检索结果-南通市图书馆

Stem Cell Regulation by Arabidopsis WOX Genes

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2016年第7期9卷 1028-1039页

作者： Alicja Dolzblasz judith Nardmann Elena Clerici Barry Causier Eric van der Graaff jinhui Chen brendan Davies Wolfgang Werr Thomas Laux BIOSS Centre for Biological Signalling Studies Faculty of Biology Albert-Ludwigs-University Freiburg 79104 Freiburg Germany Institute of Developmental Biology Biocenter Cologne University zu KoIn Zulpicher Street 47b 50674 K61n Germany Centre for Plant Sciences University of Leeds Leeds LS2 9JT UK present address: Department of Plant Developmental Biology Institute of Experimental Biology Faculty of Biological Sciences University of Wroclaw50-328 Wroclaw Poland present address: Department of Plant and Environmental Sciences Copenhagen Plant Science Center University of Copenhagen 1871 Taastrup Denmark Present address: Key Laboratory of Forest Genetics & Biotechnology Ministry of Education Nanjing Forestry University 210037 Nanjing China

Gene amplification followed by functional diversification is a major force in evolution. A typical example of this is seen in the WUSCHEL-RELATED HOMEOBOX （WOX） gene family, named after the Arabidopsis stem cell regulator WUSCHEL. Here we analyze functional divergence in the WOX gene family. Members of the WUS clade, except the cambium stem cell regulator WOX4, can substitute for WUS function in shoot and floral stem cell maintenance to different degrees. Stem cell function of WUS requires a canonical WUS-box, essential for interaction with TPL/TPR co-repressors, whereas the repressive EAR domain is dispensable and the acidic domain seems only to be required for female fertility. In contrast to the WUS clade, members of the ancient WOX13 and the WOX9 clades cannot support stem cell maintenance. Although the homeodomains are interchangeable between WUS and WOX9 clade members, a WUS- compatible homeodomain together with canonical WUS-box is not sufficient for stem cell maintenance. Our results suggest that WOX function in shoot and floral meristems of Arabidopsis is restricted to the modern WUS clade, suggesting that stem cell control is a derived function. Yet undiscovered functional domains in addition to the homeodomain and the WUS-box are necessary for this function.

关键词： Arabidopsis thaliana shoot meristem stem cells WOX genes WUSCHEL

Exploring the percentage of COVID-19 cases reported in the community in Canada and associated case fatality ratios

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2021年第1期6卷 123-132页

作者： brendan P.Dougherty Ben A.Smith Carolee A.Carson Nicholas H.Ogden Centre for Food-borne and Environmental Zoonotic Infectious Diseases Public Health Agency of Canada370 Speedvale Ave W.GuelphONN1H 7M7Canada Public Health Risk Sciences Division National Microbiology LaboratoryPublic Health Agency of Canada370 Speedvale Ave W.GuelphONN1H 7M7Canada Public Health Risk Sciences Division National Microbiology LaboratoryPublic Health Agency of CanadaSt.HyacintheQCJ2S 2M2Canada

While surveillance can identify changes in COVID-19 transmission patterns over time and space,sections of the population at risk,and the efficacy of public health measures,reported cases of COVID-19 are generally understood to only capture a subset of the actual number of *** primary objective was to estimate the percentage of cases reported in the general community,considered as those that occurred outside of long-term care facilities(LTCFs),in specific provinces and Canada as a *** applied a methodology using the delay-adjusted case fatality ratio(CFR)to all cases and deaths,as well as those representing the general *** second objective was to assess whether the assumed CFR(mean=1.38%)was appropriate for calculating underestimation of cases in *** were developed for the period from March 11th,2020 to September 16th,*** of the percentage of cases reported(PrCR)and CFR varied spatially and temporally across *** the majority of provinces,and for Canada as a whole,the PrCR increased through the early stages of the *** estimated PrCR in general community settings for all of Canada increased from 18.1%to 69.0%throughout the entire study *** were greater when considering only those data from outside of *** estimated upper bound CFR in general community settings for all of Canada decreased from 9.07%on March 11th,2020 to 2.00%on September 16th,***,the true CFR in the general community in Canada was likely less than 2%on September *** to our analysis,some provinces,such as Alberta,Manitoba,Newfoundland and Labrador,Nova Scotia,and Saskatchewan reported a greater percentage of cases as of September 16th,compared to British Columbia,Ontario,and *** could be due to differences in testing rates and criteria,demographics,socioeconomic factors,race,and access to healthcare among the *** investigation into these factors could reveal differences among provinc

关键词： SARS-CoV-2 Underestimation Coronavirus disease Long term care facilities Case fatality ratio

最大程度地延长无线家庭自动化系统中的电池寿命

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电子技术应用 2012年第3期38卷 6-8页

作者： brendan Daly ADI公司

研究将无线传感器功耗降至最低,从而延长电池寿命的方法。同时考虑那些容易被忽略但对电池寿命和系统性能具有重大影响的参数,以及功率转换、RF性能、通信协议等。介绍了几种良好做法供系统设计人员参考,帮助其深入了解以前可能未曾考... 详细信息

研究将无线传感器功耗降至最低,从而延长电池寿命的方法。同时考虑那些容易被忽略但对电池寿命和系统性能具有重大影响的参数,以及功率转换、RF性能、通信协议等。介绍了几种良好做法供系统设计人员参考,帮助其深入了解以前可能未曾考虑过的方面。

关键词：智能楼宇功率转换 RF

An Alzheimer's Disease-Relevant Presenilin-1 Mutation Augments Amyloid-Beta-Induced Oligodendrocyte Dysfunction

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2011年第2期6卷 128-141页

作者： MAYA K.DESAI brendan j.GUERCIO WADE C.NARROW WILLIAM j.BOWERS Department of Pharmacology and Physiology University of Rochester School of Medicine and DentistryRochesterNew York Center for Neural Development and Disease University of Rochester School of Medicine and DentistryRochesterNew York Department of Microbiology and Immunology University of Rochester School of Medicine and DentistryRochesterNew York Department of Neurology University of Rochester School of Medicine and DentistryRochesterNew York

研究表明,家族性阿尔茨海默病(FAD)患者处于无症状或临床前阶段时,脑白质即出现病理改变。此种改变在髓鞘破坏及阿尔茨海默病(AD)病理生理中的作用有待进一步研究阐明。笔者前期研究证实,三重转基因AD小鼠(人淀粉前体蛋白基因的Swedish... 详细信息

研究表明,家族性阿尔茨海默病(FAD)患者处于无症状或临床前阶段时,脑白质即出现病理改变。此种改变在髓鞘破坏及阿尔茨海默病(AD)病理生理中的作用有待进一步研究阐明。笔者前期研究证实,三重转基因AD小鼠(人淀粉前体蛋白基因的Swedish突变,早老素-1 M146V(PS1M146V)敲入突变及tauP301L突变)表现出类似FAD患者的髓鞘破坏,Aβ1-42促进了白质病变。本研究离体实验证实,PS1M146V变异导致小鼠少突胶质前体细胞在分化过程中易出现类似Aβ1-42诱导的变化。PS1M146V的表达损伤少突胶质前体细胞的功能并影响髓鞘碱性蛋白的分布,暴露于Aβ1-42加重此影响。由PS1M146V及Aβ1-42导致的髓鞘破坏及髓鞘碱性蛋白在亚细胞结构中的误定位可被TWS119(糖原合成激酶(GSK)-3β抑制剂)抑制,提示GSK-3β激酶活动在此病理过程中有重要作用。综上所述,本研究有助于增加对AD早期无症状阶段,由PS1M146V及Aβ1-42导致少突胶质细胞功能异常及髓鞘损伤的机制的理解,并提供了针对少突胶质细胞预防AD相关白质病变的新的治疗靶点。

关键词：阿尔茨海默病白质髓磷脂少突胶质细胞髓鞘碱性蛋白淀粉β样蛋白早老素-1 3重转基因AD

Daily heart rate variability of Paralympic gold medallist swimmers： A 17-week investigation

在线全文

学校读者我要写书评

暂无评论

journal of Sport and Health Science 2015年第4期4卷 371-376页

作者： Rohan Edmonds Anthony Leicht Mark McKean brendan Burkett School of Health and Sport Sciences University of the Sunshine Coast Sunshine Coast 4556 Australia College of Healthcare Sciences James -Cook University Townsville 4811 Australia

Objectives： Heart rate variability （HRV） can be a simple, non-invasive method of gauging cardiac autonomic nervous system fluctuations across periodised training workloads and taper in elite athlete populations. The purpose of these three case studies was to examine daily cardiac autonomic variations in Paralympic athletes leading in to the Paralympic games. Methods： Three Paralympie gold medallist swimmers were monitored daily for their resting HRV over a 17-week monitoring period leading up to the Paralympic games. Specific time- and frequency-domain measures, along with non-linear indices of HRV were calculated for all analyses. All HRV data were analysed individually using daily values, weekly average values, and average values for rest and training phases. Results： A significant difference in HRV was seen for all variables between athlete 1 and athletes 2 and 3 （amputee disabilities） during the entire monitoring period. Conclusion： Despite minimal long-term changes, both swimming classification and disability type significantly influence HRV during athlete monitoring. An increased understanding of individual responses to training, travel, and other outside influences affecting Paralympic athletes could potentially lead to improved management and monitoring of training workloads for enhanced nerformance.

关键词： Autonomic nervous system Cardiac modulation Disability Elite athlete Periodised training Testing

Rapid,high-resolution detection of environmental change over continental scales from satellite data–the Earth Observation Data Cube

在线全文

学校读者我要写书评

暂无评论

International journal of Digital Earth 2016年第1期9卷 106-111页

作者： Adam Lewis Leo Lymburner Matthew B.j.Purss brendan Brooke Ben Evans Alex Ip Arnold G.Dekker james R.Irons Stuart Minchin Norman Mueller Simon Oliver Dale Roberts Barbara Ryan Medhavy Thankappan Rob Woodcock Lesley Wyborn Geoscience Australia CanberraAustralia National Computational Infrastructure Australian National UniversityCanberraAustralia Commonwealth Scientific and Industrial Research Organisation CanberraAustralia NASA Goddard Space Flight Center GreenbeltMDUSA Research School of Finance Actuarial Studies and Applied StatisticsANUCanberraAustralia The Group on Earth Observations Secretariate GenevaSwitzerland

The effort and cost required to convert satellite Earth Observation(EO)data into meaningful geophysical variables has prevented the systematic analysis of all available *** overcome these problems,we utilise an integrated High Performance Computing and Data environment to rapidly process,restructure and analyse the Australian Landsat data *** this approach,the EO data are assigned to a common grid framework that spans the full geospatial and temporal extent of the observations–the EO Data *** approach is pixel-based and incorporates geometric and spectral calibration and quality assurance of each Earth surface reflectance *** demonstrate the utility of the approach with rapid time-series mapping of surface water across the entire Australian continent using 27 years of continuous,25 m resolution *** preliminary analysis of the Landsat archive shows how the EO Data Cube can effectively liberate high-resolution EO data from their complex sensor-specific data structures and revolutionise our ability to measure environmental change.

关键词： Earth Observation Data Cube HPD HPC surface water Landsat Australia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

特征线方向概率方法与性能分析模型研究

核动力工程 2014年第5期35卷 157-163页

作者：刘宙宇吴宏春 brendan Kochunas Benjamin Collins Yunlin Xu Thomas Downar 西安交通大学核科学与技术学院西安710049 密歇根大学核能与辐射科学学院美国48109

为了进一步提高特征线方向概率方法(CDP)的计算效率,提出了一种角度相关的边界均匀化方法。提出CDP性能分析模型,显性地比较分析特征线方法(MOC)和CDP的计算效率。数值结果表明,所提模型正确,并显示出CDP在计算效率方面的优势。

关键词：特征线方法特征线方向概率方法边界均匀化

Development of a Novel Hybrid Aluminum-Based Sol-Gel Materials: Application to the Protection of AA2024-T3 Alloys in Alkaline Environment

在线全文

学校读者我要写书评

暂无评论

Advances in Materials Physics and Chemistry 2014年第5期4卷 75-84页

作者： Mohamed Oubaha Padinchare Covilakath Rajath Varma brendan Duffy Zuhair Mattoug Gasem Steven j. Hinder Centre for Research Excellence in Corrosion King Fahd University of Petroleum and Minerals Dhahran KSA Centre for Research in Engineering Surface Technology (CREST) FOCAS Institute Dublin Institute of Technology Dublin Ireland The Surface Analysis Laboratory Faculty of Engineering and Physical Sciences University of SurreyGuildford UK

Extensive research on environmentally complaint sol-gel coatings is currently underway for a wide range of applications. Sol-gel technology combines the synergistic properties of inorganic and organic components to design nanostructured coating materials with advanced physical properties. Through a judicious choice of precursors and additives improved performances, such as chemical resistance or pH stability, it can be achieved. This is of particular interest for copper rich AA 2024-T3 aluminium alloys used on aircraft, where increase in local pH occurs at corrosion sites. This work focuses on improving the alkaline stability and anticorrosion properties of such a sol-gel coatings on AA2024-T3 by incorporating aluminium functionality into hybrid materials prepared from hydrolysis and condensation of 3-methacryloxypropyltrimethoxysilane, zirconium n-propoxide and zirconium/alkoxide precursors. Dynamic light scattering technique was used to study the particle size nature of the sol-gel materials in colloidal form. X-ray photoelectron spectroscopy was used to study the oxidation state of the aluminium and zirconium at the sol-gel coating surface. Field emission scanning electrochemical microscopy coupled with energy dispersive spectroscopy was used to assess the microstructural features. Electrochemical characterisations employing potentiodynamic scanning and electrochemical impedance spectroscopy were performed to investigate the anticorrosion performance of the hybrid sol-gel coatings. The best anti-corrosive protection of AA2024-T3 in an alkaline saline solution (pH = 10) was achieved with materials containing 10 mol% and 15 mol% aluminium doped sol-gel coatings. This study shows that presence of aluminium has a positive effect on alkaline stability of the coatings and is a potential green candidate for the protective coatings on aerospace alloys.

关键词： Sol-Gel Aluminium Zirconium Corrosion Coatings Hybrid: Organo-Silane

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

红血球图像表面曲率的计算方法

计算机工程 2008年第21期34卷 28-30,34页

作者：王瑞胡 brendan McCane 尹章群重庆文理学院数学与计算机科学系重庆402160 奥塔戈大学计算机科学系武汉大学医学院武汉430060

提出一种基于阴影恢复技术的细胞图像表面各点的曲率计算方法,利用边界轮廓提取技术分离由扫描电镜SEM得到的红血球亮度图像,对单个细胞从跟踪得到的中心点开始进行区域生长,其每个像素点的亮度变化信息决定了与之相对应的高度场深度,... 详细信息

提出一种基于阴影恢复技术的细胞图像表面各点的曲率计算方法,利用边界轮廓提取技术分离由扫描电镜SEM得到的红血球亮度图像,对单个细胞从跟踪得到的中心点开始进行区域生长,其每个像素点的亮度变化信息决定了与之相对应的高度场深度,阴影恢复技术可以将这种变化的亮度转化为不同的深度,从而得到像素的三维数据点。通过最小二乘法对三维点进行曲面拟合得到分段连续光滑的细胞表面,其形状特征由平均曲率与高斯曲率来表示。结果表明,该方法具有很强的实用性和应用价值。

关键词：红血球阴影恢复轮廓跟踪区域生长曲率