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Experimental nerve transfer model in the neonatal rat

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Neural Regeneration Research 2022年第5期17卷 1088-1095页

作者： Matthias E.Sporer Martin Aman Konstantin D.Bergmeister Dieter Depisch Katharina M.Scheuba Ewald Unger bruno K.podesser Oskar c.Aszmann christian Doppler Laboratory for the Restoration of Extremity Function Department of SurgeryMedical University of ViennaViennaAustria clinical Laboratory for Bionic Extremity Reconstruction Department of SurgeryMedical University of ViennaViennaAustria Division of Biomedical Research Medical University of ViennaViennaAustria Department of plastic Aesthetic and Reconstructive SurgeryUniversity Hospital of St.PoeltenKarl Landsteiner University of Health SciencesSt.PoeltenAustria center for Medical physics and Biomedical Engineering Medical University of ViennaViennaAustria Division of plastic and Reconstructive Surgery Medical University of ViennaViennaAustria

clinically,peripheral nerve reconstructions in neonates are most frequently applied in brachial plexus birth *** surgical concepts,however,have investigated nerve reconstructions in adult animal *** immature neuromuscular system reacts differently to the effects of nerve lesion and surgery and is poorly investigated due to the lack of reliable experimental ***,we describe an experimental forelimb model in the neonatal rat,to study these effects on both the peripheral and central nervous *** 24 hours after birth,three groups were prepared:In the nerve transfer group,a lesion of the musculocutaneous nerve was reconstructed by selectively transferring the ulnar *** the negative control group,the musculocutaneous nerve was divided and not reconstructed and in the positive control group,a sham surgery was *** animal's ability to adapt to nerve lesions and progressive improvement over time were depict by the Bertelli test,which observes the development of *** weeks postoperatively,animals were fully matured and the nerve transfer successfully reinnervated their target muscles,which was indicated by muscle force,muscle weight,and cross sectional area *** the contrary,no spontaneous regeneration was found in the negative control *** the positive control group,reference values were *** labeling indicated that the motoneuron pool of the ulnar nerve was reduced following nerve *** to this post-axotomy motoneuron death,a diminished amount of motoneurons reinnervated the biceps muscle in the nerve transfer group,when compared to the native motoneuron pool of the musculocutaneous *** findings indicate that the immature neuromuscular system behaves profoundly different than similar lesions in adult rats and explains reduced muscle ***,pathophysiologic adaptations are *** maturing neuromuscular system,however,utilizes neonatal capacity of regener

关键词： brachial plexus birth injury experimental rat model extremity reconstruction methodological paper neonatal rat nerve reconstruction nerve regeneration nerve transfer neural plasticity peripheral nerve surgery

carbon-13 Solid State NMR Techniques to Evaluate the Morphology of pp/TiO₂ composites

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Materials Sciences and Applications 2016年第1期7卷 20-25页

作者： Igor lopes Soares Maria Inês bruno Tavares André Luis B. B. e Silva Antonio Gabriel Malagueta Feio Instituto de Macromoléculas Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Federal do Mato Grosso IFMT Mato Grosso Brazil cENIMAT/I3N Departamento de Ciência dos Materiais Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa Caparica Portugal

Solid state NMR was successfully used to determine the proton spin-lattice relaxation time in the rotating frame (T1ρH) for systems based on polypropylene (pp) and pp with titanium dioxide (TiO2) organically modified or unmodified incorporated, in order to understand the molecular behavior of these systems. These techniques were employed in the samples organically modified and unmodified TiO2 to investigate the effect of organic modification on the dispersion and distribution of the particles in the pp matrix. The results were analyzed in terms of the effect of the particles organic modified or not according to the intermolecular interaction in the composites. According to the T1ρH values, all composites showed at least two domains: the short values were related to the rigid part, which included the crystalline and amorphous phase constricted in it, while the longer times were attributed to the amorphous region, which had higher molecular mobility compared to the rigid region of the materials. The increase in the relaxation time parameter in the composites compared to the pure pp was associated to the strong interaction between titanium dioxide particles and the polymer chains. This effect was more pronounced for the systems containing organically modified TiO2. According to the results, it could be inferred that intermolecular interaction occurred in the cH2 and cH groups, being more intense with cH2 groups. Finally, the solid state NMR techniques were able to evaluate the molecular dynamics of those systems.

关键词： NMR pp TiO2 composites

前陆褶皱冲断带厚皮缩短盐构造运动的物理模拟

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高校地质学报 2004年第1期10卷 39-49页

作者：戈红星 bruno c.Vendeville Martin p.A.Jackson 菲利普斯中国有限公司北京100027 美国德克萨斯大学经济地质局 austintexas78713

尺度物理实验用干石英砂和聚合硅树脂为实验材料 ,模拟了前陆褶皱冲断带厚皮缩短盐构造 ,并与薄皮缩短盐构造及无盐层的褶皱冲断带构造模型进行了对比。实验表明 ,由于塑性盐层的存在 ,厚皮缩短盐构造呈 3层式结构模式。盐上层主要形成... 详细信息

尺度物理实验用干石英砂和聚合硅树脂为实验材料 ,模拟了前陆褶皱冲断带厚皮缩短盐构造 ,并与薄皮缩短盐构造及无盐层的褶皱冲断带构造模型进行了对比。实验表明 ,由于塑性盐层的存在 ,厚皮缩短盐构造呈 3层式结构模式。盐上层主要形成敞开褶皱、箱状褶皱、前冲和背冲断层以及冲垒构造 ,盐下层形成逆冲断层及冲垒构造 ,断层通常都终止于盐层中。尽管盐层局部变薄或增厚 ,但不形成刺穿型盐构造。褶皱冲断带不具构造指向特征 ,其楔形库仑锥剖面呈平台与斜坡两段式形态。模型对比表明 ,厚皮缩短与薄皮缩短所产生的盐上层构造形态相似 ,不易区分 ;但二者的库仑锥剖面有所不同。厚皮前陆褶皱冲断盐构造与无盐层的褶皱冲断构造无论是其几何形态、还是库仑锥剖面都有极大的差别 ,极易区分。实验结果对解释前陆褶皱冲断构造和寻找盐下油气圈闭都有着重要的指导意义。

关键词：前陆褶皱冲断带厚皮缩短盐构造运动物理模拟构造地质学

Use of Intragastral Balloon and Increase in Fertility： case Report

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Journal of pharmacy and pharmacology 2018年第4期6卷 403-409页

作者： Leite Leticia Torres Araujo Anna Barbara Ribeiro Souza Luma Lorraine dos Reis Sander bruno Queiroz lopes Joanilva Ribeiro Medical school of FAMINAS-BH College of Minas-BHBelo Horizonte 30110012Brazil Bariatric Endoscopy by UFMG Belo Horizonte 30150285Brazil UNIMONTES and prominas colleges Montes Claros 39403440Brazil

The IGB （intragastric balloon） is a silicone device, inflated by endoscopy in the gastric cavity, with physiological saline and a blue dye, up to the volume of 700 mL, and used for a maximum of 6 months, It is indicated for patients with BMI〉27 kg/m^2 that have not undergone previous gastric surgery. In obese women there is a decrease in peripheral resistance fertility, and the weight loss achieved in bariatric surgery improves fertility due to reduced subcutaneous fat, with lower insulin resistance. Similar results could be achieved through the use of IGB, a less invasive method. The objective of the article is to report the case of a patient who became pregnant using IGB, considering the hypothesis that the increase in fertility was due to weight loss and/or due to the improvement in the self-esteem （and sexual life） of patient. We selected 13 articles from pubMed, UpToDate, JAMA and a case report. Results： Balloon with drawal occurred on 05/02/16 after positive pregnancy test with final weight 65.5 kg and BMI 25.91 kg/m2. conclusions： Weight loss actually favors fertility, but self-esteem may have been instrumental in improving the sex life, enabling conception.

关键词： IGB fertility pregnancy obesity.

Monitoring of Ultrafine particles in the Surrounding Urban Area of In-Land passenger Ferries

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Journal of Environmental protection 2019年第6期10卷 838-860页

作者： Margarida lopes Ana Russo célia Gouveia Francisco Ferreira Department of Sciences and Environmental Engineering NOVA School of Science and Technology NOVA University of Lisbon Caparica Portugal Instituto Dom Luiz (IDL) Faculdade de Ciências da Universidade de Lisboa Lisboa Portugal portuguese Institute for Sea and Atmosphere Lisbon Portugal centre for Environmental and Sustainability Research (cENSE) NOVA School of Science and Technology NOVA University of Lisbon Caparica Portugal

Maritime transportation, widely used both in international transport of goods and touristic purposes, has been identified as a significant source of ultrafine particles (UFp). In-land passenger ferry is a source of UFp far less addressed;however, in locations with relatively high frequency of this transportation mode, it is expected that they contribute to an increase of their concentration. Moreover, the negative effects of UFp on human health and environment are known and therefore, monitoring UFp produced by ferries is vital to assess the degree of exposure of who work or live close to ferries’ terminals or downwind to their cruising path. This work aims to study the influence of in-land ferries activities on UFp in the urban/suburban areas near ferries’ terminals and downwind across the cruising path. The UFp monitoring campaign was carried out from September to December 2018 for 19 non-consecutive periods. The sampling sites were chosen in order to maximize measurements under downwind conditions and allow the association between ferry operation and UFp concentration response. Based on data collected, correlation analysis was performed between ferry’s traffic and particle number counting (pNc) of UFp, and also with meteorological variables. Results show an increase in pNc ranging from 25 to 197% during the third minute around a ferry movement and are moderate to positive significant correlations between pNc values and the number of ferry operations (r = 0.79 to r = 0.94), showing that UFp emitted by in-land ferries contributes to pNc increase. Moreover, negative correlations (r = -0.85 to r = -0.93) between pNc and wind intensity were also found.

关键词： Air pollution pNc In-Land passenger Ferries Monitoring campaign Health

carpobrotus edulis(L.) ***. extract as a skin preserving agent: From traditional medicine to scientific validation

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Journal of Integrative Medicine 2021年第6期19卷 526-536页

作者： Miriam Bazzicalupo Laura cornara bruno Burlando Alberta cascini Marcella Denaro Antonella Smeriglio Domenico Trombetta3 Department for the Earth Environment and Life Sciences(DiSTAV)University of GenovaGenova 16132Italy Department of pharmacy University of GenovaGenova 16132Italy Department of chemical BiologicalPharmaceutical and Environmental SciencesUniversity of MessinaMessina 98166Italy

Objective:carpobrotus edulis(L.)*** a succulent perennial plant native to South Africa and grows invasively in the Mediterranean *** is commonly used for the treatment of various diseases,including skin wound healing and regeneration,for which experimental validation is *** therefore evaluated the skin healing properties by testing a *** aqueous leaf extract(cAE)on cell cultures and in enzymatic ***:Micro-morphological analysis of leaves was carried out using scanning electron microscopy and light *** features and antioxidant activity of cAE were evaluated by reversed-phase liquid chromatography coupled with diode array detection and electrospray ion trap mass spectrometry(Rp-Lc-DAD-ESI-MS),and in vitro cell-free *** activities were evaluated using keratinocytes and fibroblasts,as well as elastase,collagenase,and ***:cAE showed high carbohydrates(28.59%±0.68%),total phenols([101.9±6.0]g gallic acid equivalents/kg dry extract[DE]),and flavonoids([545.9±26.0]g rutin equivalents/kg DE).Rp-Lc-DAD-ESI-MS revealed the predominant presence of hydroxycinnamic acids(51.96%),followed by tannins(14.82%)and flavonols(11.32%).The extract was not cytotoxic,had a strong and dose-dependent antioxidant activity,and inhibited collagenase(>90%at 500 mg/m L)and hyaluronidase(100%at 1000 mg/m L).In cell culture experiments,cAE increased wound closure and collagen production,which was consistent with its high polyphenol ***:Our data support the use of the *** for skin care and the treatment of skin ***,use of *** for skin care purposes could be an eco-friendly solution to reduce its invasiveness in the environment.

关键词： Traditional medicine carbohydrates polyphenols Antioxidant Wound healing

computer-Aided Design of Some Advanced Steels and cemented carbides

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Journal of Iron and Steel Research International 2005年第6期12卷 42-48页

作者： LI Lin ZHANG Mei HE Yan-lin De cooman bruno Wollants patrick Shanghai University Shanghai 200072 China Katholieke Universiteit Leuven Leuven 13-3001 Belgium Universiteit Gent Zwijnaarde 13-9052 Belgium

Thermodynamic and kinetic study on TRIp （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIp steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIp was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-co-c （M= Ti, Ta, Nh） systems and co-V-c system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.

关键词： computer-aided composition design TRIp steel cemented carbide prehardened mould steel concentration profile thermodynamic kinetic equilibrium composition

Health care-associated hepatitis c virus infection

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World Journal of Gastroenterology 2014年第46期20卷 17265-17278页

作者： bruno pozzetto Meriam Memmi Olivier Garraud Xavier Roblin philippe Berthelot Groupe Immunité des Muqueuses et Agents pathogènes (GIMAp EA3064) Faculty of Medecine of Saint-EtienneUniversity of Lyon42023 Saint-EtienneFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-Etienne42055 Saint-EtienneFrance Institut National de la Transfusion Sanguine 75015 ParisFrance Department of Gastroenterology and Hepatology University-Hospital of Saint-Etienne42055 Saint-EtienneFrance Department of Infectious Diseases and Hygiene University-Hospital of Saint-Etienne42055 Saint-EtienneFrance

Hepatitis c virus(HcV)is a blood-borne pathogen that has a worldwide distribution and infects millions of ***-associated HcV infections represented a huge part of hepatitis c burden in the past via contaminated blood and unsafe injections and continue to be a serious problem of public *** present review proposes a panorama of health care-associated HcV infections via the three mode of contamination that have been identified:(1)infected patient to non-infected patient;(2)infected patient to non-infected health careworker(HcW);and(3)infected HcW to non infected *** each condition,the circumstances of contamination are described together with the means to prevent *** a whole,the more important risk is represented by unsafe practices regarding injections,notably with the improper use of multidose vials used for multiple *** questions of occupational exposures and infected HcWs are also *** terms of prevention and surveillance,the main arm for combating care-associated HcV infections is the implementation of standard precautions in all the fields of cares,with training programs and audits to verify their good *** must be sensitized to the risk of blood-borne pathogens,notably by the use of safety devices for injections and good hygiene practices in the operating theatre and in all the invasive *** providers performing exposed-prone procedures must monitor their HcV serology regularly in order to detect early any primary infection and to treat it without *** the need to stay vigilant because HcV infection is often a hidden risk,it can be hoped that the number of people infected by HcV via health care will decrease very significantly in the next years.

关键词： Hepatitis c virus Health care-associated infection Health care worker Standard precautions Hemodialysis Unsafe injections Occupational exposure Antiviral drugs

Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

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Bioactive Materials 2023年第11期29卷 151-176页

作者： Filipe V.Ferreira Alana G.Souza Rubina Ajdary Lucas p.de Souza Jo˜ao H.lopes Daniel S.correa Gilberto Siqueira Hernane S.Barud Derval dos S.Rosa Luiz H.c.Mattoso Orlando J.Rojas Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa Instrumentation-Rua XV de Novembro1452S˜ao CarlosSP13560-979Brazil center for Engineering Modelingand Applied Social Sciences(CECS)Federal University of ABC(UFABC)Santo Andr´eBrazil Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityP.O.Box 16300AaltoEspooFIN-00076Finland college of Engineering and physical Sciences Aston Institute of Materials ResearchAston UniversityBirminghamUK Department of chemistry Division of Fundamental Sciences(IEF)Technological Institute of Aeronautics(ITA)S˜ao Jose dos CamposSPBrazil Laboratory for cellulose&Wood Materials Empa-Swiss Federal Laboratories for Materials Science and TechnologyÜberlandstrasse 1298600DübendorfSwitzerland Biopolymers and Biomaterials Laboratory(BIOpOLMAT) University of Araraquara(UNIARA)Araraquar114801-340S˜ao PauloBrazil Bioproducts Institute Department of Chemical&Biological EngineeringDepartment of Chemistry andDepartment of Wood ScienceThe University of British Columbi12360 East MallVancouverBCV6T 1Z3Canada

We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

关键词： cellulose nanofibrils cellulose nanocrystals Regenerative medicine Biomaterial Sustainable materials Green nanomaterials