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Control of autoimmune arthritis by herbal extracts and their bioactive components

Asian Journal of Pharmaceutical Sciences 2016年第2期11卷 301-307页

作者： Shivaprasad H.Venkatesha brian Astry Siddaraju m.Nanjundaiah Hong R.Kim Rajesh Rajaiah Yinghua Yang Li Tong Hua Yu brian m.berman Kamal D.moudgil Department of microbiology and Immunology University of Maryland School of MedicineBaltimoreMD 21201United States Southern medical University GuangzhouChina Center for Integrative medicine University of Maryland School of MedicineBaltimoreMD 21201United States Division of Rheumatology Department of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201United States

Autoimmune diseases such as rheumatoid arthritis (RA) cause significant morbidity and loss of productivity. many potent conventionally used drugs are available for these diseases, but their prolonged use is accompanied by severe adverse effects besides a high ***, there is an unmet need for effective but less expensive medications for RA and other autoimmune diseases. Natural plant products belonging to the traditional systems of medicine, such as the traditional Chinese medicine and Indian Ayurvedic medicine, offer a vast and promising resource in this regard. However, herbal medicinal products are often poorly characterized for their composition as well as mechanisms of action. We review here the results of our systematically performed studies aimed at defining the anti-arthritic activity of three herbal extracts, namely, modified Huo-luo-xiao-ling dan (HLXL), Celastrus aculeatus merr., and polyphenolic fraction of green tea (Camellia sinensis), as well as a purifiedcompound Celastrol, a bioactive component of Celastrus. Specifically, we examined the effects of these herbal products on the immunological, biochemical and molecular biological effector pathways in autoimmune arthritis. We have also reviewed here related studies on these herbal products by other investigators. Taken together, we suggest further testing of these herbal products in RA patients.

关键词： Drug discovery Herbal medicine Immune response Traditional Chinese medicine Natural products Rheumatoid arthritis

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我们需要什么研究来支持将结合医学运用于临床的决策?--效益比较研究可以填补其间的沟壑吗?

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中国中西医结合杂志 2013年第8期33卷 1030-1035页

作者： Claudia m.Witt 黄文静劳力行 brian m.berman 德国柏林医科大学社会医学、流行病学及卫生经济学研究所德国柏林10117 马里兰大学医学院结合医学中心美国巴尔的摩21201 成都中医药大学针灸推拿学院成都610075 结合卫生研究所美国巴尔的摩21231

在补充和结合医学临床研究中,专家和科研工作者往往片面地追求研究纲领而没有充分考虑到最终服务对象,即患者的需求。因此,以往大多数的临床研究都集中在评价治疗措施的效力,却缺乏关于其临床效果的研究数据。效益比较研究(comparative ... 详细信息

在补充和结合医学临床研究中,专家和科研工作者往往片面地追求研究纲领而没有充分考虑到最终服务对象,即患者的需求。因此,以往大多数的临床研究都集中在评价治疗措施的效力,却缺乏关于其临床效果的研究数据。效益比较研究(comparative effectivenesresearch,CER)旨在通过提供对可能的最佳治疗方案利弊的比较证据,使决策者能明智选择最佳治疗方案。这种证据,较之传统意义上的RCT研究证据更普遍,更适用于对实际医疗方案的决策。重视CER将为临床循证医学的发展及政策制定提供支持。诚然,在补充和结合医学的大多数领域中,CER的数据还很匮乏,针灸研究已为CER提供了一定的证据。笔者将重点介绍CER,并对将来的研究方向提供建议。

关键词：效益比较研究决策结合医学中医针刺

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马里兰大学医学院结合医学中心——美国医学院最早成立的替代医学中心

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中西医结合学报 2008年第11期6卷 1205-1209页

作者：劳力行布赖恩.伯曼马里兰大学医学院结合医学中心

马里兰大学医学院的补充医学中心成立于1991年,是美国在西医学院成立的第一个以研究中医药为主的综合性补充和替代医学中心。从1995年起连续被美国国家健康研究院评为全国中医研究的杰出中心,研究主要集中在评估中医药、针灸和身心疗法... 详细信息

马里兰大学医学院的补充医学中心成立于1991年,是美国在西医学院成立的第一个以研究中医药为主的综合性补充和替代医学中心。从1995年起连续被美国国家健康研究院评为全国中医研究的杰出中心,研究主要集中在评估中医药、针灸和身心疗法如气功、冥想疗法的安全性、有效性及作用机制。补充医学中心作为马里兰大学的交叉学科中心,主要承担了科研、临床、文献和教育4个方面的工作,彼此促进,已形成一个充满凝聚力的团队。中心近年来还增加了针灸和中医药研究在国际间的交流合作,特别与中国的香港中文大学、上海中医药大学和其他中医药大学进行了合作。

关键词：结合医学补充医学替代医学美国

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加减活络效灵丹的临床前安全性评价(英文)

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中西医结合学报 2010年第5期8卷 438-447页

作者：樊蓥劳力行张瑞星周安南布来恩.伯曼美国马里兰大学医学院中西结合医学中心马里兰巴尔的摩21201 美国美京中国医学中心维吉尼亚维也纳22182

目的:评估加减活络效灵丹口服应用的安全性。方法:检索TCmlars(***)、Pubmed(mEDLINE)文献和《中华本草》1999年版、《世界卫生组织精选医用植物》(Ⅰ～Ⅲ卷)关于活络效是丹及其组成药物的毒性方面的内容。大鼠单次给予最大剂量活络效灵... 详细信息

目的:评估加减活络效灵丹口服应用的安全性。方法:检索TCmlars(***)、Pubmed(mEDLINE)文献和《中华本草》1999年版、《世界卫生组织精选医用植物》(Ⅰ～Ⅲ卷)关于活络效是丹及其组成药物的毒性方面的内容。大鼠单次给予最大剂量活络效灵丹(9.2 g/kg)评价药物急性毒性;给予4.6g/kg活络效灵丹,连续给药9 d,采用运动功能实验和行为学观察等评价药物亚慢性毒性或不良反应;活络效灵丹2.30g/kg灌胃42d,评价药物慢性毒性或不良反应。结果:文献检索提示,活络效灵丹及其11味组成中药在中文中医药文献中没有副作用或不良反应记载。在临床习用剂量下,《中华本草》和《世界卫生组织精选医用植物》中没有发现该方组成药物有毒副作用或不良反应。大鼠实验提示:(1)应用单次口服最大剂量9.2 g/kg,在14 d观察期中没有发现活络效灵丹对大鼠体征、体质量有明显影响,无大鼠死亡;(2)运动实验提示,每日喂服4.6 g/kg,连续9 d,活络效灵丹未造成运动功能的损害;(3)活络效灵丹9 d连续给药,弗氏完全佐剂致炎大鼠没有出现明显的行为改变、不良反应和体征(最大观察剂量4.6 g/kg),正常大鼠连续9日每日喂服活络效灵丹4.6 g/kg,在用药期间以及停药后14 d内,未出现明显的不良反应;(4)每日应用活络效灵丹2.30g/kg连续42 d喂服正常大鼠,未观察到大鼠出现明显的行为改变、不良反应和体征,以及血清生化和组织病理改变。结论:动物实验提示加减活络效灵丹安全,无明显毒副作用,且文献报道中未发现加减活络效灵丹临床试验或动物实验中有副作用。

关键词：方剂加减活络效灵丹安全性文献研究急性毒性试验运动功能亚慢性毒性慢性毒性试验大鼠

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats

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World Journal of Gastroenterology 2012年第20期18卷 2481-2492页

作者： Hong-Yan Qin Hai-Tao Xiao Justin CY Wu brian m.berman Joseph JY Sung Zhao-Xiang Bian School of Chinese medicine Hong Kong Baptist University Hong Kong 999077 China Faculty of medicine The Chinese University of Hong Kong.Hong Kong 999077 China Center for Integrative medicine University of Maryland School of Medicine Baltimore MD 21201 United States

AIm:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. mETHODS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from *** 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were *** 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation *** 5 d post TNBS,the pathological score and myeloperoxidase(mPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,Pmedian dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,Pministration position affected the persistence of visceral *** 4 wk post TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,Pm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,Pmmation severity and visceral *** TNBS-25%ethanol-treated group,the pathological score and mPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR thres

关键词： Post-inflammatory Irritable bowel syndrome Rat model Trinitrobenzene sulfonic acid Key factors

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Changes in oral trace gas concentrations following orthognathic surgery and intermaxillary fixation: a case study using selected ion flow tube mass spectrometry

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International Journal of Oral Science 2011年第3期3卷 160-164页

作者： brian m. Ross Division of medical Sciences at the Northern Ontario School of medicine in Thunder Bay Ontario MS 3002 Canada

Orthognathic surgery is frequently accompanied by intermaxillary fixation. Intermaxillary fixation impedes the maintenance of effective oral hygiene and prolonged fixation can result in periodontal disease. A potential shorter term effect is the generation of oral malodour. It is unclear, however, as to how the production of malodorous compounds in the oral cavity is altered post-surgery. Oral air concentration of sulphur containing compounds, short chain organic acids, ammonia, isoprene and acetone were measured using selected ion flow tube-mass spectrometry in a patient who had undergone orthognathic surgery with subsequent intermaxillary fixation. Total sulphide levels rose approximately 5-fold during fixation with metal ties, with smaller increases recorded for the other compounds measured with the exception of isoprene which remained close to baseline levels. Organic acid levels declined markedly once elastic ties had replaced metal ties, with a lesser reduction being observed in sulphide levels, with both declining further after the commencement of a chlorhexidinecontaining mouthwash. These data suggest that bacterial generation of a variety of malodorous compounds increases markedly following intermaxillary fixation. This single case also suggests that the use of elastic ties and effective oral hygiene techniques, including the use of chlorhexidine mouthwash, may help ameliorate such post-surgical effects.

关键词： oral malodour halitosis oral hygiene breath analysis organic acids sulphides mass spectrometry

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Eosinophilic esophagitis: A newly established cause of dysphagia

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World Journal of Gastroenterology 2006年第15期12卷 2328-2334页

作者： brian m Yan Eldon A Shaffer Division of Gastroenterology Department of medicine University of CalgaryCalgaryAlbertaCanada

Eosinophilic esophagitis has rapidly become a recognized entity causing dysphagia in young adults. This review summarizes the current knowledge of eosinophilic esophagitis including the epidemiology, clinical presentation, diagnostic criteria, pathophysiology, treatment, and prognosis. An extensive search of Pubmed/medline （1966-December 2005） for available English literature in humans for eosinophilic esophagitis was completed. Appropriate articles listed in the bibliographies were also attained. The estimated incidence is 43/10s in children and 2.5/10s in adults. Clinically, patients have a long history of intermittent solid food dysphagia or food impaction. Some have a history of atopy. Subtle endoscopic features may be easily overlooked, including a ＂feline＂ or corrugated esophagus with fine rings, a diffusely narrowed esophagus that may have proximal strictures, the presence of linear furrows, adherent white plaques, or a friable （crepe paper） mucosa, prone to tearing with minimal contact. Although no pathologic consensus has been established, a histologic diagnosis is critical. The accepted criteria are a dense eosinophilic infiltrate （〉20/high power field） within the superficial esophageal mucosa. In contrast, the esophagitis associated with acid reflux disease can also possess eosinophils but they are fewer in number. Once the diagnosis is established, treatment options may include specific food avoidance, topical corticosteroids, systemic corticosteroids, leukotriene inhibitors, or biologic treatment. The long-term prognosis of EE is uncertain; however available data suggests a benign, albeit inconvenient, course. With increasing recognition, this entity is taking its place as an established cause of solid food dysphagia.

关键词： Eosinophilic esophagitis Allergy Dysphagia

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Polar comonomer incorporation using cationic Ni α-diimine olefin polymerization catalysts

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Science China Chemistry 2019年第2期62卷 153-154页

作者： Jordan m.Kaiser brian K.Long Department of Chemistry University of Tennessee

Polyolefins are an indispensable class of materials that have become the most widely produced and utilized polymers *** are readily synthesized from cheap and abundant monomer feedstocks,such as ethylene and propylene,and are capable of achieving a vast array of thermal and mechanical properties based upon their composition and ***,despite their numerous advantages, polyolefins are typically devoid of functional groups which can limit their applicability to many product families,such as coatings,adhesives,and cross-linked polyolefins.

关键词： Ni α-diimine olefin polymerization catalysts

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Emerging role of galectin 3 in neuroinflammation and neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： brian m.Lozinski Khanh Ta Yifei Dong Department of Clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

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