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Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis

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Journal of Integrative Medicine 2017年第3期15卷 214-230页

作者： Jeremiah Olorunjuwon Olugbami Robert Damoiseaux bryan france Michael A. Gbadegesin Adam Z. Stieg Shivani Sharma Oyeronke A. Odunola James K. Gimzewski Cancer Research and Molecular Biology Laboratories Department of Biochemistry College of Medicine University of Ibadan Ibadan Oyo 200005 Nigeria Nano and Pico Characterization Laboratories California NanoSystems Institute University of California LosAngeles California 90095 USA Department of Chemistry and Biochemistry University of California Los Angeles California 90095 USA Molecular Screening and Shared Resources Laboratories California NanoSystems Institute University of California Los Angeles California 90095 USA Department of Molecular and Medicinal Pharmacology University of California Los Angeles California 90095 USA International Center for Materials Nanoarchitectonics Satellite National Institute for Materials Science Tsukuba 3690114 Japan

OBJECTIVE： The fatality of cancer is mostly dependent on the possibility of occurrence of metastasis. Thus, if the development of metastasis can be prevented through novel therapeutic strategies targeted against this process, then the success of cancer treatment will drastically increase. In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis and curcumin on the metastatic liver cell line HepG2, and also assessed the anticancer property of the extract. METHODS： Cells were cultured and treated with graded concentrations of test substances for 24, 48, or 72 h with provisions made for negative controls. Treated cells were assessed as follows： nanotechnologically--atomic force microscopy （AFM） was used to determine cell stiffness; biochemically--cell cytotoxicity, glutathione level and adenosine triphosphate status, caspase activation and mitochondrial toxicity were considered; and microbiologically--a carrot disk assay was used to assess the anticancer property of the extract of K. senegalensis. RESULTS： Curcumin and K. senegalensis increased the cell stiffness by 2.6- and 4.0-fold respectively, indicating their antimetastatic effects. Corresponding changes in redox （glutathione level） and energy （adenosine triphosphate） status of the cells were also demonstrated. Further mechanistic studies indicated that curcumin was not mitotoxic in HepG2 cells unlike the K. senegalensis extract. In addition the extract potently inhibited the Agrobacterium tumefaciens-induced genetic transformation based on carrot disk assay. CONCLUSION： Cell elasticity measurement data, using AFM, strongly suggested, for the first time, that both curcumin and the extract of K. senegalensis exhibited antimetastatic properties on HepG2 cells.

关键词： Curcumin Khaya senegalensis atomic force microscopy glutathione adenosine triphosphate metasis carcinoma, hepatocellular

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Defining minimal invasive surgical therapy for benign prostatic obstruction surgery: Perspectives from a global knowledge, attitude, and practice survey

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Asian Journal of Urology 2024年第1期11卷 55-64页

作者： bryan Kwun-Chung Cheng Steffi Kar-Kei Yuen Daniele Castellani Marcelo Langer Wroclawski Hongda Zhao Mallikarjuna Chiruvella Wei-Jin Chua Ho-Yee Tiong Yiloren Tanidir Jean de la Rosette Enrique Rijo Vincent Misrai Amy Krambeck Dean S.Elterman Bhaskar K.Somani Jeremy Yuen-Chun Teoh Vineet Gauhar Department of Surgery United Christian HospitalHong KongChina S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Urology University Hospital“Ospedali Riuniti”and Polytechnic University of Marche RegionAnconaItaly Hospital Israelita Albert Einstein Sao PauloSPBrazil BP—A Beneficencia Portuguesa de Sao Paulo Sao PauloSPBrazil Faculdade de Medicina do ABC Santo AndreSPBrazil Department of Urology Asian Institute of Nephrology and UrologyHyderabadTGIndia Department of Urology National University HospitalSingapore Department of Urology Marmara University School of MedicineIstanbulTurkey Department of Urology Medipol Mega University HospitalIstanbul Medipol UniversityIstanbulTurkey Department of Urology Hospital Quiron BarcelonaBarcelonaSpain Department of Urology Clinique PasteurToulouseFrance Department of Urology Indiana University School of MedicineIndianapolisINUSA Division of Urology Department of SurgeryUniversity Health NetworkUniversity of TorontoTorontoCanada Department of Urology University Hospital Southampton NHS TrustSouthamptonUK Department of Urology Ng Teng Fong General HospitalNUHSSingapore

Objective:To scrutinize the definitions of minimal invasive surgical therapy(MIST)and to investigate urologists’knowledge,attitudes,and practices for benign prostatic obstruction ***:A 36-item survey was developed with a Delphi *** on definitions of MIST and attitudes and practices of benign prostatic obstruction surgeries were *** were invited globally to complete the online *** was achieved when more than or equal to 70%responses were“agree or strongly agree”and less than or equal to 15%responses were“disagree or strongly disagree”(consensus agree),or when more than or equal to 70%responses were“disagree or strongly disagree”and less than or equal to 15%responses were“agree or strongly agree”(consensus disagree).Results:The top three qualities for defining MIST were minimal blood loss(n=466,80.3%),fast post-operative recovery(n=431,74.3%),and short hospital stay(n=425,73.3%).The top three surgeries that were regarded as MIST were Urolift®(n=361,62.2%),Rezum®(n=351,60.5%),and endoscopic enucleation of the prostate(EEP)(n=332,57.2%).Consensus in the knowledge section was achieved for the superiority of Urolift®,Rezum®,and iTIND®over transurethral resection of the prostate with regard to blood loss,recovery,day surgery feasibility,and post-operative *** in the attitudes section was achieved for the superiority of Urolift®,Rezum®,and iTIND®over transurethral resection of the prostate with regard to blood loss,recovery,and day surgery *** on both sections was achieved for EEP as the option with the better symptoms and flow improvement,lower retreatment rate,and better suitable for prostate more than 80 ***:Minimal blood loss,fast post-operative recovery,and short hospital stay were the most important qualities for defining ***®,Rezum®,and EEP were regarded as MIST by most urologists.

关键词： Benignprostate hyperplasia Minimalinvasive surgical therapy Surgery Bladderoutlet obstruction

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急性缺血性卒中血管内治疗质量改进的多学会共识

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国际脑血管病杂志 2013年第11期21卷 807-820页

作者： David Sacks Carl M. Black Christophe Cognard John J. Connors Donald Frei Rishi Gupta Tudor G. Jovin bryan Kluck Philip M. Meyers Kieran J. Murphy Stephen Ramee Daniel A. Rufenacht M.J. Bernadette Stallmeyer Dierk Vorwerk 皮燕(译) 张莉莉(译) 李敬诚(译) Department of Interventional Radiology Reading Hospital and Medical Center West Reading Center for Neuroendovascular Therapy University of Pittsburgh Medical Center Stroke Institute Pittsburgh The Heart Care Group Allentown Pennsylvania Department of Radiology Utah Valley Regional Medical Center Provo Utah Departments of Radiology Neurological Surgery and Neurology Vanderbilt University Medical Center Nashville Tennessee Department of Neurointerventional Surgery Radiology Imaging Associates and Swedish Medical Center Denver Colorado Department of Neurology Emory Clinic Atlanta Georgia Department of Neurological Surgery Columbia University College of Physicians and Surgeons New York New York Department of Interventional Cardiology Ochsner Medical Center New Orleans Louisiana Diagnostic and Therapeutic Neuroradiology Service Centre Hospitalier Universitaire de Toulouse Hopital Purpan Toulouse France Department of Medical Imaging University of Toronto Toronto Ontario Canada Neuroradiology Division Swiss Neurolnstitute Clinic Hirslanden Zurich Switzerland Institute for Diagnostic and Interventional Radiology Klinikum Ingolstadt Ingolstadt Germany 重庆第三军医大学第三附属医院野战外科研究所神经内科 400042

目的这份国际性多学科共识文件将对急性缺血性卒中诊治过程和临床转归的质量标准进行定义，并希望在质量保证程序中使用这些标准，从而评估和改善急性卒中血运重建的过程和转归。材料和方法写作组成员由美国神经放射学学会、加拿大介入... 详细信息

目的这份国际性多学科共识文件将对急性缺血性卒中诊治过程和临床转归的质量标准进行定义，并希望在质量保证程序中使用这些标准，从而评估和改善急性卒中血运重建的过程和转归。材料和方法写作组成员由美国神经放射学学会、加拿大介入放射学协会、欧洲心血管和介入放射学学会、心血管造影和介入学会、介入放射学学会、神经介入外科学会、欧洲微创神经病学治疗学会以及血管和介入神经病学学会认命。写作组回顾了1986年至2012年2月期间的相关文献，对急性缺血性卒中的诊疗过程和转归进行总结形成一份证据表，然后通过共识设立性能指标和阈值。本指南得到发起学会的批准，并计划在3年后进行全面更新。结果这份国际性多学科共识文件对诊治过程和临床转归的质量标准进行了定义，包括从入院到进行影像学检查、动脉穿刺和血运重建的时间间隔以及90d时的临床转归评估标准。结论本文件为急性缺血性卒中血管内血运重建程序提供了质量改进指南。

关键词：急性缺血性卒中血管内治疗质量改进学会介入放射学临床转归心血管造影质量标准

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Mobilizing Crop Biodiversity

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Molecular Plant 2020年第10期13卷 1341-1344页

作者： Susan McCouch Zahra Katy Navabi Michael Abberton Noelle L.Anglin Rosa Lia Barbieri Michael Baum Kirstin Bett Helen Booker Gerald L.Brown Glenn J.bryan Luigi Cattivelli David Charest Kellye Eversole Marcelo Freitas Kioumars Ghamkhar Dario Grattipaglia Robert Henry Maria Cleria Valadares Inglis Tofazzal Islam Zakaria Kehel Paul J.Kersey Graham J.King Stephen Kresovich Emily Marden Sean Mayes Marie Noelle Ndjiondjiop Henry T.Nguyen Samuel Rezende Paiva Roberto Papa Peter W.B.Phillips Awais Rasheed Christopher Richards Mathieu Flouard Maria Jose Amstalden Sampaio Uwe Scholz Paul D.Shaw Brad Sherman S.Evan Staton Nils Stein Jan Svensson Mark Tester Jose Francisco Montenegro Valls Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter Wenzl Loren H.Rieseberg Plant Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida La Molina Lima Peru 12Lima 15023Peru Embrapa Genetic Resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural Research in the Dry Areas(I CAR DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Department of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Department of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The James Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genome British Columbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat Genome Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation Lab for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,improved farm management,synthetic agrochemicals,and agricultural *** this"Green Revolution"intensified crop production,and is credited with reducing famine and malnutrition,its benefits were accompanied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stemming from increased monoculture and greater reliance on a smaller number of crops and crop varieties for the majority of our *** reduction in diversity has created vulnerabilities to pest and disease epidemics,climate variation,and ultimately to human health(Harlan,1972).

关键词： intensified crops agricultural

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