolutionary stage and provides the corresponding stability evaluation *** on the mechanical and kinematic analysis of slope blocks,the specific stage of slope movement can be identified in the field through outcrop mapping,in situ tests,surface displacement monitoring,and adit and borehole *** stability evaluation methods are established based on the limiting equilibrium theory and the strain compatibility between the undisturbed zone and the toppled ***,several sample slopes in different evolution stages have been investigated to verify the applicability and accuracy of the proposed stability evaluation *** results indicate that intense tectonic activity and rapid river incision lead to a maximum principal stress ratio exceeding 10 near the slope surface,thus triggering widespread toppling deformations along the river *** considering the losses of joint cohesion during the further rotation process,the safety factor of the slope drops by 7%e28%.The self-stabilization of toppling deformation can be recognized by the layer symmetry configuration after the free rotation of the deflected *** toppled rock blocks mainly suffer sliding failures beyond the layer symmetry *** factor of safety of the K73 rockslide decreased from 1.17 to 0.87 by considering the development of the potential sliding surface and the toesaturated zone.

关键词： Stability evaluation Deep-seated toppling Evolutionary process Reservoir impoundment Rock slope

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Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy L.Barth Rodney J.Schlosser Thomas S.Edwards Timothy L.smith Zachary m.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pme functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Pmation regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.smith Tiffany m.Zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

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Efficiency of a modular Cleanroom for Space Applications

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Fluid Dynamics & materials Processing 2024年第3期20卷 547-562页

作者： matthew R.Coburn Charlie Young Chris smith Graham Schultz miguel Robayo Zheng-Tong Xie Faculty of Engineering and Physical Sciences University of SouthamptonSouthamptonSO171BJUK Plastron UK Ltd. Westcott Venture ParkWestcottHP180XBUK Renewable Energy Group University of ExeterExeterTR109FEUK

A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of *** Reynolds Averaged Navier-Stokes(URANS)models have been used to study the related flow field and particulate matter(Pm)*** outcomes of the URANS models have been validated through comparison with equivalent large-eddy *** attention has been paid to the location and shape of the air intakes and their orientation in space,in order to balance the Pm convection and diffusion inside the *** a cyclone-type flow pattern inside the cleanroom is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES Pm RANS unsteady flow exponential decay

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Does the use of double hormone replacement therapy for trauma patient organ donors improve organ recovery for transplant

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World Journal of Transplantation 2024年第2期14卷 119-125页

作者： Eden m Gallegos Tanner Reed Paige Deville Blake Platt Claudia Leonardi Lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt Lance Stuke Patrick Greiffenstein Jonathan Schoen Alan marr Anil Paramesh Alison A smith Department of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Department of medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Trauma Surgery Tacoma General HospitalTacoma 98405United States Department of Public Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Department of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing demand for transplantable organs,optimization of donor management protocols,specifically in trauma populations,is important for obta-ining a high yield of viable organs per *** management of brain-dead potential organ donors(BPODs)is controversial,leading to heterogeneous clinical management *** studies have shown that when levo-thyroxine was combined with other treatments,including steroids,vasopressin,and insulin,BPODs had better organ recovery and survival outcomes were increased for transplant *** To determine if levothyroxine use in combination with steroids in BPODs increased the number of organs donated in trauma *** A retrospective review of adult BPODs from a single level 1 trauma center over ten years was *** criteria included patients who were not solid organ donors,patients who were not declared brain dead(donation after circulatory death),and patients who did not receive steroids in their hospital *** and steroid administration,the number of organs donated,the types of organs donated,and demographic information were *** analyses were performed with Pmet inclusion criteria,69(78%)of whom received levothyroxine and steroids(ST/LT group)vs 19(22%)receiving steroids without levothyroxine(ST group).No differences were observed between the groups for gender,race,pertinent injury factors,age,or other hormone therapies used(P>0.05).In the ST/LT group,68.1%(n=47)donated a high yield(3-5)of organ types per donor compared to 42.1%(n=8)in the ST group(P=0.038).There was no difference in the total number of organ types donated between the groups(P=0.068).CONCLUSION This study suggests that combining levothyroxine and steroid administration increases high-yield organ donation per donor in BPODs in the trauma patient *** to this study include

关键词： Organ donation Trauma Brain death Levothyroxine Hormone replacement therapy Steroids Organ donor Retrospective

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Strigolactones redefine plant hormones

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Science China(Life Sciences) 2016年第10期59卷 1083-1085页

作者： Lu Wang Steven m.smith School of Biological Sciences University of Tasmania Institute of Genetics and Developmental Biology Chinese Academy of sciences

A commonly accepted view of plant growth hormones is that their interaction with the cognate receptor protein is reversible,so that each hormone molecule can potentially interact multiple times with a receptor and so ... 详细信息

关键词：植物激素受体蛋白定义植物生长激素相互作用激素信号酸水解

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Long-term follow-up of kidney transplant recipients admitted to a tertiary care transplant center with SARS-CoV-2

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World Journal of Virology 2024年第2期13卷 87-95页

作者： Emily E Zona mina L Gibes Asha S Jain Jeannina A smith Jacqueline m Garonzik-Wang Didier A mandelbrot Sandesh Parajuli Division of Nephrology Department of MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53705United States Department of Infectious Disease University of Wisconsin Hospital and ClinicsMadisonWI 53705United States Department of Surgery University of WisconsinMadisonWI 53705United States Department of medicine University of Wisconsin School of Medicine and Public HealthMadisonWI 53705United States Department of medicine University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin MadisonMadisonWI 53705United States

BACKGROUND Kidney transplant recipients(KTR)are at risk of severe coronavirus disease 2019(COVID-19)disease and mortality after severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** predicted that hospitalization for COVID-19 and subsequent admission to the intensive care unit(ICU)would yield worse outcomes in *** was stratified by ICU *** of interest included risk factors for ICU admission and mortality,length of stay(LOS),respiratory symptoms at admission,all-cause graft failure at the last follow-up,and death related to *** 96 KTRs were hospitalized for SARS-COV-2 infection.21(22%)required ICU *** ICU group had longer hospital LOS(21.8 vs 8.6 days,Pmore likely to experience graft failure(81%vs 31%,Pmitted to the ICU,76%had death at last-follow up,and 71%had death related to *** factors for ICU admission included male sex(aHR:3.11,95%CI:1.04-9.34;P=0.04).Risk factors for all-cause mortality and COVID-19-related mortality included ICU admission and advanced age at SARS-CoV-2 *** was highest within a month of COVID-19 diagnosis,with the ICU group having increased risk of all-cause(aHR:11.2,95%CI:5.11-24.5;Pmortality(aHR:27.2,95%CI:8.69-84.9;Pmission conferred an increased risk of mortality,graft failure,and longer ***-fifth of those hospit-alized died of COVID-19,reflecting the impact of COVID-19-related morbidity and mortality among KTRs.

关键词： Kidney transplants SARS-CoV-2 Intensive care unit admission Outcomes Graft failure

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