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Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

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Congenital Heart Disease 2024年第1期19卷 19-31页

作者： Yamixa Delgado Caliani Gaytan Naydi Perez Eric Miranda Bryan colón Morales Mónica Santos Biochemistry&Pharmacology Department San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for Clinical and Translational Research University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Department of Internal Medicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Background:Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States,there is a compelling need to investigate the intricate interplay among body mass index(BMI),pregesta-tional,and gestational maternal diabetes,and their potential impact on the occurrence of congenital heart defects(CHD)during neonatal ***:Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico,we conducted a focused analysis on neonates diagnosed with CHD between 2016 and *** assessment encompassed a range of variables,including maternal age,gestational age,BMI,pregestational diabetes,gestational diabetes,hypertension,history of abortion,and presence of ***:A cohort of 673 patients was included in our *** average maternal age was 26 years,within a range of 22 to 32 *** mean gestational age measured 39 weeks,with a median span of 38 to 39 *** the 673 patients,274(41%)mothers gave birth to neonates diagnosed with *** this group,22 cases were linked to pre-gestational diabetes,while 202 were not;20 instances were associated with gestational diabetes,compared to 200 without;and 148 cases exhibited an overweight or obese BMI,whereas 126 displayed a normal ***:We identiﬁed a statistically signiﬁcant correlation between pre-gestational diabetes mellitus and the occurrence of ***,our analysis did not show a statistically signiﬁcant association between maternal BMI and the likelihood of *** results may aid in developing effective strategies to prevent and manage CHD in neonates.

关键词： Congenital heart defects(CHD) obesisty maternal health diabetes body mass index(BMI)

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Clinical implications of single cell sequencing for bladder cancer

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Oncology Research 2024年第4期32卷 597-605页

作者： REZA YADOLLAHVANDMIANDOAB MEHRSA JALALIZADEH FRANCIELE APARECIDA VECHIA DIONATO KEINI BUOSI PATRÍCIA A.F.LEME LUCIANA S.B.DAL col CRISTIANE F.GIACOMELLI ALEX DIAS ASSIS NASIM BASHIRICHELKASARI LEONARDO OLIVEIRA REIS UroScience School of Medical SciencesUniversity of CampinasUNICAMPCampinasSao Paulo13083-872Brazil ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinasSao Paulo13087-571Brazil

Bladder cancer(BC)is the 10th most common cancer worldwide,with about 0.5 million reported new cases and about 0.2 million deaths per *** this scoping review,we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA *** searched PubMed,CENTRAL,Embase,and supplemented with manual searches through the Scopus,and Web of Science for published studies until February *** included original studies that used at least one single-cell technology to study bladder ***-one publications were included in the ***-nine studies showed that this technology can identify cell subtypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhibition *** studies were able to diagnose BC by identifying neoplastic cells through single-cell sequencing urine *** remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell ***-cell sequencing technology can discriminate heterogeneity in bladder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer *** nascent tool can advance the early diagnosis,prognosis judgment,and targeted therapy of bladder cancer.

关键词： Bladder cancer Urothelial carcinoma Transitional cell carcinoma Single-cell sequencing Tumor heterogeneity Immunotherapy Scoping review Tumor microenvironment

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A novel way to study the nuclear collective excitations

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Nuclear Science and Techniques 2023年第12期34卷 109-111页

作者： Gianluca colò Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di MilanoVia Celoria 1620133 MilanoItaly INFN Sezione di MilanoVia Celoria 1620133 MilanoItaly

Typically, the unambiguous determination of the quantum numbers of nuclear states is a challenging task. Recently, it has been proposed to utilize to this aim vortex photons in the MeV energy region and, potentially, this could revolutionize nuclear spectroscopy because of the new and enhanced selectivity of this probe. Moreover, nuclei may become diagnostic tools for vortex photons. Still, some open questions have to be dealt *** exhibit intricate excitation spectra. Indeed, not all states within these spectra are equally significant. Some are not sensitive to specific terms in the nuclear Hamiltonian or do not display novel features, so that investigating them is not helpful to enhance our overall understanding of nuclear structure. On the other hand, there are states that manifest themselves as prominent peaks, e.g., in the inelastic scattering spectra. Among the best examples are the so-called Giant Resonances that lie at energies of the order of tens of MeV [1].

关键词： spectra structure excitation

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Risk Factors Associated with Unsuccessful Vaginal Birth after One Cesarean (VBAC-1) in Puerto Rico

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Open Journal of Obstetrics and Gynecology 2024年第6期14卷 888-902页

作者： Irazú Guinan Marjorie Suárez Fabiola Angulo Luis Mayol Paula Suárez Lisandris Dominicci Nathalie Chang Saribel Torres Antonio Rodríguez Raymond L. Tremblay Maricarmen colón-Díaz Department of Physiology and Pathology San Juan Bautista School of Medicine Caguas USA

Background: Cesarean section (CS) has increased steadily over the last decade, with an estimated one-third of women delivering by cesarean section worldwide. Objective: Our study aimed to investigate the demographic and associated factors influencing vaginal birth after one cesarean (VBAC-1) success focusing on variables like pre-pregnancy BMI, diabetes, hypertension, education, and smoking. Study Design and Methods: In this retrospective study, we analyzed 285 cases (81 unsuccessful VBAC-1, 204 successful VBAC-1) from San Juan City Hospital (Puerto Rico) between January 1, 2019, and December 31, 2020. We used odds ratios and model selection comparison to assess the impact of variables on successful VBAC-1, using a significance threshold of 95% CI. Model selection assessed binomial model combinations using a generalized linear approach to identify key risk factors. Results: Unsuccessful VBAC-1 (a repeat cesarean), was associated with diabetes (OR: 0.376, p = 0.086), hypertension (OR: 0.23, p = 0.006), and university-educated women (OR: 1.372, p = 0.711). High school-educated women had an OR of 3.966 (p = 0.105), while overweight women were 0.481 times more likely to have unsuccessful VBAC-1 (p = 0.041). Significant associations were not found with obesity (OR: 0.574, p = 0.122), underweight/normal (OR: 1.01, p = 0.810), or smoking (OR: 1.227, p = 0.990). Conclusion: Results revealed women with higher education levels, hypertension, or diabetes are less likely to have a successful VBAC-1. Understanding the complex interactions affecting these outcomes is aimed at establishing guidelines for healthcare professionals to conduct systematic risk/benefit assessments. This study lays a foundation for evidence-based practices and policies, offering initial insights into VBAC-1 success factors in Puerto Rico.

关键词： Diabetes Hypertension Obesity Trial of Labor Vaginal Birth after Cesarean

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Splenic abscess in typhoid fever - Surgical management

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 78-80页

作者： col Prasan Kumar Hota Surgical Specialist Military HospitalJaipur- 302006RajasthanIndia

Splenic abscess is an uncommon clinical presentation in surgical practice,associated with high morbidity and *** may be 100%if left *** abscess is also rarely encountered as a complication of typhoid *** present here a case of multiple splenic abscesses with neuropsychiatric complications due to typhoid fever,which was managed successfully with splenectomy and other supportive *** case of single splenic abscess due to enteric fever was treated successfully with CT-guided aspiration and appropriate *** a rare entity in clinical practice,splenic abscess has been poorly *** seeding of the spleen due to typhoid is a common cause of splenic abscess in the tropical *** multiple or multiloeulated abscesses aspiration usually does not succeed,which happened in our *** remains the definitive choice of ***,Ultra sonography(USG) or CT-guided aspiration may be tried in selective cases.

关键词： Splenic abscess Typhoid fever Surgical management

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Tamoxifen:an FDA approved drug with neuroprotective effects for spinal cord injury recovery

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Neural Regeneration Research 2016年第8期11卷 1208-1211页

作者： Jennifer M.colón Jorge D.Miranda Department of Physiology School of MedicineUniversity of Puerto Rico Medical Sciences Campus

Spinal cord injury（SCI） is a condition without a cure,affecting sensory and/or motor *** physical trauma to the spinal cord initiates a cascade of molecular and cellular events that generates a non-permissive environment for cell survival and axonal *** these complex set of events are damage of the blood-brain barrier,edema formation,inflammation,oxidative stress,demyelination,reactive gliosis and *** multiple events activated after SCI require a multi-active drug that could target most of these events and produce a permissive environment for cell survival,regeneration,vascular reorganization and synaptic ***,a selective estrogen receptor modulator,is an FDA approved drug with several neuroprotective properties that should be considered for the treatment of this devastating *** investigators using different animal models and injury parameters have demonstrated the beneficial effects of this drug to improve functional locomotor recovery after *** suggest that the mechanism of action of Tamoxifen administration is to modulate anti-oxidant,anti-inflammatory and anti-gliotic responses.A gap of knowledge exists regarding the sex differences in response to Tamoxifen and the therapeutic window available to administer this *** addition,the effects of Tamoxifen in axonal outgrowth or synapse formation needs to be *** review will address some of the mechanisms activated by Tamoxifen after SCI and the results recently published by investigators in the field.

关键词： selective estrogen receptor modulator trauma antioxidant anti-inflammatory regeneration reactive gliosis demyelination, estradiol

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High Temperature Oxidation of a Work Roll Grade High-Chromium White Cast Iron

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Journal of Iron and Steel Research International 2013年第10期20卷 122-129页

作者： J H Ramírez-Ramírez R colás N F Garza-Montes-de-Oca Faculty of Mechanical and Electrical Engineering Autonomous University of Nuevo Leon

High-chromium white cast iron is a common material for the manufacture of the work rolls used in the fin- ishing stands in hot strip mills. The high temperature oxidation behaviour of as-cast and heat-treated high-chromium white cast iron was studied by gravimetric means at 650 ℃ in atmospheres that included dry air and a mixture of dry air and water vapour. For both environmental and material conditions, the oxidation rate of the alloys was represen ted by parabolic trends and the oxidation phenomenon was more obvious when the samples were oxidised in water vapour. Water vapour also influenced the chemical composition of the oxides formed in the alloy and under this condi tion, the oxide scale formed on the alloy contained the oxides FeCr2O4 , （Fe,Cr）3O4 and （Fe,Cr）2 O3. In contrast, the alloys exposed to dry air conditions only experienced the formation of FeCr2O4 and （Fe,Cr）2O3. It was found that the presence of water vapour and the chromium content of the alloys increased the oxidation rate by a mechanism that involved chromium depletion of the oxide as a result of hydroxide formation. The differences observed in the oxi- dation behaviour of the alloy are discussed in terms of the composition of the oxidant atmosphere and the metallurgi cal condition of the specimens.

关键词： white cast iron oxidation water vapour work roll

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Classification of anemia for gastroenterologists

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World Journal of Gastroenterology 2009年第37期15卷 4627-4637页

作者： Jose Antonio Moreno Chulilla Maria Soledad Romero colás Martín Gutiérrez Martín Department of Hematology University Hospital "Lozano Blesa" University of Zaragoza C/San Juan Bosco 15 Zaragoza 50009 Spain

Most anemia is related to the digestive system by dietary deficiency, malabsorption, or chronic bleeding. We review the World Health Organization definition of anemia, its morphological classifi cation (microcytic, macrocytic and normocytic) and pathogenic classi-fication (regenerative and hypo regenerative), and integration of these classifications. Interpretation of laboratory tests is included, from the simplest (blood count, routine biochemistry) to the more specific (iron metabolism, vitamin B12, folic acid, reticulocytes, erythropoietin, bone marrow examination and Schilling test). In the text and various algorithms, we propose a hierarchical and logical way to reach a diagnosis as quickly as possible, by properly managing the medical interview, physical examination, appropriate laboratory tests, bone marrow examination, and other comple-mentary tests. The prevalence is emphasized in all sections so that the gastroenterologist can direct the diagnosis to the most common diseases, although the tables also include rare diseases. Digestive diseases potentially causing anemia have been studied in preference, but other causes of anemia have been included in the text and tables. Primitive hematological diseases that cause anemia are only listed, but are not discussed in depth. The last section is dedicated to simplifying all items discussed above, using practical rules to guide diagnosis and medical care with the greatest economy of resources and time.

关键词： Anemia Microcytic anemia Iron Deficiency diseases Macrocytic anemia Normocytic anemia

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GDNF to the rescue:GDNF delivery effects on motor neurons and nerves,and muscle re-innervation after peripheral nerve injuries

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Neural Regeneration Research 2022年第4期17卷 748-753页

作者： Alberto F.Cintrón-colón Gabriel Almeida-Alves Juliana M.VanGyseghem John M.Spitsbergen Biological Sciences Department Western Michigan UniversityKalamazooMIUSA

Peripheral nerve injuries commonly occur due to trauma,like a traffic *** nerves get severed,causing motor neuron death and potential muscle *** current golden standard to treat peripheral nerve lesions,especially lesions with large(≥3 cm)nerve gaps,is the use of a nerve autograft or reimplantation in cases where nerve root avulsions *** not tended early,degeneration of motor neurons and loss of axon regeneration can occur,leading to loss of *** surgical procedures exist,patients often do not fully recover,and quality of life *** nerves have limited regeneration,and it is usually mediated by Schwann cells and neurotrophic factors,like glial cell line-derived neurotrophic factor,as seen in Wallerian *** cell line-derived neurotrophic factor is a neurotrophic factor known to promote motor neuron survival and neurite *** cell line-derived neurotrophic factor is upregulated in different forms of nerve injuries like axotomy,sciatic nerve crush,and compression,thus creating great interest to explore this protein as a potential treatment for peripheral nerve *** glial cell line-derived neurotrophic factor has shown positive effects in regeneration and functional recovery when applied in experimental models of peripheral nerve *** this review,we discuss the mechanism of repair provided by Schwann cells and upregulation of glial cell line-derived neurotrophic factor,the latest findings on the effects of glial cell line-derived neurotrophic factor in different types of peripheral nerve injuries,delivery systems,and complementary treatments(electrical muscle stimulation and exercise).Understanding and overcoming the challenges of proper timing and glial cell line-derived neurotrophic factor delivery is paramount to creating novel treatments to tend to peripheral nerve injuries to improve patients'quality of life.

关键词： electrical muscle stimulation exercise glial cell line-derived neurotrophic factor glial cell line-derived neurotrophic factor delivery motor neuron nerve gap neurotrophic factor peripheral nerve injury Schwann cells skeletal muscle atrophy

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Arthrospira maxima(Spirulina)prevents endoplasmic reticulum stress in the kidney through its C-phycocyanin

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第7期22卷 603-608页

作者： Placido ROJAS-FRANCO Margarita FRANCO-colÍN Vanessa BLAS-VALDIVIA María Estela MELENDEZ-CAMARGO Edgar CANO-EUROPA Laboratorio de Metabolismo I Departamento de FisiologíaEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 07738Mexico Laboratorio de Neurobiología Departamento de FisiologíaEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 07738Mexico Laboratorio de Toxicologia Hepática y Renal Departamento de FarmaciaEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 07738Mexico

Arthrospira maxima(Spirulina)is a cyanobacterium which is considered a nutraceutical because it has antioxidant,anti-inflammatory,and cytoprotective properties in different renal disease models(RodriguezSánchez et al... 详细信息

关键词： al. protective reticulum

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