Prevalence of autoantibodies against cellular antigens in patients with HIV and leprosy coinfection in the Amazon region

作     者：Clea Nazare Carneiro Bichara Carlos David Araujo Bichara Camila Tostes Marinete Marins Povoa Juarez Antonio Simoes Quaresma Marilia Brasil Xavier Bichara Clea Nazaré Carneiro;Bichara Carlos David Araújo;Tostes Camila;Povoa Marinete Marins;Quaresma Juarez Antonio Simões;Xavier Marília Brasil

作者机构：Center of Biological and Health SciencesState University of ParaCampus II-CCBSRua Perebebui n°2623MarcoBelemPA 66087-670Brazil Evandro Chagas InstituteMinistry of HealthAnanindeuaPABrazil Tropical Medicine CenterFederal University of ParaBelemPABrazil 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2017年第6卷第1期

页      面：704-711页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：Leprosy HIV Autoantibodies Immunology Amazon region 

摘      要：Background:Infectious agents can activate self-reactive T *** general,infections trigger various mechanisms,including a lack of auto-tolerance,induction of costimulatory molecules on antigen presenting cells,and molecular simulation,in addition to cross-reactions between microbial antigens and *** and leprosy coinfections lead to self-immunity with the production of ***,not enough data on the immune behaviour associated with this coinfection are ***,this study focused on the detection of autoantibodies against cellular antigens(AACA)in individuals with HIV and leprosy coinfection in the Amazon ***:Patients were distributed into four groups according to their infections:(i)coinfection with HIV and leprosy(n=23),(ii)infection with leprosy(n=33),(iii)infection with HIV/AIDS(n=25),and(iv)healthy blood donor controls(n=100).AACA were identified by indirect immunofluorescence and the samples were tested using a commercial diagnosis kit containing the antinuclear antibody ***:Morphologically,all stages of cell division were assessed in addition to the morphological features associated with the nuclear matrix,nucleolus,mitotic spindle,and *** was a high prevalence of AACA in the coinfection group(47.8%,n=11)when compared with the control group of healthy blood donors(2.0%).The results showed predominantly cytoplasmic staining in all groups analysed,and no difference was observed between the presence or absence of AACA and the leprosy forms(paucibacillary and multibacillary)in the coinfection ***:The results of this study show that despite the tendency of coinfected patients to have higher levels of autoantibodies,no correlation was observed between clinical and laboratorial variables and morbidity associated with HIV and leprosy coinfections or the levels of AACA in the serum of coinfected *** data are important to elucidate this complex relationship between HIV a