No independent associations between physical activity and clinical outcomes among hospitalized patients with moderate to severe COVID-19

作     者：Ana J.Pinto Karla F.Goessler Alan L.Fernandes Igor H.Murai Lucas P.Sales Bruna Z.Reis Mayara Diniz Santos Hamilton Roschel Rosa M.R.Pereira Bruno Gualano Ana J.Pinto;Karla F.Goessler;Alan L.Fernandes;Igor H.Murai;Lucas P.Sales;Bruna Z.Reis;Mayara Diniz Santos;Hamilton Roschel;Rosa M.R.Pereira;Bruno Gualano

作者机构：Applied Physiology and Nutrition Research GroupSchool of Physical Education and SportClinical Hospital HCFMUSPSchool of Medicine FMUSPUniversity of Sao PauloSao PauloSP 01246903Brazil Rheumatology DivisionClinical Hospital HCFMUSPSchool of Medicine FMUSPUniversity of Sao PauloSao PauloSP 01246903Brazil Food Research CenterUniversity of Sao PauloSao PauloSP 05508080Brazil 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2021年第10卷第6期

页      面：690-696页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Sao Paulo Research Foundation-FAPESP(grants No.2015/26937-4,No.2019/18039-7,No.2019/24782-4,No.2020/11102-2,No.2016/00006-7 and No.2020/05752-4,and No.2017/13552-2) RMRP,HR,and BG were supported by Conselho Nacional de Desenvolvimento Cient-ıfico e Tecnologico(grants No.305556/2017-7,No.301571/2017-1,and No.301914/2017-6) 

主　　题：Hospital length of stay Lifestyle Physical inactivity Prognosis SARS-CoV-2 

摘      要：Background:Regular physical activity(PA)has been postulated to improve,or at least maintain,immunity across the life ***,the link between physical(in)activity and coronavirus disease 2019(COVID-19)remains to be *** small-scale prospective cohort study is nested within a randomized controlled trial aimed to investigate the possible associations between PA levels and clinical outcomes among hospitalized patients with moderate to severe ***:Hospitalized patients with COVID-19(mean age:54.9 years)were recruited from the Clinical Hospital of the School of Medicine of the University of Sao Paulo(a quaternary referral teaching hospital)and from Ibirapuera Field Hospital,both located in Sao Paulo,*** level was assessed using the Baecke Questionnaire of Habitual Physical *** primary outcome was hospital length of *** secondary outcomes were mortality,admission to the intensive care unit(ICU),and mechanical ventilation ***:The median hospital length of stay was 7.0§4.0 days,median§IQR;3.3%of patients died,13.8%were admitted to the ICU,and 8.6%required mechanical *** linear regression models showed that PA indices were not associated with hospital length of stay(work index:b=-0.57(95%confidence interval(95%CI):-1.80 to 0.65),p=0.355;sport index:b=0.43(95%CI:-0.94 to 1.80),p=0.536;leisure-time index:b=1.18(95%CI:-0.22 to 2.59),p=0.099;and total activity index:b=0.20(95%CI:-0.48 to 0.87),p=0.563).None of the PA indices were associated with mortality,admission to the ICU,or mechanical ventilation requirement(all p0.050).Conclusion:Among hospitalized patients with COVID-19,PA did not independently associate with hospital length of stay or any other clinically relevant *** findings should be interpreted as meaning that,among already hospitalized patients with more severe forms of COVID-19,being active is a potential protective factor likely outweighed by a cluster of comorbidities(e.