The translational importance of establishing biomarkers of human spinal cord injury

作     者：Sanam Salimi Elizei Brian K.Kwon 

作者机构：International Collaboration on Repair Discoveries(ICORD)University of British ColumbiaBCCanada Vancouver Spine Surgery InstituteDepartment of OrthopaedicsUniversity of British ColumbiaBCCanada 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2017年第12卷第3期

页      面：385-388页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：provided by the Rick Hansen Institute Michael Smith Foundation for Health Research Craig Neilsen Foundation supported by MITACS 

主　　题：spinal cord injury, biomarkers, cerebrospinal fluid, injury severity neurological recovery 

摘      要：The evaluation of such novel therapies for acute spinal cord injury in clinical trials is extremely challenging.Our current dependence upon the clinical assessment of neurologic impairment renders many acute SCI patients ineligible for trials because they are not examinable.Furthermore,the difficulty in predicting neurologic recovery based on the early clinical assessment forces investigators to recruit large cohorts to have sufficient power.Biomarkers that objectively classify injury severity and better predict neurologic outcome would be valuable tools for translational research.As such,the objective of the present review was to describe some of the translational challenges in acute spinal cord injury research and examine the potential utility of neurochemical biomarkers found within cerebrospinal fluid and blood.We focus on published efforts to establish biological markers for accurately classifying injury severity and precisely predict neurological outcome.