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Renal-function change after transjugular intra-hepatic portosystemic shunt placement and its relationship with survival:a single-center experience

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Gastroenterology Report 2021年第4期9卷 306-312,I0001,I0002页

作者： Min Lang Angela L.Lang brian q.tsui Weiping Wang brian K.Erly Bo Shen Baljendra Kapoor Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Anesthesia Critical Careand Pain ManagementMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Radiology UCLA Medical CenterLos AngelesCAUSA Department of Radiology Mayo ClinicJacksonvilleFLUSA Colorado School of Public Health AuroraColoradoUSA The Inflammatory Bowel Disease Center at Columbia Columbia University Irving Medical CenterNew YorkNYUSA Division of Vascular and Interventional Radiology Imaging InstituteCleveland ClinicClevelandOHUSA

Background:The effect of transjugular intra-hepatic portosystemic shunt(TIPS)placement on renal function and the correlation of post-TIPS Cr with mortality remain *** study aimed to assess the effect of TIPS placement on renal function and to examine the relationship between post-TIPS Cr and mortality ***:A total of 593 patients who underwent de novo TIPS placement between 2004 and 2017 at a single institution were included in the *** pre-TIPS Cr level(T0;within 7 days before TIPS placement)and post-TIPS Cr levels,at 1–2 days(T1),5–12 days(T2),and 15–40 days(T3),were *** of Cr change after TIPS placement and the 1-year mortality rate were analysed using multivariable linear-regression and Cox proportional-hazards models,***:Overall,21.4%of patients(n=127)had elevated baseline Cr(≤1.5 mg/dL;mean,2.5161.49 mg/dL)and 78.6%(n=466)had normal baseline Cr(<1.5 mg/dL;mean,0.9260.26 mg/dL).Patients with elevated pre-TIPS Cr demonstrated a decrease in post-TIPS Cr(difference,-0.60 mg/dL),whereas patients with normal baseline Cr exhibited no change(difference,<0.01 mg/dL).The 30-day,90-day,and 1-year mortality rates were 13%,20%,and 32%,*** bleeding as a TIPS-placement indication(hazard ratio=1.731;P=0.036),higher T0 Cr(hazard ratio=1.834;P=0.012),and higher T3 Cr(hazard ratio=3.524;P<0.001)were associated with higher 1-year mortality ***:TIPS placement improved renal function in patients with baseline renal dysfunction and the post-TIPS Cr level was a strong predictor of 1-year mortality risk.

关键词： TIPS transjugular intra-hepatic portosystemic shunt portal hypertension renal function renal failure mortality

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神经元突触内的非受体型酪氨酸激酶底物（英文）

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生理学报 2017年第5期69卷 657-665页

作者：毛利民 Ryan Geosling brian Penman 王强密苏里州立大学医学院基础医学系密苏里州立大学医学院麻醉学系

非受体型酪氨酸激酶(non-receptor tyrosine kinase,nRTK)是一个较大的激酶家族,其功能是催化蛋白的酪氨酸磷酸化。nRTK家族中的几种常见亚型,比如Src和Fyn,可以在神经系统内表达。近年来的研究表明,神经元的突触部位含有多个nRTK的底... 详细信息

非受体型酪氨酸激酶(non-receptor tyrosine kinase,nRTK)是一个较大的激酶家族,其功能是催化蛋白的酪氨酸磷酸化。nRTK家族中的几种常见亚型,比如Src和Fyn,可以在神经系统内表达。近年来的研究表明,神经元的突触部位含有多个nRTK的底物蛋白,这些底物蛋白主要包括谷氨酸受体(离子型和代谢型谷氨酸受体)、突触后构架蛋白、突触前调节蛋白和突触富含的多种蛋白激酶。在基础或刺激的状态下,nRTK可催化这些底物蛋白内特定酪氨酸的磷酸化,从而调节这些底物蛋白的多种生理、生化和生物物理功能。因为突触内的nRTK对突触变化信号非常敏感,所以突触nRTK被认为参与了突触传导活动的强度和效率等方面的调节。

关键词： N-甲基-D-天冬氨酸受体 AMPA 代谢型谷氨酸受体突触后密度蛋白95 Src Fyn ERK Cdk5 突触素突触蛋白 I

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Local and global methods in representations of Hecke algebras

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Science China Mathematics 2018年第2期61卷 207-226页

作者： Jie Du brian J.Parshall Leonard L.Scott School of Mathematics and Statistics University of New South Wales(UNSW) Department of Mathematics University of Virginia

This paper aims at developing a "local-global" approach for various types of finite dimensional algebras, especially those related to Hecke algebras. The eventual intention is to apply the methods and applications developed here to the cross-characteristic representation theory of finite groups of Lie type. We first review the notions of quasi-hereditary and stratified algebras over a Noetherian commutative ring. We prove that many global properties of these algebras hold if and only if they hold locally at every prime ideal. When the commutative ring is sufficiently good, it is often sufficient to check just the prime ideals of height at most one. These methods are applied to construct certain generalized q-Schur algebras, proving they are often quasi-hereditary(the "good" prime case) but always stratified. Finally, these results are used to prove a triangular decomposition matrix theorem for the modular representations of Hecke algebras at good primes. In the bad prime case, the generalized q-Schur algebras are at least stratified, and a block triangular analogue of the good prime case is proved, where the blocks correspond to Kazhdan-Lusztig cells.

关键词： quasi-hereditary algebra stratified algebra Hecke algebra Schur algebra left cell endomorphism algebra exact category height one prime

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A surface sampling and liquid chromatography mass spectrometry method for the analysis of quaternary ammonium compounds collected from public transportation buses in New Jersey

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Emerging Contaminants 2022年第1期8卷 318-328页

作者： Abigail Lazofsky Cathleen Doherty Patrick Szary brian Buckley Environmental and Occupational Health Sciences Institute Rutgers University170 Frelinghuysen RoadPiscatawayNJ08854USA Center for Advanced Infrastructure and Transportation Rutgers University100 Brett RoadPiscatawayNJ08854USA

quaternary ammonium compounds(qACs)are a class of antimicrobial disinfectants whose use in cleaning products increased during the COVID-19 ***,their low vapor pressure indicates a proclivity to persist on surfaces,and their presence suggests a level of protection against *** widespread application of qACs in response to the SARS CoV-2 virus created a need to evaluate their longevity on surfaces,for both efficacy and possible health *** are however,no standardized analytical methods for qAC surface sampling and analysis,and no published studies quantifying their concentrations on mass transportation vehicles-a high occupancy,close-contact microenvironment documented to facilitate the spread the SARS CoV-2 ***,we describe a robust liquid chromatography mass spectrometry(LC-MS)method for the analysis of qACs and simultaneous development of a direct surface sampling and extraction *** demonstrate the applicability of the method through the analysis of surface samples collected from in-service public transportation *** rapid,sensitive LC-MS method included 8 target qACs quantified on a q-Exactive HF Hybrid quadrupole-Orbitrap mass spectrometer using an electrospray ionization source and Dionex UltiMate 3000 UHPLC system for analyte *** standard mixtures at concentrations between 0.1 ng mL^(-1)and 2000 ng mL^(-1)were analyzed,and chromatographic separation of all analytes was achieved in less than 10 *** correlation coefficients were reported at r>0.986,and LODs ranged from 0.007 to 2.103 ng mL^(-1)for all compounds,confirming the method's sensitivity.A previously reported surface sampling and extraction protocol was modified to further simplify the procedure and expand the number of target *** new sampling protocol was optimized from 10 commercially available wipes and 4 solvent types by quantifying recovery from the ***-Aid brand small gauze pads saturated with isopropanol had

关键词： Alkyl dimethyl benzyl ammonium chloride Alkyl(ethyl benzyl)dimethyl ammonium chloride Surface sampling Orbitrap mass spectrometry Public transportation COVID-19

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Perspective on the q-bio Summer School anc Conference： 2007- 2014 and beyond

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Frontiers of Electrical and Electronic Engineering in China 2014年第1期9卷 54-58页

作者： Orna Resnekov brian Munsky William S. Hlavacek Molecular Sciences Institute Berkeley CA 94704 USA Department of Chemical and Biological Engineering Colorado State University Fort Collins CO 80523 USA New Mexico consortium Los Alamos NM87544 US-A Theoretical Division and Center for Nonlinear Studies Los Alamos National Laboratory Los Alamos NM 87545 USA

INTRODUCTIONThe q-bio Conference and the associated q-bio Summer School were started in 2007 by a prescient group of researchers based at Los Alamos National Laboratory （LANL） and the University of New Mexico （J. Edwards, J. Faeder, W. Hlavacek, Y. Jiang, I. Nemenman and M. Wall） who envisioned a systems biology community focused on modeling,

关键词： Advisory Committee Member Program Committee Member quantitative Biology Summer School Synthetic Circuit

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Genic C-Methylation in Soybean Is Associated with Gene Paralogs Relocated to Transposable Element-Rich Pericentromeres

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Molecular Plant 2018年第3期11卷 485-495页

作者： Moaine El Baidouri Kyung Do Kim brian Abernathy Ying-Hui Li Li-Juan qiu Scott A. Jackson Center for Applied Genetic Technologies University of Georgia 111 Riverbend Road Athens GA 30602 USA Corporate R&D LG Chem LG Science Park 30 Magokjungang 10-ro Gangseo-gu Seoul 07796 Republic of Korea The National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI) Institute of Crop Science Chinese Academy of Agricultural SciencesBeijing China These authors contributed equally to this article.

Most plants are polyploid due to whole-genome duplications （WGD） and can thus have duplicated genes. Following a WGD, paralogs are often fractionated （lost） and few duplicate pairs remain. Little attention has been paid to the role of DNA methylation in the functional divergence of paralogous genes. Using high- resolution methylation maps of accessions of domesticated and wild soybean, we show that in soybean, a recent paleopolyploid with many paralogs, DNA methylation likely contributed to the elimination of ge- netic redundancy of polyploidy-derived gene paralogs. Transcriptionally silenced paralogs exhibit partic- ular genomic features as they are often associated with proximal transposable elements （TEs） and are pref- erentially located in pericentromeres, likely due to gene movement during evolution. Additionally, we provide evidence that gene methylation associated with proximal TEs is implicated in the divergence of expression profiles between orthologous genes of wild and domesticated soybean, and within populations.

关键词： soybean paralog gene methylation proximal transposable element methylation spreading

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Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 78-93,I0009-I0013页

作者： Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow brian K.P.Goh Daniel q.Huang Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Division of Hepatobiliary&Pancreatic Surgery Department of SurgeryNational University HospitalSingaporeSingapore Department of Internal Medicine Yonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalYonsei University Health SystemSeoulRepublic of Korea Biostatistics and Modelling Domain Saw Swee Hock School of Public HealthNational University of Singapore and National University Health SystemSingaporeSingapore Department of Hepato-Pancreato-Biliary and Transplant Surgery Division of SurgerySingapore General HospitalSingaporeSingapore Liver Transplant Service SingHealth Duke-NUS Transplant CentreSingaporeSingapore

Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease *** aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan ***:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan ***-analyses and meta-regression were conducted using random-effects ***:We screened 2,278 studies and included 35 studies with 18,421 *** was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)*** uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to *** between LR and LT were similar in uninodular *** risk of recurrence after LR is threefold that of LT.

关键词： Hepatocellular carcinoma(HCC) liver resection(LR) liver transplant survival recurrence

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Beclin 1-Vps34 complex architecture： Understanding the nuts and bolts of therapeutic targets

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Frontiers in Biology 2015年第5期10卷 398-426页

作者： Deanna H. Morris Calvin K. Yip Yi Shi brian T. Chait qing Jun Wang Department of Molecular and Cellular Biochemistry University of Kentucky Lexington KY 40536 USA Department of Biochemistry and Molecular Biology The University of British Columbia Vancouver BC V6TIZ3 Canada Laboratory of Mass Spectrometry and Gaseous Ion Chemistry The Rockefeller University New York NY 10065 USA Department of Toxicology and Cancer Biology University of Kentucky Lexington KY 40536 USA Markey Cancer Center University of Kentucky Lexington KY 40536 USA

Autophagy is an important lysosomal degradation pathway that aids in the maintenance of cellular homeostasis by breaking down and recycling intracellular contents. Dysregulation of autophagy is linked to a growing number of human diseases. The Beclin 1-Vps34 protein-protein interaction network is critical for autophagy regulation and is therefore essential to cellular integrity. Manipulation of autophagy, in particular via modulation of the action of the Beclin I-Vps34 complexes, is considered a promising route to combat autophagy-related diseases. Here we summarize recent findings on the core components and structural architecture of the Beclin 1-Vps34 complexes, and how these findings provide valuable insights into the molecular mechanisms that underlie the multiple functions of these complexes and for devising therapeutic strategies.

关键词： Beclin 1 Vps34 Nrbf2 complex structure CX-MS EM inhibitor drag design

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基于领导成员交换关系的沟通满意度研究

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管理评论 2009年第4期21卷 72-82页

作者：张莉刘宝巍贾琼 brian Earn 哈尔滨工业大学管理学院哈尔滨150001 哈尔滨工程大学经济管理学院哈尔滨150001 Centre for Studies in Leadership University of GuelphOntarioCanadaNIG 2V7

沟通满意度作为组织有效沟通的一个重要评价指标,对提高员工的工作积极性、工作效率,增加员工对组织的责任感起着重要作用。本研究基于领导成员交换理论,分析了领导成员交换关系与沟通满意度的相关变量,并构建了沟通满意度与领导成员交... 详细信息

沟通满意度作为组织有效沟通的一个重要评价指标,对提高员工的工作积极性、工作效率,增加员工对组织的责任感起着重要作用。本研究基于领导成员交换理论,分析了领导成员交换关系与沟通满意度的相关变量,并构建了沟通满意度与领导成员交换的关系模型。在此基础上,通过调查研究,采用多元统计分析方法对沟通满意度与领导成员交换关系进行了实证研究,研究结果表明:沟通满意度与领导成员交换有正相关关系;沟通满意度中领导的下行沟通比成员的上行沟通对领导成员交换关系的影响更强;领导成员交换质量将影响个体、团队和组织层次上的沟通满意度。

关键词：沟通满意度领导成员交换有效沟通

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知识型企业领导成员交换与知识共享的关系研究

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科学学研究 2008年第S2期26卷 428-435页

作者：张莉贾琼刘宝巍 brian earn 哈尔滨工业大学管理学院黑龙江哈尔滨150001 圭尔夫大学

在分析领导成员交换关系与知识共享的相互作用基础上,构建了领导成员交换与知识共享的关系模型,采用多元统计分析方法对知识型企业领导成员交换与知识共享的相互关系进行了实证分析。研究结果表明:领导成员交换和知识共享之间存在显著... 详细信息

在分析领导成员交换关系与知识共享的相互作用基础上,构建了领导成员交换与知识共享的关系模型,采用多元统计分析方法对知识型企业领导成员交换与知识共享的相互关系进行了实证分析。研究结果表明:领导成员交换和知识共享之间存在显著的正相关关系,而且体现出维度差异,领导成员交换的沟通、信任维度可以较好地由知识共享典型变量来预测。

关键词：知识共享领导成员交换知识型企业

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