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An Unusual Case of Herpes Simplex Meningitis after Inadvertent Puncture of the Subarachnoid Space

Case Reports in Clinical Medicine 2021年第9期10卷 232-239页

作者： Richell Bastos vale bruno vítor martins santiago José Abel de Almeida Neto Luiz Otávio Ribeiro de Lemos Felgueiras Karine Grillo de Freitas Thiago dos Santos Ferreira Department of Anesthesiology Piedade Municipal Hospital Rio de Janeiro Brazil Department of Anesthesiology Marcílio Dias Naval Hospital Rio de Janeiro Brazil Interleague Association of Anesthesiology of the State of Rio de Janeiro Rio de Janeiro Brazil

The study seeks to report the clinical evolution of a patient who suffered an inadvertent subarachnoid puncture and evolved with a herpetic viral meningitis, confirmed by cerebrospinal fluid (CSF) analysis. Female, 48 years old, submitted to epidural anesthesia, for surgery, with median puncture, between L2-L3 and inadvertently accessed the subarachnoid space, with clear cerebrospinal fluid. The same puncture was used and the solution with 15 mg hyperbaric bupivacaine and 80 mcg morphine was administered. There was no complication during the entire surgical procedure. On the first postoperative day, she started complaining of headache and nausea, being treated with dipyrone, non-steroidal anti-inflammatory drugs (NSAIDs) and ondansetron. On the third day, she presented two episodes of seizure that ceased with the use of diazepam 10 mg. On the fifth day, the patient presented fever and seizures, which did not stop with medication, requiring sedation, orotracheal intubation and transfer to the intensive care unit. Lumbar puncture was performed for CSF analysis, which was positive for Herpes simplex type I. The patient was extubated, on the second day of hospitalization, maintained with a maintenance dose of phenytoin, sumatriptan, dipyrone, metoclopramide and acyclovir 500 mg, remaining intravenous, without presenting new seizures for 45 days, when she was discharged. After 30 days, he returned for a review consultation without making a complaint.

关键词： Headache Opioids Herpes Simplex Dural Puncture

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Learning to combine multiple string similarity metrics for effective toponym matching

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International Journal of Digital Earth 2018年第9期11卷 913-938页

作者： Rui Santos Patricia Murrieta-Flores bruno martins Instituto Superior Técnico and INESC-ID University of LisbonLisbonPortugal Digital Humanities Research Center University of ChesterChesterUK

Several tasks related to geographical information retrieval and to the geographical information sciences involve toponym matching,that is,the problem of matching place names that share a common *** this article,we present the results of a wide-ranging evaluation on the performance of different string similarity metrics over the toponym matching *** also report on experiments involving the usage of supervised machine learning for combining multiple similarity metrics,which has the natural advantage of avoiding the manual tuning of similarity *** with a very large dataset show that the performance differences for the individual similarity metrics are relatively small,and that carefully tuning the similarity threshold is important for achieving good *** methods based on supervised machine learning,particularly when considering ensembles of decision trees,can achieve good results on this task,significantly outperforming the individual similarity metrics.

关键词： Toponym matching supervised learning string similarity metrics duplicate detection ensemble learning geographic information retrieval

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In vitro antileishmanial effects of Physalis angulata root extract on Leishmania infantum

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Journal of Integrative Medicine 2018年第6期16卷 404-410页

作者： bruno Jose martins Da Silva Sandro Wilson Gomes Pereira Ana Paula Drummond Rodrigues Jose Luiz martins Do Nascimento Edilene Oliveira Silva Laboratory of Structural Biology Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging(INCT-INBEB) Rio de Janeiro 21941-901Brazil Laboratory of Electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil Laboratory of Molecular and Cellular Neurochemistry Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Neuroimmunomodulation(INCT-NIM) Rio de Janeiro 21040-360Brazil

Objective： In the present study, we evaluated the effects of the aqueous extract of Physalis angulata root （AEPa） on Leishmania infanturn proliferation, morphology, and the driving mechanism in leishmanicidal activity and modulatory action on macrophages. Methods： I., infantum promastigotes were treated with 50 and 100 μg/mL AEPa for 72 h and then antipro- mastigote assay was performed by counts in a Newbauer chamber, morphological changes were analyzed by transmission electron microscopy and the mechanism of the leishmanicidal activity was detected. In addition, macrophages were infected with L. infantum and were used to evaluate anti-amastigote activity of AEPa and effects of AEPa on cytokine secretion after 72-hour treatment. Results： Treatment with AEPa reduced the numbers ofL infantum promastigotes （50% inhibitory concen- tration （ICso） = 65.9μg/mL; selectivity index （SI）= 22.1） and amastigotes （ICso = 37.9 μg/mL; SI = 38.5） compared with the untreated control. Amphotericin B reduced 100% of the promastigote numbers after 72 h of treatment （IC50 = 0.2μg/mL）. AEPa induced several morphological changes and increased the production of reactive oxygen species and apoptotic death in promastigotes after treating for 72 h. AEPa （100 μg/mL） promoted tumor necrosis factor-α secretion in macrophages infected with L. infantum after 72 h of treatment, but did not induce an increase in this cytokine in noninfected macrophages. In addition, AEPa showed no cytotoxic effect on J774-A1 cells （50% cytotoxic concentration 〉1000μg/mL）. Conclusion： AEPa presented antileishmanial activity against the promastigotes and amastigotes of I.. infantum without macrophage cytotoxicity; these results show that natural products such as P. angulata have leishmanicidal potential and in the future may be an alternative treatment for leishmaniasis.

关键词： Leishmanicidal activity Leishmania infantum Reactive oxygen species Apoptosis Physalis angulata

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Somatostatin 3 loss of function impairs the innate immune response to intestinal inflammation

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Aquaculture and Fisheries 2021年第6期6卷 548-557页

作者： Jing Ma Jie Chen bruno Louro Rute S.T.martins Adelino v.M.Canario International Research Center for Marine Biosciences Ministry of Science and TechnologyShanghai Ocean UniversityShanghai201306China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China CCMAR-Centre of Marine Sciences University of the AlgarveGambelas Campus8005-139FaroPortugal

Somatostatin is a neuropeptide and a key regulator of the growth *** Sst encoding genes(sst1 to sst6)have been identified in teleost fish genomes but little is known about their *** present study aimed at replicating the context of the inflammatory bowel disease(IBD)and clarifying the involvement of sst3 in the intestine innate defence barrier in zebrafish *** first established a CRISP/Cas9 sst3 deficient line(MT)and analysed the morphological and transcriptomic response to 0.4%dextran sulfate sodium(DSS).Alcian blue staining of larval sections 6 days post fertilization showed an increased in acidic mucins in the intestinal bulb and mid-intestine,with a much stronger response in the MT compared to wild type(WT).The transcriptomic analysis revealed that WT and MT shared enriched gene ontology(GO)terms and pathways linked to catabolism,chondrocyte development,innate immune system,xenobiotic metabolism and oxidative *** contrast,the WT specific response to DSS was enriched in GO terms and pathways linked to transcription and translation,various developmental processes,regulation of biosynthetic processes,apelin signalling and apoptosis while the MT specific response included terms and pathways linked to protein metabolism and catabolic processes,extracellular matrix-receptor interaction and proteasome and chondrocyte ***,this study demonstrated that Sst3 deficiency impairs insulin growth factor and adipocytokine signalling exacerbating the inflammatory response to DSS.

关键词： Somatostatin 3 Zebrafish IBD Inflammation RNA-Seq

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Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity:a review

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Journal of Integrative Medicine 2018年第4期16卷 211-222页

作者： bruno Jose martins Da Silva Amanda Anastacia Pinto Hage Edilene Oliveira Silva Ana Paula Drummond Rodrigues Laboratory of Parasitology and Laboratory of Structural Biology Institute of Biological SdencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging Rio de JaneiroRio de Janeiro 21941-901Brazil Laboratory of Electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil

Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and com- pounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis.

关键词： Amazonian plants Leishmaniasis treatment Plant compounds Plant extracts Plant oils

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Late onset acute vogt-Koyanagi-Harada syndromechallenges on the way

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 524-527页

作者： Sandra Rodrigues-Barros Jacqueline martins Sousa bruno Carvalho Gabriel Andrade Heloisa Nascimento Department of Ophthalmology Hospital Garcia de Orta Avenida Torrado da Silva Almada 2801-951 Portugal Department of Ophthalmology and visual Sciences Escola Paulista de Medicina Universidade Federal de Sao Paulo Rua Botucatu 821 Vila Clementino Sao Paulo SP 04023-062 Brazil Department of Ophthalmology Centro Hospitalar de Lisboa Central Alameda Santo Antonio dos Capuchos Lisboa 1169- 050 Portugal

Dear Editor,We would like to share some clinical cases of late onset acute vogt-Koyanagi-Harada syndrome （vKH）, a rare diagnosis in this age range.

关键词： Late onset acute vogt-Koyanagi-Harada syndromechallenges the way

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A Contribution to the Analysis of Frequency Response and Impedance Measurements to Evaluation and Diagnosis of Power Transformers

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高电压技术 2008年第12期34卷 2655-2661页

作者： Helvio J. A. martins Cintia de Faria Ferreira bruno Urbani CEPEL-Electric Power Research Center Av. Horacio Macedo 354-Cidade Universitaria Zip Code 21941-911-Rio de Janeiro RJ Brazil

This paper has an objective to show a developed quantitative criterion,based in two mathematical variables that explicit the deviation degree of a normal situation,applying simultaneously data from terminal impedances and frequency *** in more than 100-measured equipment,of different applications(step-up transformer,transmission transformer,etc.,),for a period of 10 years,the work presents some examples of practical application of this methodology in Brazilian Electrical System.

关键词：变压器评估诊断频响阻抗传输函数关联系数

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ENSO impacts on litter stocks and water holding capacity in secondary forests in eastern Amazonia

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Journal of Forestry Research 2024年第1期35卷 83-89页

作者： Julia Isabella de Matos Rodrigues Walmer bruno Rocha martins victor Pereira de Oliveira Myriam Suelen da Silva Wanzerley Hélio Brito dos Santos Júnior Francisco de Assis Oliveira Graduate Program in Forestry Sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Institute of Amazonia Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Among the impacts of climate change,there is the intensification of phenomena such as the El Niño South-ern Oscillation(ENSO)responsible for El Niño and La Niñ***,understanding their effects on the functional pro-cesses of forests is ***,this study evaluated the effects of ENSO on litter stock and water holding capac-ity(WHC)in a successional forest in eastern *** occurred in periods with the most rainfall in El Niño(2019)and least in La Niña(2021)*** permanent plots were used to sample *** effects were evident for WHC,higher during El Niñ***,this influence was not clear for litter,as only in the rainy season effects were *** was a positive correlation of WHC with precipitation and humidity,while litter stocks were negatively correlated with temperature and wind *** the subject of this study requires long-term assessments,preliminary results suggests that,depending on the intensity of ENSO,forest functional processes can be strongly impacted and *** conclusion reinforces warnings by the scientific community about the impacts of climate change on the maintenance of litter stocks,decomposition and,consequently,the biogeochemical cycle and essential ecosystem services for the maintenance of Amazonia *** need to develop long-term research to understand the effects of climatic change on litter stocks and water holding capacity is highlighted,especially in Amazonia.

关键词： Seasonality Climate change Succession ecosystem Biogeochemical cycle Amazonia biodiversity

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Hydroethanolic extract of Smallanthus sonchifolius leaves improves hyperglycemia of streptozotocin induced neonatal diabetic rats

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 420-424页

作者： Silmara Baroni bruno Ambrosio da Rocha Juliana Oliveira de Melo Jurandir Fernando Comar Silvana martins Caparroz-Assef Ciomar Aparecida Bersani-Amado Department of Pharmacology and Therapeutic State University of MaringaParanaBrazil Department of Biochemistry State University of MaringaParanaBrazil

Objective: To evaluate the effect of hydroethanolic extract of yacon on the hyperglycemia induced by streptozotocin(STZ) in neonatal rats. Methods: Wistar rats aged two days old received an intraperitoneal injection of STZ(160 mg/kg); after seven weeks, glycosuria was determined and animals with glucose levels above 250 mg/d L were included in the study. Groups of diabetic and non-diabetic rats were treated orally with yacon extract at a dose of 400 mg/kg/d for 14 d. Tests were made for phytochemical characterization, glucose tolerance and toxicity. Results: The results showed that treatment with the extract reduced the glucose levels of fed diabetic rats and did not change the glucose levels of fasting diabetic and normal rats. Additionally, also it was observed that treatment with the extract reduced blood glucose levels of diabetic rats during the oral and intravenous glucose tolerance tests. There was no change in body weight, liver enzymes or mortality with yacon extract treatment. The phytochemical screening revealed the presence of caffeic acid, chlorogenic acid, ferulic acid and gallic acid. Conclusions: The data suggest that yacon extract reduces hyperglycemia, possibly by improving insulin sensibility through its phytochemicals constituents(phenolic compounds).

关键词： Yacon extract Hyperglycemia Insulin sensibility Streptozotocin

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SuperSAGE digital expression analysis of differential growth rate in a European sea bass population

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Aquaculture and Fisheries 2019年第1期4卷 17-26页

作者： bruno Louro Rute S.T.martins Patricia I.S.Pinto Richard Reinhardt Dirk-Jan de Koning Adelino v.M.Canario Deborah M.Power CCMAR-Centre of Marine Sciences University of AlgarveCampus de GambelasFaro 8005-139Portugal Max Planck Genome Centre Carl-von-Linne-Weg 10Köln 50829Germany The Roslin Institute and R(D)SvS University of EdinburghEaster BushMidlothian EH259RGScotland UK Department of Animal Breeding and Genetics Swedish University of Agricultural SciencesBox 7023Uppsala 75007Sweden

One of the goals of the aquaculture industry is to understand and control growth associated traits through selective *** the present study the molecular basis of growth heterogeneity in the European sea bass(Dicentrarchus labrax)was *** establish growth heterogeneity in a group of hatchery bred sea bass individuals were tagged and their specific growth rates(SGR)determined at monthly *** expression in the brain,liver and white muscle from fish with the most divergent sustained SGR(6 individuals of the first and last quartile)was assessed using SuperSAGE(Serial Analysis Gene Expression)combined with next generation SOLiD4 sequencing.A total of approx.11 million edited tags(26 bp),on average 2 million tags per SAGE library,that represented 47.071 unique transcripts were *** of transcripts in fish with high and low SGR yielded 344,698 and 601 differently expressed tags(0.01%false discovery rate and 4-fold change)in brain,liver and muscle,*** tags were mapped onto the sea bass genome and approximately one third of the tags could be assigned to annotated *** enrichment analysis revealed in liver,muscle and brain intricate gene expression changes in endocrine regulatory pathways involved in growth,metabolic and the stress axis,underlying divergent SGR in sea bass.

关键词： European sea bass Specific growth rate Gene expression SuperSAGE Pathways

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