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Obesity in people with diabetes in COVID-19 times: Important considerations and precautions to be taken

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World Journal of Clinical Cases 2021年第20期9卷 5358-5371页

作者： Adriano Alberti Fabiana Schuelter-Trevisol Betine Pinto Moehlecke Iser Eliane Traebert Viviane Freiberger Leticia Ventura Gislaine Tezza Rezin bruna Becker da Silva Fabiana Meneghetti Dallacosta Leoberto Grigollo Paula Dias Gracielle Fin Josiane Aparecida de jesus Fabiane Pertille Carina Rossoni Ben Hur Soares Rudy JoséNodari Júnior Clarissa Martinelli Comim Research Group in Neurodevelopment of Childhood and Adolescence Laboratory of Experimental NeurosciencePostgraduate Program in Health SciencesUniversity of South Santa Catarina(Unisul)Palhoça88137-270Santa CatarinaBrazil Brazil Clinical Research Center Postgraduate Program in Health SciencesUniversity of Southern Santa Catarina at TubarãoTubarão88704-900Santa CatarinaBrazil Postgraduate Programme in Health Sciences University of Southern Santa CatarinaPalhoça88137-270Santa CatarinaBrazil Postgraduate Program in Biosciences and Health University of the West of Santa CatarinaJoaçaba89600-000Santa CatarinaBrazil department of Physical Education University of the West of Santa CatarinaJoaçaba89600-000Santa CatarinaBrazil Environmental Health Institute of the Faculty of Medicine of the University of Lisbon Lisboa1649-029Portugal Health Science University of Passo FundoPasso Fundo99052-900Rio Grande do SulBrazil Research department Salus DermatoglifiaLuzerna89609-000Santa CatarinaBrazil

At the end of 2019,a new disease with pandemic potential appeared in *** was a novel coronavirus called coronavirus disease 2019(COVID-19).Later,in the first quarter of 2020,the World Health Organization declared the outbreak of this disease a *** people,people with comorbidities,and health care professionals are more vulnerable to *** has been growing exponentially worldwide,affecting several age *** is a morbidity that is associated with genetic,epigenetic,environment factors and/or interaction between *** is associated with the development of several diseases including diabetes mellitus,mainly type *** affects a significant portion of the global *** and diabetes are among the main risk factors for the development of severe symptoms of COVID-19,and individuals with these conditions constitute a risk *** on a literature review on obesity in people with diabetes in the framework of the COVID-19 pandemic,this study presents updated important considerations and care to be taken with this population.

关键词： Obesity Diabetes COVID-19 Population World Disease

Pulmonary Lymphangioleiomyomatosis on a Post-Menopausal Woman with Chronic Lymphocytic Leukaemia

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Case Reports in Clinical Medicine 2016年第3期5卷 101-104页

作者： Bernardo Cunha Diogo Morgado Conceição Carolina Cabo Nélson jesus Lèlita santos Armando de Carvalho Serviço de Medicina Interna A Centro Hospitalar e Universitário de Coimbra Coimbra Portugal

A 62 years old, post-menopausal female was admitted to the Internal Medicine Ward due to dyspnoea, cough and sputum of at least 2 months. Shortness of breath, cough and hypoxaemia persisted and the patient was submitted to a pulmonary angiogram ct which revealed numerous thin-walled air cysts affecting upper and medial zones of both lungs, typical images of pulmonary lymphangioleiomyomatosis. After discharge to Internal Medicine Consultation Service with Metilprednisolone, the patient was no longer hypoxaemic and remained asymptomatic, even after withdrawal of oral corticosteroid to inhalatory formulation. Further surveillance in short time was scheduled in order to implement rapid imunossupressive treatment when necessary.

关键词： Pulmonary Lymphangioleiomyomatosis Chronic Lymphocitic Leukaemia Post-Menopausal

<i>Conyza sumatrensis</i>Intrapopulation Variation in Response to Glufosinate

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American Journal of Plant Sciences 2019年第9期10卷 1565-1582页

作者： Ivana Paula Ferraz santos de Brito Caio Antonio Carbonari bruna Barboza Marchesi Ana Karollyna Alves de Matos Leandro Tropaldi Nilda Roma-Burgos Edivaldo Domingues Velini department of Crop Science Sao Paulo State University (UNESP) College of Agriculture Botucatu Sao Paulo Brazil department of Crop Soil and Environmental Sciences University of Arkansas Fayetteville AR USA

We aimed to study the response of Conyza sumatrensis to different doses of glufosinate, intrapopulation variation in sensitivity to the herbicide, and the heritability of phenotypic response, and model the evolution of resistance. Three studies were conducted in the greenhouse with two repetitions. First, we tested doses of glufosinate (0, 50, 100, 200, 400, 800 g a.i. ha-1) plus a nontreated check, with four replications. Second, we examined the range in sensitivity of 44 plants to 200 g a.i. ha-1 glufosinate. Third, we evaluated the sensitivity of the progeny of six glufosinate-treated plants to 200 g a.i. ha-1 glufosinate. Plant response was evaluated visually and the ammonium content in leaf tissues was measured. Glufosinate at 400 g a.i. ha-1 caused the highest injury to *** plants. Ammonia accumulation occurred in response to glufosinate treatment, regardless of dose. Ammonia accumulation was correlated strongly with the level of visible plant injury;thus, it is a good indicator of herbicide efficacy. Sensitivity to glufosinate was highly variable within the population. Plants with high ammonia concentration (high injury) after treatment with glufosinate produced progenies that also had high ammonia concentrations after herbicide treatment. The variation in ammonia accumulation among siblings was high. Simulating the exclusion of plants that accumulated more ammonia produced a population that is expected to be less sensitive to glufosinate in the next generation. The stronger the selection pressures by a simulated treatment with glufosinate, the greater the reduction in ammonia accumulation in the progeny and expected sensitivity to glufosinate.

关键词： Ammonia Accumulation Differential Tolerance Glutamine Synthetase Herbicide Selection Pressure Sumatran Fleabane

DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation andmetabolic remodeling

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Cancer Communications 2023年第7期43卷 838-843页

作者： Sara Mellid Fernando García Luis Javier Leandro-García Alberto Díaz-Talavera Ángel Mario Martínez-Montes Eduardo Gil bruna Calsina María Monteagudo Rocío Letón Juan María Roldán-Romero María santos Javier Lanillos Carlos Valdivia Natalia Martínez-Puente Javier de Nicolás-Hernández Scherezade Jiménez Manuel Pérez-Martínez Emiliano Honrado Javier Coloma Ana Cerezo Clara María Santiveri Manel Esteller Ramón Campos-Olivas Eduardo Caleiras Cristina Montero-Conde Cristina Rodríguez-Antona Javier Muñoz Mercedes Robledo Alberto Cascón Hereditary Endocrine Cancer Group Spanish National Cancer Research Centre(CNIO)MadridSpain Proteomics Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) MadridSpain Monoclonal Antibodies Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Confocal Microscopy Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Anatomical Pathology Service Hospital of LeónLeónCastilla y LeónSpain Structural Biology Programme Spanish National Cancer Research Centre(CNIO)MadridSpain CNIO-Lilly Cell Signalling and Immunometabolism Section Spanish National Cancer Research Centre(CNIO)MadridSpain Spectroscopy and Nuclear Magnetic Resonance Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Josep Carreras Leukaemia Research Institute(IJC) BadalonaBarcelonaSpain Centro de Investigacion Biomedica en Red Cancer(CIBERONC) MadridSpain Institucio Catalana de Recerca i Estudis Avançats(ICREA) BarcelonaSpain Physiological Sciences department School of Medicine and Health SciencesUniversity of Barcelona(UB)L’HospitaletBarcelonaSpain Histopathology Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Cell Signaling and Clinical Proteomics Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability *** 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new PPGL susceptibility gene[2].

关键词： glioma remodeling cytoma

空间、环境和历史因素对热带森林树种周转的影响

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Journal of Plant Ecology 2021年第4期14卷 717-729页

作者： Alisson Borges Miranda santos Vinicius Andrade Maia Cleber Rodrigo de Souza Nathalle Cristine Alencar Fagundes Fernanda Moreira Gianasi Aurelio de jesus Rodrigues Pais Natalia de Aguiar-Campos Gabriela Gomes Pires Diego Teixeira Girardelli Jean Daniel Morel Mariana Caroline Moreira Morelli Felipe de Carvalho Araujo Rubens Manoel dos santos department of Forestry Sciences Federal University of LavrasUniversity CampusLavrasBrazil Biological Sciences University of the State of Minas GeraisItuiutaba UnitItuiutabaBrazil department of Biology Federal University of LavrasUniversity CampusLavrasBrazil Faculty of Environmental Engineering and Natural Resources Zambeze UniversityChimoioMozambique

本文通过回答以下问题来分析空间距离、当前和过去的环境差异及这几个因素对树木群落分类和系统发育转换的影响:(i)树木群落分类和系统发育转换是否与空间距离通过环境差异产生的间接影响相关?(ii)树木群落分类和系统发育转换是否随古气... 详细信息

本文通过回答以下问题来分析空间距离、当前和过去的环境差异及这几个因素对树木群落分类和系统发育转换的影响:(i)树木群落分类和系统发育转换是否与空间距离通过环境差异产生的间接影响相关?(ii)树木群落分类和系统发育转换是否随古气候(末次盛冰期和中全新世)的变化而变化?本文对巴西的14个大西洋雨林样点(采样面积20.4 ha)83个科615个种进行了研究,获得了当前、中全新世和末次盛冰期的地块地理坐标、土壤变量和样点生物气候变量。我们使用基于距离的结构方程模型(SEM)来(i)检测空间距离和环境差异的直接影响,以及(ii)检测空间距离通过环境差异对分类(Bray-Curtis距离)和系统发育转换(Comdist和Comdistnt距离)的间接影响。研究结果表明,空间距离通过环境差异对分类和系统发育转换的间接影响较弱。基于生态位中性的历史过程带来的直接影响驱动了树木群落的转换。因此,我们推断古气候(历史过程)促进了产生当前植物区系分支的选择,而空间距离(中性的过程)限制了物种从区域种库向外扩散的范围,环境条件(基于生态位的过程)则在本地选择能够持续生存的分类群。

关键词：聚类过程系统发育群落环境过滤中性群落系统发育转换生态位古气候效应

No independent associations between physical activity and clinical outcomes among hospitalized patients with moderate to severe COVID-19

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Journal of Sport and Health Science 2021年第6期10卷 690-696页

作者： Ana J.Pinto Karla F.Goessler Alan L.Fernandes Igor H.Murai Lucas P.Sales bruna Z.Reis Mayara Diniz santos Hamilton Roschel Rosa M.R.Pereira Bruno Gualano Applied Physiology and Nutrition Research Group School of Physical Education and SportClinical Hospital HCFMUSPSchool of Medicine FMUSPUniversity of Sao PauloSao PauloSP 01246903Brazil Rheumatology Division Clinical Hospital HCFMUSPSchool of Medicine FMUSPUniversity of Sao PauloSao PauloSP 01246903Brazil Food Research Center University of Sao PauloSao PauloSP 05508080Brazil

Background:Regular physical activity(PA)has been postulated to improve,or at least maintain,immunity across the life ***,the link between physical(in)activity and coronavirus disease 2019(COVID-19)remains to be *** small-scale prospective cohort study is nested within a randomized controlled trial aimed to investigate the possible associations between PA levels and clinical outcomes among hospitalized patients with moderate to severe ***:Hospitalized patients with COVID-19(mean age:54.9 years)were recruited from the Clinical Hospital of the School of Medicine of the University of Sao Paulo(a quaternary referral teaching hospital)and from Ibirapuera Field Hospital,both located in Sao Paulo,*** level was assessed using the Baecke Questionnaire of Habitual Physical *** primary outcome was hospital length of *** secondary outcomes were mortality,admission to the intensive care unit(ICU),and mechanical ventilation ***:The median hospital length of stay was 7.0§4.0 days,median§IQR;3.3%of patients died,13.8%were admitted to the ICU,and 8.6%required mechanical *** linear regression models showed that PA indices were not associated with hospital length of stay(work index:b=-0.57(95%confidence interval(95%CI):-1.80 to 0.65),p=0.355;sport index:b=0.43(95%CI:-0.94 to 1.80),p=0.536;leisure-time index:b=1.18(95%CI:-0.22 to 2.59),p=0.099;and total activity index:b=0.20(95%CI:-0.48 to 0.87),p=0.563).None of the PA indices were associated with mortality,admission to the ICU,or mechanical ventilation requirement(all p>0.050).Conclusion:Among hospitalized patients with COVID-19,PA did not independently associate with hospital length of stay or any other clinically relevant *** findings should be interpreted as meaning that,among already hospitalized patients with more severe forms of COVID-19,being active is a potential protective factor likely outweighed by a cluster of comorbidities(e.

关键词： Hospital length of stay Lifestyle Physical inactivity Prognosis SARS-CoV-2

Unsupervised Methods to Classify Real Data from Offshore Wells

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American Journal of Operations Research 2021年第5期11卷 227-241页

作者： Antônio Orestes de Salvo Castro Mayara de jesus Rocha santos Fabiana Rodrigues Leta Cláudio Benevenuto C. Lima Gilson Brito Alves Lima Rio de Janeiro State University (UERJ) Rio de Janeiro Brazil department of Engineering of Fluminense Federal University (UFF) Niterói Brazil Petróleo Brasileiro S.A Rio de Janeiro Brazil

In the petroleum industry, sensor data and information are valuable. It can detect, predict and help to understand processes during oil production. Offshore wells require more attention. Once workovers, maintenance, and intervention are more costly than onshore wells. Coupling data-driven methods for well-monitoring applications, two unsupervised classification methods, one statistical and one machine learning-based, are proposed to detect anomalies in well data. The novelty is presented by applying a Control Chart using a 3 standard deviations window for the Permanent Downhole Gauge Pressure sensor (P-PDG), and a Fuzzy C-means algorithm to classify data from pressure and temperature sensors in an offshore field. The main goal in structuring a classified data set is using it to train machine learning models to monitor and manage petroleum production. Modeling applications for early fault detection systems in offshore production, based on real-time data from production sensors, require classified data sets. Then, labeling two target classes: “normal” and “fault” is a key step to be implemented in order to train the machine learning models. Therefore, this paper applies two methodologies to classify a real-time data set to create a training data set divided into “normal” and “fault” classes. Thus, it is possible to visualize the abnormal events pointed out by the methodologies and compare how sensible is each method. In addition, it is proposed a random forest application to test the per

关键词： Unsupervised Classification Fuzzy C-Means Control Chart

Incorporation of SCBA in Red Ceramics and Sintering in Microwave Oven

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Non-Metallic Material Science 2021年第2期3卷 6-16页

作者： Gabriela Pitolli Lyra Valdemir santos Eliria Maria de jesus Agnolon Pallone Ruth Herta Goldschmidt Aliaga Kiminami Bruno Carlos de Santis João Adriano Rossignolo Postgraduate Programme in Materials Science and Engineering University of São PauloUSP/FZEAPirassunungaBrazil department of Materials Engineering Federal University of Sao CarlosSao CarlosBrazil

The present study investigated the incorporation of sugarcane bagasse ash(SCBA)in red ceramics,sintered in conventional oven and microwave oven,aiming to provide an alternative product,and a sintering process with higher energy efficiency in the production of red *** raw materials were characterized by XRF,XRD,thermogravimetry,particle size distribution and specific mass *** specimens were shaped by extrusion in two different compositions,red clay and red clay with addition of 20%SCBA and sintered at temperatures from 700 to 1100℃.The conventional sintering occurred for 60 min with heating rate of 10℃/*** the microwave oven the sintering occurred in a hybrid way,with heating rate of 50℃/min for 5,10 and 15 *** sintering the tests of linear shrinkage,compressive strength,water absorption,apparent porosity and apparent specific mass were *** addition of SCBA causes an increase in the values of water absorption and decreases the compressive strength and specific mass of the red *** occurs due to the creation of pores inside the material from the volatilization of organic matter present in the *** sintering in microwave oven,when compared to conventional sintering,promotes an increase in the values of compressive strength and specific mass and reduction of water absorption values of ceramics,probably due to the refinement of the microstructure and the higher *** the incorporation of ashes can be partially compensated by a more efficient *** use of SCBA and the sintering in microwave oven,showed to be viable alternatives in the development of a more sustainable and light material,promoting the management of waste,reduction in the consumption of raw materials and energy saving.

关键词： Red clay Agroindustrial waste Non-conventional sintering Energy efficiency

Polyphenol Oxidase Activity and Colour Changes of ‘Starking’ Apple Cubes Coated with Alginate and dehydrated with Air

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Food and Nutrition Sciences 2011年第5期2卷 451-457页

作者： Susana Daniela Sousa Fernandes Catarina Araújo da Silva Ribeiro Maria Filomena de jesus Raposo Rui Manuel santos Costa de Morais Alcina Maria Miranda Bernardo de Morais 不详

The objective was to study the effect of alginate coating on polyphenol oxidase (PPO) activity and colour of ‘Starking’ apple cubes during dehydration with hot air. Apple cubes were dehydrated at 20oC, 35oC, or 40oC, with a parallel airflow. Analysis of PPO activity, colour (L*, a*, b*) and dry matter were performed along the dehydration process at each temperature. All samples presented a peak in relative PPO activity in the beginning of the drying. Exponential models fitted well the experimental data after the peak. Cubes without coating presented lower PPO activity, suggesting lower browning, than coated samples throughout the dehydration process, for all temperatures. Better results for coated samples were obtained with a perpendicular airflow drying at 40oC, after dipping the whole apple in water at 60oC for 10 min. In order to prevent coated samples from browning, drying by perpendicular airflow preceded by a thermal treatment of the whole apple is required.

关键词： Alginate Coating Apple Cubes Colour Hot Air Drying Polyphenol Oxidase