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Assessment of Susceptibility, Pharmacodynamics, and Therapeutic Response for Interpretation of Piperacillin-Tazobactam <i>in Vitro</i>Activity in the Treatment of <i>Pseudomonas aeruginosa</i>Infection

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Open Journal of medical microbiology 2012年第3期2卷 101-109页

作者： Toni-marie Gonzalzles mira Suseno Joseph m. Gaydos Paul C. Schreckenberger Carrie Sincak maitry S. mehta Lance R. peterson Cleveland VAmC Cleveland USA Departments of Pathology and medicine University of Chicago Chicago USA Departments of Pathology Medicine and Pharmacy NorthShore University HealthSystem (NorthShore) Evanston USA Loyola University medical Center Maywood USA

Pseudomonas aeruginosa remains an important pathogen. Our purpose was to determine the minimum inhibitory con-centration (mIC) and pharmacodynamic (PD) parameters predicting a positive response to therapy with piperacil-lin-tazobactam. medical records were retrospectively reviewed at 3 centers. Data were recorded to assess age, type of disease, renal function, weight (body mass), mIC, antimicrobial treatment, and clinical outcome. Success was response to piperacillin-tazobactam alone, or in combination with another active agent;failure was lack of response. Of 78 eva-luable patients, 63 responded (7 UTI;56 non-UTI) and 15 did not;26 responding received combination therapy and 37 monotherapy. Piperacillin-tazobactam treatment was successful in 53 of 63 of non-UTI disease with a mIC of ≤64/4 μg/mL, but in only 3 of 7 with a mIC of >64/4 μg/mL (P = 0.023);overall 9 of 10 infections by strains with mICs = 32 - 64 μg/mL had a successful outcome. Piperacillin estimated time above mIC at 20% separated those responding from those that did not (P = 0.019).

关键词： Pseudomonas Aeruginosa Piperacillin-Tazobactam multidrug Resistance Pharmacodynamics

克拉屈滨治疗巨球蛋白血症后早期发生自身免疫性溶血性贫血

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国际输血及血液学杂志 2006年第3期29卷 277-278页

作者： Aslan DL peterson BA Long-Tsai m 徐健无

Waldenstr(o)ms巨球蛋白血症(Wm)是一种罕见的惰性B细胞淋巴瘤,其特点为骨髓中有浆细胞样淋巴细胞浸润,常伴有单克隆Igm副蛋白.Igm副蛋白引起高粘滞血症、冷凝集素性溶血性贫血、冷球蛋白血症、多发性神经病.Wm的这些典型特征通常表现... 详细信息

Waldenstr(o)ms巨球蛋白血症(Wm)是一种罕见的惰性B细胞淋巴瘤,其特点为骨髓中有浆细胞样淋巴细胞浸润,常伴有单克隆Igm副蛋白.Igm副蛋白引起高粘滞血症、冷凝集素性溶血性贫血、冷球蛋白血症、多发性神经病.Wm的这些典型特征通常表现出症状.Wm对化疗有反应、多次复发和生存期长等特点.

关键词：自身免疫性溶血性贫血巨球蛋白血症克拉屈滨单克隆Igm 早期治疗 B细胞淋巴瘤淋巴细胞浸润冷球蛋白血症多发性神经病

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小肠肠壁中性轴位置在无载荷状态下的确定

小肠肠壁中性轴位置在无载荷状态下的确定

modeling the Sediment Fill of the Upper Troy Pre-Glacial Bedrock Valley, mcHenry County, Illinois, USA

天津市生物医学工程学会第三十一届学术年会

作者：李江 brent m.Witgen 刘海英门玉涛高丽兰叶金铎张春秋天津理工大学机械工程学院 PANUm Institure Copenhagen University

＜正＞目的小肠等胃肠道组织的功能在很大程度上是其食糜输运的力学功能。肠壁的力学属性、平滑肌（smooth muscle）的张紧性收缩（tonic contraction）和平滑肌的相收缩（phasic contraction）共同对肠道内容物的输运起着重要作用。有...

＜正＞目的小肠等胃肠道组织的功能在很大程度上是其食糜输运的力学功能。肠壁的力学属性、平滑肌（smooth muscle）的张紧性收缩（tonic contraction）和平滑肌的相收缩（phasic contraction）共同对肠道内容物的输运起着重要作用。有文献报道平滑肌的张紧性收缩对其生理功能和生物力学属性影响很大,可以通过度量小肠各段在有无平滑肌的张紧性收缩下的开放角和残余应变来评估其大小。肠壁内存在残余应力和应变,并且在人体

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Journal of Geoscience and Environment Protection 2016年第6期4卷 107-122页

作者： Jodi Lau Jason F. Thomason David H. malone Eric W. peterson Department Geography-Geology Illinois State University Normal IL USA Illinois State Geological Survey Champaign IL USA

The Troy Bedrock Valley (TBV) and its tributary valleys are the principal pre-glacial drainage in southern Wisconsin and northern Illinois, USA. This study focused on the headwaters of a tributary that occurs in mcHenry County, IL. Drilling, geophysical surveys, and the analysis of existing geologic and water well data were used to determine the lithologic and geometric characteristics of the sediments that fill the paleovalley. A 3D geologic model of these sediments was then developed in Petrel. more than 65 m of Quaternary sediments filled the paleovalley. The model domain covers approximately 30 km2. The valley drains to the west and meanders, which is distinct from the straight course of the overlying modern Kishwaukee River. The sediments that filled the valley were subdivided into five units. These units include Illinois-age Glasford Formation coarse-grained proglacial outwash and alluvial deposits (GS2, GS1) and fine-grained lacustrine and diamicton deposits (G2 and G1). The Wisconsin-age Henry Formation sand and gravel cap the valley fill, and Cahokia alluvium buries everything.

关键词： Buried Bedrock Valley Glasford Formation Illinois 3D Geologic model Quaternary

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野红燕麦籽实中蛋白质的分布

北方农业学报 1983年第2期 21-25页

作者： Vernon L、youngs David m.peterson 叶福钧

25份野红燕麦选系的籽实去壳后,去壳燕麦徒手解剖为胚芽、小盾片、麸皮与淀粉胚乳,各部分分别称重后用以化验蛋白质,并以一份普通燕麦栽培品种马克顿为对照。野红燕麦的去壳燕麦产量以及大小均低于马克顿。野红燕麦选系蛋白质百分率较高... 详细信息

25份野红燕麦选系的籽实去壳后,去壳燕麦徒手解剖为胚芽、小盾片、麸皮与淀粉胚乳,各部分分别称重后用以化验蛋白质,并以一份普通燕麦栽培品种马克顿为对照。野红燕麦的去壳燕麦产量以及大小均低于马克顿。野红燕麦选系蛋白质百分率较高,但由于去壳燕麦较小,每粒去壳燕麦蛋白质含量则较低。野红燕麦去壳燕麦总重中大部分是淀粉胚乳,占58.0％,麸皮占39.1％,而胚芽与小盾片部分只占很少比例,这些数值与马克顿类似。尽管在较大去壳燕麦中胚乳部分比例高,麸皮、胚乳两者的重量与去壳燕麦大小呈正相关。淀粉胚乳的蛋白质百分率是最低的,除一些选系外,野红燕麦各部分蛋白质百分率比马克顿高。高蛋白选系表现为麸皮与淀粉胚乳的蛋白质百分率较高。作为单一部分的麸皮,比其他三部分可含有籽实蛋白质总量最大比例。

关键词：燕麦胚乳麦类作物去壳籽实选系蛋白质含量蛋白质

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牛金属硫蛋白基因序列测定及结构分析

科学通报 1992年第12期37卷 1124-1127页

作者：杨靖沈孝宙杨卫民 m. G. peterson J. F. B. mercer Savio L. C. Woo 中国科学院发育生物学研究所北京100080 中国科学院动物研究所生殖生物学开放研究实验室北京100080 澳大利亚皇家儿童医院美国贝勒医学院细胞生物系

金属硫蛋白(metallothionein,简称mT)是一类能特异性地结合重金属,并富含半胱氨酸的低分子量蛋白质,它们广泛地存在于从酵母到人类的真核细胞生物体中。mT基因是动物细胞基因表达调控中一直受人重视的实验模型。为了在转基因家畜的研究... 详细信息

金属硫蛋白(metallothionein,简称mT)是一类能特异性地结合重金属,并富含半胱氨酸的低分子量蛋白质,它们广泛地存在于从酵母到人类的真核细胞生物体中。mT基因是动物细胞基因表达调控中一直受人重视的实验模型。为了在转基因家畜的研究中提供可诱导的调控元件,我们克隆了牛金属硫蛋白基因(bmT),并发现牛的mT基因家族至少含有4个成员。本文对其中一个具有功能的基因(bmTc)进行了序列测定,在此基础上对该基因的结构特性作了分析。

关键词：牛金属硫蛋白基因 DNA序列测定

Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness:Lessons from a contemporary single institution radical prostatectomy series

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Asian Journal of Urology 2015年第1期2卷 53-58页

作者： Zachary B.Koloff Daniel A.Hamstra John T.Wei Jeffrey S.montgomery Scott A.Tomlins Angela J.Wu Todd m.morgan Javed Siddiqui Kellie Paich Arul m.Chinnaiyan Felix Y.Feng Alon Z.Weizer Lakshmi P.Kunju brent K.Hollenbeck David C.miller Ganesh S.Palapattu Rohit mehra Department of Urology University of Michigan Medical SchoolAnn ArborMIUSA Department of Radiation Oncology University of Michigan Medical SchoolAnn ArborMIUSA Department of Pathology University of Michigan Medical SchoolAnn ArborMIUSA

Objective:To better evaluate tertiary Gleason pattern reporting and to evaluate the impact of tertiary Gleason pattern 5(TP5)on prostate cancer pathological features and biochemical recurrence at our large single ***:We retrospectively reviewed 1962 patients who underwent radical prostatectomy(RP)for prostate cancer;TP5 was reported in 159 cases(8.1%).men with Gleason score(GS)7 and GS 8 disease were divided into subgroups with and without TP5,and histopathological features were *** analyses were conducted to assess the impact on TP5 on biochemical-free survival(BFS).Results:Tumors possessing GS 3+4 with TP5 were more likely to exhibit extraprostatic extension(EPE)and had a larger tumor diameter(TD)than GS 3+4 *** 3+4 with TP5 was also associated with positive surgical margins(Sm),seminal vesicle involvement(SVI),and higher pre-operative prostate-specific antigen(PSA)values,but without statistical *** 4+3 with TP5 more commonly presented with EPE,positive Sm,SVI,and greater TD and pre-operative PSA level than GS 4+3 *** multivariate analysis,Gleason score,EPE,and TP5 were overall independent risk factors for PSA recurrence in this ***,GS 4+3 with TP5 was associated with shorter time to recurrence versus GS 4+3 ***:Our results emphasize the importance of TP5 and suggest that criteria for tertiary pattern reporting in prostate cancer should be *** studies are needed to evaluate the role of tertiary patterns in prognostic models.

关键词： Tertiary Gleason pattern Prostate cancer Prostatic neoplasm Gleason score Radical prostatectomy Disease-free survival

脂质体-阿霉素诱导完全缓解的严重日晒患者出现3级皮肤毒性反应

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 38-39页

作者： markman m. Kulp B. peterson G. 马向东 Dept.ofObstetrics and Gynecolog y M.D.Anderson Can-cer Center1515Holcombe Blvd.#4377030-4009HoustonTXUnited States

***-plantar erythrodysestehsia(PPE)is a potentially serious toxicity of a nu mber of cytotoxic chemotherapeutic agents,includin g liposomal *** that may increase the ris k of this toxicity should be *** report.A patient wi th platinum-resistant ovarian cancer,responded to,and to lerated(including no skin rash)an initial cycle of liposomal doxoru bicin(40mg /m 2 ).Unfortunately,several days before her next scheduled cycle,she developed sign ificant sunburn(intense erythemawithout blisterin g).Despite an additional1-week delay(total of 5weeks from the prior liposo maldoxorubicin),and complete visual recovery from t he effects of the sunburn,the patient developed severe(grade 3)PPE involving both hands(pain,pronounced erythema,blistering,without ulceration),and a slightly less exten-sive reaction of both feet,followin g subsequent treatmen-twith a 25%reduced dose of the agent (30mg /m 2 ).*** is advised when considering the ad-ministration of liposomal doxorubi cin following a major sunburn,despite total resolution o f the visible effects on the skin.A delay of several weeks may be appropriate to avoid exacerbation by the chemotherapeutic agent of per-sistent subclinical damage to norma l epithelial cells.

关键词：皮肤毒性毒性反应晒伤化疗药物亚临床损害感觉障碍局部反应细胞毒性上皮细胞持续性

Review of Divertor Studies in LHD

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Plasma Science and Technology 2006年第1期8卷 14-18页

作者： T. mORISAKI S. mASUZAKI A. KOmORI N. OHYABU m. KOBAYASHI J. mIYAZAWA m. SHOJI 高翔 K. IDA K. IKEDA O. KANEKO K. KAWAHATA S. KUBO S. mORITA K. NAGAOKA H. NAKANISHI K. NARIHARA Y. OKA m. OSAKABE B. J. peterson S. SAKAKIBARA R. SAKAmOTO T. SHImOZUmA Y. TAKEIRI K. TANAKA K. TOI, K. TSUmORI K. Y. WATABABE T. WATARI H. YAmADA I. YAmADA 严龙文杨青巍杨愚 Y.YOSHImURA m. YOSHINUmA O. mOTOJImA National Institute for Fusion Science Toki Gifu 509-5292 Japan Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China Southwesteru Institute of Physics Chengdu 610041 China

In the Large Helical Device （LHD）, two different divertor configurations, i.e. helical divertor （HD） and local island divertor （LID）, are utilized to control the edge plasma. The HD with two X-points is an intrinsic divertor for heliotron devices, accompanied with a relatively thick ergodic layer outside the confinement region. Edge and divertor plasma behavior from low density to high density regimes is presented, referring to the divertor detachment. The effect of the ergodic layer on the edge transport is also discussed. On the other hand, the LID is an advanced divertor concept which realizes a high pumping efficiency by the combination of an externally induced magnetic island and a closed pumping system. Experimental results to confirm the fundamental divertor performance of the LID are presented.

关键词： LHD divertor ergodic layer magnetic island edge plasma