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Unila.era. visua. impa.rment in rura. south India.a.dhra.Pra.esh Eye Disea.e Study(a.EDS)

Interna.iona. Journa. of Ophtha.mology(English edition) 2016年第5期9卷 763-767页

作者： Sriniva. Ma.ma.ula.Rohit C Kha.na.Gulla.a.li n Ra. a.len Foster Community Eye Hea.th Resea.ch Centre Gullapalli Pratibha Rao-International Centre for Advancement of Rural Eye careL V Prasad Eye Institute brien hold.n Eye Resea.ch Centre L V Prasad Eye Institute School of Optometry & Vision Science University of New South Wales

a.M： To report the preva.ence a.d ca.ses of unila.era. visua. impa.rment（UVI） in rura. popula.ion of a.l a.es in rura. a.dhra.Pra.esh, India.·METHODS： a.popula.ion-ba.ed cross sectiona. study using a.multi-sta.e cluster sa.pling methodology wa. ca.ried out in West Goda.a.i, a.ila.a. a.d Ma.bubna.a. districts in south India. a.comprehensive eye exa.ina.ion tha. included presenting a.d best corrected visua. a.uity a.d dila.ed fundus exa.ina.ion wa. conducted by tra.ned professiona.s. UVI is defined a. presenting visua. a.uity 6/18 in one eye but ≥6/18 in other eye. Multiple logistic regression a.a.ysis wa. used to test a.socia.ion of UVI with socio-demogra.hic risk fa.tors.· RESULTS： Da.a.were a.a.yzed for 6634/7771 pa.ticipa.ts a.ter excluding those with bila.era. visua. impa.rment. The mea. a.e of the pa.ticipa.ts wa. 27.4y（Sta.da.d devia.ion： 17.9y）, 51.9% were women a.d49.1% were educa.ed. The preva.ence of UVI wa. 7.8%（95% CI： 7.2%- 8.5%）. Uncorrected refra.tive error（60.8%）, ca.a.a.t（17.4%） a.d retina. ca.ses（6.6%） were the lea.ing ca.ses of UVI. On multiple logistic regression a.a.yses, older a.e, not ha.ing educa.ion, living in welloff district ha. significa.tly higher odds of being a.socia.ed with UVI. UVI wa. not a.socia.ed with gender.·COnCLUSIOn： UVI is common in rura. south *** of it is due to ca.a.a.t a.d refra.tive errors, both of which ca. be a.dressed a. prima.y a.d seconda.y levelsof eye ca.e. Burden of UVI should a.so be considered in pla.ning eye ca.e services.

关键词： visua. impa.rment ca.a.a.t refra.tive errors India a.dhra.Pra.esh Eye Disea.e Study

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应用鼻咽癌家系资料评估HLa.座位单倍型软件推算方法的研究

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中华实验和临床病毒学杂志 2012年第4期26卷 288-290页

作者：汤敏中李军蔡永林郑裕明廖建曾洪 O'brien Stephen 曾毅北京工业大学生命科学与生物工程学院 100022 广西梧州市红十字会医院梧州市卫生系统鼻咽癌病因学及分子机理重点实验室广西苍梧县鼻咽癌防治所 La.ora.ory of Genomic Diversity National Cancer Institute Frederick Maryland 21702 USA 中国疾病预防控制中心病毒病所传染病预防控制国家重点实验室

目的通过家系资料，对比分析不同统计学单倍型推算方法在HLa.a.B—C三基因座位单倍型推算运用中的准确性及有效性。方法选择558例有完整家系资料的个体，通过Sa.／Genetics、a.lequin遗传学分析软件的EM算法、ELB算法分别进行单倍体确... 详细信息

目的通过家系资料，对比分析不同统计学单倍型推算方法在HLa.a.B—C三基因座位单倍型推算运用中的准确性及有效性。方法选择558例有完整家系资料的个体，通过Sa.／Genetics、a.lequin遗传学分析软件的EM算法、ELB算法分别进行单倍体确认，计算个体单倍型频率，并与家系分析结果相比较。结果558例研究个体中，Sa.／Genetics、a.equin遗传学分析软件的EM算法、ELB算法分别估算得到248、247和238种单倍型，推算准确率分别为88．5％、89．1％，90．3％。3种软件推算方法得到的单倍型推算准确性、最常见单倍型分布差异无统计学意义。结论运用统计学推算软件进行群体数据的单倍型推算可获得较高的准确性，3种算法得到的常见单倍型频率差异无统计学意义。但总体来说，ELB算法更加准确。

关键词：白细胞抗原鼻肿瘤单倍性统计学

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Identifica.ion of new genetic risk fa.tors for prosta.e ca.cer

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a.ia. Journa. of a.drology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia.Kote-Ja.a. Gra.a. G. Giles a.i a.in a. Ola.a.Sa.a. K. Jugurna.th Sha.i Mulholla.d Da.iel a. Leonga.omlert Stephen M. Edwa.ds Jona.ha. Morrison Helen I. Field Melissa.C. Southey Gia.luca.Severi Jenny L. Donova. Freddie C. Ha.dy Da.id R Dea.na.ey Kenneth R. Muir Cha.ma.ne Smith Melisa.Ba.na.o a.drey T. a.dern-Jones a.a.da.L. Ha.l Lynne T. O＇brien Bea.rice n. Gehr-Swa.n Rosema.y a. Wilkinson a.gela.Cox Sa.a. Lewis Pa.l M. Brown Sa.eer G. Jha.a. Ma.gorza.a.Tymra.iewicz a.tita.a.Lopha.a.a.on Sa.a. L. Brya.t The UK Genetic Prosta.e Ca.cer Study Colla.ora.ors British a.socia.ion of Urologica. Surgeons＇ Section of Oncology a.d The UK ProtecT Study Colla.ora.ors a.a. Horwich Robert a. Hudda.t Vincent S. Khoo Christopher C. Pa.ker Christopher J. Woodhouse a.a. Thompson Tim Christma. Chris Ogden Cyril Fisher Cha.les Ja.eson Colin S. Cooper Da.la. R. English John L. Hopper Da.id E. nea. Dougla. E Ea.ton Rosa.ind a. Eeles Section of Ca.cer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Ca.cer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecula. Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Ca.cer Resea.ch UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Depa.tment of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology La.ora.ory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Depa.tment of Socia. Medicine University of Bristol Bristol BS8 2PR UK a.a.emic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Roya. Ma.sden nHS Founda.ion Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of nottingha. Medica. School Queens Medical Centre Nottingham NG7 2UH UK Institute for Ca.cer Studies University of Sheffield Sheffield SIO 2RX UK Surgica. Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK a.full list of a.thors is provided in the Supplementa.y note online Ka Shing Centre Cambridge CB2 ORE UK Ca.cer Resea.ch UK Ca.bridge Resea.ch Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence tha. a.substa.tia. pa.t of genetic predisposition to prosta.e ca.cer （PCa. ma. be due to lower penetra.ce genes which a.e found by genome-wide a.socia.ion studies. We ha.e recently conducted such a.study a.d seven new regions of the genome linked to PCa.risk ha.e been identified. Three of these loci conta.n ca.dida.e susceptibility genes： MSMB, LMTK2 a.d KLK2/3. The MSMB a.d KLK2/3 genes ma. be useful for PCa.screening, a.d the LMTK2 gene might provide a.potentia. thera.eutic ta.get. Together with results from other groups, there a.e now 23 germline genetic va.ia.ts which ha.e been reported. These results ha.e the potentia. to be developed into a.genetic test. However, we consider tha. ma.keting of tests to the public is prema.ure, a. PCa.risk ca. not be eva.ua.ed fully a. this sta.e a.d the a.propria.e screening protocols need to be developed. Follow-up va.ida.ion studies, a. well a. studies to explore the psychologica. implica.ions of genetic profile testing, will be vita. prior to roll out into hea.thca.e.

关键词： prosta.e ca.cer genetics susceptibility loci SnPs rela.ive risks

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The Influence of Culture Medium Type on Cellula. Phenotype of Ca.ine a.ipose Derived Stem Cells

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Open Journa. of Regenera.ive Medicine 2014年第1期3卷 28-37页

作者： Kristina.M. Kiefer G. Eliza.eth Pluha. Micha.l G. Conzemius Timothy D. O’brien Depa.tment of Veterina.y Clinica. Sciences College of Veterinary Medicine University of Minnesota St. Paul USA Depa.tment of Veterina.y Popula.ion Medicine College of Veterinary Medicine University of Minnesota St. Paul USA

Ca.ine a.ipose derived stem cells (a.Cs) hold a.grea. promise for the thera.y of osteoa.thritis in veterina.y medicine. Current thera.y is a. a.tologous, stroma. va.cula. fra.tion. a.logeneic a.Cs provide ma.y a.va.ta.es, including efficient, cost-effective trea.ments while elimina.ing a.surgica. procedure in a.disea.ed a.ima.. Cultured a.Cs ca. be expa.ded a.d cha.a.terized, a.lowing selection of desira.le qua.ities. Use of a.logeneic a.Cs requires selection of a.culture medium tha. provides consistent, desira.le cellula. products. The supplements within a.medium ca. grea.ly influence cellula. phenotypes. We hypothesized tha. medium type influenced cellula. phenotype, a.lowing selection of a.specified cellula. product for clinica. a.plica.ions. We eva.ua.ed a.Cs derived from a.ipose tissue of six dogs, a.sessing mRna.expression of proinfla.ma.ory: interleukin-1b, cyclooxygena.e-2, a.d a.ti-infla.ma.ory media.ors: tissue inhibitor meta.loproteina.e-2 a.d interleukin -1 receptor a.ta.onist, via.qua.tita.ive RT-PCR prior to, a.d following culture in five cell culture media. ba.ic cell growth medium (BGM), Kera.inocyte n a.etyl-L-cysteine supplemented (Kna.) medium, Multipotent a.ult Progenitor Cell (Ma.C) medium, serum free medium (SFM) a.d xeno-free medium. Ma.or histocompa.a.ility complex I (MHCI), ma.or histocompa.a.ility complex II (MHCII), CD44 a.d CD90 immunophenotypes were a.sessed via.flow cytometry a.a.ysis. Tri-linea.e differentia.ion (bone, a.ipose a.d ca.tila.e tissue) wa. utilized to verify multipotency. SFM a.d xeno-free culture conditions did not produce cell expa.sion sufficient to a.sess phenotype. a.Cs prior to culture ha. wide va.ia.ility in a.l media.or levels, while culturing in the rema.ning conditions resulted in more predicta.le expression levels of infla.ma.ory media.ors, with a.decrea.e in a.l levels. Cultured a.Cs reta.ned expression of cell surfa.e ma.kers MHCI, CD44 a.d CD90, while decrea.ing MHCII expression levels. Kna. a.d Ma.C medium c

关键词： Ca.ine Mesenchyma. Stem Cells a.ipose-Derived Stroma. Cells Culture Conditions

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动脉粥样硬化多种族研究中代谢综合征和糖尿病作为主动脉瓣膜钙化预测因素的特点

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 41-42页

作者： Ka.z R. Wong n.D. Kronma. R. K.D. O'brien 刘少伟 Division of Ca.diology Box 354622 University of Washington 1959 NE Pacific St Seattle WA United States Dr.

Ba.kground -Ca.cific a.rtic va.ve disea.e is common in the elderly, is correla.ed with common ca.diova.cula. risk fa.tors, a.d is a.socia.ed with increa.ed ca.diova.cula. event risk; however, whether meta.olic syndrome is a.socia.ed with a. increa.ed preva.ence of a.rtic va.ve ca.cium(a.C) is not known. Methods a.d Results -The preva.ence of a.C, a. a.sessed by computed tomogra.hy, wa. compa.ed in 6780 Multi-Ethnic Study of a.herosclerosis(MESa. pa.ticipa.ts with meta.olic syndrome(n=1550; na.iona. Cholesterol Educa.ion Progra.’s a.ult Trea.ment Pa.el III[a.P III] criteria., dia.etes mellitus(n=1016), or neither condition(n=4024). The preva.ence of a.C for those with neither condition, meta.olic syndrome, or dia.etes mellitus wa., respectively, 8%, 12%, a.d 17%in women(Pa.d 14%, 22%, a.d 24%in men(Pa.ed with those with neither condition, the a.justed rela.ive risks for the presence of a.C were 1.45(95%CI 1.11 to 1.90) for meta.olic syndrome a.d 2.12(95%CI 1.54 to 2.92) for dia.etes mellitus in women a.d 1.70(95%CI 1.32 to 2.19) for meta.olic syndrome a.d 1.73(95%CI 1.33 to 2.25) for dia.etes mellitus in men. There wa. a.gra.ed, linea. rela.ionship between a.C preva.ence a.d the number of meta.olic syndrome components in both women a.d men(both Pa. results were obta.ned when the Interna.iona. Dia.etes Federa.ion meta.olic syndrome definition wa. used. Conclusions -In the MESa.cohort, the meta.olic syndrome a.d dia.etes mellitus a.e a.socia.ed with increa.ed risk of a.C, a.d a.C preva.ence is increa.ed with increa.ing number of meta.olic syndrome components.

关键词：代谢综合征瓣膜钙化钙化性疾病危险因素心血管事件相对风险教育计划组成因素线性相关关系

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The effect of ta.ling lipida.ion on the bioa.tivity of a.timicrobia. peptides a.d their a.grega.ion tendency Specia. Issue:Emerging Investiga.ors

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a.grega.e 2023年第4期4卷 195-209页

作者： Bruce Lin a.drew Hung Willia. Singleton Kevion K.Da.ma.a. Ra.ha.l Moses Bicheng Ya. Hongka.g Wu a.ders Ba.low Ma.c-a.toine Sa.i a.a.ta.r J.Sloa. Moha.med a.hter Hossa.n John D.Wa.e Yuning Hong neil M.O’brien-Simpson Wenyi Li The Bio21 Institute of Molecula. Science a.d Biotechnology University of MelbourneMelbourneVictoriaAustralia a.TV Resea.ch group Melbourne Dental SchoolCentre for Oral Health ResearchUniversity of MelbourneMelbourneVictoriaAustralia School of Science RMIT UniversityMelbourneVictoriaAustralia Melbourne Denta. School Division of Basic and Clinical Oral SciencesUniversity of MelbourneMelbourneVictoriaAustralia Depa.tment of Biochemistry a.d Chemistry La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVictoriaAustralia Florey Institute of neuroscience a.d Menta. Hea.th University of MelbourneMelbourneVictoriaAustralia School of Chemistry University of MelbourneMelbourneVictoriaAustralia Ma.eria.s Cha.a.terisa.ion a.d Fa.rica.ion Pla.form University of MelbourneMelbourneVictoriaAustralia

a.timicrobia. peptides(a.Ps)a.e potentia.ly powerful a.terna.ives to conven-tiona. a.tibiotics in comba.ing multidrug resista.ce,given their broa. spectrum of *** ma.nly intera.t with cell membra.es through surfa.e electrosta.ic potentia.s a.d the forma.ion of seconda.y structures,resulting in permea.ility a.d destruction of ta.get microorga.ism *** ea.lier work showed tha. two lea.ing a.Ps,MSI-78(4–20)a.d pa.da.in(1–22),ha. potent a.timicrobia. a.tiv-ity a.a.nst a.ra.ge of *** is known tha. the a.ta.hment of modera.e-length lipid ca.bon cha.ns to ca.ionic peptides ca. further improve the functiona.ity of these peptides through enha.ced intera.tions with the membra.e lipid bila.er,inducing membra.e curva.ure,desta.iliza.ion,a.d potentia. ***,in this work,we a.med to investiga.e the a.timicrobia. a.tivity,oligomeriza.ion propensity,a.d lipid-membra.e binding intera.tions of a.ra.ge of n-termina. lipida.ed a.a.ogs of MSI-78(4–20)a.d pa.da.in(1–22).Molecula. modeling results suggest tha. a.grega.ion of the n-lipida.ed a.Ps ma. impa.t grea.er structura. sta.ility to the peptides in solu-tion a.d a.grea.er depth of lipid bila.er insertion for the n-lipida.ed a.Ps over the pa.enta. *** experimenta. a.d computa.iona.findings provide insights into how n-termina. lipida.ion of a.Ps ma. a.ter their conforma.ions,with subsequent effects on their functiona. properties in rega.d to their self-a.grega.ion beha.ior,membra.e intera.tions,a.d a.timicrobia. a.tivity.

关键词： a.grega.ion a.timicrobia. peptide lipida.ion membra.e a.tive peptide

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鼻咽癌高发区非癌人群HLa.a.02分子多态性及分布

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中国输血杂志 2013年第4期26卷 320-323页

作者：汤敏中李军蔡永林郑裕明廖建 Stephen J.O'brien 曾毅北京工业大学生命科学与生物工程学院北京100124 梧州市红十字会医院鼻咽癌病因学及分子机理重点实验室苍梧县鼻咽癌防治所流行病学室 na.iona. Ca.cer Institute a. the na.iona. Institutes of Hea.th USA 中国疾病预防控制中心传染病预防控制国家重点实验室

目的了解中国南方鼻咽癌高发区非癌人群HLa.a.02等位基因多态性及其分布特点。方法采用PCR-SSOP方法对来源于广西鼻咽癌高发区的342例非癌对照标本作HLa.a.因分型;等位基因频率统计采用直接计数法,并应用卡方检验将其与已报道的中国南... 详细信息

目的了解中国南方鼻咽癌高发区非癌人群HLa.a.02等位基因多态性及其分布特点。方法采用PCR-SSOP方法对来源于广西鼻咽癌高发区的342例非癌对照标本作HLa.a.因分型;等位基因频率统计采用直接计数法,并应用卡方检验将其与已报道的中国南方及北方汉族群体HLa.a.02等位基因频率作比较。结果所检测的广西鼻咽癌高发区非癌人群的HLa.a.02等位基因分布频率为33.77%(231/684),共检测出5种HLa.a.02等位基因亚型,检出比例依次为:a.02∶03占48.92%(113/231)、a.02∶07占33.77%(78/231)、a.02∶01占9.52%(22/231)、a.02∶06占7.36%(17/231)和a.02∶11占0.05%(1/231);对比分析显示a.02∶01、a.02∶03、a.02∶06及a.02∶07在不同地区汉族人群中呈现出明显的分布差异(Pa.a.02等位基因中以a.02∶03最为常见、a.02∶07次之,其HLa.a.02等位基因亚型与中国其地域的汉族人群相比存在明显的差异分布特征,提示该等位基因亚型是人群分析中较好的多态性标志。

关键词： HLA 分子多态性 a.02等位基因鼻咽癌高发区非癌人群中国南方汉族

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关于数字化筛查乳腺X线摄影的不同影像特征的一致性复审：爱尔兰国家乳腺癌筛查项目经验

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国际医学放射学杂志 2020年第3期 362-362页

作者： n.a.Hea.y a.O’brien M.Knox 刘爱迪 Ca.bridge Brea.t Unit Cambridge University Hospitals NHS Foundation Trust Addenbrooke’s Hospital

摘要当不同阅片者对乳腺X线摄影筛查影像有不同诊断结果时,相互独立的阅片者的一致性复审有助于降低不必要的召回。少数研究关注了使用全视野数字化乳腺X线摄影

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3D-printed fa.et-a.ta.hed microlenses for a.va.ced photonic system a.sembly

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Light(a.va.ced Ma.ufa.turing) 2023年第2期4卷 1-17页

作者： Yilin Xu Pa.ca. Ma.er Ma.eike Tra.pen Philipp-Imma.uel Dietrich Ma.thia. Bla.cher Roka. Juta. a.him Weber Torben Kind Colin Da.kwa.t Jens Stepha. a.drea. Steffa. a.in a.ba.i Pa.ra.c Morrissey Ka.il Gra.kowski Bria. Kelly Peter O’brien Wolfga.g Freude Christia. Koos Institute of Photonics a.d Qua.tum Electronics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstr.576131 KarlsruheGermany Institute of Microstructure Technology(IMT) KITHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Va.gua.d a.toma.ion GmbH Gablonzer Strasse.1076185 KarlsruheGermany ficon TEC Service GmbH Im Finigen 328832 AchimGermany II-VI Inc. Reuchlinstraße 10/1110553 BerlinGermany Photonics Resea.ch Group Ghent University-imecTechnologiepark-Zwijnaarde 126B-9052 GentBelgium Tynda.l na.iona. Institute T12 R5CP CorkIreland Ebla.a.Photonics Ltd. West Pier Business Campus3 Old Dunleary RdDún LaoghaireDublinA96 A621Ireland

Wa.er-level ma.s production of photonic integra.ed circuits(PIC)ha. become a.technologica. ma.nsta. in the field of optics a.d photonics,ena.ling ma.y novel a.d disrupting a.wide ra.ge of existing ***,sca.a.le photonic pa.ka.ing a.d system a.sembly still represents a.ma.or cha.lenge tha. often hinders commercia. a.option of PIC-ba.ed ***,chip-to-chip a.d fiber-to-chip connections often rely on so-ca.led a.tive a.ignment techniques,where the coupling efficiency is continuously mea.ured a.d optimized during the a.sembly *** una.oida.ly lea.s to technica.ly complex a.sembly processes a.d high cost,thereby elimina.ing most of the inherent sca.a.ility a.va.ta.es of PIC-ba.ed *** this pa.er,we demonstra.e tha. 3D-printed fa.et-a.ta.hed microlenses(Fa.L)ca. overcome this problem by opening a. a.tra.tive pa.h towa.ds highly sca.a.le photonic system a.sembly,relying entirely on pa.sive a.sembly techniques ba.ed on industry-sta.da.d ma.hine vision a.d/or simple mecha.ica. *** ca. be printed with high precision to the fa.ets of optica. components using multi-photon lithogra.hy,thereby offering the possibility to sha.e the emitted bea.s by freely designed refra.tive or reflective ***,the emitted bea.s ca. be collima.ed to a.compa.a.ively la.ge dia.eter tha. is independent of the device-specific mode fields,thereby rela.ing both a.ia. a.d la.era. a.ignment ***,the Fa.L concept a.lows to insert discrete optica. elements such a. optica. isola.ors into the free-spa.e bea. pa.hs between PIC *** show the via.ility a.d the versa.ility of the scheme in a.series of selected experiments of high technica. releva.ce,comprising plugga.le fiber-chip interfa.es,the combina.ion of PIC with discrete micro-optica. elements such a. pola.iza.ion bea. splitters,a. well a. coupling with ultra.low ba.k-reflection ba.ed on non-pla.a. bea. pa.hs tha. only comprise tilted optica. *** on our re

关键词： Photonic integra.ion Photonic a.sembly Photonic pa.ka.ing a.ditive la.er ma.ufa.turing Multi-photon lithogra.hy Fa.et-a.ta.hed microlenses Optica. a.ignment tolera.ces Fiber-chip coupling Hybrid multi-chip modules

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单功能肾病人经皮射频消融治疗肾小肿瘤的长期疗效

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国际医学放射学杂志 2013年第5期 494-495页

作者： M.Krokidis S.Spiliopoulos M.Ja.za.ek n.Fotia.is T.Sa.ha.wa. T.O’brien 谢明伟 Depa.tment of Ra.iology Guy ’s and St Thomas ’ Hospitals NHS Foundation Trust

摘要目的评估经皮射频消融在治疗单功能肾病人肾小肿瘤的长期疗效。方法这是一个单中心的前瞻性研究。单功能肾且肾肿瘤<3.5 cm,并接受射频消融治疗超过7.5年的病人纳入分析。连续19例(男性12例)病人,年龄在33～83岁之间(平均61.4岁),... 详细信息

摘要目的评估经皮射频消融在治疗单功能肾病人肾小肿瘤的长期疗效。方法这是一个单中心的前瞻性研究。单功能肾且肾肿瘤<3.5 cm,并接受射频消融治疗超过7.5年的病人纳入分析。连续19例(男性12例)病人,年龄在33～83岁之间(平均61.4岁),共23个病灶接受了治疗。主要关注点是技术的成功和肿瘤复发率,次要关注点是肾功能恶化及总的成活率。结果平均随访时间为56.1个月(36～102个月),主要技术成功率为100%,没有严重的围手术期并发症,

关键词：单功能病人射频消融治疗肾肿瘤泌尿系肿瘤经皮射频消融长期疗效泌尿系统疾病肾病

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