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Electrospun poly（vinylidene fluoride-trifluoroethylene）/ zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation

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Nano Research 2017年第10期10卷 3358-3376页

作者： Robin Augustine Pan Dan Alejandro Sosnik Nandakumar Kalarikkal Nguyen Tran brice vincent Sabu Thomas Patrick Menu Didier Rouxel Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and Engineering Technion-lsrael Institute of Technology De-Jur Building Technion City Haifa 3200003 Israel Intemationaland Inter University Centre for Nanoscience and Nanotechnology Mahatma Gandhi University Kottayam Kerala 686560 India Ingenierie Moleculaire et Physiopathologie Articulaire UMR 7365 CNRS-Universite de Lorraine Vandoeuvre-Ies Nancy F-54500 France School of Pure and Applied Physics Mahatma Gandhi University Kottayam Kerala 686560 India School of Surgery Faculty of Medicine Universite de Lorraine Vandoeuvre-Ies-Nancy F-54500 France Institut Jean Lamour UMR 7198 CNRS-Universite de Lorraine Vandoeuvre-Ies-Nancy F-54500 France School of Chemical Sciences Mahatma Gandhi University Kottayam Kerala 686560 India

Piezoelectric materials that generate electrical signals in response to mechanical strain can be used in tissue engineering to stimulate cell proliferation. Poly （vinylidene fluoride-trifluoroethylene）（P（VDF-TrFE））, a piezoelectric polymer, is widely used in biomaterial applications. We hypothesized that incorporation of zinc oxide （ZnO） nanoparticles into the P（VDF-TrFE） matrix could promote adhesion, migration, and proliferation of cells, as well as blood vessel formation （angiogenesis）. In this study, we fabricated and comprehensively characterized a novel electrospun P（VDF-TrFE）/ZnO nanocomposite tissue engineering scaffold. We analyzed the morphological features of the polymeric matrix by scanning electron microscopy, and utilized Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry to examine changes in the crystalline phases of the copolymer due to addition of the nanoparticles. We detected no or minimal adverse effects of the biomaterials with regard to blood compatibility in vitro, biocompatibility, and cytotoxicity, indicating that P（VDF-TrFE）/ZnO nanocomposite scaffolds are suitable for tissue engineering applications. Interestingly, human mesenchymal stem cells （hMSCs） and human umbilical vein endothelial cells cultured on the nanocomposite scaffolds exhibited higher cell viability, adhesion, and proliferation compared to cells cultured on tissue culture plates or neat P（VDF-TrFE） scaffolds. Nanocomposite scaffolds implanted into rats with or without hMSCs did not elicit immunological responses, as assessed by macroscopic analysis and histology. Importantly, nanocomposite scaffolds promoted angiogenesis, which was increased in scaffolds pre-seeded with hMSCs. Overall, our results highlight the potential of these novel P（VDF-TrFE）/ZnO nanocomposites for use in tissue engineering, due to their biocompatibility and ability to promote cell adhesion and angiogenesis.

关键词： scaffolds electrospinning poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) ZnO angiogenesis cell adhesion stem cells

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay vincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Non-native plant species richness and influence of greenhouses and human populations in the conterminous United States

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Ecological Processes 2023年第1期12卷 388-401页

作者： brice B.Hanberry USDA Forest Service Rocky Mountain Research StationRapid CitySD 57702USA

Background One issue in invasive plant ecology is identification of the factors related to the invasion process that increase number of non-native *** invasion by non-native species increases,so does the probability that some non-native species will become harmful,or classified as invasive species,which disrupt natural ecosystems with attendant economic and social costs.I quantified patterns of how non-native species richness varied with vegetation types and human *** evaluate the relative importance of different predictor variables for invasion pathways in the conterminous United States,I modeled non-native plant species richness by county compared to current and historical human populations;greenhouses and nurseries;railroads,pipelines,transmission lines,and oil and gas wells;and land covers of impervious surface,development intensity categories,agriculture,and vegetation types.I also modeled these variables within vegetation types,excluding vegetation *** To summarize patterns,non-native plant species richness increased from 72 to 200 with increasing human population density *** and forest land use mosaics had the greatest mean number of non-native plant species,ranging from 121 to 166,whereas grasslands and grassland mosaics had the least number of non-native plant species,about *** modeling variable importance,all combined variables had R^(2)values of 56%(random forests regressor)and 54%(cubist regressor)for predictions of withheld observations of non-native plant species rich-ness,with greenhouse density and percent forestlands as most influential *** variables of greenhouses(R^(2)=29%),historical and current human populations(R^(2)=27%and 23%),impervious surface(25%),and medium intensity development(23%)were most associated with non-native plant species *** vegetation types,greenhouse and historical human population densities were influential variables particularly in forestlands,shrubland

关键词： Agriculture Energy Forest Grassland Invasive Propagule Rural Transport Urban

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Looking Back and Beyond Sendai:25 Years of International Policy Experience on Disaster Risk Reduction

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International Journal of Disaster Risk Science 2015年第1期6卷 1-7页

作者： Sálvano briceo Science Committee Integrated Research on Disaster Risk(IRDR) Program of International Council for Science (ICSU)/International Social Science Council (ISSC)/United NationsInternational Strategy for Disaster Reduction (UNISDR)

The evolution in knowledge and application of disaster risk reduction in the 25 years of global cooperation on this issue has been uneven. While advances in knowledge have improved our understanding of the full nature of risk—the combination of hazards meeting vulnerability—the application of such knowledge has not been conducive to the development of institutional and technical mechanisms to address the full range of risk elements. Governance of risk(policies, legislation, and organizational arrangements) still focuses largely on preparing to respond to the hazards and planning for recovery. This leaves largely unattended the vulnerability component of risk, which is the only component on which change can be *** arrangements, risk assessments, early warning systems, and other institutional and technical capacities still concentrate on natural hazards and this is the main change that remains to be substantively addressed.

关键词： Climate change adaptation Disaster risk reduction Risk governance Risk management

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Trajectory from beech and oak forests to eastern broadleaf forests in Indiana, USA

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Ecological Processes 2019年第1期8卷 21-28页

作者： brice B.Hanberry USDA Forest Service Rocky Mountain Research StationRapid CitySD 57702USA

Background:Historical forests(circa 1799 to 1846)of Indiana were predominantly composed of American beech(25%of all trees)and upland oaks(27%of all trees).I compared historical forest composition,using studies of smaller areas to approximate composition for uncommon species or genera(<4.5%of all trees)and forest types,to current forest composition and forest types in Indiana.I also compiled published historical density estimates from small studies and estimated current density for the ***:Current forests are diverse with an even composition of many eastern broadleaf *** addition to upland oaks,which decreased to 13%of all trees,only sugar maple currently comprises greater than 10%of all *** increasing species were yellow-poplar,red maple,black cherry,and eastern *** redcedar increased from no presence to one of the most abundant ten species(≥3.5%of composition),similarly to the pine genus,becoming more common currently than American *** or oak or beech-oak forest types(≥24%of all trees)became eastern broadleaf forests,with no dominant species,and black cherry,red maple,and eastern redcedar forest types now *** of historical oak or beech forests ranged from 28 trees per hectare to 175 trees per hectare,which probably represent savannas and *** mean density of Indiana forests is 385 trees per hectare,ranging from 180 trees per hectare to 450 trees per *** forests likely contain dense layers of woody vegetation,filling the midstory and replacing herbaceous vegetation in the ground ***:Historically dominant beech and oak forests in the eastern United States have transitioned to an alternative state of closed eastern broadleaf forests due to uncontrolled establishment of many tree species.

关键词： Fire Historical Range of variability Transition

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Recent shifts in shade tolerance and disturbance traits in forests of the eastern United States

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Ecological Processes 2019年第1期8卷 391-401页

作者： brice B.Hanberry Rocky Mountain Research Station USDA Forest ServiceRapid CitySD 57702USA

Background:Current forests of the eastern USA have the potential to succeed in composition to more shade-tolerant ***,long-term processes of transition from fire-tolerant tree species to fire-sensitive species and effects of current land use on forests may interfere with successional ***:I examined if forests in three regions have increased in shade tolerance and if life history strategy groups that represent response to disturbance(i.e.,fire-tolerance,early-successional species based on low shade tolerance,mid-successional species,late-successional species,and trees valued for traits related to short harvest rotations)have changed,using Forest Inventory and Analysis surveys,adjusted for comparison,and generalized linear mixed models to assess approximately 30 year trends,with adjustments to equalize different survey ***:Although statistically significant,a slight increase of 2 to 4%in regional mean shade tolerance may not be ecologically *** the central East,mid-successional species replaced early-successional species and early-successional species replaced fire-tolerant oaks,resulting in an overall shift from fire-tolerant oaks to mid-successional *** fire-tolerant pine species and increased planted pine species were the major changes in the northern Southeast and Coastal ***:The successional process of increased composition by shade-tolerant species over time was overshadowed by land use changes that resulted in decreased fire-tolerant species and increased planted ***,frequent land use disturbance may continue to prevent the slow progress of compositional succession to very shade-tolerant species.

关键词： Disturbance Eastern United States Fire Land use Mesophication Oak Pine Succession Traits

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Mountaineering incidents in France: analysis of search and rescue interventions on a 10-year period(from 2008 to 2018)

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Journal of Mountain Science 2021年第2期18卷 446-461页

作者： VANPOULLE Maud LEFEVRE brice SOULE Bastien Laboratory on Vulnerabilities and Innovation in Sport(L-VIS EA7428)University Claude Bernard Lyon1LyonDoua Campus27/29 Boulevard du 11 Novembre 1918Villeurbanne Cedex 69622France

In Europe and especially in France,there is a growing enthusiasm for outdoor sports and *** the meantime,the risk of both severe and frequent injuries associated with active pursuits is acknowledged,especially in mountainous *** effectiveness of prevention must rely on detailed knowledge of typical circumstances and scenarios but thorough understanding of the mechanisms of accidentality remains limited by the fragmentation of sources and by mostly heterogeneous *** paper aims at giving insights on victims’profiles,season,location,and circumstances of mountaineering accidents in the French Alps,through the study of rescue interventions data from 2008 to *** to the analysis of the exhaustive database of search and rescue interventions from the French mountain national police force,and while questioning its limitations,we strive to answer two questions:what are the characteristics of the hazardous situations leading to a rescue intervention in mountaineering?Among these situations,what are the characteristics that tend to make them more harmful?

关键词： Accident studies Mountaineering Outdoor recreation Mountain rescue Victim profiles Multilevel logistic regression

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Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids

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Chinese Journal of Polymer Science 2018年第9期36卷 999-999,1000-1010页

作者： Silvana Alfei Gaby brice Taptue Silvia Catena Angela Bisio Dipartimento di Farmacia Sezione di Chimica e Tecnologie Farmaceutiche e Alimentari Università di Genova

Dendrimers are macromolecules characterized by high controlled size, shape and architecture, presence of inner cavities able to accommodate small molecules and many peripheral functional groups to bind target entities. They are of eminent interest for biomedical applications, including gene transfection, tissue engineering, imaging, and drug delivery. The well-known pharmacological activities of ursolic and oleanolic acids are limited by their small water solubility, non-specific cell distribution, low bioavailability, poor pharmacokinetics, and their direct administration could result in the release of thrombi. To overcome such problems, in this paper we described their physical incorporation inside amino acids-modified polyester-based dendrimers which made them highly water-soluble. IR, NMR, zeta potential, mean size of particles, buffer capacity and drug release profiles of prepared materials were reported. The achieved water-soluble complexes harmonize a polycationic character and a buffer capacity which presuppose efficient cell penetration and increased residence time with a biodegradable cell respectful scaffold, thus appearing as a promising team of not toxic prodrugs for safe administration of ursolic and oleanolic acids.

关键词： Polyester-based amino acids-modified dendrimers Physical encapsulation Water-soluble dendriplexes Buffer capacity NMR investigations

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Heat Transfer Model with Two Heat Transfer Coefficients Along a M ultiperforated Plate-Application to Combustion Chamber Wall Cooling

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Journal of Thermal Science 2003年第4期12卷 363-366页

作者： brice Petre Eva Dorignac Jean Jacques Vullierme Laboratoire d'Etudes Thermiques U.M.R C.N.R.S 6608-ENSMA BP 40109 86961 Futuroscope Chasseneuil Cedex FRANCELaboratoire d'Etudes Thermiques U.M.R C.N.R.S 6608-ENSMA BP 40109 86961 Futuroscope Chasseneuil Cedex FRANCELaboratoire d'Etudes Thermiques U.M.R C.N.R.S 6608-ENSMA BP 40109 86961 Futuroscope Chasseneuil Cedex FRANCE

Walls' cooling of aeronautic propeller combustion chamber is performed with the injection, through the combustion chamber wall, of a part of the air coming from compressors placed upstream. Measurements of the wall thermal fields are made by infrared thermography along the injection wall. This injection wall is pierced by 9 rows of 8 holes (α=90°) in staggered configuration (p/D=s/D=6). We propose a model using two heat transfer coefficients to represent the convective exchanges. The results are non-dimensioned and presented in comparison with the case without holes. The use of this model allows us to define 4 zones. Those 4 zones exist for the 5 blowing rates.

关键词： multiperforation cooling heat transfer coefficients infrared thermography.

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Does white-tailed deer density affect tree stocking in forests of the Eastern United States?

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Ecological Processes 2019年第1期8卷 371-382页

作者： brice B.Hanberry Marc D.Abrams USDA Forest Service Rocky Mountain Research StationRapid CitySD 57702USA Department of Ecosystem Science and Management Pennsylvania State University307 Forest Resources BldgUniversity ParkPA16802USA

Background:White-tailed deer(Odocoileus virginianus)have increased during the past century in the *** deer densities may reduce tree regeneration,leading to forests that are understocked,where growing space is not filled completely by *** deer pressure,a major transition in eastern forests has resulted in increased tree ***:To reconcile conflicting trends,we applied generalized linear mixed models to compare deer densities during 1982 and then 1996 to tree stocking after about 30 years and 15 years of potential reductions of small trees by deer,for the entire eastern US and 11 ecological *** also compiled deer browse preferences and compared preferred browse with trends in tree species composition from historical(1620–1900)and current tree ***:The forested area of the eastern US,including a prairie ecological province,was equally well-stocked(52%)and understocked(48%)during 2011–2017 tree *** 1982 deer densities,38%of area had deer densities>5.8 deer/km2 and for 1996,66%of area had deer densities>5.8 deer/*** densities and tree stocking were not related significantly for the entire eastern *** may reduce tree stocking in the Laurentian Mixed Forest;however,this province had both lower deer densities and greater tree stocking than other ***,major tree species trends did not match tree browse ***:Rather than too few trees,too many trees is an ecological problem where historical open oak and pine forests had herbaceous understories,and currently,trees have captured growing *** attribute other drivers than deer to explain this transition.

关键词： Driver Fire Herbivory Open forests Transition Tree density

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