Translational genomics in cancer research: converting profiles into personalized cancer medicine

作     者：Lalit Patel Brittany Parker Da Yang Wei Zhang 

作者机构：Department of Pathology The University of Texas MD Anderson Cancer Center The University of Texas Graduate School of Biomedical Sciences 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2013年第10卷第4期

页      面：214-220页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported in part by the National Institutes of Health through MD Anderson's Cancer Center Support Grant CA016672 

主　　题：Cancer genomics translation personalized medicine 

摘      要：Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole *** the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis,it is also challenging our approach to managing patients suffering from this deadly *** cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis,prognostication,and treatment *** review here recent work undertaken in cancer genomics with an emphasis on translation of genomic ***,we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.