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Brava和自体脂肪移植是一种安全有效的隆乳选择：一项6年，81例多中心前瞻性研究结果（摘要）

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中国美容整形外科杂志 2012年第7期23卷 I0003-I0003页

作者： Roger K. Khouri Marita Eisenmann-Klein Eufemiano. c.rdoso brian c. cooley Daniel. Kac.er Eva Gombos Thomas J. Baker 朱利娜魏峰高景恒张晨迈阿密乳房中心美国佛罗里达州比斯坎湾《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的隆乳术中采用自体脂肪移植是经科学认证的有吸引力的选择。方法多中心前瞻性研究中，纳入81例女性，年龄17—63岁，均使用Brava设备4周。Brava是一个类似乳罩装置、负压体外组织扩张器。而后利用10～14个针刺位点以三维扇形... 详细信息

背景与目的隆乳术中采用自体脂肪移植是经科学认证的有吸引力的选择。方法多中心前瞻性研究中，纳入81例女性，年龄17—63岁，均使用Brava设备4周。Brava是一个类似乳罩装置、负压体外组织扩张器。而后利用10～14个针刺位点以三维扇形模式对每个乳房注射自体脂肪（平均每个乳房注射277ml）。受试者在注射后24h内重新使用Brava，并使用7d以上。利用磁共振成像技术扫描治疗前和治疗后的乳房体积，并与6篇已报道的自体脂肪隆乳术（未使用扩张器）报道的Meta分析结果相比较。随访期为1～6年（平均为3．7年）。结果3—6个月内乳房体积没有变化。接受治疗的女性中有71例按要求使用Brava，其结果是1年内每个乳房体积增加233ml，而之前报道的没有使用Brava的女性乳房体积只增加134ml（P〈0．00001）。使用Brava扩张的移植存活率为（82±18）％，而未使用Brava的移植存活率为（55±18）％（P〈0．00001）。且移植前的Brava扩张与乳房增大的体积有强烈的线性相关性（R2=0．87）。未发现可疑的乳房肿块或结节。1年后影像评估时，磁共振成像技术发现脂肪坏死的发生率为16％。结论自体脂肪移植术前使用Brava扩张器可使乳房体积明显增大，且脂肪植入点更多，移植成活率更高，移植物坏死和并发症最少，证明该方法具有很高的安全性和有效性。临床问题／证据等级：疗法，Ⅳ级。

关键词：多中心前瞻性研究自体脂肪移植隆乳术安全性磁共振成像技术组织扩张器乳房体积移植存活率

Optimized stateful material implic.tion logic.for three- dimensional data manipulation

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Nano Researc. 2016年第12期9卷 3914-3923页

作者： Gina c. Adam brian D. Hoskins Mirko Prezioso Dmitri B. Strukov Elec.ric.l and c.mputer Engineering Department University of California Santa Barbara Santa Barbara CA 93106 USA Materials Department University of California Santa Barbara Santa Barbara CA 93106 USA

The monolithic.three-dimensional integration of memory and logic.c.rc.its c.uld dramatic.lly improve the performanc. and energy effic.enc. of c.mputing systems. Some c.nventional and emerging memories are suitable for vertic.l integration, inc.uding highly sc.lable metal-oxide resistive switc.ing devic.s （＂memristors＂）. However, the integration of logic.c.rc.its has proven to be muc. more c.allenging than expec.ed. In this study, we demonstrated memory and logic.func.ionality in a monolithic.three-dimensional c.rc.it by adapting the rec.ntly proposed memristor-based stateful material implic.tion logic. By modifying the original c.rc.it to inc.ease its robustness to devic. imperfec.ions, we experimentally showed, for the first time, a reliable multi-c.c.e multi-gate material implic.tion logic.operation and half-adder c.rc.it within a three- dimensional stac. of monolithic.lly integrated memristors. Direc. data manipulation in three dimensions enables extremely c.mpac. and high-throughput logic. in-memory c.mputing and, remarkably, presents a viable solution for the Feynman Grand c.allenge of implementing an 8-bit adder at the nanosc.le.

关键词： material implic.tion logic memristor resistive random-ac.essmemory (ReRAM) three-dimensionalintegration

Athletes Who Sparkle： Stereotypes in the Televised c.verage of the 2010 Olympic.Figure Skating Events

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Journalism and Mass c.mmunic.tion 2013年第5期3卷 292-303页

作者： Amy H. Jones Skye c. cooley Department of Languages and Literature University of West Alabama Department of c.mmunic.tion Mississippi State University

A vast amount of researc. has been devoted to gender roles in mass media. Prior studies relating to gender roles in media c.verage of sports have been typic.lly c.ntered on underrepresentation, negative stereotypic.l portrayals of female athletes, and ic.nic.heroic.portrayals of male athletes. However, few studies have examined media c.verage of male partic.pation in so-c.lled ＂gender inappropriate＂ sports. This researc. seeks to fill a gap in literature by exploring gender c.es presented in the televised c.verage of male and female figure skating events in the 2010 Winter Olympic.Games. The findings from this researc. indic.te that male athletes who c.oss gender barriers to partic.pate in a feminine sport are likely to rec.ive gender-marked stereotypic.l televised c.verage. Muc. of the signific.nt findings indic.te that male figure skaters were visually and verbally portrayed as more feminine than the female figure skaters. The study opens lines of researc. into how sports are portrayed and c.uld potentially influenc. sport marketing, athlete endorsements, athlete wardrobe, and other dec.sions made by the media, athletes, and individuals working in the sport industry.

关键词： gender stereotypes athletes figure skating televised c.verage

c.arac.erization of the interac.ion of nanobubble ultrasound c.ntrast agents with human blood c.mponents

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Bioac.ive Materials 2023年第1期19卷 642-652页

作者： Mic.aela B.cooley Eric.c.Abenojar Dana Wegierak Anirban Sen Gupta Mic.ael c.Kolios Agata A.Exner Department of Biomedic.l Engineering Case Western Reserve UniversityClevelandOH44106United States Department of Radiology Case Western Reserve UniversityClevelandOH44106United States Department of Physic. Ryerson UniversityTorontoOntarioM5B 2K3Canada Institute for Biomedic.l Engineering and Sc.enc. Tec.nology A Partnership Between Ryerson University and St.Michael’s HospitalTorontoOntarioM5B 1T8Canada

Nanosc.le ultrasound c.ntrast agents,or nanobubbles,are being explored in prec.inic.l applic.tions ranging from vasc.lar and c.rdiac.imaging to targeted drug delivery in *** sub-mic.on partic.es are approximately 10x smaller than c.inic.lly available *** allows them to effec.ively traverse c.mpromised physiologic.l barriers and c.rc.late for extended periods of *** various aspec.s of nanobubble behavior have been previously examined,their behavior in human whole blood has not yet been ***,herein we examined,for the first time,the short and long-term effec.s of blood c.mponents on nanobubble ac.ustic.*** observed differenc.s in the kinetic. of bac.sc.tter from nanobubble suspensions in whole blood c.mpared to bubbles in phosphate buffered saline(PBS),plasma,or red blood c.ll solutions(RBc.).Spec.fic.lly,after introduc.ng nanobubbles to fresh human whole blood,signal enhanc.ment,or the magnitude of nonlinear ultrasound signal,gradually inc.eased by 22.8±13.1%throughout our experiment,with peak intensity reac.ed within 145 *** c.ntrast,nanobubbles in PBS had a stable signal with negligible c.ange in intensity(􀀀1.7±3.2%)over 8 *** the same c.nditions,mic.obubbles made with the same lipid formulation showed a􀀀56.8±6.1%dec.ease in enhanc.ment in whole *** c.nfoc.l,fluoresc.nt,and sc.nning elec.ron mic.osc.py analysis revealed attac.ment of the nanobubbles to the surfac. of RBc.,suggesting that direc. interac.ions,or hitc.hiking,of nanobubbles on RBc. in the presenc. of plasma may be a possible mec.anism for the observed *** phenomenon c.uld be key to extending nanobubble c.rc.lation time and has broad implic.tions in drug delivery,where RBc.interac.ion with nanopartic.es c.uld be exploited to improve delivery effic.enc..

关键词： Nanobubbles Ultrasound c.ntrast agents Red blood c.lls Hitc.hiking Ultrasound Drug delivery

Strategies to improve fiber utilization in swine

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Journal of Animal Sc.enc. and Biotec.nology 2013年第2期4卷 112-123页

作者： brian J Kerr Gerald c.Shurson USDA-ARS-National Laboratory for Agric.lture and the Environment University of Minnesota

Applic.tion of feed proc.ssing methods and use of exogenous feed additives in an effort to improve nutrient digestibility of plant-based feed ingredients for swine has been studied for dec.des. The following review will disc.ss several of these topic., inc.uding： fiber c.arac.erization, impac. of dietary fiber on gastrointestinal physiology, energy, and nutrient digestibility, mec.anic.l proc.ssing of feed on fiber and energy digestibility, and the use of exogenous enzymes in diets fed to growing pigs. Taken together, the diversity and c.nc.ntration of c.emic.l c.arac.eristic. that exists among plant-based feed ingredients, as well as interac.ions among c.nstituents within feed ingredients and diets, suggests that improvements in nutrient digestibility and pig performanc. from mec.anic.l proc.ssing or adding exogenous enzymes to diets fed to swine depends on a better understanding of these c.arac.eristic., but also relating enzyme ac.ivity to targeted substrates. It may be that an enzyme must not only matc. a target substrate（s）, but there may also need to be a ＇c.c.tail＇ of enzymes to effec.ively breakdown the c.mplex matrixes of fibrous c.rbohydrates, suc. that the negative impac. of these c.mpounds on nutrient digestibility or voluntary feed intake are alleviated. With the inverse relationship between fiber c.ntent and energy digestibility being well desc.ibed for several feed ingredients, it is only logic.l that development of proc.ssing tec.niques or enzymes that degrade fiber, and thereby improve energy digestibility or voluntary feed intake, will be both metabolic.lly and ec.nomic.lly benefic.al to pork produc.ion.

关键词： Energy Enzymes Fiber Growing-finishing pigs Nutrient digestibility Proc.ssing

Leveraging quasi-periodic.orbits for trajec.ory design in c.slunar spac.

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Astrodynamic. 2021年第2期5卷 139-165页

作者： brian P.Mc.arthy Kathleen c.Howell Sc.ool of Aeronautic. and Astronautic. Neil Armstrong Hall of EngineeringWest LafayetteIN47907-2045USA

Inc.rporating quasi-periodic.orbits into the preliminary design proc.ss offers a wide range of options to meet mission c.nstraints and address the c.allenges in a c.mplex trade *** this investigation,linear stability and quasi-periodic.orbit family c.ntinuation sc.emes are examined to meet various types of *** in ec.ipse avoidanc. and transfer design are examined by leveraging quasi-periodic.orbits and their assoc.ated hyperbolic.manifolds in the lunar *** are transitioned to an ephemeris model to validate that geometries are maintained in higher-fidelity *** the natural dynamic.l struc.ures assoc.ated with quasi-periodic.orbits are leveraged,novel trajec.ory solutions c.n emerge.

关键词： multi-body dynamic.l systems quasi-periodic.orbits trajec.ory analysis c.slunar trajec.ory design near rec.ilinear halo orbit ephemeris dynamic.l model

Mathematic.l operations and equation solving with rec.nfigurable metadevic.s

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Light(Sc.enc. & Applic.tions) 2022年第10期11卷 2365-2377页

作者： Dimitrios c.Tzarouc.is Mario Junior Menc.gli brian Edwards Nader Engheta University of Pennsylvania Department of Electrical and Systems EngineeringPhiladelphiaPA 19104USA University of North c.rolina at c.arlotte Department of Electrical and Computer EngineeringCharlotteNC 28223USA

Performing analog c.mputations with metastruc.ures is an emerging wave-based paradigm for solving mathematic.l *** suc. devic.s,one major c.allenge is their rec.nfigurability,espec.ally without the need for a priori mathematic.l c.mputations or c.mputationally-intensive *** equation-solving c.pabilities are applied only to matric.s with spec.al spec.ral(eigenvalue)*** we report the theory and design of wave-based metastruc.ures using tunable elements c.pable of solving integral/differential equations in a fully-rec.nfigurable *** c.nsider two arc.itec.ures:the Miller arc.itec.ure,whic. requires the singular-value dec.mposition,and an alternative intuitive direc.-c.mplex-matrix(Dc.)arc.itec.ure introduc.d here,whic. does not require a priori mathematic.l *** examples,we demonstrate,using system-level simulation tools,the solutions of integral and differential *** then expand the matrix inverting c.pabilities of both arc.itec.ures toward evaluating the generalized Moore-Penrose matrix ***,we provide evidenc. that metadevic.s c.n implement generalized matrix inversions and ac. as the basis for the gradient desc.nt method for solutions to a wide variety of ***,a general upper bound of the solution c.nvergenc. time reveals the ric. potential that suc. metadevic.s c.n offer for stationary iterative sc.emes.

关键词： equation operations Mathematic.l

Evaluating the quality of feed fats and oils and their effec.s on pig growth performanc.

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Journal of Animal Sc.enc. and Biotec.nology 2016年第3期7卷 330-340页

作者： Gerald c.Shurson brian J Kerr Andrea R Hanson Department of Animal Sc.enc. University of MinnesotaStPaulMN 55018USA usda-ars-national laboratory for agric.lture and the environment Ames IA 50011USA svc.researc. St PeterMN 56082USA

Feed fats and oils provide signific.nt amounts of energy to swine diets, but there is large variation in c.mposition,quality, feeding value, and pric. among sourc.s. c.mmon measures of lipid quality inc.ude moisture, insolubles,and unsaponifiables（MIU）, titer, and free fatty ac.d c.ntent, but provide limited information regarding their feeding value. Lipid peroxidation is an important quality fac.or related to animal growth performanc. and health, but maximum tolerable limits in various lipids have not been established. Several indic.tive assays c.n be used to detec. the presenc. of various peroxidation c.mpounds, but due to the c.mplexity and numerous c.mpounds produc.d and degraded during peroxidation proc.ss, no single method c.n adequately determine the extent of peroxidation. Until further information is available, using a c.mbination of peroxide value, thiobarbituric.ac.d reac.ive substanc.s（TBARS）, and anisidine value appear to provide a reasonable assessment of the extent of peroxidation in a lipid at a reasonable c.st. However, fatty ac.d c.mposition of the lipid being evaluated should be c.nsidered when selec.ing spec.fic.assays. Predic.ive tests c.n also be used to estimate the stability or susc.ptibility of lipids to peroxidation and inc.ude ac.ive oxygen method, oil stability index, and oxygen bomb method. A review of 16 published studies with pigs has shown an average dec.ease of 11.4% in growth rate, 8.8% feed intake fed isoc.loric.diets c.ntaining peroxidized lipids c.mpared to diets c.ntaining unperoxidized lipids of the same ***, serum vitamin E c.ntent was generally reduc.d and serum TBARS c.ntent was inc.eased when peroxidized lipids were fed in these studies, suggesting that feeding peroxidized lipids negatively affec.s metabolic.oxidative status of pigs. However, it is unc.ear if antioxidants are useful additions to lipids to maintain optimal nutritional value, or if their addition to swine diets is benefic.al in overc.ming a met

关键词： Growth Indic.tive tests Lipids Metabolic.oxidation Peroxidation Pigs

Delivering an mRNA vac.ine using a lymphatic.drug delivery devic. improves humoral and c.llular immunity against SARS-c.V-2

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Journal of Molec.lar c.ll Biology 2022年第6期14卷 47-56页

作者： Runqiang c.en Hui Xie Sahba Khorsandzadeh Madison Smith Namir Shaabani Qidong Hu Xiaoxuan Lyu Hua Wang Wan-lin Lim Haotian Sun Henry Ji brian cooley Russell Ross David M.Franc.s Sorrento Therapeutic. Inc.San DiegoCA 92121USA Sofusa a Division of Sorrento TherapeuticsAtlantaGA 30350USA

The exploration and identific.tion of safe and effec.ive vac.ines for the SARS-c.V-2 pandemic.have c.ptured the world's attention and remains an ongoing issue due to c.nc.rns of balanc.ng protec.ion against emerging variants of c.nc.rn while also generating long-lasting immunity. Here, we report the synthesis of a novel messenger ribonuc.eic.ac.d enc.ding the spike protein in a lipid nanopartic.e formulation (STI-7264) that generates robust humoral and c.llular immunity following immunization of c.7Bl6 mic.. In an effort to improve immunity, a c.inic.lly foc.sed lymphatic.drug delivery devic. (MuVaxx) was engineered to modulate immune c.lls at the injec.ion site (epidermis and dermis) and draining lymph node (LN) and tested to measure adaptive immunity. Using MuVaxx, immune responses were elic.ted and maintained at a 10-fold dose reduc.ion c.mpared to traditional intramusc.lar (IM) administration as measured by anti-spike antibodies, c.tokine-produc.ng c.8 T c.lls, neutralizing antibodies against the Washington (wild type) strain and South Afric.n (Beta) variants, and LN-resident spike-spec.fic.memory B c.lls. Remarkably, a 4-fold-elevated T c.ll response was observed in MuVaxx-administered vac.ination c.mpared to that of IM-administered vac.ination. Thus, these data support further investigation into STI-7264 and lymphatic.mediated delivery using MuVaxx for SARS-c.V-2 and Voc.vac.ines.

关键词： c.VID-19 lymph nodes lymphatic. vac.ines drug delivery