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Fusion genes in solid tumors: an emerging target for cancer diagnosis and treatment

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Chinese Journal of Cancer 2013年第11期32卷 594-603页

作者： brittany C.Parker Wei Zhang Department of Pathology Unit 85The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA The University of Texas Graduate School of Biomedical Sciences HoustonTX 77030USA

Studies over the past decades have uncovered fusion genes, a class of oncogenes that provide immense diagnostic and therapeutic advantages because of their tumor-specific expression. Originally associated with hemotologic cancers, fusion genes have recently been discovered in a wide array of solid tumors, including sarcomas, carcinomas, and tumors of the central nervous system. Fusion genes are attractive as both therapeutic targets and diagnostic tools due to their inherent expression in tumor tissue alone. Therefore, the discovery and elucidation of fusion genes in various cancer types may provide more effective therapies in the future for cancer patients.

关键词：融合基因癌症患者治疗性实体瘤肿瘤组织中枢神经系统诊断工具特异性表达

Translational genomics in cancer research: converting profiles into personalized cancer medicine

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Cancer Biology & Medicine 2013年第4期10卷 214-220页

作者： Lalit Patel brittany Parker Da Yang Wei Zhang Department of Pathology The University of Texas MD Anderson Cancer Center The University of Texas Graduate School of Biomedical Sciences

Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole *** the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis,it is also challenging our approach to managing patients suffering from this deadly *** cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis,prognostication,and treatment *** review here recent work undertaken in cancer genomics with an emphasis on translation of genomic ***,we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.

关键词： Cancer genomics translation personalized medicine

Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared spectroscopy： Implications for enabling cell culture process analytical technology

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Frontiers of Chemical Science and Engineering 2015年第3期9卷 386-406页

作者： Huiquan Wu Erik Read Maury White brittany Chavez Kurt Brorson Cyrus Agarabi Mansoor Khan Division of Product Quality Research (DPQR HFD-940) Office of Testing and Research (OTR) Office of Pharmaceutical Quality (OPQ) Center for Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA Process Assessment Branch II Division of Process Assessment 1 (DPA 1) Office of Process and Facilities (OPF) Office of Pharmaceutical Quality (OPQ) Center for Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA Division of Biotechnology Review and Research II (DBRRII) Office of Biotechnology Products (OBP) Office of Pharmaceutical Quality (OPQ) Center for' Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA

Compared to small molecule process analytical technology （PAT） applications, biotechnology product PAT applications have certain unique challenges and opportunities. Understanding process dynamics of bioreactor cell culture process is essential to establish an appropriate process control strategy for biotechnology product PAT applications. Inline spectroscopic techniques for real time monitoring of bioreactor cell culture process have the distinct potential to develop PAT approaches in manufac- turing biotechnology drug products. However, the use of inline Fourier transform infrared （FTIR） spectroscopic techniques for bioreactor cell culture process monitoring has not been reported. In this work, real time inline FTIR Spectroscopy was applied to a lab scale bioreactor mAb IgG3 cell culture fluid biomolecular dynamic model. The technical feasibility of using FTIR Spectroscopy for real time tracking and monitoring four key cell culture metabolites （including glucose, glutamine, lactate, and ammonia） and protein yield at increasing levels of complexity （simple binary system, fully formulated media, actual bioreactor cell culture process） was evaluated via a stepwise approach. The FTIR fingerprints of the key metabolites were identified. The multivariate partial least squares （PLS） calibration models were established to correlate the process FTIR spectra with the concentrations of key metabolites and protein yield of in-process samples, either individually for each metabolite and protein or globally for all four metabolites simultaneously. Applying the 2＇ld derivative pre-processing algorithm to the FTIR spectra helps to reduce the number of PLS latent variables needed significantly and thus simplify the interpretation of the PLS models. The validated PLS models show promise in predicting the concentration profiles of glucose, glutamine, lactate, and ammonia and protein yield over the course of the bioreactor cell culture process. Therefore, this work demonstrated the t

关键词： process analytical technology (PAT) Fouriertransform infrared (FTIR) spectroscopy partial least squares (PLS) regression mouse IgG3 bioreactor cell culture process real time process monitoring

Factors and expectations influencing concussion disclosure within NCAA DivisionⅠathletes:A mixed methodological approach

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Journal of Sport and Health Science 2023年第3期12卷 388-397页

作者： Melissa C.Kay Heidi Hennink-Kaminski Zachary Y.Kerr Paula Gildner brittany M.Ingram Kenneth L.Cameron Megan N.Houston Laura A.Linnan Stephen W.Marshall Karen Y.Peck Johna K.Register-Mihalik School of Health Professions College of Nursing and Health ProfessionsUniversity of Southern MississippiHattiesburgMS 39406USA School of Media and Journalism University of North Carolina at Chapel HillChapel HillNC 27599USA Injury Prevention Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Exercise and Sport Science College of Arts and SciencesUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA Center for the Study of Retired Athletes University of North Carolina at Chapel HillChapel HillNC 27599USA Keller Army Hospital United States Military AcademyWest PointNY 10996USA Departments of Physical Medicine and Rehabilitation and Surgery Uniformed Services University of the Health SciencesBethesdaMD 20814USA Department of Health Behavior School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Epidemiology School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Background:Participation in sports is associated with many benefits to all aspects of health;however,it also comes with the risk of injury,particularly ***-disclosure and care seeking following a concussion are especially important because of the lack of outwardly visible signs and/or *** recent research has explored factors affecting concussion disclosure,use of isolated methodologies limits the ability to contextualize how disclosure or nondisclosure ***,the purpose of this study was to describe the factors and expectations of National Collegiate Athletic Association(NCAA)athletes that may influence concussion ***:This mixed-methods convergent parallel research study included 25 NCAA Division I athletes representing 13 sports,all of whom completed a concussion-education session with pre-/post-test surveys and a semistructured *** athletes were at least 18 years old and on an NCAA *** surveys focused on previous concussion-related disclosure behaviors,knowledge,attitudes,beliefs,norms,and intentions about disclosing *** focused on the athletes’experiences related to concussion *** data were analyzed using descriptive statistics and Mann-Whitney U *** were analyzed using a Consensual Qualitative Research ***:Participants had good concussion knowledge(median=46.0),positive attitudes(median=38.0),strong beliefs(median=13.0),and strong intentions to disclose concussion symptoms(median=7.0).None of the constructs differed by participants’*** quantitative findings were mostly positive,interview data highlighted factors that may explain why some participants are successful in disclosing concussions and why others may find disclosure *** efforts,sport culture,and medical professional presence were the primary facilitators discussed by ***,pressure,and a lack of team support were perceived as di

关键词： Education Medical professional presence Mixed methodological research Reporting Sport culture