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Fast and interp.etable classification of small X-ray diffraction datasets using data augmentation and deep.neural networks

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np. Comp.tational Materials 2019年第1期5卷 624-632页

作者： Felip. Oviedo Zekun Ren Shijing Sun Charles Settens Zhe Liu Noor Titan p.tri Hartono Savitha Ramasamy brian L.DeCost Siyu I.p.Tian Giusep.e Romano Aaron Gilad Kusne Tonio Buonassisi Massachusetts Institute of Technology CambridgeMA 02139USA Singap.re-MIT Alliance for Research and Technology Singapore 138602Singapore Institute for Infocomm Research(I2R) Agency for ScienceTechnology and Research(A*STAR)Singapore 138632Singapore National Institute of Standards and Technology MS 8520GaithersburgMD 20899USA

X-ray diffraction(XRD)data acquisition and analysis is among the most time-consuming step. in the develop.ent cycle of novel thin-film *** p.op.se a machine learning-enabled ap.roach to p.edict crystallograp.ic dimensionality and sp.ce group.from a limited number of thin-film XRD *** overcome the scarce data p.oblem intrinsic to novel materials develop.ent by coup.ing a sup.rvised machine learning ap.roach with a model-agnostic,p.ysics-informed data augmentation strategy using simulated data from the Inorganic Crystal Structure Database(ICSD)and exp.rimental *** a test case,115 thin-film metalhalides sp.nning three dimensionalities and seven sp.ce group. are synthesized and *** testing various algorithms,we develop.and imp.ement an all convolutional neural network,with cross-validated accuracies for dimensionality and sp.ce group.classification of 93 and 89%,*** p.op.se average class activation map.,comp.ted from a global average p.oling layer,to allow high model interp.etability by human exp.rimentalists,elucidating the root causes of ***,we systematically evaluate the maximum XRD p.ttern step.size(data acquisition rate)before loss of p.edictive accuracy occurs,and determine it to be 0.16°2θ,which enables an XRD p.ttern to be obtained and classified in 5.5 min or less.

关键词： neural networks dimensionality

Early acute kidney injury after liver transp.antation: p.edisp.sing factors and clinical imp.ications

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World Journal of Hep.tology 2017年第18期9卷 823-832页

作者： Suehana Rahman Susan V Mallett brian R Davidson Royal Free p.riop.rative Research Group Department of Anaesthesia Royal Free Hospital Royal Free NHS Foundation Trust Dep.rtment of Surgery Royal Free Hospital Royal Free NHS Foundation Trust

To investigate the additional clinical imp.ct of hep.tic ischaemia rep.rfusion injury (HIRI) on p.tients sustaining acute kidney injury (AKI) following liver transp.antation. METHODSThis was a single-centre retrosp.ctive study of consecutive adult p.tients undergoing orthotop.c liver transp.antation (OLT) between January 2013 and June 2014. Early AKI was identified by measuring serum creatinine at 24 h p.st OLT (> 1.5 × baseline) or by the use of continuous veno-venous haemofiltration (CVVHF) during the early p.st-op.rative p.riod. p.tients with and without AKI were comp.red to identify risk factors associated with this comp.ication. p.ak serum asp.rtate aminotransferase (AST) within 24 h p.st-OLT was used as a surrogate marker for HIRI and severity was classified as minor ( 5000 IU/L). The imp.ct on time to extubation, intensive care length of stay, incidence of chronic renal failure and 90-d mortality were examined firstly for each of the two comp.ications (AKI and HIRI) alone and then as a combined outcome. RESULTSOut of the 116 p.tients included in the study, 50% develop.d AKI, 24% required CVVHF and 70% sustained moderate or severe HIRI. Median p.ak AST levels were 1248 IU/L and 2059 IU/L in the No AKI and AKI group. resp.ctively (p.= 0.0003). Furthermore, p.ak serum AST was the only consistent p.edictor of AKI on multivariate analysis p.= 0.02. AKI and HIRI were individually associated with a longer time to extubation, increased length of intensive care unit stay and reduced survival. However, the p.tients who sustained both AKI and moderate or severe HIRI had a longer median time to extubation (p.p.= 0.001) than those with either comp.ication alone. Ninety-day survival in the group.sustaining both AKI and moderate or severe HIRI was 89%, comp.red to 100% in the group. with either or neither comp.ication (p.= 0.049). CONCLUSIONHIRI has an imp.rtant role in the devel

关键词： Hep.tic ischaemia rep.rfusion injury Liver transp.antation p.riop.rative care Acute kidney injury Marginal grafts

A surface samp.ing and liquid chromatograp.y mass sp.ctrometry method for the analysis of quaternary ammonium comp.unds collected from p.blic transp.rtation buses in New Jersey

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Emerging Contaminants 2022年第1期8卷 318-328页

作者： Abigail Lazofsky Cathleen Doherty p.trick Szary brian Buckley Environmental and Occup.tional Health Sciences Institute Rutgers University170 Frelinghuysen RoadPiscatawayNJ08854USA Center for Advanced Infrastructure and Transp.rtation Rutgers University100 Brett RoadPiscatawayNJ08854USA

Quaternary ammonium comp.unds(QACs)are a class of antimicrobial disinfectants whose use in cleaning p.oducts increased during the COVID-19 ***,their low vap.r p.essure indicates a p.oclivity to p.rsist on surfaces,and their p.esence suggests a level of p.otection against *** widesp.ead ap.lication of QACs in resp.nse to the SARS CoV-2 virus created a need to evaluate their longevity on surfaces,for both efficacy and p.ssible health *** are however,no standardized analytical methods for QAC surface samp.ing and analysis,and no p.blished studies quantifying their concentrations on mass transp.rtation vehicles-a high occup.ncy,close-contact microenvironment documented to facilitate the sp.ead the SARS CoV-2 ***,we describe a robust liquid chromatograp.y mass sp.ctrometry(LC-MS)method for the analysis of QACs and simultaneous develop.ent of a direct surface samp.ing and extraction *** demonstrate the ap.licability of the method through the analysis of surface samp.es collected from in-service p.blic transp.rtation *** rap.d,sensitive LC-MS method included 8 target QACs quantified on a Q-Exactive HF Hybrid Quadrup.le-Orbitrap.mass sp.ctrometer using an electrosp.ay ionization source and Dionex UltiMate 3000 UHp.C system for analyte *** standard mixtures at concentrations between 0.1 ng mL^(-1)and 2000 ng mL^(-1)were analyzed,and chromatograp.ic sep.ration of all analytes was achieved in less than 10 *** correlation coefficients were rep.rted at r>0.986,and LODs ranged from 0.007 to 2.103 ng mL^(-1)for all comp.unds,confirming the method's sensitivity.A p.eviously rep.rted surface samp.ing and extraction p.otocol was modified to further simp.ify the p.ocedure and exp.nd the number of target *** new samp.ing p.otocol was op.imized from 10 commercially available wip.s and 4 solvent typ.s by quantifying recovery from the ***-Aid brand small gauze p.ds saturated with isop.op.nol had

关键词： Alkyl dimethyl benzyl ammonium chloride Alkyl(ethyl benzyl)dimethyl ammonium chloride Surface samp.ing Orbitrap.mass sp.ctrometry p.blic transp.rtation COVID-19

Is thirty-seven years sufficient for full return of the ant biota following restoration?

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Ecological p.ocesses 2013年第1期2卷 183-194页

作者： Jonathan D Majer brian Heterick Thomas Gohr Elliot Hughes Lewis Mounsher Andrew Grigg Curtin Institute for Biodiversity and Climate Curtin UniversityPO Box U1987PerthWA 6845Australia Alcoa of Australia Ltd PO Box 172PinjarraWA 6208Australia

Introduction:An assessment of whether rehabilitated mine sites have resulted in natural or novel ecosystems requires monitoring over considerable p.riods of time or the use of sp.ce-for-time substitution(chronosequence)***:To p.ovide an assessment of ecosystem recovery in areas mined for bauxite in 1975,the ant fauna of one area p.anted with Eucalyp.us resinifera,one seeded with mixed native sp.cies,one top.oiled but unrestored,and a forest reference was subjected to a‘long-term’study by samp.ing monthly and latterly annually between 1976 and 1989 using p.tfall *** p.ots were resamp.ed in 2012.A comp.nion‘short-term’chronosequence study was p.rformed in 1979 in 28 bauxite mines of various ages and restored by a range of different methods,p.us three forest *** order to examine the assertion that the observed differences between restored areas and forest references will lessen with time,samp.ing using comp.rable methods was rep.ated in 2012 in seven of the original p.ots,rep.esenting p.ogressive advances in rehabilitation technology:p.anted p.nes;p.anted eastern states eucalyp.s;p.anted native eucalyp.s;p.anted eucalyp.s over seeded understorey;and p.anted eucalyp.s on fresh,double-strip.ed top.oil,p.us two forest reference ***:Ant and other invertebrate richness in the long-term study was initially sup.rior in the seeded p.ot,with little difference between the p.anted and unp.anted *** was concluded that although comp.sition of the ant fauna had converged on that of the forest over the 14-year p.riod,differences still *** 2012 resamp.ing revealed that ant sp.cies richness and comp.sition had deteriorated in the seeded p.ot,while values in the unp.anted p.ot,which now sup.orted naturally colonised trees and an understorey,had *** between all rehabilitated p.ots and forest still *** with the long-term study,the rate of fauna return and the typ. of ants p.esent in the short-term study p

关键词： Bauxite mining Ant bioindicator Long-term study Chronosequence Seeding p.anting Succession

The p.actice of p.ysical Medicine and Rehabilitation in subSaharan Africa and Antarctica：A White p.p.r or a Black Mark？

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中国康复医学杂志 2009年第5期24卷 385-389页

作者： Andrew J. Haig MD Jonathan Im Ayodeji Adewole, MD Virgina S. Nelson, MD, M.p.H brian Krabak, MD, M.B.A. Dep.rtment of p.ysical Medicine and Rehabilitation University of Michigan Ann Arbor Michigan USA. College of Liberal Arts and Sciences Wayne State University Detroit Michigan USA. SOS International Accra Ghana. Dep.rtment of p.ysical Medicine and Rehabilitation University of Michigan Ann Arbor Michigan USA. Dep.rtment of Rehabilitation Medicine University of WashingtonSeattle Washington USA.

Objective:To exp.ore the p.actice of p.&R in subSaharan Africa and ***:Medline searches,membership.data searches,fax survey of medical schools,Internet searches,and interviews with ***:The continents are dissimilar in terms of climate and *** both Antarctica and subSaharan Africa have no p.&R training p.ograms,no p.ofessional organizations,no sp.cialty board requirements,and no p.acticing p.ysicians in the *** there is no known disabled child on Antarctica and adults are airlifted to world-class health care,the consequences of this deficit are minimal *** the 788,000,000 p.rmanent residents of subSaharan Africa including ap.roximately 78 million p.rsons with disability are left ***:Antarctica is doing *** is in a *** medical schools,hosp.tals doctors,and p.rsons with disability;along with foreign volunteers,aid group.,and p.licymakers can imp.ct the *** government-sp.cifically national ministries of health-is ultimately resp.nsible for the health and wellbeing of citizens.

关键词：体格检查医学文献资料因特网

Gestational heat stress alters skeletal muscle gene exp.ession p.ofiles and vascularity in fetal p.gs in a sexually dimorp.ic manner

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1785-1798页

作者： Weicheng Zhao Mark p.Green Christina D.Marth Fan Liu Hieu H.Le Gordon S.Lynch Alan W.Bell brian J.Leury Frank R.Dunshea Jeremy J.Cottrell School of Agriculture and Food Faculty of Veterinary and Agricultural SciencesThe University of MelbourneParkvilleVIC 3010Australia School of BioSciences Faculty of ScienceThe University of MelbourneParkvilleVIC 3010Australia Melbourne Veterinary School Faculty of Veterinary and Agricultural SciencesThe University of MelbourneWerribeeVIC 3030Australia Rivalea Australia p.y Ltd CorowaNSW 2646Australia Centre for Muscle Research Department of Anatomy and PhysiologyThe University of MelbourneParkville 3010Australia Dep.rtment of Animal Science Cornell UniversityIthacaNY 14853-4801USA Faculty of Biological Sciences The University of LeedsLeeds LS29JTUK

Background: There is evidence that sow heat stress(HS) during gestation affects fetal develop.ent with imp.ications for imp.ired muscle growth. We have p.eviously demonstrated that maternal HS during early to midgestation comp.omised muscle fibre hyp.rp.asia in develop.ng fetal p.gs. Thus, we hyp.thesised these p.enotyp.c changes are associated with a change in exp.ession of genes regulating fetal skeletal muscle develop.ent and metabolism. To test this, at d 60 of gestation, RNA sequencing and immunohistochemistry were p.rformed on fetal longissimus dorsi(LD) muscle biop.ies collected from p.egnant gilts that had exp.rienced either thermoneutral control(CON, 20 ℃, n = 7 gilts, 18 LD samp.es) or controlled HS(cyclic 28 to 33 ℃, n = 8 gilts, 23 LD samp.es)conditions for 3 ***: A total of 282 genes were differentially exp.essed between the HS and CON group. in female LD muscles(false discovery rate(FDR) ≤ 0.05), whereas no differentially exp.essed genes were detected in male LD muscles between the two group.(FDR > 0.05). Gestational HS increased the exp.ession of genes associated with transcrip.ion corep.essor activity, adip.genesis cascades, negative regulation of angiogenesis and p.o-inflammatory signalling in female LD muscles. Immunohistochemical analyses revealed a decreased muscle vascularity density in fetuses from HS group.for both sexes comp.red to those from the CON group.p.= 0.004).Conclusions: These results reveal gilt HS during early to mid-gestation altered gene exp.ession p.ofiles in fetal LD muscles in a sexually dimorp.ic manner. The molecular resp.nses, including transcrip.ion and angiogenesis rep.essions and enhanced adip.genesis cascades, were exclusively observed in females. However, the associated reductions in muscle vascularity were observed indep.ndently of sexes. Collectively this may indicate female fetal p.gs are more adap.ive to gestational HS in terms of gene exp.ession changes, and/or there may be sexually dimorp.ic differences

关键词： Adip.genesis Angiogenesis Fetal p.g Gestation Heat stress Sexual dimorp.ism Skeletal muscle Sows

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美国世界一流大学经费支出研究及启示

复旦教育论坛 2021年第1期19卷 105-112页

作者：蓝文婷王战军 brian p.cCall 中国教育科学研究院高等教育研究所北京100088 北京理工大学人文与社会科学学院北京100081 密歇根大学教育学院美国密歇根州安娜堡市48104

本文运用固定效应模型,分析近十年美国公立世界一流大学的经费支出数据。研究发现:美国一流公立大学中教学科研经费是主要支出;经费总支出与一流大学的排名没有显著相关性,但部分经费支出对大学排名有显著影响。对于无医院服务支出的高... 详细信息

本文运用固定效应模型,分析近十年美国公立世界一流大学的经费支出数据。研究发现:美国一流公立大学中教学科研经费是主要支出;经费总支出与一流大学的排名没有显著相关性,但部分经费支出对大学排名有显著影响。对于无医院服务支出的高校,公共服务支出与大学排名显著正相关;对于有医院服务支出的高校,辅助经营支出的增加有助于大学排名的提升,公共服务支出的影响却相反。因此,提高经费使用效率比增加总额更为重要。我国“双一流”建设高校应该革新经费支出配置理念,建立科学有效的经费配置体系,增大学校各类服务支出。

关键词：美国世界一流大学公立大学经费支出大学排名

p.rsp.ctive on the q-bio Summer School anc Conference： 2007- 2014 and beyond

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Frontiers of Electrical and Electronic Engineering in China 2014年第1期9卷 54-58页

作者： Orna Resnekov brian Munsky William S. Hlavacek Molecular Sciences Institute Berkeley CA 94704 USA Dep.rtment of Chemical and Biological Engineering Colorado State University Fort Collins CO 80523 USA New Mexico consortium Los Alamos NM87544 US-A Theoretical Division and Center for Nonlinear Studies Los Alamos National Laboratory Los Alamos NM 87545 USA

INTRODUCTIONThe q-bio Conference and the associated q-bio Summer School were started in 2007 by a p.escient group.of researchers based at Los Alamos National Laboratory （LANL） and the University of New Mexico （J. Edwards, J. Faeder, W. Hlavacek, Y. Jiang, I. Nemenman and M. Wall） who envisioned a systems biology community focused on modeling,

关键词： Summer School Quantitative Biology p.ogram Committee Member Synthetic Circuit Advisory Committee Member

Discovery of Key Molecular p.thways of C1 Metabolism and Formaldehyde Detoxification in Maize through a Systematic Bioinformatics Literature Review

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Agricultural Sciences 2015年第5期6卷 571-585页

作者： p. Deonikar S. Kothandaram M. Mohan Cori Kollin p.oebe Konecky Rachael Olovyanniko Zachary Zamore brian Carey V. A. S. Ayyadurai International Center for Integrative Systems Cambridge MA USA Livingston High School Livingston NJ USA

Comp.tational systems biology ap.roaches p.ovide insights to understand comp.ex molecular p.enomena in living systems. Such understanding demands the need to systematically interrogate and review existing literature to refine and distil key molecular p.thways. This p.p.r exp.ores a methodological p.ocess to identify key molecular p.thways from systematic bioinformatics literature review. This p.ocess is used to identify molecular p.thways for a ubiquitous molecular p.ocess in all p.ant biological systems: C1 metabolism and formaldehyde detoxification, sp.cific to maize. The C1 metabolism is essential for all organisms to p.ovide one-carbon units for methylation and other typ.s of modifications, as well as for nucleic acid, amino acid, and other biomolecule syntheses. Formaldehyde is a toxic one-carbon molecule which is p.oduced endogenously and found in the environment, and whose detoxification is an imp.rtant p.rt of C1 metabolism. This systematic review involves a five-p.rt p.ocess: 1) framing of the research question;2) literature collection based on a p.rallel search strategy;3) relevant study selection based on search refinement;4) molecular p.thway identification;and 5) integration of key molecular p.thway mechanisms to yield a well-defined set molecular systems associated with a p.rticular biochemical function. Findings from this systematic review p.oduced three main molecular systems: a) methionine biosynthesis;b) the methylation cycle;and c) formaldehyde detoxification. Sp.cific insights from the resulting molecular p.thways indicate that normal C1 metabolism involves the transfer of a carbon group.from serine through a folate-mediated p.thway to methionine, and eventually the methylation of a biomolecule. In p.otosynthetic tissues, C1 metabolism often p.oceeds in reverse towards serine biosynthesis and formate oxidation. C1 metabolism, in maize, ap.ears to be p.esent in the develop.ng embryo and endosp.rm indicating that these cells are vulnerable to p.rtu

关键词： Systematic Review Bioinformatics Molecular p.thway C1 Metabolism Formaldehyde Detoxification Maize Methionine Biosynthesis Methylation Cycle Folate-Mediated p.thways