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Genetic differentiation in functional traits among wild cherry (Prunus avium L.) half-sib lines

Journal of Forestry Research 2022年第3期33卷 991-1003页

作者： Srđan Stojnić branislav Kovačević Marko Kebert Verica Vasić Vanja Vuksanović branislav trudić Saša Orlović Institute of Lowland Forestry and Environment University of Novi SadAntonaČehova 13dNovi Sad21000Serbia Faculty of Agriculture University of Novi SadTrg Dositeja Obradovića 8Novi Sad21000Serbia Food and Agriculture Organization of the United Nations Viale delle Terme di Caracalla00153RomeItaly

Understanding intra-specific variation in leaf functional traits is one of the key requirements for the evaluation of species adaptive capacity to ongoing climate change, as well as for designing long-term breeding and conservation strategies. Hence, data of 19 functional traits describing plant physiology, antioxidant properties, anatomy and morphology were determined on 1-year-old seedlings of wild cherry (Prunus avium L.) half-sib lines. The variability within and among half-sib lines, as well as the estimation of multi-trait association, were examined using analysis of variance (ANOVA) followed by Tukey's honestly significant difference test and multivariate analyses: principal component analysis (PCA), canonical discriminant analysis (CDA) and stepwise discriminant analysis (SDA). Pearson’s correlation coefficient was used to evaluate linear correlation between the study parameters. The results of the ANOVA showed the presence of statistically significant differences (P < 0.01) among half-sib lines for all study traits. The differences within half-sib lines, observed through the contribution of the examined sources of variation to the total variance (%), had higher impact on total variation in the majority of the examined traits. Pearson’s correlation analysis and PCA showed strong relationships between gas exchange in plants and leaf size and stomatal density, as well as between leaf biomass accumulation, intercellular CO_(2) concentration and parameters related to antioxidant capacity of plants. Likewise, the results of SDA indicate that transpiration and stomatal conductance contributed to the largest extent, to the discrimination of the wild cherry half-sib lines. In addition, PCA and CDA showed separation of the wild cherry half-sib lines along the first principal component and first canonical variable with regards to humidity of their original sites. Multiple adaptive differences between the wild cherry half-sib lines indicate high potential of the specie

关键词： Wild cherry Common garden experiment Variability Multivariate statistics Leaf functional traits

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Methyl acetate-methanol mixture separation by extractive distillation:Economic aspects

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Frontiers of Chemical Science and Engineering 2018年第4期12卷 670-682页

作者： Elena Graczova branislav Sulgan Samuel Barabas Pavoi Steltenpohl Institute of Chemical and Environmental Engineering Faculty of Chemical and Food Technology Slovak University of Technology in Bratislava81237 BratislavaSlovakia

Methyl acetate is considered low toxicity volatile solvent produced either as a by-product during methanol carbonylation or via acetic acid esterification with methanol. In both cases, pure methyl acetate has to be isolated from the reaction mixture. Simulation of methyl acetate separation from its mixture with methanol by extraction distillation was carried out in ASPEN+ software. In total three case studies were assumed using two different extraction solvents and two solvent regeneration strategies. In case A, novel extraction solvent 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ionic liquid, was considered. Raw material separation was achieved in an extraction distillation column while the solvent regeneration was accomplished in a second distillation column in this case. In case study B, the same extraction solvent was used; however, its regeneration was carried out in a single-effect evaporator. Dimethyl sulfoxide was the second extraction solvent selected. Its use in methyl acetate-methanol separation is presented in case study C. As high purity of dimethyl sulfoxide was required for the methyl acetate-methanol azeotrope breaking, its regeneration was carried out in the second distillation column only. To simulate the ternary methyl acetate–methanol–extraction solvent mixtures separation, vapor–liquid equilibrium was predicted based on the NRTL equation. Further, unknown properties of the considered ionic liquid and variation of these properties with temperature were predicted and introduced into the ASPEN+ components properties database. Based on these data, optimum operation parameters of the respective separation equipment were established. In all case studies, the same condition had to be fulfilled, namely minimum methyl acetate content in the distillate from the extraction distillation column of 99.5mol-%. Results of simulations using the respective optimum operation parameters were employed in the economic evaluation of the three separation unit

关键词： methyl acetate 1-ethyl-3-methylimidazolium trifluoromethanesulfonate extraction distillation dimethyl sulfoxide economic evaluation

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Comparison of two nutritional assessment methods in gastroenterology patients

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World Journal of Gastroenterology 2010年第16期16卷 1999-2004页

作者： Branka F Filipovi Milan Gaji Nikola Milini branislav Milovanovi branislav R Filipovi Mirjana Cvetkovi Nela ibali Department of Gastroenterohepatology Clinical and Hospital Center "Bezanijska Kosa" School of Medicine Institute for Medical Statistics Faculty of Cardiology School of Medicine Laboratory for Neurocardiology Clinical and Hospital Center "Bezanijska Kosa" Institute of Anatomy "Niko Miljanic" School of Medicine Biochemical Laboratory Clinical and Hospital Center "Bezanijska Kosa"

AIM:To investigate and compare efficacy and differences in the nutritional status evaluation of gastroenterology patients by application of two methods:subjective global assessment(SGA) and nutritional risk index(NRI).METHODS:The investigation was performed on 299 hospitalized patients,aged 18-84 years(average life span 55.57 ± 12.84),with different gastrointe-stinal pathology,admitted to the Department of Gastroenterohepatology,Clinical and Hospital Center "Bezanijska Kosa" during a period of 180 *** the patients,after being informed in detail about the study and signing a written consent,underwent nutritional status analysis,which included two different nutritional indices:SGA and NRI,anthropometric parameters,bioelectrical impedance analysis,and biochemical markers,within 24 h of ***:In our sample of 299 hospitalized patients,global malnutrition prevalence upon admission varied from 45.7% as assessed by the SGA to 63.9% by *** applied methods required different parameters for an adequate approach:glucose level(5.68 ± 1.06 mmol/L vs 4.83 ± 1.14 mmol/L,F = 10.63,P = 0.001);body mass index(26.03 ± 4.53 kg/m2 vs 18.17 ± 1.52 kg/m2,F = 58.36,P < 0.001);total body water(42.62 ± 7.98 kg vs 36.22 ± 9.32 kg,F = 7.95,P = 0.005);basal metabolic rate(1625.14 ± 304.91 kcal vs 1344.62 ± 219.08 kcal,F = 9.06,P = 0.003) were very important for SGA,and lymphocyte count was relevant for NRI:25.56% ± 8.94% vs 21.77% ± 10.08%,F = 11.55,P = *** number of malnourished patients rose with the length of hospital stay according to both nutritional *** discriminative function analysis(DFA) delineated the following parameters as important for prediction of nutritional status according to SGA assessment:concentration of albumins,level of proteins,SGA score and body *** DFA extracted MAMC,glucose level and NRI scores were variables of importance for the prediction of whether admitted patients would be classif ied as well or ***:SGA

关键词： Nutritional status Subjective global assessment Nutritional risk index Comparison

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Psychiatric comorbidity in the treatment of patients with inflammatory bowel disease

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World Journal of Gastroenterology 2014年第13期20卷 3552-3563页

作者： branislav R Filipovic Branka F Filipovic Faculty of Medicine Institute of Anatomy "Niko Miljanic"11000 BelgradeSerbia Branislav R FilipovicBranka F FilipovicFaculty of MedicineUniversity of Belgrade11000 BelgradeSerbia Department of Gastroenterohepatology Clinical and Hospital Center "Bezanijska Kosa"11080 BelgradeSerbia

Ulcerative colitis and Crohn’s disease, commonly known as inflammatory bowel disease (IBD), draw attention from specialists of various disorders, including gastroenterology, psychiatry, and radiology. The involvement of a cortical influence in the brain-gut axis as well as the interaction of the hypothalamic-pituitary-adrenal axis and the peripheral nervous system provide an initial explanation of the psychological symptoms associated with IBD. The involvement of structures the limbic system, such as the anterior cingulate cortex, the prefrontal cortex, and the amygdala, paves the way for the discovery of the mechanisms underlying depression depression, anxiety, alexithymia, personality traits, and other psychological impairments following the onset of IBD. Psychiatric therapy in IBD patients is almost as important as the gastroenterological approach and consists of pharmacological treatment and psychotherapy. Neither of the available psychiatric treatment methods is considered the golden standard because both methods have side effects, and psychotropic medication can provoke the worsening of IBD symptoms. Thus, both approaches must be applied with awareness of the possibility of side effects. We suggest that psychiatrists and gastroenterologists work together to reach a consensus on IBD therapy to ensure success and to reduce side effects and relapse to the lowest possible rates.

关键词： Inflammatory bowel disease Psychiatry Treatment Personality traits Depression Anxiety

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Decoding of Factorial Experimental Design Models Implemented in Production Process

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Computers, Materials & Continua 2022年第4期71卷 1661-1675页

作者： Borislav Savkovic Pavel Kovac branislav Dudic Michal Gregus University of Novi Sad Faculty of Technical SciencesNovi Sad 21000Serbia Comenius University in Bratislava Faculty of ManagementBratislava820054 Slovakia University Business Academy Faculty of Economics and Engineering ManagementNovi Sad 21000Serbia

The paper deals with factorial experimental design models *** the ease of calculation of the experimental mathematical models,it is convenient first to code the independent *** selecting independent variables,it is necessary to take into account the range covered by each.A wide range of choices of different variables is presented in this *** calculating the regression model,its variables must be returned to their original values for the model to be easy recognized and *** the paper,the procedures of simple first order models,with interactions and with second order models,are presented,which could be a very complicated *** without and with the mutual influence of independent variables *** encoding and decoding procedure on a model with two independent first-order parameters is presented in ***,the procedure of model decoding is presented in the experimental surface roughness parameters models’determination,in the face milling machining process,using the first and second order model central compositional experimental *** simple calculation procedure is recommended in the case ***,a large number of examples using mathematical models obtained on the basis of the presented methodology are presented throughout the paper.

关键词： Mathematical modeling design of experiments functions coding decoding variable regression coefficienta

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Carcinosarcoma of the stomach:A case report and review of the literature

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World Journal of Gastroenterology 2007年第41期13卷 5533-5536页

作者： Tomislav Randjelovic Branka Filipovic Darko Babic Vesna Cemerikic branislav Filipovic Department of Gastrointestinal Surgery Clinical and Hospital Center "Bezanijska Kosa" BelgradeSerbia Department of Gastroenterohepatology Clinical and Hospital Center "Bezanijska Kosa " Belgrade 11080Serbia Department of Pathology Clinical and Hospital Center "Bezanijska Kosa" Belgrade 11080Serbia Laboratory for Histopathological and Cytological Diagnostics "Histolab " Belgrade 11080Serbia Institute of Anatomy School of MedicineUniversity of BelgradeBelgrade 11080Serbia

Carcinosarcomas are rare,malignant,biphasic tumors. We report the case of a 62-year-old man with gastric carcinosarcoma,along with its clinical,macroscopic and histopathological features. Macroscopically,a specimen of deformed stomach was obtained that measured 200 mm×150 mm×100 mm. A 150 mm×100 mm× 50 mm exophytic tumoral mass (Borrmann typeⅠ) was found,which involved the posterior wall from the cardia to the antrum. Histopathologically,a mixed type of malignancy was revealed: an adenocarcinoma with intestinal metaplasia,with interposed fascicles of fusiform atypical cells and numerous large,rounded and oval cells. The tumor showed positive histochemistry for cytokeratin 18,epithelial membrane antigen,carcinoembryonic antigen,chromogranin A and vimentin. Liver metastases were diagnosed 8 mo postoperatively,and the patient died 4 mo later. A review of the available literature is also presented.

关键词： Carcinosarcoma Histochemistry Pathology Stomach

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Leader-following synchronization of a multi-agent system with heterogeneous delays

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Frontiers of Information Technology & Electronic Engineering 2021年第1期22卷 97-106页

作者： branislav REHAK Volodymyr LYNNYK The Czech Academy of Sciences Institute of Information Theory and AutomationPraha 18200Czech Republic

An algorithm is presen ted for leader-following synchronization of a multi-agen t system composed of linear agents with time *** presence of different delays in various agents can cause a synchronization error that does not converge to ***,the norm of this error can be bounded and this boundary is presen *** proof of the main results is formulated by means of linear matrix inequalities,and the size of this problem is independent of the number of *** are illustrated through examples,highlighting the fact that the steady error is caused by heterogeneous delays and demonstrating the capability of the proposed algorithm to achieve synchronization up to a certain error.

关键词： Multi-agent system Time delay Linear matrix inequality

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Depression and anxiety levels in therapy-nave patients with inflammatory bowel disease and cancer of the colon

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World Journal of Gastroenterology 2007年第3期13卷 438-443页

作者： branislav R Filipovi Branka F Filipovi Mirko Kerkez Nikola Milini Tomislav Ran■elovi Institute of Anatomy School of Medicine Belgrade Clinical and Hospital Center "Be■anijska Kosa" Department of Gastroenterology Belgrade Serbia Department of Gastrointestinal Surgery Clinical Center of Serbia Serbia Department of Gastrointestinal Surgery Clinical and Hospital Center "Be■anijska Kosa" Belgrade Serbia

AIM: To assess whether depression and anxiety are more expressed in patients with the first episode of inflammatory bowel disease (IBD) than in individuals with newly discovered cancer of the colon (CCa). METHODS: A total of 32 patients with IBD including 13 males and 19 females, aged 27 to 74, and 30 patients with CCa including 20 males and 10 females, aged 39-78, underwent a structured interview, which comprised Hamilton’s Depression Rating Inventory, Hamilton’s Anxiety Rating Inventory and Paykel’s Stressful Events Rating Scale. RESULTS: Patients of the IBD group expressed both depression and anxiety. Depressive mood, sense of guilt, psychomotor retardation and somatic anxiety were also more pronounced in IBD patients. The discriminant function analysis revealed the total depressive score was of high importance for the classification of a newly diagnosed patient into one of the groups. CONCLUSION: Newly diagnosed patients with IBD have higher levels of depression and anxiety. Moreover, a psychiatrist in the treatment team is advisable from the beginning.

关键词： Crohn's disease Ulcerative colitis Colon cancer Mood disorder

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Knowledge presentation by the MNSM-based controller for swimming motion of a snake-like robot

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High Technology Letters 2018年第1期24卷 103-112页

作者：卢振利 Xie Yafei Xu Huigang Borovac branislav Li Bin School of Electrical Engineering and Automation Changshu Institute of Technology Changshu 215500 P. R. China State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Shenyang 110014 P. R. China School of Information and Electrical Engineering China University of Mining and Technology Xuzhou 221116 P. R. China Faculty of Technical Sciences University of Novi Sad Novi Sad 21000 Serbia

A MNSM( mirror neuron system mechanism)-based controller is developed to present the swimming rhythm of a snake-like robot in Cartesian space. From engineering viewpoint,the proposed controller is composed of a neuron for rhythm angle and two neurons for motion knowledge in XY plane. The given knowledge is a rhythm curve for swimming motion of a snake-like robot. Experimental results show that the proposed controller can present the knowledge of swimming rhythm,which represents the corresponding control law to drive the snake-like robot to swim with different speeds and turning motion. This work provides a novel method to present the knowledge for swimming motion of snake-like robots.

关键词： mirror neuron system mechanism (MNSM) swimming motion snake-like robot knowledge presentation

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Thermomineral water promotes axonal sprouting but does not reduce glial scar formation in a mouse model of spinal cord injury

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Neural Regeneration Research 2014年第24期9卷 2174-2181页

作者： Dubravka Aleksi? Milan Aksi? Nevena Divac Vidosava Radonji? branislav Filipovi? Igor Jakov?evski Institute of Anatomy "Niko Miljani?" Faculty of Medicine University of Belgrade Institute of Pharmacology Clinical Pharmacology and Toxicology Faculty of Medicine University of Belgrade Center for Molecular Neurobiology Hamburg University Medical Center Hamburg-Eppendorf

Thermomineral water from the Atomic Spa Gornja Trepca has been used for a century in the treatment of neurologic disease. The thermomineral water contains microelements, including lithium and magnesium, which show neural regeneration-promoting effects after central nervous system injury. In this study, we investigated the effects of oral intake of thermomineral water from the Atomic Spa Gornja Trepca on nerve regeneration in a 3-month-old mouse model of spinal cord injury. The mice receiving oral intake of thermomineral water showed better locomotor recovery than those without administration of thermomineral water at 8 and 12 weeks after lower thoracic spinal cord compression. At 12 weeks after injury, sprouting of catecholaminergic axons was better in mice that drank thermomineral water than in those without administration of thermomineral water, but there was no difference in glial reaction to injury between mice with and without administration of thermomineral water. These findings suggest that thermomineral water can promote the nerve regeneration but cannot reduce glial scar formation in a mouse model of spinal cord injury.

关键词： astrocyte scar catecholaminergic innervations lithium magnesium thermomineral water locomotor recovery microglia neuroprotection magnesium spinal cord injury nerve regeneration

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