Effect of combined use of Chinese-made implants and testosterone undecanoate on pituary-gonadal axis in Chinese men

作     者：Chang-Hai HE Cui-Hong LIN W. J. Bremner You-Lun GUI La-Mei LI Er-Sheng GAO Shanghai Institute of Planned Parenthood Research,Shanghai 200032,China Fudan University Medical College,Shanghai 200032,China Dept.of Medicine,Washington University,USA 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志(英文版))

年 卷 期：2001年第2期

页      面：158-158页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：levonorgestrel implant testosterone undecanoate male contraception 

摘      要：Aim: To study the effect of the title drugs on the serum FSH, LH andtestosterone (T) levels in Chinese men in a contraceptive trial. Methods:Sixteen male volunteers were administered Chinese-made implant (tworods, each containing 75 mg of levonorgestrel, LNG) plus testosterone un-decanoate (TU) (250 mg, i.m. monthly for3 months). FSH, LH and Tlevels were determined with RIA. Results: The serum FSH and LH lev-els declined after the insertion of implants. They declined further after the1st TU injection and one week later, both FSH and LH levels reached thelowest levels, after which, they rose slightly. The profiles of serum LH andFSH levels after the 2nd and 3rd TU injection were similar to that followingthe 1st TU injection. After insertion of the implants, the serum T levels alsodeclined. However, after the 1st dose of TU, the T levels increased, oneweek later they reached the peak level, and then declined again. The pro-files of serum T levels after the 2nd and 3rd TU injection were also similarto that