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Transcranial Direct Current Stimulation: Effects on Motor and Non-Motor Symptoms of Parkinson’s Disease

Journal of Behavioral and Brain Science 2024年第5期14卷 135-160页

作者： Fayda Protásio Carlos Alberto Bezerra Tomaz Joaquim brasil-Neto Pedro Brandão Nasser Allam Maria Clotilde Henriques Tavares Laboratory of Neuroscience and Behavior Department of Physiological Sciences Institute of Biology University of Braslia Braslia Brazil Master Program in Environment University CEUMA So Lus MA and Faculty of Medicine Euro-American University Center-UNIEURO Braslia Brazil Faculty of Medicine Euro-American University Center-UNIEURO Braslia Brazil NA Neurologistas Associados Braslia Brazil

Introduction: In the last thirty years, brain neuromodulation techniques have been used as an alternative to pharmacological treatment of neurological disorders. Parkinson’s disease (PD) is a neurodegenerative disorder leading to bradykinesia, rest tremor, postural changes, and non-motor symptoms such as depression, anxiety, sleep disorders, pain, and cognitive decline that compromises executive functions (EFs), responsible for the orderly execution of behaviors and tasks of daily life and intentional and directed actions. To this date, a few studies with transcranial direct current stimulation (tDCS) have shown beneficial effects in PD patients concerning specific motor and non-motor symptoms, targeting the motor cortex and/or prefrontal regions. Objective: The main objective of this study was to evaluate the effects of left prefrontal tDCS across a broad spectrum of motor and non-motor symptoms of PD using established validated scales. Method: Single-blind randomized clinical trial with 18 volunteers with PD, aged between 45 and 80 years (66.1 ± 9.65), who met inclusion and exclusion criteria. Participants were submitted to assessments of motor and non-motor functions employing psychometric scales and tests to evaluate EFs and were randomly divided into two groups: control (sham stimulation) and experimental (active stimulation). All participants were involved in three separate tDCS sessions. The anode was positioned over the left dorsolateral prefrontal cortex and the cathode over the right supraorbital region, with a direct current intensity of 2 mA, lasting 20 minutes. At the end of the three sessions, all participants were reassessed. Results: Significant effects of tDCS on non-motor functions were observed for cognition (verbal fluency of actions, clock copy test, appointment by visual confrontation, and verbal memory with immediate free recall) and subjective assessment of sleep quality (overall restlessness and discomfort in the arms and legs at night, leg

关键词： Parkinson’s Disease Neuromodulation Transcranial Direct Current Stimulation—tDCS Movement Disorders Mood Sleep Cognition

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Por el bien de la humanidad

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今日中国（西文版） 2024年第3期 62-62页

作者： brasil ACOSTA PEÑA 不详

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Thermodynamic aspects of inclusion engineering in steels

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Rare Metals 2006年第5期25卷 412-419页

作者： A.Costa e Silva EEIMVR-UFF Av.Trabalhadores 420Volta RedondaRJBrasil IBQN- Rio de JaneiroRJBrasil

Tailoring non-metallic inclusions in accordance to the desired effect on steel properties has gained widespread acceptance in the last decades and has become known as “inclusion engineering”. Effective inclusion engineering involves three steps：（a） a good knowledge of how inclusions influence properties, （b） understanding what is the effect of each type of inclusions on these properties and thus which is the most desirable inclusion in a given product and （c） adjusting the processing parameters to obtain these inclusions. A significant portion of the process adjustment is done during steel refining, where the steel can be tailored so that the desired chemical composition of the non-metallic inclusions that will precipi- tate can be altered. Understanding the relations between steel chemistry, processing variables and inclusion chemical composition requires significant understanding of the thermodynamics of the systems involved. These complex equilibrium calculations are best done using computational thermodynamics. In this work some of the basic techniques used to control inclusion composition are reviewed and the thermodynamic information required to perform this task is presented. Several examples of the application of computational thermodynamics to inclusion engineering of different steels grades are presented and compared with experimental results, whenever possible. The potential and limitations of the method are highlighted, in special those related to thermodynamic data and databases.

关键词： computational thermodynamics steel non-metallic inclusions

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A Pseudo-Stokes Mesh Motion Algorithm

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Advances in Applied Mathematics and Mechanics 2013年第2期5卷 194-211页

作者： Luciano Goncalves Noleto Manuel N.D.Barcelos Jr. Antonio C.P.brasil Jr. Universidade de Brasılia Faculdade de TecnologiaDepartamento de Engenharia MecanicaLaboratorio de Energia e Ambiente.Asa Norte.Brasılia-DFBrasil70.910-900 Universidade de Brasılia no Gama.Complexo de Educa¸c˜ao CulturaEsporte e Lazer.A rea Especial de Industria 1Setor LesteFaculdade Lote 1.Gama-DFBrasil72.444-210

This work presents a moving mesh methodology based on the solution of a pseudo flow *** mesh motion is modeled as a pseudo Stokes problem solved by an explicit finite element projection *** mesh quality requirements are satisfied by employing a null divergent velocity *** methodology is applied to triangular unstructured meshes and compared to well known approaches such as the ones based on diffusion and pseudo structural *** of the test cases is an airfoil with a fully meshed domain.A specific rotation velocity is imposed as the airfoil boundary *** other test is a set of two cylinders that move toward each other.A mesh quality criteria is employed to identify critically distorted elements and to evaluate the performance of each mesh motion *** results obtained for each test case show that the pseudo-flow methodology produces satisfactory meshes during the moving process.

关键词： Moving boundaries mesh motion strategy finite element projection methods

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DETERMINANTS AND STAGES OF BEHAVIOR CHANGE TO PHYSICAL ACTIVITY AMONG NORTHEAST BRAZILIAN ADOLESCENTS

DETERMINANTS AND STAGES OF BEHAVIOR CHANGE TO PHYSICAL ACTIV...

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The 2004 Pre-Olympic Congress

作者： polis-Brazil polis-brasil Physical Education Course UNISULFlorian_polis-Brazil Universidade Federal de Santa Catarina Centro de DesportosNuPAFFlorian_polis-Brasil

＜正＞Introduction Although physical activity practice has been indicated as a health behavior,some concerns have been showed by scientific *** among adolescents,the physical activity level has been declining,specifically between15 and 17 years of *** reason of this behavior among adolescents,however,is not yet sufficiently *** aim of this study was to describe the determinants and stages of behavior change（SBC）[1]to physical activity among northeast（Recife-Pernambuco）

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Prevalence of autoantibodies against cellular antigens in patients with HIV and leprosy coinfection in the Amazon region

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Infectious Diseases of Poverty 2017年第1期6卷 704-711页

作者： Clea Nazare Carneiro Bichara Carlos David Araujo Bichara Camila Tostes Marinete Marins Povoa Juarez Antonio Simoes Quaresma Marilia brasil Xavier Center of Biological and Health Sciences State University of ParaCampus II-CCBSRua Perebebui n°2623MarcoBelemPA 66087-670Brazil Evandro Chagas Institute Ministry of HealthAnanindeuaPABrazil Tropical Medicine Center Federal University of ParaBelemPABrazil

Background:Infectious agents can activate self-reactive T *** general,infections trigger various mechanisms,including a lack of auto-tolerance,induction of costimulatory molecules on antigen presenting cells,and molecular simulation,in addition to cross-reactions between microbial antigens and *** and leprosy coinfections lead to self-immunity with the production of ***,not enough data on the immune behaviour associated with this coinfection are ***,this study focused on the detection of autoantibodies against cellular antigens(AACA)in individuals with HIV and leprosy coinfection in the Amazon ***:Patients were distributed into four groups according to their infections:(i)coinfection with HIV and leprosy(n=23),(ii)infection with leprosy(n=33),(iii)infection with HIV/AIDS(n=25),and(iv)healthy blood donor controls(n=100).AACA were identified by indirect immunofluorescence and the samples were tested using a commercial diagnosis kit containing the antinuclear antibody ***:Morphologically,all stages of cell division were assessed in addition to the morphological features associated with the nuclear matrix,nucleolus,mitotic spindle,and *** was a high prevalence of AACA in the coinfection group(47.8%,n=11)when compared with the control group of healthy blood donors(2.0%).The results showed predominantly cytoplasmic staining in all groups analysed,and no difference was observed between the presence or absence of AACA and the leprosy forms(paucibacillary and multibacillary)in the coinfection ***:The results of this study show that despite the tendency of coinfected patients to have higher levels of autoantibodies,no correlation was observed between clinical and laboratorial variables and morbidity associated with HIV and leprosy coinfections or the levels of AACA in the serum of coinfected *** data are important to elucidate this complex relationship between HIV a

关键词： Leprosy HIV Autoantibodies Immunology Amazon region

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Transcranial Direct Current Stimulation: Effects on Motor and Non-Motor Symptoms of Parkinson’s Disease

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Journal of Behavioral and Brain Science（行为与脑科学期刊） 2024年第5期 135页

作者： Fayda Protásio Carlos Alberto Bezerra Tomaz Joaquim brasil-Neto Pedro Brandão Nasser Allam Maria Clotilde Henriques Tavares

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Ignition　and　Extinction　of　Monopropellant　Droplet　with　Lewis　Number　Different　from　Unity

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Journal of Thermal Science 1994年第1期3卷 53-60页

作者： Fernando F. Fachini(Instituto Nacional de Pesquisas Espaciais-INPE, Rodovia Presidente Dutra Km 40, 12630-000 Cachoeira Paulista-SP, brasil)Amable M. Linan Instituto Nacional de Pesquisas Espaciais-INPE Cachoeira Paulista-SP Brasil E.T.S.I. Aeronáuticos Univ. Ploitécnica de Madrid Madrid España

E.T.S.I. Aeronauticos, Univ. Ploitecnica de Madrid, Plaza Cardenal Cisneros 3, 28400-Madrid, Espana

关键词： ignition extinction monopropellant Lewis number effects

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Soil and climate equally contribute to changes in the species compositions of Brazilian dry forests across 300 km

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Journal of Plant Ecology 2020年第2期13卷 171-176页

作者： Daniel M.Arruda Luiz F.S.Magnago Ricardo R.C.Solar Reinaldo Duque-brasil Priscyla M.S.Rodrigues Rubens M.Santos Carlos E.G.R.Schaefer Instituto de Geociências Universidade Federal de Minas GeraisBelo HorizonteMinas GeraisBrazil Centro de Formação em Ciências e Tecnologias Agroflorestais Universidade Federal do Sul da BahiaItabunaBahiaBrazil Instituto de Ciências Biológicas Universidade Federal de Minas GeraisBelo HorizonteMinas GeraisBrazil Instituto de Ciências da Vida Universidade Federal de Juiz de ForaGovernador ValadaresMinas GeraisBrazil Colegiado de Ecologia Universidade Federal do Vale do São FranciscoSenhor do BonfimBahiaBrazil Departamento de Ciências Florestais Universidade Federal de LavrasLavrasMinas GeraisBrazil Departamento de Solos Universidade Federal de ViçosaViçosaMinas GeraisBrazil

Aims Understanding the factors that control biodiversity distributions at different spatial scales has been a key challenge for conservation *** biodiversity,reflected in differences in species compositions among sites(beta diversity),can be derived from species replacement(turnover)and is driven by multiple ***,we sought to tackle this issue through two questions related to threatened Brazilian seasonally dry forests:(i)what is the contribution of species turnover to beta diversity?and(ii)which factors drive variations in species compositions among forest patches?Methods We sampled tree species and environmental variables(soils and climate)in 17 dry forest patches spaced almost 300 km *** used the beta diversity partitioning framework to determine the contribution of *** used redundancy analysis,with properly controlled spatial structure,to assess the contributions of the environmental and spatial factors to the variations of the species *** Findings Beta diversity among the patches was mainly represented by the turnover component(98.2%),with Simpson dissimilarity superior to other regions of the country(means of 0.89 and 0.71 in multiple site and pairwise measures,respectively).The environmental factors measured explained more than space,representing 30.3%of the variation of the species composition,of which 28.1%was nonspatially *** suggest that 300 km represents a threshold at which edaphic and climatic predictors have similar effects in determining community turnover(14.9%and 12.6%,respectively,without spatial structure).Thus,conservation strategies should be considered across landscapes to effectively protect tropical forest diversity,as even considering the different climatic aspects covered by the scale,landscaped edaphic varieties are important drivers of species turnover.

关键词： beta diversity environmental filter habitat fragmentation landscape structure phytogeography

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Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

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World Journal of Psychiatry 2017年第2期7卷 106-113页

作者： Felipe José Nascimento Barreto Frederico Duarte Garcia Paulo Henrique Teixeira Prado Paulo Marcos brasil Rocha Nádia Souza Las Casas Felipe Barbosa Vallt Humberto Correa Maila Castro Lourenco Neves Department of Mental Health Federal University of Minas Gerais Postgraduation Program in Molecular Medicine School of Medicine Federal University of Minas Gerais Molecular Medicine National Institute of Science and Technology Avenida Alfredo Balena Federal University of Minas Gerais Hospital das Clínicas Federal University of Minas Gerais

AIM To identify factors associated with depressive symptoms among inpatients with cardiovascular disease(CVD). METHODS This is a cross-sectional study performed in a subsample of a large cross-sectional research that investigated affective disorders and suicide behaviour among inpatients hospitalized in non-surgical wards of the University Hospital of the Federal University of Minas Gerais from November 2013 to October 2015. Sociodemographic and clinical data were obtained through a structured interview and medical record review. Depression was assessed by the depression subscale of the Hospital Anxiety and Depression Scale, with scores ≥ 8 considered as positive screening for depression. We used the Fagestr?m Test for Nicotine Dependence to characterize nicotine dependence. For assessing resilience and early-life trauma, we used the raw scores of the Wagnild and Young Resilience Scale and Childhood Trauma Questionnaire, *** At endpoint, we included 137 subjects. Thirty-eight(27.7%) subjects presented depressive symptoms and nine(23.7%) of those were receiving antidepressant treatment during hospitalization. The female sex; a lower mean educational level; a greater prevalence of previous suicide attempts; a higher level of pain; a higher prevalence of family antecedents of mental disorders; a lower resilience score; and higher childhood trauma score were the factors significantly associated with screening positive for major depression(P < 0.05). Multivariate analysis demonstrated that the factors independently associated with the depressive symptoms were a higher childhood trauma severity(OR = 1.06; P = 0.004); moderate to severe nicotine dependence(OR = 8.58; P = 0.008); and the number of previous hospital admissions(OR = 1.11; P = 0.034). The obtained logistic model was considered valid, indicating that the three factors together distinguished between having or not depressive symptoms, and correctly classified 74.6% of individuals in the ***

关键词： Inpatients Depression Cardiovascular disease Depressive symptoms General hospital

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