Long-term follow-up of kidney transplant recipients admitted to a tertiary care transplant center with SARS-CoV-2

作     者：Emily E Zona Mina L Gibes Asha S Jain Jeannina A Smith Jacqueline M Garonzik-Wang Didier A Mandelbrot Sandesh Parajuli 

作者机构：Division of NephrologyDepartment of MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53705United States Department of Infectious DiseaseUniversity of Wisconsin Hospital and ClinicsMadisonWI 53705United States Department of SurgeryUniversity of WisconsinMadisonWI 53705United States Department of MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53705United States Department of MedicineUniversity of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin MadisonMadisonWI 53705United States 

出 版 物：《World Journal of Virology》 (世界病毒学杂志)

年 卷 期：2024年第13卷第2期

页      面：87-95页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Kidney transplants SARS-CoV-2 Intensive care unit admission Outcomes Graft failure 

摘      要：BACKGROUND Kidney transplant recipients(KTR)are at risk of severe coronavirus disease 2019(COVID-19)disease and mortality after severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** predicted that hospitalization for COVID-19 and subsequent admission to the intensive care unit(ICU)would yield worse outcomes in *** was stratified by ICU *** of interest included risk factors for ICU admission and mortality,length of stay(LOS),respiratory symptoms at admission,all-cause graft failure at the last follow-up,and death related to *** 96 KTRs were hospitalized for SARS-COV-2 infection.21(22%)required ICU *** ICU group had longer hospital LOS(21.8 vs 8.6 days,P0.001)and were more likely to experience graft failure(81%vs 31%,P0.001).Of those admitted to the ICU,76%had death at last-follow up,and 71%had death related to *** factors for ICU admission included male sex(aHR:3.11,95%CI:1.04-9.34;P=0.04).Risk factors for all-cause mortality and COVID-19-related mortality included ICU admission and advanced age at SARS-CoV-2 *** was highest within a month of COVID-19 diagnosis,with the ICU group having increased risk of all-cause(aHR:11.2,95%CI:5.11-24.5;P0.001)and COVID-19-related mortality(aHR:27.2,95%CI:8.69-84.9;P0.001).CONCLUSION ICU admission conferred an increased risk of mortality,graft failure,and longer ***-fifth of those hospit-alized died of COVID-19,reflecting the impact of COVID-19-related morbidity and mortality among KTRs.