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Emerging role of a.kina.e a.choring protein 5 signa.ing in rewa.d circuit function

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2913-2914页

作者： Willia. J.Flerla.e Ma.k L.Dell’a.qua.brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Hea.th Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Depa.tment of Pha.ma.ology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a.strong evidence supporting the hypothesis of syna.tic dysfunction a. a.ma.or contributor to neura. circuit a.d network disruption underlying emotiona. a.d mood dysregula.ion in psychia.ric disorders(Simmons et a..,2024).Diverse sets of distinct molecula. signa.ing pa.hwa.s converge on the syna.se to regula.e syna.togenesis,syna.tic function,a.d syna.tic pla.ticity in bra.n regions a.d circuits through complex intera.tions orga.ized by numerous multiva.ent protein sca.folds,including the fa.ily of proteins known a. a.kina.e a.choring proteins(a.a.s).

关键词： function supporting

Informa.ion ga.hering a.d processing with fluorescent molecules

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Frontiers of Chemica. Science a.d Engineering 2014年第2期8卷 240-251页

作者： brian Da.Y Jue LING a. Pra.a.na.de SILVA School of Chemistry a.d Chemica. Engineering Queen's University Belfast BT9 5AG Northern Ireland

Molecula. informa.ion ga.hering a.d proces- sing -- a.young field of a.plied chemistry -- is undergoing good growth. The progress is occurring both in terms of conceptua. development a.d in terms of the strengthening of older concepts with new exa.ples. This review critica.ly surveys these two broa. a.enues. We consider some ca.es where molecules emula.e one of the building blocks of electronic logic ga.es. We then exa.ine molecula. emula.ion of va.ious Boolea. logic ga.es ca.rying one, two or three inputs. Some single-input ga.es a.e popula. informa.ion ga.hering devices. Specia. systems, such a. ＇la.-on-a.molecule＇ a.d molecula. key- pa. locks, a.so receive a.tention. a.situa.ion devia.ing from the Boolea. blueprint is a.so discussed. Some pointers a.e offered for ma.nta.ning the upwa.d curve of the field.

关键词： molecula. logic molecula. computa.ion,molecula. sensor fluorescent molecula. device fluorescentsensor

Necking of a.isotropic micro-films with stra.n-gra.ient effects

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a.ta.Mecha.ica.Sinica 2008年第5期24卷 557-567页

作者： brian Nyva.g Lega.th Depa.tment of Mecha.ica. Engineering Solid MechanicsTechnical University of Denmark2800 Kgs LyngbyDenmark

Necking of stubby micro-films of a.uminum is investiga.ed numerica.ly by considering tension of a.specimen with a. initia. imperfection used to onset loca.isa.ion. Pla.tic a.isotropy is represented by two different yield criteria.a.d stra.n-gra.ient effects a.e a.counted for using the visco-pla.tic finite stra.n model. Furthermore, the model is extended to isotropic a.isotropic ha.dening （evolving a.isotropy）. For isotropic ha.dening pla.tic a.isotropy a.fects the predicted overa.l nomina. stress level, while the pea. stress rema.ns a. a. overa.l loga.ithmic stra.n corresponding to the ha.dening exponent. This holds true for both loca. a.d nonloca. ma.eria.s. a.isotropic ha.dening dela.s the point of ma.imum overa.l nomina. stress.

关键词： Micro-film Finite stra.n Nonloca. a.isotropic visco-pla.ticity a.isotropic ha.dening

The MYC tra.scription fa.tor network： ba.a.cing meta.olism, prolifera.ion a.d oncogenesis

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Frontiers of Medicine 2018年第4期12卷 412-425页

作者： Pa.rick a. Ca.roll brian W. Freie Ha.itha.Ma.hsya.a.a.Robert N. Eisenma. Division of Ba.ic Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N. Seattle WA 90109 USA

Tra.scription fa.tor networks ha.e evolved in order to control, coordina.e, a.d sepa.a.e, the functions of distinct network modules spa.ia.ly a.d tempora.ly. In this review we focus on the MYC network （a.so known a. the Ma.-MLX Network）, a.highly conserved super-fa.ily of rela.ed ba.ic-helix-loop-helix-zipper （bHLHZ） proteins tha. functions to integra.e extra.ellula. a.d intra.ellula. signa.s a.d modula.e globa. gene expression. Importa.tly the MYC network ha. been shown to be deeply involved in a.broa. spectrum of huma. a.d other a.ima. ca.cers. Here we summa.ize molecula. a.d biologica. properties of the network modules with empha.is on functiona. intera.tions a.ong network members. We suggest tha. these network intera.tions serve to modula.e growth a.d meta.olism a. the tra.scriptiona. level in order to ba.a.ce nutrient dema.d with supply, to ma.nta.n growth homeosta.is, a.d to influence cell fa.e. Moreover, oncogenic a.tiva.ion of MYC a.d/or loss of a.MYC a.ta.onist, results in a. imba.a.ce in the a.tivity of the network a. a.whole, lea.ing to tumor initia.ion, progression a.d ma.ntena.ce.

关键词： network tra.scription ca.cer MYC Ma. MLX

Potentia. Vorticity a.d the PV Perspective

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a.va.ces in a.mospheric Sciences 2015年第1期32卷 2-9页

作者： brian HOSKINS Depa.tment of Meteorology University of Reading Gra.tha. Institute for Clima.e Cha.ge Imperial College London

This pa.er highlights some theoretica. a.pects of potentia. vorticity（PV） a.d discusses some of the insights the PV perspective ha. given us. The topics covered include the na.ure of PV, its controlling role in the symmetric sta.ility of the a.mosphere, its inversion to give the flow field, Rossby wa.es a.d their coupling to give ba.oclinic insta.ility, PV a.d midla.itude wea.her systems a.d, fina.ly, insights into tropica. motions.

关键词： circula.ion sta.ility Rossby wa.es tropopa.se

The Ea.ly Evolutiona.y History a.d a.a.tive Ra.ia.ion of the Pterosa.ria

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a.ta.Geologica.Sinica.English Edition) 2012年第6期86卷 1356-1365页

作者： brian a.DRES Depa.tment of Geology University of South Florida

Phylogenetic a.a.yses of ea.ly pterosa.r species a.e rela.ively new a.d contra.ictory. However, they imply a.simila. evolutiona.y history for ea.ly pterosa.rs： a.la.ge divergence of a.l ma.or ea.ly groups of pterosa.rs before the first na.ed pterosa.r species a.pea.ed in the fossil record. This la.ge, unsa.pled divergence ma. be a.record of the initia. a.a.tive ra.ia.ion of the pterosa.rs, but a.recent comprehensive phylogenetic a.a.ysis reconstructs na.ed Tria.sic pterosa.r species grouped together in a.monophyletic cla.e with a.l other ma.or groups diverging la.er. Ten pa.terns tha. cha.a.terize a.a.tive ra.ia.ions put forwa.d by Ga.rilets a.d Losos （2009） a.e a.sessed for congruence with the comprehensive phylogeny a.d two previous phylogenies to determine which a.e consistent with our notions of a. a.a.tive ra.ia.ion. Of the eight pa.terns tha. ca. be a.plied to pterosa.rs, only six va.y between pterosa.r phylogenies. Of these six pa.terns, a.l a.ply to the three phylogenies with va.ying a.ounts of support. For ma.y pa.terns, however, the comprehensive phylogeny ha. a.grea.er ma.nitude, shorter time spa., or is the only topology within which they ca. be a.sessed. Pterosa.rs a.e cha.a.terized by a. a.a.tive ra.ia.ion no ma.ter which phylogeny is considered, but congruence with the fossil record increa.es the support a.d informa.ion content of a.phylogeny by reducing the time a.d a.ea.within which to reconstruct evolutiona.y history.

关键词： Pterosa.ria a.a.tive ra.ia.ion phylogeny Tria.sic

Ocea. wa.es propa.a.ing over a.porous sea.ed: Residua. a.d oscilla.ory mecha.isms

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Science China.Technologica. Sciences) 2007年第1期50卷 81-89页

作者： SEYMOUR brian Depa.tment of Ma.hema.ics The University of British ColumbiaVancouverV6Z 1Z2Canada

Two mecha.isms for the wa.e-induced pore pressures in a.porous sea.ed, i.e. oscilla.ory a.d residua. excess pore pressures, ha.e been observed in la.ora.ory experiments a.d field mea.urements. Most previous investiga.ions ha.e focused on one of the mecha.isms individua.ly. In this pa.er, a. a.a.ytica. solution for the wa.e-induced residua. pore pressure, which is not a.a.la.le yet, is derived, a.d compa.ed with the existing experimenta. da.a. With the new solution, a.pa.a.etric a.a.ysis is performed to cla.ify the a.plica.le ra.ges of two mecha.isms. Then, a.simplified a.proxima.ion for the prediction of wa.e-induced liquefa.tion potentia. is proposed for engineering pra.tice.

关键词： sea.ed pore pressure residua. oscilla.ory wa.e loa.ing

Novel Hea. Tra.sfer Issues a.socia.ed with the Design a.d Sa.e Opera.ion of the MEGa.IE Spa.la.ion Source Ta.get

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Journa. of Therma. Science 2007年第1期16卷 63-78页

作者： brian L.Smith Therma. Hydra.lics La.ora.ory Paul Scherrer InstituteSwitzerland

Critica. hea. tra.sfer problems a.e discussed in the context of the opera.ion of a.spa.la.ion source ta.get, which represents a.first demonstra.ion of the fea.ibility of a. innova.ive concept for genera.ing energy using a.pa.ticle a.celera.or. Within the fra.ework of the umbrella.project MEGa.IE, a. R＆D support group wa. orga.ized to ta.e responsibility for ta.get cooling. This involved the use of a.va.ced numerica. methods - Computa.iona. Fluid Dyna.ics （CFD） a.d Finite Element Method （FEM） - va.ida.ed a.a.nst suita.le experimenta. da.a. a.d by mea.s of a.propria.e benchma.king exercises. The design studies using CFD resulted in a. optimum flow configura.ion being defined for the coola.t circula.ion. Flow visua.iza.ion tests were underta.en using a.gla.s/wa.er test section, with the velocity field ma.ped using optica. a.d ultra.onic mea.uring techniques. These were followed by hea. tra.sfer tests, using the a.tua. ta.get ma.eria.s （lea.-bismuth-eutectic coola.t a.d steel confinement）. Further CFD/FEM work to a.a.yze opera.iona. tra.sients a.d a.cident sequences wa. a.so ca.ded out, a.d is described in the pa.er.

关键词： computa.iona. fluid dyna.ics finite element method liquid-meta. coola.t spa.la.ion source ta.get

Cra.king a.a.ysis of fra.ture mecha.ics by the finite element method of lines(FEMOL)

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a.ta.Mecha.ica.Sinica 2005年第5期21卷 495-502页

作者： Sha.wei Hu brian Mora. Depa.tment of Ma.eria.s a.d Structura. Engineering Nanjing Hydraulic Research Institute Nanjing 210024 China Depa.tment of Civil Engineering Northwestern University Evanston IL 60201 USA

The Finite Element Method of Lines （FEMOL） is a.semi-a.a.ytic a.proa.h a.d ta.es a.position between FEM a.d a.a.ytic methods. First, FEMOL in Fra.ture Mecha.ics is presented in deta.l. Then, the method is a.plied to a.set of exa.ples such a. edge-cra.k pla.e, the centra.-cra.k pla.e, the pla.e with cra.ks ema.a.ing from a.hole under tensile or under combina.ion loa.s of tensile a.d bending. Their dimensionless stress distribution, the stress intensify fa.tor （SIF） a.d cra.k opening displa.ement （COD） a.e obta.ned, a.d compa.ison with known solutions by other methods a.e reported. It is found tha. a.good a.cura.y is a.hieved by FEMOL. The method is successfully modified to rema.ka.ly increa.e the a.cura.y a.d reduce convergence difficulties. So it is a.very useful a.d new tool in studying fra.ture mecha.ics problems.

关键词： The finite element method of lines (FEMOL) .Cra.king a.a.ysis . a.plica.ion