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cellular & Molecular Immunology 2010年第3期7卷 211-220页

作者： Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner brandon Teng christina K chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight Benaroya Research Institute SeattleWAUSA

Hyaluronan(HA)production by dendritic cells(Dcs)is known to promote antigen presentation and to augment T-cell activation and *** hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–Dc *** primary human cells,we observed HA-dependent binding between T cells and Dcs,which was abrogated upon pre-treatment of the Dcs with 4-methylumbelliferone(4-MU),an agent which blocks HA ***,T cells regulate HA production by Dcs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA *** effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of Dc–T cell binding in this system were the nature of the pre-treatment the Dcs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th *** data support the existence of a feedforward loop wherein T-cell cytokines influence Dc production of HA,which in turn affects the extent of Dc–T cell *** also document the presence of focal deposits of HA at the immune synapse between T-cells and APc and on dendritic processes thought to be important in antigen *** data point to a pivotal role for HA in Dc–T cell interactions at the IS.

关键词： dendritic cell hyaluronan immune synapse pericellular matrix Th1

Look into my eyes:What can eye-based measures tell us about the relationship between physical activity and cognitive performance?

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Journal of Sport and Health Science 2023年第5期12卷 568-591页

作者： Liye Zou Fabian Herold Sebastian Ludyga Keita Kamijo Notger G.Muller Matthew B.Pontifex Matthew Heath Ryuta Kuwamizu Hideaki Soya charles H.Hillman Soichi Ando brandon L.Alderman Boris cheval Arthur F.Kramer Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen 518060China Research Group Degenerative and chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Department of Sport Exerciseand HealthUniversity of BaselBasel 4052Switzerland Faculty of Liberal Arts and Sciences Chukyo UniversityNagoya 466-8666Japan Department of Kinesiology Michigan State UniversityEast LansingMI 48824USA School of Kinesiology Faculty of Health SciencesUniversity of Western OntarioLondon ON N6A 3K7Canada canadian centre for Activity and Aging University of Western OntarioLondon ONN6A 3K7Canada Graduate Program in Neuroscience University of Western OntarioLondon ONN6A 3K7Canada Laboratory of Exercise Biochemistry and Neuroendocrinology Faculty of Health and Sport SciencesUniversity of TsukubaTsukuba 305-0006Japan Sport Neuroscience Division Advanced Research Initiative for Human High Performance(ARIHHP)Faculty of Health and Sport SciencesUniversity of TsukubaTsukuba 305-0006Japan center for cognitive and Brain Health Department of PsychologyDepartment of Physical TherapyMovementand Rehabilitation SciencesNortheastern UniversityBostonMA 02115USA Graduate School of Informatics and Engineering The University of Electro-CommunicationsTokyo 182-8585Japan Department of Kinesiology and Health Rutgers UniversityNew BrunswickNew BrunswickNJ 08854USA Swiss center for Affective Sciences University of GenevaGeneva 1205Switzerland Laboratory for the Study of Emotion Elicitation and Expression(E3Lab) Department of PsychologyUniversity of GenevaGeneva 1205Switzerland Department of Psychology Center for Cognitive and Brain HealthNortheastern UniversityBostonMA 02115USA Beckman Institute University of Illinois at Urbana-ChampaignChampaignIL 61820USA

Background:There is a growing interest to understand the neurobiological mechanisms that drive the positive associations of physical activity and fitness with measures of cognitive *** better understand those mechanisms,several studies have employed eye-based measures(e.g., eye movement measures such as saccades,pupillary measures such as pupil dilation,and vascular measures such as retinal vessel diameter)deemed to be proxies for specific neurobiological ***,there is currently no systematic review providing a comprehensive overview of these studies in the field of exercise-cognition ***,this review aimed to address that gap in the ***:To identify eligible studies,we searched 5 electronic databases on October 23,*** researchers independently extracted data and assessed the risk of bias using a modified version of the Tool for the assEssment of Study qualiTy and reporting in EXercise(TESTEX scale,for interventional studies) and the critical appraisal tool from the Joanna Briggs Institute(for cross-sectional studies).Results:Our systematic review(n=35 studies) offers the following main findings:(a) there is insufficient evidence available to draw solid conclusions concerning gaze-fixation-based measures;(b) the evidence that pupillometric measures,which are a proxy for the noradrenergic system,can explain the positive effect of acute exercise and cardiorespiratory fitness on cognitive performance is mixed;(c) physical training-or fitness-related changes of the cerebrovascular system(operationalized via changes in retinal vasculature) are,in general,positively associated with cognitive performance improvements;(d) acute and chronic physical exercises show a positive effect based on an oculomotor-based measure function(operationalized via antisaccade tasks);and(e) the positive association between cardiorespiratory fitness and cognitive performance is partly mediated by the dopaminergic system(operationalized via spo

关键词： cognition Exercise Fitness Pupil size RetinaTagedAPTARAEnd

Educational, psychosocial, and clinical impact of SARS-coV-2 (cOVID-19) pandemic on medical students in the United States

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World Journal of Virology 2022年第3期11卷 150-169页

作者： Veronica Frank Anjali Doshi Natalie L Demirjian brandon K K Fields catherine Song Xiaomeng Lei Sravanthi Reddy Bhushan Desai Drayton c Harvey Steven cen Ali Gholamrezanezhad Semmelweis University Faculty of Medicine Semmelweis University Faculty of MedicineBudapest 1085Hungary Keck School of Medicine of University of Southern california Los AngelesCA 90033United States Department of Integrative Anatomical Sciences Keck School of Medicine of University of Southern CaliforniaLos AngelesCA 90033United States Department of Radiology Keck School of Medicine of University of Southern CaliforniaLos AngelesCA 90033United States

BAcKGROUND The coronavirus disease 2019(cOVID-19)pandemic altered education,exams,and residency applications for United States medical *** To determine the specific impact of the pandemic on US medical students and its correlation to their anxiety *** An 81-question survey was distributed via email,Facebook and social media groups using *** investigate risk factors associated with elevated anxiety level,we dichotomized the 1-10 anxiety score into low(≤5)and high(≥6).This cut point represents the 25th *** were 90(29%)shown as low anxiety and 219(71%)as high *** descriptive analyses,we used contingency tables by anxiety categories for categorical measurements with chi square test,or mean±STD for continuous measurements followed by t-test or Wilcoxson rank sum test depending on data *** Absolute Shrinkage and Selection Operator was used to select important predictors for the final multivariate *** Poisson regression model was used to fit the final multivariate model by considering the nested data structure of students clustered within *** 397 medical students from 29 states were *** half of respondents reported feeling depressed since the pandemic onset.62%of participants rated 7 or higher out of 10 when asked about anxiety *** correlated with higher anxiety scores included“concern about being unable to complete exams or rotations if contracting cOVID-19”(RR 1.34;95%cI:1.05-1.72,P=0.02)and the use of mental health services such as a“psychiatrist”(RR 1.18;95%cI:1.01-1.3,P=0.04).However,those students living in cities that limited restaurant operations to exclusively takeout or delivery as the only measure of implementing social distancing(RR 0.64;95%cI:0.49-0.82,Pcted“does not apply”for financial assistance available if needed(RR 0.83;95%cI:0.66-0.98,P=0.03)were less likely to have a high *** cOVID-19 significantly

关键词： Medical student SARS-coV-2 Anxiety Stress Psychological Impact clinical

High-content Screening and Analysis of Stem cell-Derived Neural Interfaces Using a combinatorial Nanotechnology and Machine Learning Approach

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研究(英文) 2023年第1期2022卷 153-167页

作者： Letao Yang Brian M.conley Jinho Yoon christopher Rathnam Thanapat Pongkulapa brandon conklin Yannan Hou Ki-Bum Lee Department of chemistry and chemical Biology Rutgers UniversityThe State University of New JerseyPiscatawayNJ 08854USA

A systematic investigation of stem cell-derived neural interfaces can facilitate the discovery of the molecular mechanisms behind cell behavior in neurological disorders and accelerate the development of stem cell-based ***,high-throughput investigation of the cell-type-specific biophysical cues associated with stem cell-derived neural interfaces continues to be a significant obstacle to *** this end,we developed a combinatorial nanoarray-based method for high-throughput investigation of neural interface micro-/nanostructures(physical cues comprising geometrical,topographical,and mechanical aspects)and the effects of these complex physical cues on stem cell fate ***,by applying a machine learning(ML)-based analytical approach to a large number of stem cell-derived neural interfaces,we comprehensively mapped stem cell adhesion,differentiation,and proliferation,which allowed for the cell-type-specific design of biomaterials for neural interfacing,including both adult and human-induced pluripotent stem cells(hiPScs)with varying genetic *** short,we successfully demonstrated how an innovative combinatorial nanoarray and ML-based platform technology can aid with the rational design of stem cell-derived neural interfaces,potentially facilitating precision,and personalized tissue engineering applications.

关键词： overcome neural rational

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审判者传奇（卷2）：火凤凰 1

Single low-dose lipopolysaccharide preconditioning:neuroprotective against axonal injury and modulates glial cells

丛书名：独角兽书系

2019年

作者：（美）布兰登·桑德森（brandon Sanderson）

本书继第一卷钢铁心被清算者组织除掉后，整个以超能者强权构建的世界开始了新的秩序建设，而火凤凰的真实身份也浮出水面，清算者组织迎来了前所未有的挑战。本以为复仇之路告一段落的戴维发现超能者与超能力使用间的矛盾关系，原来一... 详细信息

ISBN: (纸本)9787229134112

本书继第一卷钢铁心被清算者组织除掉后，整个以超能者强权构建的世界开始了新的秩序建设，而火凤凰的真实身份也浮出水面，清算者组织迎来了前所未有的挑战。本以为复仇之路告一段落的戴维发现超能者与超能力使用间的矛盾关系，原来一切并没有结束，为了世界光明的反抗也在继续着，父亲的信念也让戴维明白：英雄终将崛起，弱小的阶级也得到保护、正义。

关键词：长篇小说美国现代

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Neuroimmunology and Neuroinflammation 2017年第1期4卷 6-15页

作者： Ryan c.Turner Zachary J.Naser brandon P.Lucke-Wold Aric F.Logsdon Reyna L.Vangilder Rae R.Matsumoto Jason D.Huber charles L.Rosen Department of Neurosurgery West Virginia UniversitySchool of MedicineMorgantownWV26506USA center for Neuroscience West Virginia UniversitySchool of MedicineMorgantownWV 26506USA Department of Basic Pharmaceutical Sciences West Virginia UniversitySchool of PharmacyMorgantownWV 26506USA center for Health Restoration West Virginia UniversitySchool of NursingMorgantownWV 26506USA

Aim:Over 7 million traumatic brain injuries (TBI) are reported each year in the United ***,treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly *** (LPS) administration before controlled cortical impact can contribute to ***,the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains ***:The authors hypothesized that preconditioning with a low dose of LPS (0.2 mg/kg) would regulate glial reactivity and protect against diffuse axonal injury induced by weight *** was administered 7 days prior to *** administration reduced locomotion,which recovered completely by time of ***:LPS preconditioning significantly reduced the post-injury gliosis response near the corpus callosum,possibly by downregulating the oncostatin M *** novel findings demonstrate a protective role of LPS preconditioning against diffuse axonal *** preconditioning successfully prevented neurodegeneration near the corpus callosum,as measured by fluorojade ***:Further work is required to elucidate whether LPS preconditioning confers long-term protection against behavioral deficits and to elucidate the biochemical mechanisms responsible for LPS-induced neuroprotective effects.

关键词： Lipopolysaccharide preconditioning oncostatin M receptor diffuse axonal injury gliosis neuroprotection

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新的非镇静性抗组胺药将代替老药吗

国外医药.合成药.生化药.制剂分册 1986年第5期 264-265页

作者： brandon ML 王正吕松风罗信兴

近十年来,人们对抗组胺药及其作用的兴趣重新增加。这是由于开发了特非那定、阿司咪唑和其它可能无镇静作用的抗组胺药如美喹他嗪、BW825c(一种类似安太乐和美克洛嗪的药物)和UcB—PO71(一种新的赛克利嗪类化合物)。另外正在评价一些无... 详细信息

近十年来,人们对抗组胺药及其作用的兴趣重新增加。这是由于开发了特非那定、阿司咪唑和其它可能无镇静作用的抗组胺药如美喹他嗪、BW825c(一种类似安太乐和美克洛嗪的药物)和UcB—PO71(一种新的赛克利嗪类化合物)。另外正在评价一些无镇静作用抗组胺药,其中有SK&F 3944,它正试用于变应性鼻炎。 1.新老非镇静性抗组胺药的活性差别上述各药在常用量时,均不易通过血脑屏障,比较起来,大多数老药由于脂溶性很强,容易透过血脑屏障。理想的纯粹的H_—

关键词：抗组胺药老药特非那定抗胆碱能组织胺H1受体阻断药敏必治镇静作用过敏性鼻炎变应性鼻炎

Rh催化的烯烃/炔烃对邻二酮α-位烷基化/烯基化的研究

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Rh催化的烯烃/炔烃对邻二酮α-位烷基化/烯基化的研究

Nitric Oxide Inhibits Apoptosis-Related Gene Expression Vias-Nitrosyiation in a caspase-9 Dependent Fashion

中国化学会全国第十一届有机合成化学学术研讨会

作者：王智谦 brandon J.Reinus Guangbin Dong Department of chemistry and Biochemistry University of Texasat Austin AustinTexas 78712United States 北京化工大学理学院

过渡金属参与的c-H键活化及官能团化反应是一种思路上比较简洁有效、并正在被广泛研究的合成方法。本工作利用可脱除的氨基吡啶作为导向基团,将1,2-二酮转化为烯胺结构,以烯烃或炔烃为烷基化试剂利用Rh(Ⅰ)参与的c-H键活化反应,再结合... 详细信息

过渡金属参与的c-H键活化及官能团化反应是一种思路上比较简洁有效、并正在被广泛研究的合成方法。本工作利用可脱除的氨基吡啶作为导向基团,将1,2-二酮转化为烯胺结构,以烯烃或炔烃为烷基化试剂利用Rh(Ⅰ)参与的c-H键活化反应,再结合后续的导向基团的水解,便实现了对原1,2-二酮结构α-位的烷基化或烯基化。以AlO作为添加剂可以实现烯胺的形成和c-H键活化的一锅完成,而反应依然保持很高的转化率。对于某些以单取代炔烃为原料的烯基化反应,由于炔烃反应活性很高反应难以控制,加入NaI并采用缓慢滴加的操作,能有效解决问题实现该反应优良的转化率。

关键词： c-H键活化 1,2-二酮烷基化或烯基化

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Nitric Oxide Inhibits Apoptosis-Related Gene Expression Vias...

Anticancer Effects of curcumin, Artemisinin, Genistein, and Resveratrol, and Vitamin c: Free Versus Liposomal Forms

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： James A.Radosevich Benjamin J. Vesper Kim Elseth brandon G.Bentz Kenneth W.Altman G. Kenneth Haines center for Molecular Biology of Oral Diseases college of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA center for Molecular Biology of Oral Diseases college of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA center for Molecular Biology of Oral Diseases college of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Department of Surgery University of Utah 2000 Circle of Hope Dr.Salt Lake CityUT84112USA Department of Otolaryngology Head ＆ Neck Surgery Mt. Sinai School of Medicine One Gustave L. Levy PlaceNew YorkNYUSA Department of Pathology Northwestern University 303 E.Chicago Ave.ChicagoIL60611USA

＜正＞Background/Aims:Nitric Oxide （NO） and its interrelated redox species （collectively denoted as NOx） play a multi - faceted role in cancer progression. NOx production induces mutational events,and it has also been found to simultaneously inhibit apoptosis. In an effort to define the underlying mechanisms of apoptosis inhibition arising from nitric oxide exposure, we here develop a novel mouse model of lung adenocarcinoma. Methods: Four NOx donor compounds （DETA - NONOate, Spermine - NONOate, SNAP, and glyco - SNAP） were exposed to a novel murine lung adenocarcinoma cell line at increasing *** extent of NOx production was measured by the Griess reaction,spectrophotometrically,and via nitrotyrosine *** alkaline single- cell gel electrophoresis assay （the cOMET assay） was used to measure DNA strand breaks （DSB’ s） and was correlated with cell viability. A fluorescence caspase activity assay was used to determine apoptosis and was correlated with apoptosis - related gene products using cDNA microarrays. Results:Kinetics,concentration,and mode of delivery all had an effect on NOx mediated DSB’s. At the highest concentration of NONOate donors, the DSB’ s correlated with cell death in a caspase - 9 dependent fashion. caspase -9 activity appeared to be inhibited by thiol - based NOx donors, and since DTT reversed NO’s effect of apoptosis, inhibition is believed to have occurred via a S - nitrosylation pathway. This change in caspase activity was found to correlate with a number of transcriptional changes, suggesting that several key apoptosis steps are likely under transcriptional control via S - nitrosylation. conclusions: The results of our murine model of lung cancer progression were found to parallel those previously reported in a human lung adenocarcinoma cell line. The model suggests that various apoptosis related gene products are likely regulated through S - nitrosylation in a caspase - 9 dependent manner. With this model in hand, we c

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Advances in Biological chemistry 2017年第1期7卷 27-41页

作者： Jerry T. Thornthwaite Hare R. Shah Spencer R. England Lee H. Roland Seth P. Thibado Thomas K. Ballard brandon T. Goodman cancer Research Institute of West Tennessee Henderson TN USA Union University Department of chemistry Jackson TN USA University of Tennessee Department of Biochemistry Knoxville TN USA

cancer prevention supplements, which also provide effective treatment with minimal side effects, are urgently needed. An accurate, fast assay system is described that reveals the ability of chemically defined products, such as curcumin, genistein, resveratrol, artemisinin, and vitamin c, to kill K562 Erythroleukemic cells in vitro. In addition, curcumin and vitamin c were encapsulated into fatty acid micelles named NutraNanoSpheresTM (NNS) using all natural products. A unique viability stain, which allows the rapid staining of dead cells by membrane penetration using Propidium Iodide, was used to measure the cell viability by flow cytometry. cell death by alteration of the cell membranes could be seen within 30 s of exposure to curcumin. The other free components required 0.5 - 70 h to see maximum killing, suggesting a more metabolic and/or apoptotic route of cancer cell destruction. Vitamin c up to 1 × 104 μmol/well did not affect K562 cell viability. The vitamin c-NNS (3.2 nm diameter-60 mg/50 μL) showed an LD50 = 133 μmol/well ± 11 SD (n = 4), which was over 75 times more potent than the free vitamin c. The curcumin-NNS (7.4 nm diameter-25 mg/50 μL) resulted in an LD50 = 41.3 μmol/well ± 5.6 SD (n = 8) and represented a 264 fold increase in activity to destroy the cancer cells. The clinical goal is to develop water-soluble mixtures of anti-cancer compounds in the NNS with their high bioavailability (>90%) and without degradation in the stomach for preventing and curing cancer.

关键词： curcumin Artemisinin cancer Micelle Natural