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Asian journal of Andrology 2008年第2期10卷 193-200页

作者： Stephanie T. Page Beth A. Mohr Carol L. Link Amy B. O＇Oonnell William j. bremner john B. McKinlay Department of Medicine University of Washington Seattle 98195 USA New England Research Institutes Watertown 02472 USA

Aim： To study the relationship between circulating androgens （total testosterone [TT], free testosterone [IT] and dihydrotestosterone [DHT]） and high-density lipoprotein cholesterol （HDL-C） in men with and without cardiovascular disease （CVD）. Methods： Cross-sectional analyses included 1 661 baseline samples from the Massachusetts Male Aging Study （MMAS）, a population-based cohort of men ages 40-70 years. Serum hormones were measured by radioimmunoassay and HDL-C was determined following precipitation of the lower density lipoproteins. CVD was determined by self-report. Analyses were performed using multiple linear regression. Results： TT and HDL-C were positively correlated in the entire sample （r = 0.11, P = 0.0001）. After adjusting for confounders, we found this relationship was mostly limited to the 209 men with CVD. Among men with CVD, TT （P = 0.0004）, iT （P = 0.0172） and DHT （P = 0.0128） were all positively correlated with HDL-C, whereas in men without CVD only TT correlated with HDL-C （P = 0.0099）. Conclusion： Our results suggest that if androgens contribute to CVD in middle-aged men, the effect is not related to a suppressive effect of endogenous T on HDL-C. （Asian jAndrol 2008 Mar; 10： 193-200）

关键词： testosterone high-density lipoprotein cholesterol androgens epidemiology

Testicular fine-needle aspiration for the assessmen＇ of intratesticular hormone concentrations

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Asian journal of Andrology 2016年第1期18卷 21-24页

作者： Ada P Lee Mara Y Roth jean-jacques Nya-Ngatchou Kat Lin Thomas j Walsh Stephanie T Page Alvin M Matsumoto William j bremner john K Amory Bradley D Anawalt Department of Medicine University of California San Francisco San Francisco CA USA Department of Medicine and Center for Research in Reproduction and Contraception University of Washington Seattle WA USA Department of Obstetrics and Gynecology University of Washington Seattle WA USA Department of Urology University of Washington Seattle WA USA Department of Medicine Geriatric Research Education and Clinical Center VA Puget Sound Health Care System Seattle WA USA.

Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration （FNA） completed as part of six clinical trials. From 2001 through 2011, a total of 404 procedures were conducted among 163 research volunteers, 85.9% of which were successful in obtaining sufficient fluid for the measurement of intratesticular steroid concentrations. Pain was the most common side effect, with 36.8% of procedures associated with moderate procedural pain and 4.7% with severe procedural pain. Postprocedural pain was uncommon and abated within a few days. Mild local bruising occurred with 14.9% of procedures. Two serious adverse events （0.5%） required surgical intervention. The risk of an adverse event was not associated with age, body mass index, testicular size, or the volume of fluid aspirated. Testicular FNA to obtain fluid for measurement of intratesticular steroid concentrations frequently causes mild to moderate procedural pain, but serious adverse events occur rarely. Testicular FNA has been instrumental for defining human intratesticular hormone physiology and is a minimally-invasive, safe, effective method for obtaining fluid for research on testicular physiology and pathology.

关键词： male contraception physiology reproductive and urinary testis

Study on Differences in Spermatogenic Suppression between Azoospermic and Oligozoospermic Responders Treated with Levonorgestrel Implant Plus Testosterone Undecanoate Injectable in Chinese Men

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journal of Reproduction and Contraception 2003年第4期14卷 217-226页

作者： Si-tianLIU You-lunGUI W.j.bremner Er-shengGAO Chang-haiHE ShanghaiMedicalCollege FudanUniversityShanghai200032China ShanghaiInstituteofPlannedParenthoodResearch Shanghai200032China DepartmentofMedicine UniversityofWashingtonSeattleWAUSA

Objective To investigate possible causes resulting in the differences in the spermatogenesis suppression on individual treated with levonorgestrel (LNG) implants and testosterone undecanoate (TU) injectableMethods Totally 21 Chinese male volunteers were given treatment with LNG implants (four rods, 75 mg/rod) and intramuscular injection of TU (500 mg,bimonthly for 3 times). According to the effects of treatment, they were divided into two groups, namely, azoospermia group (group A) and oligozoospermia group (group O). Then seminal FSH, LH, T and estradiol (E2) were determined by immunoenzymetric assay, while seminal and serum dihydrotachysterol (DHT) and serum sex hormone binding globulin (SHBG) were by radioimmunoassay, and seminal transferrin (Tf) by scatter turbidimetry assay.Results Seminal FSH, LH and serum DHT, SHBG, FTI (T/SHBG ×100) levels were significantly lower in group A than in group O, while higher seminal concentrations ofE2 were observed in azoospermia group.Conclusion The differences in the spermatogenic suppression in Chinese men might be attributed to different rate of peripheral androgen metabolism, variations in serum SHBG levels, 5á-reductase activity and individual aromatase activity during LNG plus TU administration. In addition, seminal sex hormones might be more sensitive indexes to assess the extent of feedback inhibition on hypothalamus-pituitary-testis with exogenous testosterone plus progestogen in the efficacy hormone male contraceptive trials.

关键词： heterogeneity levonorgestrel (LNG) male contraception spermatogenesis testosterone undecanoate(TU)

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雄性激素避孕发展前景如何

国际内科双语杂志（中英文） 2006年第9期6卷 15-16,42-43页

作者： john K Amory William j bremner 美国西雅图华盛顿大学内科学副教授美国西雅图华盛顿大学内科学系教授和主席

鉴于男性避孕措施的不足，人们在努力开发一种与女用雌孕激素避孕药类似的男用激素避孕方法。这种方法要安全、有效并且使用方便。在调查中，大部分男性自愿使用这种避孕方法，同时98％的女性也愿意并信赖她们的性伴侣使用这种方法。

关键词：雄性激素孕发孕激素避孕药避孕方法避孕措施男性

十一酸睾酮和长效醋酸甲孕酮联合应用对精子发生抑制效果的临床研究

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十一酸睾酮和长效醋酸甲孕酮联合应用对精子发生抑制效果的临床研...

国产两根型皮埋剂配伍十一酸睾酮(TU)对中国男子垂体-性腺轴的影响

中华医学会第五次全国男科学学术会议

作者：唐文豪谷翊群童建孙马鼎志王兴海袁冬陈振文 William j.bremner 北京大学第三医院泌尿外科国家人口和计划生育委员会科学技术研究所江苏省计划生育委员会科学技术研究所 University of Washington SeattleWashington 98195

目的:观察正常中国男性每2个月注射一次长效醋酸甲孕酮/十一酸睾酮(DMPA/TU)抑制精子发生的效果。方法:30例年龄在25-40岁已婚的健康中国男性在体检及化验筛查合格后参加本试验,并被随机分成3组:1个TU单用组(1 000 mgTU)和2个DMPA/TU合...

目的:观察正常中国男性每2个月注射一次长效醋酸甲孕酮/十一酸睾酮(DMPA/TU)抑制精子发生的效果。方法:30例年龄在25-40岁已婚的健康中国男性在体检及化验筛查合格后参加本试验,并被随机分成3组:1个TU单用组(1 000 mgTU)和2个DMPA/TU合用组(1 000 mg Tu+150 mg DMPA,1 000 mg Tu+300 mg DMPA),每组各10例,以8周间隔进行注射。试验共计56周,对照期8周,抑制期24周和恢复期24周。结果在抑制其,除了TU(?)用组有2例精子密度出现后。

关键词：

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生殖与避孕 2001年第2期21卷 86-91页

作者：贺昌海林翠鸿 W.j.bremner 桂幼伦李腊梅高尔生上海市计划生育科学研究所上海200032 复旦大学医学院上海200032 Dept.ofedicine

目的 :观察国产两根型皮埋剂 Sino-implant及十一酸睾酮 (TU)针剂联合应用对中国男性垂体促性腺激素和睾酮水平的影响。方法 :共征集自愿对象 1 6名 ,前臂埋植 Sino-im-plant,每根含左旋 1 8-甲基炔诺酮 75mg,并于 3周后每月肌注针剂十... 详细信息

目的 :观察国产两根型皮埋剂 Sino-implant及十一酸睾酮 (TU)针剂联合应用对中国男性垂体促性腺激素和睾酮水平的影响。方法 :共征集自愿对象 1 6名 ,前臂埋植 Sino-im-plant,每根含左旋 1 8-甲基炔诺酮 75mg,并于 3周后每月肌注针剂十一酸睾酮 (TU) ,(2 50 mg) ,共 3次。结果 :放置皮埋剂后血清中 FSH、L H水平有所下降。注射第 1针 TU后 ,FSH、L H水平进一步下降 ,于注射后 1周达到谷值 ,之后 FSH、L H水平又有所上升 ;注射第 2、3针 TU后 ,FSH、L H水平变化情况与第 1针时相似。此外 ,皮埋后对象血清睾酮水平也有所下降 ,注射第 1针 TU后 ,则睾酮水平升高 ,并于注射后 1周达峰值 ,之后睾酮水平又有所下降 ;注射第 2、3针 TU后血清睾酮水平变化情况与第 1针时相似。结论 :皮埋剂Sino-implant和 TU配伍应用可对垂体促性腺激素分泌产生协同抑制作用 ,从而使内源性睾酮水平下降 ;但注射 TU可补充睾酮 ,使之维持正常水平。故国产皮埋剂配伍

关键词：两根型皮埋剂十一酸睾酮男性避孕垂体一性腺轴

十一酸睾酮和长效醋酸甲孕酮联合应用对精子发生抑制效果的临床研究

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中华男科学杂志 2004年第8期10卷 572-577,581页

作者：唐文豪谷翊群童建孙马鼎志王兴海袁冬陈振文 William j.bremner 北京大学第三医院泌尿外科北京100083 国家人口和计划生育委员会科学技术研究所北京100081 江苏省计划生育委员会科学技术研究所江苏南京210036 Department of Medicine

目的 :观察正常中国男性每 2个月注射一次长效醋酸甲孕酮 /十一酸睾酮 (DMPA/TU)抑制精子发生的效果。　方法 :30例年龄在 2 5～ 4 0岁已婚的健康中国男性在体检及化验筛查合格后参加本试验 ,并被随机分成 3组 :1个TU单用组 (1 0 0 0mg... 详细信息

目的 :观察正常中国男性每 2个月注射一次长效醋酸甲孕酮 /十一酸睾酮 (DMPA/TU)抑制精子发生的效果。　方法 :30例年龄在 2 5～ 4 0岁已婚的健康中国男性在体检及化验筛查合格后参加本试验 ,并被随机分成 3组 :1个TU单用组 (1 0 0 0mgTU)和 2个DMPA/TU合用组 (1 0 0 0mgTU +1 5 0mgDMPA ,1 0 0 0mgTU +30 0mgDMPA) ,每组各 1 0例 ,以 8周间隔进行注射。试验共计 5 6周 :对照期 8周、抑制期 2 4周和恢复期 2 4周。　结果 :在抑制期 ,除了TU单用组有 2例精子密度出现反跳 ,其余所有受试者均达到无精子状态。所有志愿者都能耐受试验 ,没有发生严重不良反应。　结论 :在本试验条件下 ,TU单用能抑制精子发生但抑制效果不恒定 ,而DMPA/TU合用能恒定地抑制精子发生 ,1 0 0 0mgTU +1 5 0mgDMPA是最佳剂量组合 ,可用于进一步的临床扩大试验或避孕有效性试验。

关键词：雄激素孕激素促性腺激素精子发生

Effect of combined use of Chinese-made implants and testosterone undecanoate on pituary-gonadal axis in Chinese men

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Asian journal of Andrology 2001年第2期 158-158页

作者： Chang-Hai HE Cui-Hong LIN W. j. bremner You-Lun GUI La-Mei LI Er-Sheng GAO Shanghai Institute of Planned Parenthood Research,Shanghai 200032,China Fudan University Medical College,Shanghai 200032,China Dept.of Medicine,Washington University,USA

Aim: To study the effect of the title drugs on the serum FSH, LH andtestosterone (T) levels in Chinese men in a contraceptive trial. Methods:Sixteen male volunteers were administered Chinese-made implant (tworods, each containing 75 mg of levonorgestrel, LNG) plus testosterone un-decanoate (TU) (250 mg, i.m. monthly for3 months). FSH, LH and Tlevels were determined with RIA. Results: The serum FSH and LH lev-els declined after the insertion of implants. They declined further after the1st TU injection and one week later, both FSH and LH levels reached thelowest levels, after which, they rose slightly. The profiles of serum LH andFSH levels after the 2nd and 3rd TU injection were similar to that followingthe 1st TU injection. After insertion of the implants, the serum T levels alsodeclined. However, after the 1st dose of TU, the T levels increased, oneweek later they reached the peak level, and then declined again. The pro-files of serum T levels after the 2nd and 3rd TU injection were also similarto that

关键词： levonorgestrel implant testosterone undecanoate male contraception

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端粒缩短,再生能力与心血管预后

中华高血压杂志 2016年第12期24卷 1174-1174页

作者：刘莉叶鹏 Hammadah M Mheid IA Wilmot K Ramadan R Abdulhadi N Alkhoder A Obideen M Pimple P Levantsevych O Kelli H Shah A Sun Y Pearce B Kutner M Long Q Ward L Ko YA Mohammed KH Lin j Zhao j bremner j Kim j Waller E Raggi P Sheps D Quyyumi A Vaccarino V

白细胞端粒长度（leucocyte telomere length,LTL）是衰老的生物标志物,较短的LTL与不良的心血管预后相关。端粒再生能力降低可能是其机制之一。骨髓来源的循环祖细胞（progenitor cells,PCs）参与组织修复和再生。该研究的目的是研究LT... 详细信息

白细胞端粒长度（leucocyte telomere length,LTL）是衰老的生物标志物,较短的LTL与不良的心血管预后相关。端粒再生能力降低可能是其机制之一。骨髓来源的循环祖细胞（progenitor cells,PCs）参与组织修复和再生。该研究的目的是研究LTL与PCs之间的关系及其对不良心血管预后的影响。方法：通过定量聚合酶链反应测定566例冠状动脉疾病（coronary artery disease, CAD）门诊患者[年龄（63±9）岁，76％为男性]的LTL。

关键词：端粒 telomere leucocyte 骨髓来源 progenitor 生物标志物祖细胞组织修复 length 四分位数

LITHIUM MEASUREMENTS BY MAGNETIC RESONANCE IMAGING AND PORE SOLUTION EXPRESSION

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LITHIUM MEASUREMENTS BY MAGNETIC RESONANCE IMAGING AND PORE ...