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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Peng Peng Xinping Wang brian F.Windley Jinghui guo Mingguo Zhai Yun Li State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences School of Earth and Environment Sciences The University of Western Australia Department of Geology University of Leicester

Great progress has been made in the last twenty years in understanding the unification of the North China *** to a prevailing model it developed by amalgamation of four sub-blocks by three spatially and temporally separate orogenic belts:the first at950 Ma formed the Western Block,the second at900 Ma created the Eastern Block,and the third at850 Ma unified the Eastern and Western ***,new data show that the 1950 Ma orogen was affected by granulite facies reequilibration at 1800 Ma,and parts of the 1850 Ma orogen have evidence of metamorphism at 1950–1900 *** zircon U–Pb ages enable the Paleoproterozoic metamorphic events to be statistically sub-divided into four:at955 Ma(M1),920 Ma(M2),885 Ma(M3)and850Ma(M4).The M1–2events always appear together,mainly in two belt areas including the Helanshan–Qianlishan,northern Ordos,Yinshan,Liangcheng,Huai’an,Lushan,Jiaobei and Liaodong regions;whereas the M3–4events are distributed over larger areas and were superimposed on the M1–*** age distribution is inconsistent with previous models of three separate *** should also be noted that the igneous rocks contemporary with the regional(ultra-)high-temperature/high-pressure granulite facies metamorphisms(M1–2)were previously described as arc-related series,i.e.,the gabbro-norites,I-/S-type granites and trimodal *** on the spatial distribution of the Paleoproterozoic metamorphic events(M1–4),and of the coeval igneous rocks,we speculate that the assembly of the NCC was created by one orogen,which formed between the Eastern and Western Cratons in two tectonic stages:two marginal arcs,the Korean and Xuwujia,developed against both eastern sides of the two sub-cratons,and were both accreted and deformed at 1965–1900 Ma(M1–2).Subsequently the amalgamation of the two sub-cratons resulted in metamorphism on the western side of the Eastern Craton,and in metamorphism that was superimposed on both accreted arcs at 1900–1790 Ma(M3–4).

关键词： North China Craton Paleoproterozoic Tectonic subdivision Metamorphism Orogens

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Genesis of the Hengling magmatic belt in the North China Craton:Implications for Paieoproterozoic tectonics

Genesis of the Hengling magmatic belt in the North China Cra...

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中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： Peng Peng Jinghui guo Mingguo Zhai brian F.Windley Tiesheng Li Fu Liu State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences Department of Geology University of Leicester

The 2200-1880 Ma igneous rocks in the central and eastern parts of the North China Craton(NCC) constitute a new Hengling magmatic belt(HMB),which includes the -2147 Ma Hengling mafic sill/dyke swarm,the -2060 Ma Yixingzhai mafic dyke swarm,and the -1973 Ma Xiwangshan mafic dyke *** three swarms are contiguous and have experienced variable degrees of metamorphism from greenschist to low amphibolite facies(Hengling),medium granulite facies(Yixingzhai),and medium/high-pressure granulite fades(Xiwangshan).They are all tholeiitic in composition typically with 47-52 wt.%SiO and 4-10 wt.% MgO,and all show light rare earth element enrichments and Nb- and *** Nd T ages are in the range of 2.5-3.0 ***,the Hengling and Yixingzhai dykes/sills are depleted in Th,U,Zr,Hf and Ti,whereas the Xiwangshan dykes are enriched in U and weakly depleted in other *** Sr-anomalies indicate significant feldspar accumulation(positive anomalies) or ***εNd(t)) values of the three swarms are:-3.2-+3.0(Hengling),-1.7-+1.8(Yixingzhai) and -1.4-+1.0 (Xiwangshan). These mafic representatives of the HMB originated from the>2.5 Ga sub-continental lithospheric mantle of the NCC,and with A-type granites and other igneous associations in this belt they likely evolved in an intracontinental *** progressive changing compositions of the three swarms are interpreted in terms of their source regions at different depths,i.e.,shallower and shallower through *** the decrease in scale and size of the intrusions and their magma volumes indicate the progressive weakening of magmatism in this rift. The rocks in this belt are different chronologically,petrologically and chemically from those in the Xuwujia magmatic belt(XMB).We propose that the two magmatic belts represent two different magmatic systems in different blocks of the NCC,i.e.,an eastern block(with the HMB) and a western block(with the XMB). Terminal collision was possibly a result of r

关键词： North China Craton Paleoproterozoic Mafic dyke swarm Hengling magmatic belt Intra-continental rift Tectonics

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弗罗斯特诗歌“万事万物好景不长”的风格与哲理(英文)

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外国文学研究 2008年第4期30卷 112-119页

作者：郭萍布莱恩·M·理德中国地质大学(武汉)外语学院美国华盛顿大学英语副教授

罗伯特·弗罗斯特的诗歌既有20世纪的"音调",又有接近于传统诗歌的诗体。通过使用简单的口语和传统的韵律,弗罗斯特形成了自己独特的风格。本文试从四个方面对他的诗歌"万事万物好景不长"进行探讨:1)诗歌的选词特点;2)诗歌的单音节词;3... 详细信息

罗伯特·弗罗斯特的诗歌既有20世纪的"音调",又有接近于传统诗歌的诗体。通过使用简单的口语和传统的韵律,弗罗斯特形成了自己独特的风格。本文试从四个方面对他的诗歌"万事万物好景不长"进行探讨:1)诗歌的选词特点;2)诗歌的单音节词;3)诗歌的句法结构;4)诗歌的韵律模式。研究发现,此诗外在结构简洁明了,但深层结构错综复杂。读者只有细细品读才能真正了解此诗的深刻哲理。

关键词：罗伯特·弗罗斯特风格哲理 “万事万物好景不长”

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美国的心房颤动治疗状况

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中华心律失常学杂志 1998年第2期2卷 138-144页

作者： brian Olshansky Hongsheng guo Samuel Levy 姚焰美国伊利诺州Loyola大学医学中心法国马赛大学医学院心血管病科

最近进行的一项调查中，当被问到“良好的健康状况是否是生命中最重要的?”时，83％接受调查的中国人对此表示认同，而只有53％的美国人持有相同的观点。这表明在关于健康的重要性方面，中美之间存在着明显的差异。不仅如此．美国拥有... 详细信息

最近进行的一项调查中，当被问到“良好的健康状况是否是生命中最重要的?”时，83％接受调查的中国人对此表示认同，而只有53％的美国人持有相同的观点。这表明在关于健康的重要性方面，中美之间存在着明显的差异。不仅如此．美国拥有世界上最发达的医学系统之．并且．美国公众很关心寿命的长短及享受良好健康的能力。

关键词：治疗状况心房颤动健康状况调查严重重症医学享受中国人寿命

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Secukinumab provided significant and sustained improvement in the signs and symptoms of ankylosing spondylitis:results from the 52-week,PhaseⅢChina-centric study,MEASURE 5

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Chinese Medical Journal 2020年第21期133卷 2521-2531页

作者： Feng Huang Fei Sun Wei-guo Wan Li-Jun Wu Ling-Li Dong Xiao Zhang Tae-Hwan Kim Raj Sengupta Ladislav Senolt Yi Wang Hao-Min Qiu brian Porter Sibylle Haemmerle Department of Rheumatology Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Rheumatology Huashan HospitalFudan UniversityShanghai 200040China Department of Rheumatology&Immunology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Rheumatology&Immunology Tongji HospitalTongji Medical College of Huazhong University of Science&TechnologyWuhanHubei 430030China Department of Rheumatology&Immunology Guangdong General HospitalGuangzhouGuangdong 510000China Hanyang University Hospital for Rheumatic Diseases SeoulRepublic of Korea Royal National Hospital for Rheumatic Disease Upper Borough WallsBath BA11RLUK Institute of Rheumatology PragueCzech Republic Novartis Pharmaceuticals Corporation East HanoverNJUSA China Novartis Institutes for Biomedical Research Shanghai 201203China Novartis Pharma AG BaselSwitzerland

Background:Secukinumab demonstrated sustained efficacy in patients with ankylosing spondylitis(AS)through 5 years in pivotal Phase III ***,we present efficacy and safety results(52-week)of secukinumab in patients with AS from the MEASURE 5 ***:MEASURE 5 was a 52-week,Phase III,China-centric *** patients were randomly assigned(2:1)to receive subcutaneous secukinumab 150 mg or placebo weekly for the first five doses and then once every 4 weeks(q4w).All placebo patients switched to secukinumab 150 mg q4w starting at Week *** endpoint was Assessments of SpondyloArthritis international Society(ASAS)20 at Week *** was stratified by region(China ***-China).Results:Of 458 patients(secukinumab 150 mg,N=305;placebo,N=153)randomized,327(71.4%)were from China and 131(28.6%)were not from *** these,97.7%and 97.4%patients completed Week 16 and 91.1%and 95.3%(placebo-secukinumab)patients completed Week 52 of *** primary endpoint was met;secukinumab significantly improved ASAS20 response at Week 16 ***(58.4%vs.36.6%;P<0.0001);corresponding rate in the Chinese population was 56.0%vs.38.5%(P<0.01).All secondary efficacy endpoints significantly improved with secukinumab 150 mg in the overall population at Week 16;responses were maintained with a trend toward increased efficacy from Week 16 to *** new or unexpected safety signals were reported up to Week ***:Secukinumab 150 mg demonstrated rapid and significant improvement in signs and symptoms of *** was well tolerated and the safety profile was consistent with previous *** and safety results were comparable between the overall and Chinese populations.

关键词： Ankylosing spondylitis Biologics Cytokines Interleukin 17A Tumor necrosis factor

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Editorial

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Chinese Chemical Letters 2015年第4期26卷 393-394页

作者： Zhan Chen brian P.Coppola Carol A.Fierke Department of Chemistry University of Michigan

We convey our sincere thanks for the publication of this special University of Michigan issue of Chinese Chemical Letters. The idea to publish this special issue came from a meeting between Dr. Zhan Chen （Professor of Chemistry at the University of Michigan） and Dr. Huanfang guo （associate editor-in-chief, Chinese Chemical Letters） when Dr. guo visited the University of Michigan during May 2014. On behalf of Prof. Xuhong Qian, the editor-in-chief of Chinese Chemical Letters, Dr. guo invited Prof. Chen to contact various professors at the University of Michigan to make contributions to a special issue. Prof. Chen received many immediate responses, resulting in the eighteen mini-reviews and research papers published in this issue and authored by members of research groups at the University of Michigan. Nineteen professors, their postdoctoral fellows, students, and collaborators contributed to this special issue, including professors associated with College of Literature, Science and Arts （Chemistry, Biophysics, Applied Physics）, College of Engineering （Chemical Engineering, Electrical Engineering）, School of Medicine （Radiology, Internal Medicine, Surgery）, School of Pharmacy, and School of Dentistry at the University of Michigan. The co-authors for these articles also include many researchers from universities in China such as Nanjing University, China University of Geosciences, Nanjing Medical University, Nanjing College of Chemical Technology, and Southeast University. The research reported in these articles covers many areas in chemistry and related sciences, as well as many interdisciplinary research projects, fitting the nature and scope of Chinese Chemical Letters, which publishes mini-reviews and research articles in all areas of chemistry, satisfying a real and urgent need for the dissemination of new and exciting research results.

关键词： Folate binding protein Serum protein Drug delivery Folate conjugate Folic acid

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心房颤动的体内转复

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中华心律失常学杂志 1997年第2期1卷 150-153页

作者： brian Olshansky Hongsheng guo Samuel Levy 陈柯萍美国伊利诺州Loyola大学医学中心法国马赛大学医学院心血管病科

窦性心律显然优于心房颤动(房颤)。心房收缩先于心室和对心率的适当调节是两个可能的重要优点；体外心律转复能使大多数房颤转为窦性心律，但却并不总能成功。另一方面一若体外转复不成功，体内转复却能有效。体内转复具有另一些特有的... 详细信息

窦性心律显然优于心房颤动(房颤)。心房收缩先于心室和对心率的适当调节是两个可能的重要优点；体外心律转复能使大多数房颤转为窦性心律，但却并不总能成功。另一方面一若体外转复不成功，体内转复却能有效。体内转复具有另一些特有的优点。体内植^器械能有效地将房颤自动或手动地转复为窦性心律，并且伴随的危险性小。我们现在仅仅是刚开始了解这种新技术的优点。

关键词：体内心律转复窦性心律心房颤动体外心室心率危险性优点器械

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心房颤动的流行病学

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中华心律失常学杂志 1998年第4期2卷 298-302页

作者： brian Olshansky Hongsheng guo Saumuel Levy 张海澄美国依利诺斯州Loyola大学医学中心电生理室法国马赛大学医学院心内科

“这种卒中，易发生于生活懒散者，肥胖者、颜面手足经常青紫，以及脉率不整者。”[1]尽管曾有许多有关脉率不齐与心房颤动(房颤)关系的猜想，但直到近80年前才由心电图记录得以明确。某些特殊人群较他人多房颤高危因素，古时候这样的... 详细信息

“这种卒中，易发生于生活懒散者，肥胖者、颜面手足经常青紫，以及脉率不整者。”[1]尽管曾有许多有关脉率不齐与心房颤动(房颤)关系的猜想，但直到近80年前才由心电图记录得以明确。某些特殊人群较他人多房颤高危因素，古时候这样的猜疑部分被证实。不过，这个问题无处不在．事实上可影响任何年龄的成人。

关键词：心房颤动脉率心电图流行病学青紫手足颜面肥胖者特殊人群卒中

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Provenance and tectonic settings of Permian turbidites from the Beishan Mountains,NW China:Implications for the Late Paleozoic accretionary tectonics of the southern Altaids

Provenance and tectonic settings of Permian turbidites from ...

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中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： Qianqian guo Wenjiao Xiao brian F.Windley Qigui Mao Chunming Han Junfeng Qu Songjian Ao Jiliang Li Dongfang Song Yong Yong State Key Laboratory of Lithosphenc Evolution Institute of Geology and GeophysicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences Department of Geology University of Leicester Beijing Institute of Geology for Mineral Resources State Key laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences

The Beishan orogenic belt,which connects the Tianshan suture on the west and Solonker suture on the east,contains key evidence for the termination time of the southern *** for evaluating different controversial tectonic models are Permian marine volcaniclastic arenites in the Liuyuan and Heishankou areas,which are dominated by greywackes and lenticular pebbly litharenites that contain grading,groove marks,and erosional bases,which provide evidence of turbidity *** from the Liuyuan section are dominated by angular basaltic,andesitic,and feldspar fragments,but sandstones from the Heishankou section mainly consist of andesitic and felsic volcanic *** relations suggest derivation from two different *** element compositions suggest that the source rocks of the Heishankou litharenites were more SiO-rich than those at *** at Heishankou are characterized by lower Ni-Co-Cr-V and slightly higher Th and La contents than those at *** indicates that the litharenites in the Liuyuan and Heishankou areas were derived from intermediatemafic and intermediate-felsic source rocks,*** setting discrimination plots suggest that the Liuyuan sandstones were deposited as detritus from an oceanic island arc,but the Heishankou sediments from an Andean continental *** petrological and geochemical data from these two types of Permian turbidites suggest that an arc-continent collision took place in the Early Permian,and this is consistent with the Permian termination of the southern Altaids.

关键词： Eeishan Mountains Permian turbidites Geochemistry Provenance Tectonic setting Southern Altaids

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Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy against Human Cervical Cancer Cells in Vitro and in Mice

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Advances in Biological Chemistry 2016年第6期6卷 193-215页

作者： Jill A. Gadzinski Jianxia guo brian J. Philips Per Basse Ethan K. Craig Lisa Bailey Joseph Latoche John T. Comerci Julie L. Eiseman Department of Obstetrics/Gynecology/Reproductive Sciences Magee Women’s Hospital of the University of Pittsburgh Pittsburgh PA USA Cancer Therapeutics Program University of Pittsburgh Cancer Institute and Department of Pharmacology and Chemical Biology School of Medicine University of Pittsburgh Pittsburgh PA USA Cancer Immunology Program University of Pittsburgh Cancer Institute and Department of Immunology School of Medicine University of Pittsburgh Pittsburgh PA USA School of Medicine University of Pittsburgh Pittsburgh PA USA Department of Cardiology Molecular Imaging Center University of Pittsburgh School of Medicine Pittsburgh PA USA

Background: Cervical cancer is the second most common cancer in women worldwide [1]. Photodynamic therapy has been used for cervical intraepithelial neoplasia with good responses, but few studies have used newer phototherapeutics. We evaluated the effectiveness of photodynamic therapy using Pc 4 in vitro and in vivo against human cervical cancer cells. Methods: CaSki and ME-180 cancer cells were grown as monolayers and spheroids. Cell growth and cytotoxicity were measured using a methylthiazol tetrazolium assay. Pc 4 cellular uptake and intracellular distribution were determined. For in vitro Pc 4 photodynamic therapy, cells were irradiated at 667 nm at a fluence of 2.5 J/cm2 at 48 h. SCID mice were implanted with CaSki and ME-180 cells both subcutaneously and intracervically. Forty-eight hours after Pc 4 photodynamic therapy was administered at 75 and 150 J/cm2. Results: The IC50s for Pc 4 and Pc 4 photodynamic therapy for CaSki and ME-180 cells as monolayers were, 7.6 μM and 0.016 μM and >10 μM and 0.026 μM;as spheroids, IC50s of Pc 4 photodynamic therapy were, 0.26 μM and 0.01 μM. Pc 4 was taken up within cells and widely distributed in tumors and tissues. Intracervical photodynamic therapy resulted in tumor death, however mice died due to gastrointestinal toxicity. Photodynamic therapy resulted in subcutaneous tumor death and growth delay. Conclusions: Pc 4 photodynamic therapy caused death within cervical cancer cells and xenografts, supporting development of Pc 4 photodynamic therapy for treatment of cervical cancer. Support: P30-CA47904, CTSI BaCCoR Pilot Program.

关键词： Cervical Cancer Lasers Silicon Phthalocyanine 4 Photodynamic Therapy

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