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Synthesis of ZnO： AI： F Thin Films by Sol-Gel Process： Applications as Transparent Electrodes, and for Detecting Carbon Monoxide

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材料科学与工程（中英文B版） 2011年第3期1卷 288-295页

作者： Salvador Tirado guerra Escuela Superior de Fisica y Matem6ticas del Instituto Politdcnico Nacional Edificio 9 U.P. A.L.M San Pedro Zacatenco C.P. 07738 Mdxico D.F. Mdxico

m6A levels and expression of its modification genes show significant differences in breast cancer molecular subtypes

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Genes & Diseases 2023年第5期10卷 1751-1754页

作者： Tamara Kleinbielen Felix Olasagasti Elena Beristain Amparo Viguri-Díaz Isabel guerra-Merino Africa García-Orad Marian Mde Pancorbo BIOMICs Research Group Lascaray Research CenterUniversity of the Basque Country UPV/EHUVitoria-GasteizAraba 01006Spain Bioaraba Health Research Institute Vitoria-GasteizAraba 01009Spain Department of Biochemistry and Molecular Biology University of the Basque CountryUPV/EHUVitoria-GasteizAraba 01006Spain Molecular Genetics Laboratory Araba University HospitalOsakidetza Basque Health ServiceVitoria-GasteizAraba 01009Spain Pathology Department Araba University HospitalVitoria-GasteizAraba 01009Spain Department of Genetics Physical Anthropology and Animal PhysiologyUniversity of the Basque Country(UPV/EHU)LeioaBizkaia 48940Spain BioCruces Bizkaia Health Research Institute BarakaldoBizkaia 48903Spain Department of Zoology and Animal Biology.University of the Basque Country(UPV/EHU) LeioaBizkaia 48940Spain

N6-methyladenosine(m6A)is the most abundant modification in eukaryotic messenger RNA.1 This modification is dynamic,reversible,and mediated by proteins characterized as methyltransferases and *** investigations have found that aberrant expression of methyltransferases and demethylases results in m6A dysregulation and,in consequence,affects the biological functions in which this modification is ***,m6A dysregulation affects the development and maintenance of various diseases,including cancer.2 For this reason,we explored the potential role that m6A modification has in invasive breast cancer of no special type(IBC-NST)and its molecular subtypes luminal A,luminal B HER2-,luminal B HER2+,HER2+,and triple-negative breast cancer(TNBC)whose degree of global m6A methylation has not yet been studied.

关键词： breast cancer HER2

Inexpensive and combined technique: Use of suction tracheal catheter and hydrogen peroxide for the evacuation of intravesical clots

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Asian Journal of Urology 2022年第1期9卷 99-100页

作者： Fred Alain Montelongo-Rodriguez Carlos Daniel guerra-Catanon Mario Vazquez-Herrera Adrian Gutierrez-Gonzalez Lauro Salvador Gomez-guerra Urology Department Hospital Universitario“Dr.Jose Eleuterio Gonzalez”Universidad Autonoma de Nuevo LeonMonterreyMexico

Dear Editor,Persistent hematuria could trigger urinary retention,leading the patient to the emergency department for abdominal pain,decreased urinary output,anemia,and azotemia[1,2].Conventional bladder clot evacuation requires a three-way catheter with continuous irrigation and aspiration with a syringe or Ellik evacuator[3].Sometimes a large and well-organized hematoma requires an open cystostomy[1,4].We want to introduce a combined method using hydrogen peroxide as well as suction technique with an endotracheal catheter to evacuate intravesical clots.

关键词： urinary bladder catheter

BASKETBALL SCORING IN NBA GAMES:AN EXAMPLE OF COMPLEXITY

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Journal of Systems Science & Complexity 2013年第1期26卷 94-103页

作者： DE SA guerra Yves MARTíN GONZALEZ Juan Manuel SARMIENTO MONTESDEOCA Samuel RODRIGUEZ RUIZ David ARJONILLA LóPEZ Nieves GARCíA-MANSO Juan Manuel Departament of Phisical Education University of Las Palmas de Gran Canaria Departament of Physics University of Las Palmas de Gran Canaria

Scoring in a basketball game is a highly dynamic, non-linear process. NBA teams try to be more and more competitive each season. For instance, they incorporate into their rosters the best players in the world. This and other mechanisms concur to make the scoring process in NBA games exciting and rarely predictable. This paper is to study the behavior of timing and scoring in basketball gaines. The authors analyze all the games in five NBA regular seasons （2005-06, 2006-07, 2007-08, 2008-09, 2009-10）, for a total of 6150 games. Scoring does not behave uniformly; therefore, the authors also analyze the distributions of the differences in points in the basketball games. To further analyze the behavior of the tail of the distribution, the authors also carry out a semilog-plot and a log-log plot to verify whether this trend approaches a Poisson distribution or a PL. This paper reveals different areas of behavior related to the score, with specific instances of time that could be considered tipping points of the game. The presence of these critical points suggests that there are phase transitions where the dynamic scoring of the games varies significantly.

关键词： Complexity NBA non-linear Poisson power law.

Slope Processes, Mass Movement and Soil Erosion： A Review

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Pedosphere 2017年第1期27卷 27-41页

作者： Antonio Jos Teixeira guerra Michael Augustine FULLEN Maria do Carmo Oliveira JORGE Joss Fernando Rodrigues BEZERRA Mohamed S. SHOKR Department of Geography Federal University of Rio de Janeiro Rio de Janeiro 21941-972 (Brazil) Faculty of Science and Engineering University of Wolverhampton Wolverhampton WV1 1LY (UK) Department of Geography State University of Maranhao SSo Luis 65055-970 (Brazil) Soil and Water Department Faculty of Agriculture Tanta University Tanta 31527 (Egypt)

Soil erosion and land degradation are global problems and pose major issues in many countries. Both soil erosion and mass movement are two forms of land degradation and humans play important roles in these geomorphological processes. This paper reviews slope processes associated with mass movement and soil erosion and contributory factors, including physical and human agents. Acting together, these cause diverse geomorphological features. Slope processes are illustrated by reference to case studies from Brazil and UK. The causes and impacts of erosion are discussed, along with appropriate remedial bioengineering methods and the potential of the measures to prevent these types of environmental degradation. Although there are several agents of erosion, water is the most important one. Cultivation can promote soil erosion, due to ploughing and harvesting, which moves soil down slopes. Soil erosion and mass movement data would inform the viability of soil conservation practices. Integrated management of drainage basins offers a Dromising way forward for effective soil conservation and soil remedial bioengineering in Brazil and UK.

关键词： geomorphological feature land degradation hazards risks slope processes soil recuperation

Role of serendipity in the discovery of classical antidepressant drugs:Applying operational criteria and patterns of discovery

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World Journal of Psychiatry 2022年第4期12卷 588-602页

作者： Francisco López-Muñoz Pilar D’Ocón Alejandro Romero JoséA guerra CecilioÁlamo Faculty of Health University Camilo JoséCelaVillanueva de la Cañada 28692MadridSpain “Hospital 12 de Octubre”Research Institute(i+12) Avda.de Córdobas/nMadrid 28041Spain Department of Pharmacology Faculty of PharmacyUniversity of ValenciaAvda.Vicent Andres Estelless/nValencia 46100Spain Department of Pharmacology and Toxicology Faculty of Veterinary MedicineComplutense UniversityAvda.Puerta de Hierros/nMadrid 28040Spain Department of Pharmacology and Toxicology Faculty of PharmacyComplutense UniversityPl.de Ramón y Cajals/nMadrid 28040Spain Department of Biomedical Sciences(Pharmacology Area) Faculty of Medicine and Health SciencesUniversity of AlcaláCampus Científico-TecnológicoCrta.de Madrid-BarcelonaAlcaláde Henares 28871MadridSpain

The role played by serendipity in the origin of modern psychopharmacology has proven to be controversial in scientific *** its original meaning(Walpole),serendipity refers to discoveries made through a combination of accidents and *** have implemented an operational definition of serendipity based on finding something unexpected or unintended,regardless of the systematic process that led to the accidental observation,and we have established four different patterns of serendipitous *** this paper,we have analyzed the role of serendipity in the discovery and development of classical antidepressant drugs,tricyclic antidepressants and monoamine oxidase inhibitors as well as heterocyclic,“atypical”or“second generation”*** discovery of the antidepressant properties of imipramine and iproniazid,the prototypes of tricyclic antidepressants and monoamine oxidase inhibitors,respectively,fits the mixed type II pattern;initial serendipitous discoveries(imipramine was an antipsychotic and iproniazid was an antituberculosis agent)led secondarily to non-serendipitous *** the other components of these two families of drugs were developed specifically as antidepressants,modifying the chemical structure of the series leaders,thereby allowing all of them to be included in the type IV pattern,characterized by the complete absence of *** the heterocyclic drugs,mianserin(originally developed as an antihistamine)also falls into the type II pattern.

关键词： Serendipity Antidepressants Imipramine Iproniazid Psychopharmacology History of neurosciences

Characterization and application of tourmaline and beryl from Brazilian pegmatite in adsorption process with divalent metals

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International Journal of Mining Science and Technology 2012年第5期22卷 711-718页

作者： Denis L.guerra Silze P.Oliveira Ricardo A.R.Silva Victor Leidens Adriano C.Batista Federal University of Mato Grosso DRM-ICET-UFMTCuiabá 78060900Brazil Universidade Estadual do Norte Fluminense Rio de Janeiro 2801302Brazil

In this study,the original tourmaline and beryl mineral samples have been collected from a Brazilian *** objective of this study was to examine the adsorption behavior of Brazilian ciclosilicate samples,towards divalent metals(Pb 2+,Mn 2+,and Zn 2+) in ethanol solution has been studies by a batch *** ciclosilicate samples were characterized by elemental analysis,Fourier transform infrared spectroscopy,helium picnometry,mercury porosity,and nitrogen *** Langmuir expression for adsorption isotherm was applied in order to determine the adsorption capacity to form a monolayer and the constant related to the adsorption *** aqueous solution there was a significant adsorption increase with the temperature and pronounced synergistic effects were *** maximum number of moles adsorbed was determined to be 12.48 and 11.49 mmol/g for systems Pb 2+ /beryl and Pb 2+ /tourmaline,*** energetic effects caused by metal cations adsorption were determined through calorimetric *** indicated the existence of favorable conditions for such Pb 2+-,Mn 2+-,and Zn 2+-OH interactions.

关键词： Industrial minerals Environmental Pollution Surface modification Wasteprocesing

Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system

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Neural Regeneration Research 2017年第8期12卷 1231-1240页

作者： Julia J.Segura-Uribe Rodolfo Pinto-Almazán Angélica Coyoy-Salgado Claudia E.Fuentes-Venado Christian guerra-Araiza Unidad de Investigacion Modica en Enfermedades Neurologicas Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico Seccion de Estudios de Posgrado e Investigacion Escuela Superior de Medicina Instituto Politecnico Nacional Mexico City Mexico Unidad de Investigacion Hospital Regional de Alta Especialidad Ixtapaluca Ixtapaluca Mexico Institute for the Developing Mind Children's Hospital Los Angeles Los Angeles CA USA Department of Pediatrics Keck School of Medicine University of Southern California Los Angeles CA USA Consejo Nacional de Ciencia y Tecnologia Mexico City Mexico Clinica de Trastornos del Sueno Universidad Autonoma Metropolitana-Iztapalapa Mexico City Mexico Servicio de Medicina Fisica y Rehabilitacion Hospital General de Zona No. 197 Texcoco Mexico Unidad de Investigacion Modica en Farmacologla Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico

Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacteric symptoms. Similar to estrogens, neuroprotective effects of estrogen receptor modulators have been described in different models. However, the mechanisms of action of these compounds in the central nervous system have not been fully described. We conducted a systematic search to investigate the effects of estrogen receptor modulators in the central nervous system, focusing on the modulation of cytoskeletal proteins. We found that raloxifene, tamoxifen, and tibolone modulate some cytoskeletal proteins such as tau, microtuble-associated protein 1（MAP1）, MAP2, neurofilament 38（NF38） by different mechanisms of action and at different levels： neuronal microfilaments, intermediate filaments, and microtubule-associated proteins. Finally, we emphasize the importance of the study of these compounds in the treatment of neurodegenerative diseases since they present the benefits of estrogens without their side effects.

关键词： estrogen receptor modulators selective estrogen receptor modulators microtubules neurofilaments tibolone tamoxifen raloxifene

Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice

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Neural Regeneration Research 2017年第4期12卷 588-595页

作者： Teresa Neri-Gomez Judith Espinosa-Raya Sofia Diaz Cintra Julia Segura-Uribe Sandra Orozco-Suarez Juan Manuel Gallardo Christian guerra-Araiza Unidad de Investigación Médica en Farmacología Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México Laboratorio de Farmacología Conductual Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Sto. Tomás Ciudad de México México Departamento de Neurobiología del Desarrollo y Neurofisiología Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Querétaro México Enfermedades Neurológicas (Neurological Diseases) Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México Enfermedades Nefrológicas (Kidney Diseases) Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de Mexico Mexico

Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles （NFTs）; these hormones can regulate Tau phosphorylation and the principal kinase GSK3β involved in this process. Hormone replacement therapy decreases NFTs, but it increases the risk of some types of cancer. However, other synthetic hormones such as tibolone （TIB） have been used for hormone replacement therapy. The aim of this work was to evaluate the long-term effects of TIB （0.01 mg/kg and 1mg/kg, intragastrically for 12 weeks） on the content of total and hyperphosphorylated Tau （PHF-1） proteins and the regulation of GSK3β/Akt/PI3K pathway and CDK5/p35/p25 complexes in the hippocampus of aged male mice. We observed that the content of PHF-1 decreased with TIB administration. In contrast, no changes were observed in the active form of GSK3β or PI3K. TIB decreased the expression of the total and phosphorylated form of Akt while increased that of p110 and p85. The content of CDK5 was differentially modified with TIB： it was increased at low doses and decreased at high doses. When we analyzed the content of CDK5 activators, an increase was found on p35; however, the content of p25 decreased with administration of low dose of TIB. Our results suggest a possible mechanism of action of TIB in the hippocampus of aged male mice. Through the regulation of Tau and GSK3β/Akt/PI3K pathway, and CDK5/p35/p25 complexes, TIB may modulate neuronal plasticity and regulate learning and memory processes.

关键词： nerve regeneration Tibolone hippocampus aged mice sex steroids Akt GSK3β PI3K neuralplasticity Tau neurofibrillary tangles neural regeneration