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A Flexible Boundary Procedure for Hyperbolic Problems: Multiple Penalty Terms Applied in a Domain

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Communications in Computational Physics 2014年第7期16卷 541-570页

作者： Jan Nordstrom Qaisar Abbas brittany A.Erickson Hannes Frenander Department of Mathematics Division of Computational MathematicsLinkoping UniversitySE-58183 Link¨opingSweden Department of Information Technology Division of Scientific ComputingUppsala UniversitySE-75105 UppsalaSweden Department of Geological Sciences San Diego State UniversitySan DiegoCA 92182-1020USA Department of Mathematics Division of Computational MathematicsLinkoping UniversitySE-58183 Link¨opingSweden.

A new weak boundary procedure for hyperbolic problems is *** consider high order finite difference operators of summation-by-parts form with weak boundary conditions and generalize that *** new boundary procedure is applied near boundaries in an extended domain where data is *** show how to raise the order of accuracy of the scheme,how to modify the spectrum of the resulting operator and how to construct non-reflecting properties at the *** new boundary procedure is cheap,easy to implement and suitable for all numerical methods,not only finite difference methods,that employ weak boundary *** results that corroborate the analysis are presented.

关键词： Summation-by-parts weak boundary conditions penalty technique high-order accuracy finite difference schemes stability steady-state non-reflecting boundary conditions

FIRING PROPERTY OF INFERIOR COLLICULUS NEURONS AFFECTED BY FMR1 GENE MUTATION

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Journal of Otology 2014年第2期9卷 86-90页

作者： brittany Mott SUN Wei Department of Communicative Disorders and Sciences State University of New York at Buffalo137 Cary Hall3435 Main StreetBuffaloNY 14214

Fragile X syndrome is the most common form of inherited mental retardation affecting up to 1 in 4000 individuals. The syn- drome is induced by a mutation in the FMR1 gene, causing a deficiency in its gene by-product FMRP. Impairment in the nor- mal functioning of FMRP leads to learning and memory deficits and heightened sensitivity to sensory stimuli, including sound （hyperacusis）. The molecular basis of fragile X syndrome is thoroughly understood; however, the neural mechanisms underly- ing hyperacusis have not yet been determined. As the inferior colliculus （IC） is the principal midbrain nucleus of the auditory pathway, the current study addresses the questions underlying the neural mechanism of hyperacusis within the IC of fragile X mice. Acute experiments were performed in which electrophysiological recordings of the IC in FMR1-KO and WT mice were measured. Results showed that Q-values for WT were significantly larger than that of FMR-1 KO mice, indicating that WT mice exhibit sharper tuning curves than FMR1-KO mice. We also found the ratio of the monotonic neurons in the KO mice was much higher than the WT mice. These results suggest that lack of FMRP in the auditory system affects the developmental maturation and function of structures within the auditory pathway, and in this case specifically the IC. The dysfunction ob- served within the auditory neural pathway and in particular the IC may be related to the increased susceptibility to sound as seen in individuals with fragile X syndrome. Our study may help on understanding the mechanisms of the fragile X syndrome and hyperacusis.

关键词： Fragile X syndrome inferior colliculus hyperacusis

We Have No Art the Mutual Influence of Corita Kent's Pedagogy and Creative Practice

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We Have No Art the Mutual Influence of Corita Kent's Pedagog...

作者： brittany CATHERINE LANE 中国美术学院

学位级别：硕士

科里塔·肯特(1918-1986)是美国艺术家和教育家。现有的关于肯特的评论文献大多关注其作品在艺术史中的地位,或者她在罗马天主教圣母圣心修女会中的生活。肯特曾在修女会的附属文理学院任教32年,在此期间她也持续创作了大量的艺术作品... 详细信息

科里塔·肯特(1918-1986)是美国艺术家和教育家。现有的关于肯特的评论文献大多关注其作品在艺术史中的地位,或者她在罗马天主教圣母圣心修女会中的生活。肯特曾在修女会的附属文理学院任教32年,在此期间她也持续创作了大量的艺术作品。为了弥补研究上的空白,本文对肯特教育学所产生的背景、理论和实现方式进行了研究,研究发现这与她同一时期艺术作品的材料、创作过程和作品内容具有相关性。肯特的教学和艺术实践都致力于持续性的学习,这种学习在合作条件下更加推崇个人自主意识;直接的视觉感官刺激被用作培养创造力的关键工具。以上两种方式都与当代艺术和社会息息相关,而科里塔·肯特的教学方法和艺术创作则为此打开了一个入口。

关键词：科里塔·肯特教育丝网印刷创造力视觉艺术协作过程

Translational genomics in cancer research: converting profiles into personalized cancer medicine

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Cancer Biology & Medicine 2013年第4期10卷 214-220页

作者： Lalit Patel brittany Parker Da Yang Wei Zhang Department of Pathology The University of Texas MD Anderson Cancer Center The University of Texas Graduate School of Biomedical Sciences

Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole *** the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis,it is also challenging our approach to managing patients suffering from this deadly *** cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis,prognostication,and treatment *** review here recent work undertaken in cancer genomics with an emphasis on translation of genomic ***,we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.

关键词： Cancer genomics translation personalized medicine

New hope for hepatitis C virus:Summary of global epidemiologic changes and novel innovations over 20 years

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World Journal of Gastroenterology 2021年第29期27卷 4818-4830页

作者： brittany B Dennis Leen Naji Yasmin Jajarmi Aijaz Ahmed Donghee Kim Department of Medicine McMaster UniversityHamilton L8S 4L8ONCanada Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCA 94304United States Department of Family Medicine McMaster UniversityHamilton L8P 1H6ONCanada Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamilton L8S 4K1ONCanada

Hepatitis C virus(HCV)is a global health concern associated with significant morbidity and *** the approval of second-generation direct-acting antiviral agents(DAAs),interferon therapy and liver transplantation constituted the mainstay of *** introduction of well-tolerated oral DAAs in late 2013 has revolutionized HCV management with over 95%cure *** predominance of HCV-related liver transplantations has declined following the widespread approval of *** the unparallel efficacy observed among these novel therapies,pharmaceutical costs continue to limit equitable access to healthcare and likely contribute to the differential HCV infection rates observed *** reduce the burden of disease worldwide,essential agenda items for all countries must include the prioritization of integrated care models and access to DAAs *** transparent negotiations with the pharmaceutical industry,the consideration for compassionate release of medications to promote equitable division of care is *** we provide a literature review of HCV,changes in epidemiologic trends,access issues for current therapies,and global inequities in disease burden.

关键词： Hepatitis C virus Direct-acting antivirals Global health Liver transplantation People who inject drugs Liver cirrhosis

Synthesis of Silver Nanoparticles from Honeybees and Its Antibacterial Potential

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Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared spectroscopy： Implications for enabling cell culture process analytical technology

Open Journal of Medical Microbiology（医学微生物学） 2024年第1期 77页

作者： Akamu J. Ewunkem Niore’s Johnson A’lyiha F. Beard Ilunga Tshimanga brittany Justice Jeffery Meixner

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Frontiers of Chemical Science and Engineering 2015年第3期9卷 386-406页

作者： Huiquan Wu Erik Read Maury White brittany Chavez Kurt Brorson Cyrus Agarabi Mansoor Khan Division of Product Quality Research (DPQR HFD-940) Office of Testing and Research (OTR) Office of Pharmaceutical Quality (OPQ) Center for Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA Process Assessment Branch II Division of Process Assessment 1 (DPA 1) Office of Process and Facilities (OPF) Office of Pharmaceutical Quality (OPQ) Center for Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA Division of Biotechnology Review and Research II (DBRRII) Office of Biotechnology Products (OBP) Office of Pharmaceutical Quality (OPQ) Center for' Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA

Compared to small molecule process analytical technology （PAT） applications, biotechnology product PAT applications have certain unique challenges and opportunities. Understanding process dynamics of bioreactor cell culture process is essential to establish an appropriate process control strategy for biotechnology product PAT applications. Inline spectroscopic techniques for real time monitoring of bioreactor cell culture process have the distinct potential to develop PAT approaches in manufac- turing biotechnology drug products. However, the use of inline Fourier transform infrared （FTIR） spectroscopic techniques for bioreactor cell culture process monitoring has not been reported. In this work, real time inline FTIR Spectroscopy was applied to a lab scale bioreactor mAb IgG3 cell culture fluid biomolecular dynamic model. The technical feasibility of using FTIR Spectroscopy for real time tracking and monitoring four key cell culture metabolites （including glucose, glutamine, lactate, and ammonia） and protein yield at increasing levels of complexity （simple binary system, fully formulated media, actual bioreactor cell culture process） was evaluated via a stepwise approach. The FTIR fingerprints of the key metabolites were identified. The multivariate partial least squares （PLS） calibration models were established to correlate the process FTIR spectra with the concentrations of key metabolites and protein yield of in-process samples, either individually for each metabolite and protein or globally for all four metabolites simultaneously. Applying the 2＇ld derivative pre-processing algorithm to the FTIR spectra helps to reduce the number of PLS latent variables needed significantly and thus simplify the interpretation of the PLS models. The validated PLS models show promise in predicting the concentration profiles of glucose, glutamine, lactate, and ammonia and protein yield over the course of the bioreactor cell culture process. Therefore, this work demonstrated the t

关键词： process analytical technology (PAT) Fouriertransform infrared (FTIR) spectroscopy partial least squares (PLS) regression mouse IgG3 bioreactor cell culture process real time process monitoring

Rapid Green Synthesis of Silver Nanoparticles by Reishi and Their Antibacterial Activity and Mechanisms

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From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress

Journal of Biomaterials and Nanobiotechnology（生物材料与纳米技术） 2024年第3期 51页

作者： Akamu J. Ewunkem T’nasia Priester Desia Williams Bailey Ariyon Ilunga Tshimanga brittany Justice Dinesh K. Singh

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5270-5302页

作者： brittany Dewdney Misty RJenkins Sarah ABest Saskia Freytag Krishneel Prasad Jeff Holst Raelene Endersby Terrance GJohns Cancer Centre Telethon Kids InstituteNedlandsWA6009Australia Centre For Child Health Research University of Western AustraliaPerthWA6009Australia Immunology Division The Walter and Eliza Hall Institute of Medical ResearchMelbourne3052Australia Department of Medical Biology University of MelbourneMelbourne3010Australia Personalised Oncology Division The Walter and Eliza Hall Institute of Medical ResearchMelbourne3052Australia School of Biomedical Sciences University of New South WalesSydney2052Australia

Glioblastoma,a rare,and highly lethal form of brain cancer,poses significant challenges in terms of therapeutic resistance,and poor survival rates for both adult and paediatric patients *** advancements in brain cancer research driven by a technological revolution,translating our understanding of glioblastoma pathogenesis into improved clinical outcomes remains a critical unmet *** review emphasises the intricate role of receptor tyrosine kinase signalling pathways,epigenetic mechanisms,and metabolic functions in glioblastoma tumourigenesis and therapeutic *** also discuss the extensive efforts over the past two decades that have explored targeted therapies against these *** therapeutic approaches,such as antibody-toxin conjugates or CAR T cell therapies,offer potential by specifically targeting proteins on the glioblastoma cell *** strategies incorporating protein-targeted therapy and immune-based therapies demonstrate great promise for future clinical ***,gaining insights into the role of cell-of-origin in glioblastoma treatment response holds the potential to advance precision medicine *** these challenges is crucial to improving outcomes for glioblastoma patients and moving towards more effective precision therapies.

关键词： glioblastoma therapies targeted