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中国病理生理杂志 2012年第11期 2086-2087页

作者： Patricia NGUYEN Divya NAG Preston D.LAVINGHOUSEZ Jordan R.PLEW Andrew S.LEE bruno c.huber Won Hee LEE Patricia E.de ALMEIDA Jennfier LYONS Fumi IKENO Robert c.ROBBINS Michael T.LONGAKER Joseph c.WU Department of Medicine Division of Cardiovascular MedicineStanford University School of MedicineStanfordCA 94305-5101USA Department of Pediatrics Stanford University School of MedicineStanfordCA 94305-5101USA Department of Radiology Molecular Imaging ProgramStanford University School of MedicineStanfordCA 94305-5101USA Department of cardiothoracic Surgery Stanford University School of MedicineStanfordCA 94305-5101USA Department of Plastic Surgery Stanford University School of MedicineStanfordCA 94305-5101USA

AIM:Induced pluripotent stem cells(iPScs)hold great promise for the development of patient-specific therapies for cardiovascular ***,clinical translation will require preclinical optimization and validation of large a... 详细信息

关键词： iPSc cell Microfluidic single cell analysis shows porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation stem

Planar matrices and arrays of Feynman diagrams

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communications in Theoretical Physics 2024年第3期76卷 15-32页

作者： Freddy cachazo Alfredo Guevara bruno Umbert Yong Zhang Perimeter Institute for Theoretical Physics WaterlooON N2L 2Y5Canada Department of Physics and Astronomy University of WaterlooWaterlooON N2L 3G1Canada cEcs Valdivia y Departamento de Física Universidad de ConcepciónCasilla 160-CConcepciónChile center for the Fundamental Laws of Nature Society of Fellows and Black Hole InitiativeHarvard UniversityCambridgeMA 02138United States of America Department of Applied Mathematics Western UniversityLondonON N6A 5B7Canada cAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China

Recently,planar collections of Feynman diagrams were proposed by Borges and one of the authors as the natural generalization of Feynman diagrams for the computation of k=3 biadjoint *** collections are one-dimensional arrays of metric trees satisfying an induced planarity and compatibility *** this work,we introduce planar matrices of Feynman diagrams as the objects that compute k=4 biadjoint *** are symmetric matrices of metric trees satisfying compatibility *** introduce two notions of combinatorial bootstrap techniques for finding collections from Feynman diagrams and matrices from *** applications of the first,we find all 693,13612 and 346710 collections for(k,n)=(3,7),(3,8)and(3,9),*** applications of the second kind,we find all90608 and 30659424 planar matrices that compute(k,n)=(4,8)and(4,9)biadjoint amplitudes,*** an example of the evaluation of matrices of Feynman diagrams,we present the complete form of the(4,8)and(4,9)biadjoint *** also start a study of higher-dimensional arrays of Feynman diagrams,including the combinatorial version of the duality between(k,n)and(n-k,n)objects.

关键词： Feynman diagrams biadjoint amplitudes tropical Grassmannian

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Protective effect of long-chain polyunsaturated fatty acids on hepatorenal syndrome in rats

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World Journal of Nephrology 2024年第3期13卷 49-61页

作者： João bruno Beretta Duailibe cassiana Macagnan Viau Jenifer Saffi Sabrina Alves Fernandes Marilene Porawski Department of Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Department of Basic Health Sciences Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Department of Hepatology and Basic Health Sciences Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil

BAcKGROUND Hepatorenal syndrome(HRS)is the most prevalent form of acute kidney injury in cirrhotic *** is characterized by reduced renal blood flow and represents the most severe complication in cirrhotic patients with advanced *** research has indicated that antioxidants can delay the onset of a hyperdynamic circulatory state in cirrhosis and improve renal function in HRS *** omega-3 supplementation has significantly reduced the risk of liver *** supplementation could represent an additional therapy for individuals with *** To evaluated the antioxidant effect of omega-3 polyunsaturated fatty acid supplementation on the kidneys of cirrhotic *** Secondary biliary cirrhosis was induced in rats by biliary duct ligation(BDL)for 28 *** used 24 male Wistar rats divided into the following groups:I(control);II(treated with omega-3,1 g/kg of body weight);III(BDL treated with omega-3,1 g/kg of body weight);and IV(BDL without treatment).The animals were killed by overdose of anesthetic;the kidneys were dissected,removed,frozen in liquid nitrogen,and stored in a freezer at-80℃for later *** evaluated oxidative stress,nitric oxide(NO)metabolites,DNA damage by the comet assay,cell viability test,and apoptosis in the *** were analyzed by one-way analysis of variance,and means were compared using the Tukey test,with P≤*** Omega-3 significantly decreased the production of reactive oxygen species(Pcirrhotic rats treated with omega-3(Pctivity of the antioxidant enzymes superoxide dismutase and catalase increased in the BDL+omega-3 group compared to the BDL group(Pction,DNA damage,and caspase-9 cleavage decreased significantly in the omega-3-treated BDL *** was an increase in mitochondrial electrochemical potential(Pcompared to *** changes in the cell survival index in HRS with omega-3 c

关键词： Long-chain polyunsaturated fatty acids Antioxidant effect Hepatorenal syndrome Liver cirrhosis Reactive oxygen species Apoptosis

The root-knot nematode effectorMi2G02 hijacks a host plant trihelix transcription factor to promote nematode parasitism

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Plant communications 2024年第2期5卷 151-168页

作者： Jianlong Zhao Kaiwei Huang Rui Liu Yuqing Lai Pierre Abad bruno Favery Heng Jian Jian Ling Yan Li Yuhong Yang Bingyan Xie Michael Quentin Zhenchuan Mao State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China INRAE Universite´Cote d’AzurCNRSISA06903 Sophia AntipolisFrance Department of Plant Pathology and Key Laboratory of Pest Monitoring and Green Management of the Ministry of Agriculture China Agricultural UniversityBeijing 100193China

Root-knot nematodes(RKNs)cause huge agricultural losses every *** secrete a repertoire of effectors to facilitate parasitism through the induction of plant-derived giant feeding cells,which serve as their sole source of ***,the mode of action of these effectors and their targeted host pro-teins remain largely *** this study,we investigated the role of the effector Mi2G02 in Meloidogyne incognita ***-derived Mi2G02 RNA interference in Arabidopsis thaliana affected giant cell development,whereas ectopic expression of Mi2G02 promoted root growth and increased plant sus-ceptibility to *** used various combinations of approaches to study the specific interactions between Mi2G02 and *** GT-3a,a trihelix transcription ***-3a knockout in *** affected feeding-site development,resulting in production of fewer egg masses,whereas GT-3a overex-pression in *** increased susceptibility to *** and also root ***,we demon-strated that Mi2G02 plays a role in maintaining GT-3a protein stabilization by inhibiting the 26S proteasome-dependent pathway,leading to suppression of TOZ and RAD23c expression and thus promoting nematode *** work enhances our understanding of how a pathogen effector manipulates the role and regulation of a transcription factor by interfering with a proteolysis pathway to reprogram gene expression for development of nematode feeding cells.

关键词： Meloidogyne incognita effector giant cell Mi2G02 transcription factor interaction

Driving factors behind multiple populations

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Science china(Physics,Mechanics & Astronomy) 2024年第5期67卷 172-181页

作者： Ruoyun Huang Baitian Tang chengyuan Li Doug Geisler Mario Mateo Ying-Yi Song Holger Baumgardt Julio A.carballo-Bello Yue Wang Jundan Nie bruno Dias JoséG.Fernández-Trincado School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China cSST Science center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China Departamento de Astronomía Universidad de ConcepcionConcepcionChile Instituto de Investigación Multidisciplinario en ciencia y Tecnología Universidad de La SerenaLa SerenaChile Departamento de Astronomía Facultad de CienciasUniversidad de La SerenaChile Department of Astronomy University of MichiganAnn Arbor 48109USA David A.Dunlap Department of Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada Dunlap Institute for Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada School of Mathematics and Physics The University of QueenslandSt.Lucia QLD 4072Australia Instituto de Alta Investigación Universidad de TarapacáAricaChile cAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Instituto de Astrofísica Departamento de Ciencias FísicasFacultad de Ciencias ExactasUniversidad Andres BelloSantiagoChile Instituto de Astronomía Universidad Católica del NorteAntofagastaChile

Star clusters were historically considered simple stellar populations,with all stars sharing the same age and initial chemical ***,the presence of chemical anomalies in globular clusters(Gcs),called multiple stellar populations(MPs),has challenged star formation theories in dense *** studies show that mass,metallicity,and age are likely controlling parameters for the manifestation of *** the limit between clusters with/without MPs in physical parameter space is crucial to reveal the driving mechanism behind their *** this study,we look for MP signals in Whiting 1,which is traditionally considered a young *** the Magellan telescope,we obtained low-resolution spectra withinλλ=3850-5500?for eight giants of Whiting *** measured the c and N abundances from the cN and cH spectral indices.c and N abundances have variations comparable with their measurement errors(~0.1 dex),suggesting that MPs are absent from Whiting *** these findings with literature studies,we propose a limit in the metallicity *** compactness index parameter space,which relatively clearly separates star clusters with/without MPs(Gcs/open clusters).This limit is physically *** a larger scale,the galactic environment determines cluster compactness and metallicity,leading to metal-rich,diffuse,old clusters formed ex *** proposed limit also impacts our understanding of the formation of the Sagittarius dwarf galaxy:star clusters formed after the first starburst(age≤8-10 Gyr).These clusters are simple stellar populations because the enriched galactic environment is no longer suitable for MP formation.

关键词： stellar galactic galaxy

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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： Paulo Ricardo Prado Nunes Pamela castro-e-Souza Anselmo Alves de Oliveira bruno de Freitas camilo Gislaine cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University center of Planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPcEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate Program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older ***:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and *** controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(cG) were *** reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) *** body and abdominal adiposity,blood lipids,glucose,and c-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%cI) were used for ***:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were *** groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to ***,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%cI:-1.63 to-0.74;LVRT=-0.78;95%cI:-1.15 to-0.41) and c-reactive protein(HVRT=-1.00;95%cI:-1.32 to-0.67;LVRT=-0.34;95%cI,-0.63 to-0.04)) when compared to ***:compared to cG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： c-reactive protein Fat mass Lipid profile Menopause Strength training

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Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre Maëva Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu bruno Pereira Richard Bonnet Nicolas Barnich Frédéric Antonio carvalho Denis Pezet Mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France Universitéclermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BAcKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(cRc),as demonstrated with colibactin-producing Escherichia coli(coPEc).AIM To evaluate the association between coPEc prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a cRc surgery and for whom the prevalence of coPEc has been investigated underwent a psychiatric *** were compared according to the coPEc *** parallel c57BL6/J wild type mice and mice with a cRc susceptibility were chronically infected with a coPEc *** behavior was assessed using the Elevated Plus Maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with coPEc colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without coPEc *** result was confirmed in c57BL6/J wildtype mice and in a cRc susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a coPEc *** This finding provides the first evidence that coPEc infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： colorectal cancer colibactin Escherichia coli colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

Gravity-Driven Listric Growth Fault and Sedimentation in the Lagoa do Peixe, Rio Grande do Sul coastal Plain, Brazil

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Open Journal of Geology 2024年第4期14卷 594-616页

作者： bruno Silva da Fontoura Adelir José Strieder Iran carlos Stalliviere corrêa Paulo Rogério Mendes Instituto de Geociê ncias UFRGS Porto Alegre Brazil Engenharia Geoló gica Centro de Engenharias UFPel Pelotas Brasil HIDROSERV— Servi&#231os Geol&#243gicos e Geof&#237sicos Ltda. Porto Alegre Brazil

High frequency, high resolution GPR surveys are successfully applied to investigate near-surface stratification architecture of sedimentary units in coastal plains and to define their depositional conditions. However, low frequency GPR surveys to investigate fault-related depositional systems at greater depths are scarce. This survey was designed investigate a > 100 km long linear escarpment that controls the northwest margin of the Lagoa do Peixe, an important lagoon in Rio Grande do Sul coastal Plain (RGScP, Brazil). The traditional approach points that RGScP was developed by juxtaposition of four lagoons/barrier systems as consequence of sea level changes;no deformational structure is admitted to exist before. The low frequency GPR (50 MHz, RTA antenna) and geological surveys carried out in the RGScP showed the existence of a large, gravity-driven listric growth fault controlling the Lagoa do Peixe escarpment and hangingwall sedimentation. The radargrams in four subareas along the Lagoa do Peixe Growth Fault could be interpreted following the seismic expression of rift-related depositional systems. The radargrams enabled to distinguish three main lagoonal deposition radarfacies. The lower lagoonal radarfacies is a convex upward unit, thicker close to growth fault;the radarfacies geometry indicates that fault displacement rate surpasses the sedimentation rate, and its upper stratum is aged ~3500 l4c years BP. The second lagoonal radarfacies is a triangular wedge restricted to the lagoon depocenter, whose geometry indicates that fault displacement and the sedimentation rates kept pace. The upper lagoonal radarfacies is being deposited since 1060 ± 70 l4c years BP, under sedimentation rate higher than fault displacement rate. The results indicate that low frequency GPR surveys can help in investigating fault-related depositional systems in coastal zones. They also point to a new approach in dealing with RGScP stratigraphy.

关键词： GPR (Ground-Penetrating Radar) Growth Fault Sedimentation Radarfacies coastal Plain

Microbial community with Potential for Metal Release Isolated from Palca Mine Tailings Pond in Peru

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Journal of Geoscience and Environment Protection 2024年第7期12卷 109-121页

作者： césar Wilber Guzmán Moreno bruno Karolski Solange Kazue Utimura Roberto castellanos cabrera Jhon Albert centeno Torres Daladier Miguel castillo cotrina Elisabete de Santis Braga Dayana Sarai Gamonal Fermandez Denise crocce Romano Espinosa Joel Barbujiani Sigolo Department of Sedimentary and Environmental Geology Institute of Geoscience USP So Paulo Brazil Department of chemical Engineering LAREX USP So Paulo Brazil cEPEMA Environment Training and Research Center USP So Paulo Brazil Facultad de ciencias Universidad Nacional Jorge Basadre Grohmann UNJBG Tacna Per Department of Physical Chemical and Geological Oceanography USP So Paulo Brazil Facultad de ciencias Biolgicas Universidad Nacional Pedro Ruiz Gallo UNPRG Lambayeque Per

The improvement of microbial characterization has increased the comprehension of microbial population and their ability in the microbiological metal dissolution. Bioleaching processes have been expanded to use microorganisms for the recovery of metals from ores and wastes. This study introduces Palca mine tailings pond in Peru which turned into acid mine drainage (AMD). AMD is a source of microbial communities whose microorganisms may support the aqueous extractive metallurgy for metal recovery. Four samples of AMD were collected from different locations and the elemental characterization showed concentrations of metals, such as cu, Zn, Al, Mn, and Fe. The pH of the samples showed variation between 1.9 - 6.8. Twenty-one microorganisms were isolated and selected according the cell morphology. 16s rRNA gene sequences identified five species of which three belong to the bacterial kingdom and two to the Fungi kingdom. Two of the bacterial species were ferrous ion oxidizing bacteria, identified as Acidithiobacillus ferriphilus and Acidithiobacillus ferridurans;and the other one a ferric ion reducing bacteria identified as Acidiphilium acidophilum. The fungi species identified were Rhodotorula sinensis and Exophiala xenobiotica, a filamentous fungus isolated for the first time from an AMD.

关键词： Acidophilic Microorganisms Acid Mine Drainage—AMD Bioleaching Process Metals Recovery Acidithiobacillus

Dehydrated Natural Feed for cats: Influence on Apparent Digestibility coefficient, Feces Scores, and Serum Immune, Antioxidant, and Metabolic Biomarkers

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Food and Nutrition Sciences 2024年第7期15卷 594-611页

作者： bruno Giorgio de Oliveira cécere Guilherme Luiz Deolindo Bianca F. Bissacotti Priscila Marquezin copetti Maria Rosa chitolina Schetinger Bruna Klein Matheus Delamea Baldissera Thiago Pereira Ribeiro Walter Hugo cuelho Suarez Daniel Pigatto Monteiro Aleksandro Schafer Da Silva Graduate Multicenter Program in Biochemistry and Molecular Biology University of the State of Santa Catarina Lages Brazil Department of Biochemistry and Molecular Biology Universidade Federal de Santa Maria (UFSM) Santa Maria Brazil Department of Animal Science Universidade Federal de Santa Maria (UFSM) Chapec Brazil Department of Health Science Universidade Franciscana (UFN) Santa Maria Brazil Department of Animal Nutrition Tectron-Tecnologia e Inovao Toledo Brazil

The present study aimed to determine whether natural dehydrated feed (DNF) can replace dry extruded feed while preserving the required daily intake, nutrient digestibility and benefits for immunity and antioxidant response in cats. The animals were divided into two groups of seven animals each. One group received DNF, and the other consumed commercial extruded dry feed (DcF). The experiment lasted 45 days and we measured daily consumption and collected blood and feces samples. The animals in the DNF group showed greater digestibility of fiber and mineral matter than DcF. cats in the DNF group had a higher volume of feces. DNF cats had lower leukocyte and granulocyte counts and cholesterol levels. Serum enzymatic antioxidant responses and non-enzymatic were higher in DNF cats. cats in the DNF group showed lower serum acute phase proteins in addition to a tendency toward a higher concentration of transferrin than in the DcF group. Fecal Escherichia coli and total coliform counts of cats fed DNF were higher than DcF. We conclude that the daily consumption of cats is adequate. This feed had greater digestibility of fiber and mineral matter, in addition to an improvement in antioxidant and immunological responses.

关键词： Alternative Feed Antioxidant companion Animals Health