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Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

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World Journal of Gastrointestinal Pathophysiology 2017年第3期8卷 117-126页

作者： brian k mcfarlin Andrea L Henning Erin M Bowman Melody A Gary kimberly M Carbajal Applied Physiology Laboratory University of North Texas Department of Biological Sciences University of North Texas

To determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia. METHODSApparently healthy men and women (n = 75) were screened for post-prandial dietary endotoxemia. Subjects whose serum endotoxin concentration increased by at least 5-fold from pre-meal levels at 5-h post-prandial were considered “responders” and were randomized to receive either placebo (rice flour) or a commercial spore-based probiotic supplement [Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, and Bacillus licheniformis, and Bacillus clausii] for 30-d. The dietary endotoxemia test was repeated at the conclusion of the supplementation period. Dietary endotoxin (LAL) and triglycerides (enzymatic) were measured using an automated chemistry analyzer. Serum disease risk biomarkers were measured using bead-based multiplex assays (Luminex and Milliplex) as secondary, exploratory measures. RESULTSData were statistically analyzed using repeated measures ANOVA and a P key findings of the present study is that oral spore-based probiotic supplementation reduced symptoms indicative of “leaky gut syndrome”.

关键词： Metabolic endotoxemia Chronic disease Leaky gut syndrome Probiotics Multiplex Cardiovascular disease Inflammatory cytokines High-fat meal challenge

Polar comonomer incorporation using cationic Ni α-diimine olefin polymerization catalysts

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Science China Chemistry 2019年第2期62卷 153-154页

作者： Jordan M.kaiser brian k.Long Department of Chemistry University of Tennessee

Polyolefins are an indispensable class of materials that have become the most widely produced and utilized polymers *** are readily synthesized from cheap and abundant monomer feedstocks,such as ethylene and propylene,and are capable of achieving a vast array of thermal and mechanical properties based upon their composition and ***,despite their numerous advantages, polyolefins are typically devoid of functional groups which can limit their applicability to many product families,such as coatings,adhesives,and cross-linked polyolefins.

关键词： Ni α-diimine olefin polymerization catalysts

The translational importance of establishing biomarkers of human spinal cord injury

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Neural Regeneration Research 2017年第3期12卷 385-388页

作者： Sanam Salimi Elizei brian k.kwon International Collaboration on Repair Discoveries(ICORD) University of British ColumbiaBCCanada Vancouver Spine Surgery Institute Department of OrthopaedicsUniversity of British ColumbiaBCCanada

The evaluation of such novel therapies for acute spinal cord injury in clinical trials is extremely *** current dependence upon the clinical assessment of neurologic impairment renders many acute SCI patients ineligible for trials because they are not ***,the difficulty in predicting neurologic recovery based on the early clinical assessment forces investigators to recruit large cohorts to have sufficient *** that objectively classify injury severity and better predict neurologic outcome would be valuable tools for translational *** such,the objective of the present review was to describe some of the translational challenges in acute spinal cord injury research and examine the potential utility of neurochemical biomarkers found within cerebrospinal fluid and *** focus on published efforts to establish biological markers for accurately classifying injury severity and precisely predict neurological outcome.

关键词： spinal cord injury, biomarkers, cerebrospinal fluid, injury severity neurological recovery

Season of birth influences on breastfeeding incidence and duration

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World Journal of Pediatrics 2020年第6期16卷 635-636页

作者： Claudia W.Strow brian k.Strow Western kentucky University 1906 College Heights Blvd.Bowling GreenKY 42101USA

Recent research suggests that an individual’s season of birth can influence his or her health,educational,professional,and behavioral outcomes[1-10].The consumption of breastmilk in infancy is also believed to be correlated with these *** existing studies identify breastfeeding seasonality patterns in developing nations[11-14].However,existing studies do not examine if seasonal differences in breastfeeding exist in the United *** whether or not the season of birth affects one’s breastfeeding likelihood is the first step in recognizing whether breastfeeding seasonality may contribute to the correlation between one’s season of birth and his or her outcomes.

关键词： season seasonal breast

Thermal stability of additively manufactured austenitic 304L ODS alloy

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Journal of Materials Science & Technology 2021年第24期83卷 208-218页

作者： Milad Ghayoor Saereh Mirzababaei Anumat Sittiho Indrajit Charit brian k.Paul Somayeh Pasebani School of Mechanical Industrial and Manufacturing EngineeringOregon State UniversityCorvallisOR97330United States Advanced Technology and Manufacturing Institute(ATAMI) CorvallisOR97330United States Materials Science and Engineering University of IdahoMoscowID83844United States

Thermal stability and high-temperature mechanical properties of a 304 L austenitic oxide dispersion strengthened(ODS)alloy manufactured via laser powder bed fusion(LPBF)are examined in this *** manufactured 304 L ODS alloy samples were aged at temperatures of 1000,1100,and 1200℃for 100 h in an argon *** characterization of LPBF 304 L ODS alloy before and after the thermal stability experiments revealed that despite the annihilation of dislocations,induced cellular substructure by the LPBF process was partially retained in the ODS alloy even after aging at1200℃.The size of Y-Si-O nanoparticles after aging at 1200℃increased from 25 to 50 *** analysis revealed that nanoparticles retained the microstructure of LPBF 304 L ODS and hindered recrystallization and further grain *** 600℃and 800℃,the yield stress of the 290 and 145 MPa were measured,respectively,which are substantially higher than 113 MPa,and 68 MPa for 304 L at the same ***,the creep properties of LPBF 304 L ODS alloy were evaluated at a temperature of 700℃under three applied stresses of 70,85,and 100 MPa yielding a stress exponent(n)of 7.7;the minimum creep rate at 100 MPa was found to be about two orders of magnitude lower than found in the literature for wrought 304 L stainless steel.

关键词： Laser powder bed fusion(LPBF) Oxide dispersion strengthened(ODS)alloy High-temperature Aging Thermal stability

Simulation of Automatically Annotated Visible and Multi-/Hyperspectral Images Using the Helios 3D Plant and Radiative Transfer Modeling Framework

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Plant Phenomics 2024年第3期6卷 579-594页

作者： Tong Lei Jan Graefe Ismael k.Mayanja Mason Earles brian N.Bailey Department of Plant Sciences University of CaliforniaDavisCAUSA Leibniz Institute of Vegetable and Ornamental Crops e.V.(IGZ) GroßbeerenGermany Department of Biological and Agricultural Engineering University of CaliforniaDavisCAUSA Department of Viticulture and Enology University of CaliforniaDavisCAUSA

Deep learning and multimodal remote and proximal sensing are widely used for analyzing plant and crop traits,but many of these deep learning models are supervised and necessitate reference datasets with image *** these datasets often demands experiments that are both labor-intensive and ***,extracting traits from remote sensing data beyond simple geometric features remains a *** address these challenges,we proposed a radiative transfer modeling framework based on the Helios 3-dimensional(3D)plant modeling software designed for plant remote and proximal sensing image *** framework has the capability to simulate RGB,multi-/hyperspectral,thermal,and depth cameras,and produce associated plant images with fully resolved reference labels such as plant physical traits,leaf chemical concentrations,and leaf physiological *** offers a simulated environment that enables generation of 3D geometric models of plants and soil with random variation,and specification or simulation of their properties and *** approach differs from traditional computer graphics rendering by explicitly modeling radiation transfer physics,which provides a critical link to underlying plant biophysical *** indicate that the framework is capable of generating high-quality,labeled synthetic plant images under given lighting scenarios,which can lessen or remove the need for manually collected and annotated *** example applications are presented that demonstrate the feasibility of using the model to enable unsupervised learning by training deep learning models exclusively with simulated images and performing prediction tasks using real images.

关键词： framework simulation helios modeling plant annotated automatically hyperspectral images

Editorial comment on: surgical outcomes of two-stage hepatectomy for colorectal liver metastasis: comparison to a benchmark procedure

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 570-572页

作者： Zhongkai Wang brian k.P.Goh Department of Hepatopancreatobiliary and Transplant Surgery Singapore General HospitalSingaporeSingapore Duke-National University of Singapore Medical School SingaporeSingapore

With advancements in surgical techniques,locoregional therapy and systemic therapy,patients suffering from colorectal cancer with liver metastasis now have numerous therapeutic options for local and systemic disease *** resection of the primary cancer and all metastases remains the primary objective,offering patients the best chance for long-term survival.

关键词： metastasis colorectal surgical

Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis

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World Journal of Gastroenterology 2006年第28期12卷 4511-4516页

作者： Martin H Bluth Sameer A Patel brian k Dieckgraefe Hiroshi Okamoto Michael E Zenilman Department of Surgery State University of New York-Downstate Medical CenterBrooklynNew YorkUnited States Department of Surgery Montefiore Medical Center and Albert Einstein College of MedicineBronxNew YorkUnited States Department of Medicine Division of GastroenterologyWashington University School of MedicineSt. LouisMissouriUnited States Department of Biochemistry Tohoku University Graduate School of MedicineSendaiJapan

AIM： Pancreatic regenerating protein （reg Ⅰ ） stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal and 13-cells. This suggests that reg Ⅰand its receptor may play a role in recovery after pancreatic injury. We hypothesized that reg Ⅰ and its receptor are induced in acute pancreatitis. METHODS： Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls （4 rats/group）. Reg Ⅰ receptor mRNA, serum reg Ⅰ protein, and tissue reg Ⅰ protein levels were determined by Northern analysis, enzymelinked immunosorbent assay （ELISA）, and Western analysis, respectively. Immunohistochemistry was used to localize changes in reg Ⅰ and its receptor. RESULTS： Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum reg Ⅰ concentrations from controls. However, Western blot demonstrated increased tissue levels of reg Ⅰ at 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in reg Ⅰ receptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION： Acute pancreatitis results in increased tissue reg Ⅰ protein levels localized to the acinar and ductal cells, and a parallel threefold induction of reg Ⅰ receptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg Ⅰand its receptor may be important for recovery from acute pancreatitis.

关键词： Acute pancreatitis Reg, reg receptor Taurocholate Regeneration

Ovarian autoimmune disease： clinical concepts and anima models

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Cellular & Molecular Immunology 2014年第6期11卷 510-521页

作者： Bryce D Warren William k kinsey Lynda k McGinnis Lane k Christenson Susmita Jasti Anne M Stevens brian k Petroff Margaret G Petroff Department of Anatomy and Cell Biology University of Kansas Medical Center Kansas City KS USA Department of Molecular and Integrative Physiology University of Kansas Medical Center Kansas City KS USA Research Center for Immunity and I mmunotherapies Children's Hospital and Regional Medical Center and Division of Rheumatology Department of Pediatrics University of Washington Seattle WA USA Department of Internal Medicine University of Kansas Medical Center Kansas City KS USA Present address: Department of Pathobiology and Diagnostic Investigation Michigan State University College of Veterinary Medicine East Lansing MI USA

The ovary is not an immunologically privileged organ, but a breakdown in tolerogenic mechanisms for ovary-specific antigens has disastrous consequences on fertility in women, and this is replicated in murine models of autoimmune disease. Isolated ovarian autoimmune disease is rare in women, likely due to the severity of the disease and the inability to transmit genetic information conferring the ovarian disease across generations. Nonetheless, autoimmune oophoritis is often observed in association with other autoimmune diseases, particularly autoimmune adrenal disease, and takes a toll on both society and individual health. Studies in mice have revealed at least two mechanisms that protect the ovary from autoimmune attack. These mechanisms include control of autoreactive T cells by thymus-derived regulatory T cells, as well as a role for the autoimmune regulator （AIRE）, a transcriptional regulator that induces expression of tissue-restricted antigens in medullary thymic epithelial cells during development of T cells. Although the latter mechanism is incompletely defined, it is well established that failure of either results in autoimmune-mediated targeting and depletion of ovarian follicles. In this review, we will address the clinical features and consequences of autoimmune-mediated ovarian infertility in women, as well as the possible mechanisms of disease as revealed by animal models.

关键词： Ovarian autoimmune clinical concepts animal models