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Advances in Microbiology 2015年第10期5卷 699-710页

作者： brendan Kiefer John L. Dahl Department of Biology University of Minnesota Duluth Duluth MN USA

Environmental mycobacteria are capable of forming biofilms in low-nutrient environments, and these biofilms may act as reservoirs for opportunistic infections. The purpose of this study was to determine if bacteriophages could disrupt existing biofilms of acid-fast staining Mycobacterium smegmatis. Using the MBEC 96-well plastic peg assay system, M. smegmatis biofilms were created and then tested for their stability in the presence of mycobacteriophages isolated from a Minnesota sphagnum peat bog. All phages tested were lytic and were observed to have weak, intermediate, and strong abilities to disrupt M. smegmatis biofilms. The formation of biofilms was severely impaired in the presence of mycobacteriophages. Phage treatment was also shown to augment?M. smegmatis biofilm disruption by mechanical forces of sonication or water flow. Our study shows that, as with biofilms of Gram-positive and Gram-negative bacteria, mycobacterial biofilms are also susceptible to destruction by bacteriophages.

关键词： Mycobacterium smegmatis Biofilm Mycobacteriophage Bacteriophage

Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions

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Regenerative Biomaterials 2020年第3期7卷 247-258页

作者： Marley J.Dewey Eileen M.Johnson Simona T.Slater Derek J.Milner Matthew B.Wheeler brendan A.C.Harley Department of Materials Science and Engineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Bioengineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Carl R.Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Animal Sciences University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA

Defects in craniofacial bones occur congenitally,after high-energy impacts,and during the course of treatment for stroke and *** injuries are difficult to heal due to the overwhelming size of the injury area and the inflammatory environment surrounding the *** inflammatory response after injury may greatly inhibit regenerative *** have developed mineralized collagen scaffolds that can induce osteogenic differentiation and matrix biosynthesis in the absence of osteogenic media or supplemental *** amniotic membrane is derived from placentas and has been recently investigated as an extracellular matrix to prevent chronic ***,we hypothesized that a mineralized collagen-amnion composite scaffold could increase osteogenic activity in the presence of inflammatory *** report mechanical properties of a mineralized collagen-amnion scaffold and investigated osteogenic differentiation and mineral deposition of porcine adipose-derived stem cells within these scaffolds as a function of inflammatory *** of amniotic membrane matrix promotes osteogenesis similarly to un-modified mineralized collagen scaffolds,and increases in mineralized collagen-amnion scaffolds under inflammatory ***,these findings suggest that a mineralized collagen-amnion scaffold may provide a beneficial environment to aid craniomaxillofacial bone repair,especially in the course of defects presenting significant inflammatory complications.

关键词： mineralized collagen scaffolds amniotic membrane inflammation stem cell osteogenesis

Flexible Vertex Engineers the Controlled Assembly of Distorted Supramolecular Tetrahedral and Octahedral Cages

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Research 2022年第2期2022卷 333-344页

作者： Shu-Jin Bao Ze-Ming Xu Tian-Chen Yu Ying-Lin Song Heng Wang Zheng Niu Xiaopeng Li brendan F.Abrahams Pierre Braunstein Jian-Ping Lang Collge of Chemistry Chemical Enginering and Materias ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of rgnomallic Chemistry Shanghai Jnstitute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Plysical Science and Techmology Soochow UinversitySuzhou 215006China College of Chemistry and Enwironmenrial Engineering Shenzhen UniversilyShenzhen 518071China School of Chemistry University of MelbourneVictoria 3010Australia Universite de Strasbourg-CNRS Institut de Chimie(UMR 7177 CNRS)4 Rue Blaise Pascal CS 9003267081 StrasbourgFrance

Designing and building unique cage asemblies atrat increasing interet from supramolecular chemists but remain synthetically ***,we propose the use of a flexible vertex with adjustable angles to selectively form highly distorted tetrahedral and octahedral cages,for the first time,in which the flexible ve rtex forms from the synergistic eft of coordination and covalent *** inherent interligand angle of the vertex can be modulated by guest anions present,which allows for the fine-tuning of diferent cage ***,the reversible structural transformation between tetrahedral and octahedral cages was achieved by anion exchange monitored by mass spectrometric technique,the smaller anions favoring tetrahedral cages,while the larger anions supporting octahedral ***,the KBr-based cage thin films exhibited prominent enhancement of their third-order NLO responses in two or three orders of magnitude compared to those obtained for their corresponding *** work not only provides a new methodology to build irregular polyhedral structures in a controlled and tunable way but also provides access to new kinds of promising functional optical materials.

关键词： vertex tetrahedral synergistic

Insomnia in Cancer Care: Analyzing Oncologists’ Knowledge and Practice in Singapore

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Open Journal of Psychiatry 2024年第S2期14卷 504-513页

作者： Jing Yun Leong brendan Seng Hup Chia Department of Psychological Medicine Changi General Hospital Singapore Raffles Cancer Centre Raffles Hospital Singapore Division of Radiation Oncology National Cancer Centre Singapore Singapore

Introduction: Insomnia is a common but often underdiagnosed and undertreated condition among cancer patients, significantly impacting their quality of life (QoL). Oncologists play a crucial role in managing insomnia, yet their knowledge and practices in this area remain unclear. This study aims to assess the current practices of oncologists in Singapore regarding insomnia management and to identify areas where additional education may be needed. Methods: We conducted a cross-sectional survey of practicing medical and radiation oncologists in Singapore. The survey, based on the 2023 ESMO Clinical Practice Guideline for managing insomnia in adult cancer patients, included 12 multiple-choice, checkbox, and open-ended questions. Data were analyzed descriptively to identify trends in screening, assessment, and management of insomnia among oncologists. Results: A total of 25 oncologists responded to the survey. The majority (84%) do not routinely screen for sleep disturbances, and only a small fraction uses validated tools to assess insomnia severity. Time constraints and a lack of knowledge were identified as the primary barriers to comprehensive sleep assessments. Pharmacological treatments, particularly melatonin and Z-class drugs, were commonly initiated, with 32% of oncologists using them as first-line therapy. Non-pharmacological strategies, such as cognitive behavioral therapy for insomnia, were underutilized. Additionally, many oncologists expressed uncertainty about when to refer patients to sleep specialists, indicating a gap in their training and confidence in managing insomnia. Conclusion: This study reveals significant gaps in the routine screening and comprehensive management of insomnia among oncologists in Singapore. Despite the high prevalence of sleep disturbances in cancer patients, oncologists often prioritize other symptoms and lack the necessary tools and knowledge to address insomnia effectively. The findings underscore the need for targeted educati

关键词： Insomnia Sleep Disorder Cancer Patients Oncology Education Quality of Life

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Daily heart rate variability of Paralympic gold medallist swimmers： A 17-week investigation

作者： (美)brendan Gregg

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Journal of Sport and Health Science 2015年第4期4卷 371-376页

作者： Rohan Edmonds Anthony Leicht Mark McKean brendan Burkett School of Health and Sport Sciences University of the Sunshine Coast Sunshine Coast 4556 Australia College of Healthcare Sciences James -Cook University Townsville 4811 Australia

Objectives： Heart rate variability （HRV） can be a simple, non-invasive method of gauging cardiac autonomic nervous system fluctuations across periodised training workloads and taper in elite athlete populations. The purpose of these three case studies was to examine daily cardiac autonomic variations in Paralympic athletes leading in to the Paralympic games. Methods： Three Paralympie gold medallist swimmers were monitored daily for their resting HRV over a 17-week monitoring period leading up to the Paralympic games. Specific time- and frequency-domain measures, along with non-linear indices of HRV were calculated for all analyses. All HRV data were analysed individually using daily values, weekly average values, and average values for rest and training phases. Results： A significant difference in HRV was seen for all variables between athlete 1 and athletes 2 and 3 （amputee disabilities） during the entire monitoring period. Conclusion： Despite minimal long-term changes, both swimming classification and disability type significantly influence HRV during athlete monitoring. An increased understanding of individual responses to training, travel, and other outside influences affecting Paralympic athletes could potentially lead to improved management and monitoring of training workloads for enhanced nerformance.

关键词： Autonomic nervous system Cardiac modulation Disability Elite athlete Periodised training Testing

Investigation of coupled cobalt-silver nanoparticle system by plan view TEM

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Progress in Natural Science:Materials International 2012年第3期22卷 186-192页

作者： Daniel Fox Ruggero Verre brendan J. O'Dowd Sunil K. Arora Colm C. Faulkner Igor V. Shvets School of Physics and CRANN Trinity College Dublin CRANN Advanced Microscopy Laboratory Trinity College Dublin

We present a transmission electron microscopy (TEM) investigation of a coupled cobalt and silver nanoparticle system. A plan view in situ lift-out method for preparing samples for TEM using the focused ion beam (FIB) microscope was used. This technique is used to prepare high quality TEM samples with site specificity in a short time and with a high success rate. We demonstrate the ability of the plan view sample preparation technique to provide information about an ordered system of nanoparticles which could not be observed using standard FIB cross sectioning of the sample. High resolution TEM and energy dispersive X-ray spectroscopy mapping of both cross sectional and plan view samples are presented, clearly showing the significant benefit of plan view TEM analysis for certain samples.

关键词： Focused ion beam Transmission electron microscopy Lift-out Co Ag Nanoparticle

The Potential for Excess Correlation (Entanglement) between Flow States in Pairs of Gamers Sharing Specific Circumcerebral Rotating Magnetic Fields

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Journal of Signal and Information Processing 2016年第3期7卷 115-122页

作者： brendan S. Lehman Michael A. Persinger Behavioural Neuroscience Program and Department of Biology Laurentian University Sudbury Canada

Excess correlation between the activity or properties of two particles separated by non-local distances has been demonstrated for photons, shifts in relative proton and hydroxyl ratios in spring water, and the distribution of values from random number generators if both loci shared a specific type of rotational magnetic field. Previous experiments had shown that specific responses from pairs of people who shared circumcerebral magnetic fields with changing angular velocities revealed significant excess correlation. The most significant differences occurred during the component of the field exposure that has previously been associated with “excess correlation”. In the present experiments, we found evidence of excess correlation of performance (serial in-game scores) occurred between pairs (separated by 10 m) of experienced gamers during the relative measures for the central portion of the protocol but was diminished when the “excess correlation” electromagnetic fields were activated, suggesting a similar competing mechanism. The results are consistent with the interpretation that shared video systems and activities may enhance excess correlation of responses. This can be simulated in novice players by experimentally inducing excess correlation through appropriate application of changing, circumcerebral angular velocity magnetic fields that were similar in magnitude to those associated with computer systems and time frames that define human consciousness.

关键词： Excess Correlation Entanglement Digital Games Learning Magnetic Fields Consciousness

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特征线方向概率方法与性能分析模型研究

核动力工程 2014年第5期35卷 157-163页

作者：刘宙宇吴宏春 brendan Kochunas Benjamin Collins Yunlin Xu Thomas Downar 西安交通大学核科学与技术学院西安710049 密歇根大学核能与辐射科学学院美国48109

为了进一步提高特征线方向概率方法(CDP)的计算效率,提出了一种角度相关的边界均匀化方法。提出CDP性能分析模型,显性地比较分析特征线方法(MOC)和CDP的计算效率。数值结果表明,所提模型正确,并显示出CDP在计算效率方面的优势。

关键词：特征线方法特征线方向概率方法边界均匀化

Osteoclast fusion and regulation by RANKL-dependent and independent factors

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World Journal of Orthopedics 2012年第12期3卷 212-222页

作者： Lianping Xing Yan Xiu brendan F Boyce Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY 14642 United States

Osteoclasts are the bone resorbing cells essential for bone *** are formed from hematopoietic progenitors in the monocyte/macrophage *** is composed of several steps including progenitor survival,differentiation to mononuclear pre-osteoclasts,fusion to multi-nuclear mature osteoclasts,and activation to bone resorbing *** regulation of osteoclastogenesis has been extensively studied,in which the receptor activator of NF-κB ligand(RANKL)-mediated signaling pathway and downstream transcription factors play essential ***,less is known about osteoclast fusion,which is a property of mature osteoclasts and is required for osteoclasts to resorb *** proteins that affect cell fusion have been *** them,dritic cell-specific transmembrane protein(DC-STAMP)is directly associated to osteoclast fusion in *** and factors influence osteoclast fusion through regula-tion of *** we review the recently discovered new factors that regulate osteoclast fusion with specific focus on DC-STAMP.A better understanding of the mechanistic basis of osteoclast fusion will lead to the development of a new therapeutic strategy for bone disorders due to elevated osteoclast bone ***-cell fusion is essential for a variety of cellular biological *** mammals,there is a limited number of cell types that fuse to form multinucleated cells,such as the fusion of myoblasts for the formation of skeletal muscle and the fusion of cells of the monocyte/macrophage lineage for the formation of multinucleated osteoclasts and giant *** most cases,cellcell fusion is beneficial for cells by enhancing *** fusion increases myofiber size and diameter and thereby increases contractile *** osteoclasts have far more bone resorbing activity than their mono-nuclear *** giant cells are much more efficient in the removal of implanted materials

关键词： Osteoclasts Fusion Dritic cell-specific transmembrane protein Receptor activator of NF-κB ligand Bone resorption