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Seroprevalence of Dengue Viral Infection among Adults Attending the University of Cape Coast Hospital

Advances in Infectious Diseases 2021年第1期11卷 60-72页

作者： Ebenezer Aniakwaa-Bonsu daniel Amoako-Sakyi Kwabena Dankwa James Kojo Prah samuel Victor Nuvor Department of Microbiology and Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana Directorate of University Health Services University of Cape Coast Cape Coast Ghana

Introduction: Most febrile illnesses in Ghana are often misdiagnosed and presumptively treated as malaria. This situation may be due to the inappropriate diagnostic tool, clinical oversight and lack of awareness of some of the disease conditions that might have been present in the country. This study sought to investigate the seroprevalence of dengue virus, geographical location of participants with circulating antibodies and finally evaluate the diagnostic accuracy of a Rapid diagnostic kit (RDT) using Enzyme Linked Immuno-Sorbent Assay (ELISA) as a gold standard for confirmation. Method: A hospital-based cross-sectional study was conducted among adults (≥18) attending the University of Cape Coast Hospital. From each participant, 3 - 4 ml of venous blood was drawn and serum was tested for IgG and IgM using RDT methods. Positive samples were selected for ELISA confirmation. Statistical analysis was performed using SPSS (v.20) and STATA (v.14) software. Results: A total of 270 participants were enrolled in the study. The geometric mean age was 32 years. Overall, Dengue virus (DENV) IgG seroprevalence by RDT was 10 (3.7%). Seroprevalence of IgG and IgM by the ELISA method was 34 (12.6%) and 6 (2.2%) respectively. Females recorded a high seroprevalence (7.4%) than males (5.2%) in terms of past exposure (IgG). On current exposure (IgM), females recorded a high seroprevalence (1.5%) than males (0.7%). Seroprevalence of individuals with dual positivity ((IgG + IgM+) (acute secondary infection) was 1.9%. Those with primary and recent infection (IgM+ only) were 0.4% whiles those with past and probably secondary infection (IgG+ only) were 10.7%. The odds of dengue exposure were significantly high among participants with ages 50 - 59 as compared to their other counterparts (AOR = 3.5, p = 0.03). Diagnostic accuracy of RDT kit was poor (Kappa value = 0.373 and 0.0001). Elmina was noted to record the highest seroprevalence valu

关键词： Seroprevalence ELISA RDT Dengue Virus

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Basophile:Accurate Fragment Charge State Prediction Improves Peptide Identification Rates

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Genomics, Proteomics & Bioinformatics 2013年第2期11卷 86-95页

作者： Dong Wang Surendra Dasari Matthew C.Chambers Jerry D.Holman Kan Chen daniel C.Liebler daniel J.Orton samuel O.Purvine Matthew E.Monroe Chang Y.Chung Kristie L.Rose David L.Tabb Department of Biomedical Informatics Vanderbilt University Medical Center Division of Biomedical Statistics and Informatics Mayo Clinic Department of Biochemistry Vanderbilt University Medical Center Biological Sciences Division and Environmental Molecular Sciences Laboratory Pacific Northwest National Laboratory Department of Pharmacology Vanderbilt University Medical Center Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine

In shotgun proteomics, database search algorithms rely on fragmentation models to pre- dict fragment ions that should be observed for a given peptide sequence. The most widely used strat- egy （Naive model） is oversimplified, cleaving all peptide bonds with equal probability to produce fragments of all charges below that of the precursor ion. More accurate models, based on fragmen- tation simulation, are too computationally intensive for on-the-fly use in database search algorithms. We have created an ordinal-regression-based model called Basophile that takes fragment size and basic residue distribution into account when determining the charge retention during CID/higher- energy collision induced dissociation （HCD） of charged peptides. This model improves the accuracy of predictions by reducing the number of unnecessary fragments that are routinely predicted for highly-charged precursors. Basophile increased the identification rates by 26% （on average） over the Naive model, when analyzing triply-charged precursors from ion trap data. Basophile achieves simplicity and speed by solving the prediction problem with an ordinal regression equation, which can be incorporated into any database search software for shotgun proteomic identification.

关键词： Fragmentation Basicity Fragment size Ordinal regression

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Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

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Bioactive Materials 2022年第10期7卷 173-186页

作者： Mauricio Gonçalves da Costa Sousa Gabriela Conceiçao de Almeida Danilo Cesar Martins Mota Rosiane Andrade da Costa Simoni Campos Dias samuel Nunes Limberger Frank Ko Li Ting Lin Evan FHaney Hashem Etayash Beverlie Baquir Michael J.Trimble Ya Shen Zheng Su Markus Haapasalo daniel Pletzer Letícia Chaves de Souza Glaucia Schuindt Teixeira Renato M.Silva Robert E.W.Hancock Octavio Luiz Franco Taia Maria Berto Rezende Post-Graduation Program in Genomic Sciences and Biotechnology Catholic University of BrasíliaBrasíliaBrazil Dentistry Course Catholic University of BrasíliaBrasíliaBrazil Post-Graduation Program in Health Sciences University of BrasíliaBrazil LIMA Chemistry InstituteUniversity of Brasília-UNBBrasíliaBrazil Animal Biology Department Campus Darcy RibeiroUniversidade de BrasíliaBrazil Department of Materials Engineering Faculty of Applied ScienceUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of British ColumbiaVancouverBCCanada Department of Oral Biological and Medical Sciences Faculty of DentistryUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Department of Endodontics School of DentistryUniversity of Texas Health Science Center at HoustonHoustonUSA Department of Prosthesis Faculty of DentistryRio de Janeiro State UniversityRio de JaneiroBrazil Post-Graduation Program in Biotechnology Catholic University Dom BoscoCampo GrandeMato Grosso do SulBrazil

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for ***,different scaffolds were tested for use during the pulp revascularization process,including poly(vinyl alcohol)-PVA hydrogels or resins,collagen hydrogels and poly(vinyl alcohol)PVA/Chitosan(PVA/CS)*** on time to degradation(21 days),nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002(each at 50 mg/g).Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis,Staphylococcus aureus and a multispecies oral biofilm,besides anti-inflammatory *** in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation,when compared to empty teeth ***,we designed a strong antimicrobial,immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

关键词： Regenerative endodontics Scaffolds Nanofibers Host defense peptides Ciprofloxacin IDR-1002

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单髁与全膝关节置换治疗内侧间室膝骨关节炎:5年假体在位率比较

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中国组织工程研究 2015年第53期19卷 8543-8548页

作者：梁宁 samuel Yih Shyan Wong Nick Clement Deborah MacDonald daniel E Porter 清华大学第一附属医院骨科北京市100016 英国爱丁堡皇家医院骨科

背景:单髁置换越来越多的被应用于治疗单纯内侧胫股间室型膝关节骨关节炎。目的:比较膝关节单髁置换与全膝关节置换对膝关节单纯内侧间室骨关节炎的修复效果。方法:纳入单纯内侧间室型膝关节骨关节炎患者109例,根据修复方式分为两组,单... 详细信息

背景:单髁置换越来越多的被应用于治疗单纯内侧胫股间室型膝关节骨关节炎。目的:比较膝关节单髁置换与全膝关节置换对膝关节单纯内侧间室骨关节炎的修复效果。方法:纳入单纯内侧间室型膝关节骨关节炎患者109例,根据修复方式分为两组,单髁置换组41例,全膝关节置换组68例。比较两组患者的平均住院时间、置换后并发症发生率、身体健康总评分、精神健康总评分、牛津膝关节评分以及置换后5年假体在位率。结果与结论:单髁置换组患者平均住院时间(4.21±2.44)d,较全膝关节置换组(6.11±2.23)d短(P=0.001)。两组患者置换后并发症发生率、身体健康总评分、精神健康总评分、牛津膝关节评分等方面差异均无显著性意义(P>0.05)。置换后5年,单髁置换组假体在位率(90%)较全膝关节置换组(100%)低(P<0.05)。提示对于单纯内侧胫股间室型膝关节骨关节炎患者,单髁置换与全膝关节置换具有相似的修复效果,但单髁置换后5年假体在位率稍低。

关键词：关节成形术置换,膝假体植入组织工程

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Langerhans cell histiocytosis masquerading as acute appendicitis: Case report and review

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World Journal of Gastrointestinal Endoscopy 2017年第3期9卷 139-144页

作者： Mohammad M Karimzada Michele N Matthews samuel W French daniel De Ugarte Dennis Y Kim Department of Surgery Harbor-UCLA Medical Center Department of Pathology Harbor-UCLA Medical Center

Langerhans cell histiocytosis(LCH) is a rare syndrome characterized by unifocal,multifocal unisystem,or disseminated/multi-system disease that commonly involves the bone,skin,lymph nodes,pituitary,or sometimes lung(almost exclusively in smokers) causing a variety of symptoms from rashes and bone lesions to diabetes insipidus or pulmonary *** present a previously unreported case of gastrointestinal LCH as well as a novel characteristic lesion affecting the colon of a young woman who presented with signs and symptoms mimicking acute on chronic *** analysis of appendectomy specimen and nodular specimens on colonoscopy demonstrated S-100,CD1a,and langerin *** patient underwent systemic chemotherapy with cytarabine and demonstrated excellent response to therapy.

关键词： Langerhans cell histiocytosis Adult histiocytosis Appendicitis Gastrointestinal histiocytosis Right lower quadrant pain

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Lessons learned:Symbiotic autonomous robot ecosystem for nuclear environments

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IET Cyber-Systems and Robotics 2023年第4期5卷 63-86页

作者： daniel Mitchell Paul Dominick Emor Baniqued Abdul Zahid Andrew West Bahman Nouri Rahmat Abadi Barry Lennox Bin Liu Burak Kizilkaya David Flynn David John Francis Erwin Jose Lopez Pulgarin Guodong Zhao Hasan Kivrak Jamie Rowland Douglas Blanche Jennifer David Jingyan Wang Joseph Bolarinwa Kanzhong Yao Keir Groves Liyuan Qi Mahmoud A.Shawky Manuel Giuliani Melissa Sandison Olaoluwa Popoola Ognjen Marjanovic Paul Bremner samuel Thomas Harper Shivoh Nandakumar Simon Watson Subham Agrawal Theodore Lim Thomas Johnson Wasim Ahmad Xiangmin Xu Zhen Meng Zhengyi Jiang James Watt School of Engineering Autonomous Systems and Connectivity DivisionUniversity of GlasgowGlasgowUK Department of Electrical and Electronic Engineering The University of ManchesterManchesterUK Bristol Robotics Laboratory University of the West of EnglandBristolUK Heriot-Watt University EdinburghUK

Nuclear facilities have a regulatory requirement to measure radiation levels within Post Operational Clean Out(POCO)around nuclear facilities each year,resulting in a trend towards robotic deployments to gain an improved understanding during nuclear decommissioning *** UK Nuclear Decommissioning Authority supports the view that human-in-the-loop(HITL)robotic deployments are a solution to improve procedures and reduce risks within radiation characterisation of nuclear *** authors present a novel implementation of a Cyber-Physical System(CPS)deployed in an analogue nuclear environment,comprised of a multi-robot(MR)team coordinated by a HITL operator through a digital twin *** development of the CPS created efficient partnerships across systems including robots,digital systems and *** was presented as a multi-staged mission within an inspection scenario for the hetero-geneous Symbiotic Multi-Robot Fleet(SMuRF).Symbiotic interactions were achieved across the SMuRF where robots utilised automated collaborative governance to work together,where a single robot would face challenges in full characterisation of *** contributions include the demonstration of symbiotic autonomy and query-based learning of an autonomous mission supporting scalable autonomy and autonomy as a *** coordination of the CPS was a success and displayed further challenges and improvements related to future MR fleets.

关键词： cyber-systems field robotics hazardous inspection human robot interaction industrial robotics mobile robots multi-agent systems multi-robot systems robotics service robots

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Nutraceutical with Anti-Inflammatory Activity for the Management of Airway Remodeling in Bronchial Asthma: <i>Kalanchoe integra</i>Var. Crenata (Andr.) Cuf Leaf Extract

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Pharmacology & Pharmacy 2014年第3期5卷 250-261页

作者： Asiedu-Gyekye Isaac Julius Awortwe Charles Nyamekye Effah samuel Antwi daniel Ansong Seidu Mahmood Adjei samuel Banga N’guessan Benoit Kwame Amoateng Patrick Nkansah Edwin Department of Animal Experimentation Noguchi Memorial Institute for Medical Research College of Health Sciences Legon Ghana Department of Chemical Pathology School of Allied Health Sciences College of Health Sciences Korle-Bu Ghana Department of Pharmacology and Toxicology University of Ghana School of Pharmacy College of Health Sciences Legon Ghana Department of Physiology University of Ghana Medical School Col-lege of Health Sciences Korle-Bu Ghana Division of Pharmacology Faculty of Health Sciences University of Stellenbosch Cape Town South Africa

Background: Kalanchoe integra is widely used in folklore medicine as an antiasthmatic agent. Previous studies have shown the ameliorating effect of Kalanchoe integra leaf extract [KILE] on bronchial hyperesponsiveness and inflammation. Further, the stabilizing effect of Kalanchoe sp on mast cell degranulation, suggests that Kalanchoe species are suitable candidates for allergic asthma therapy. This study is designed to investigate the anti-asthmatic potential of KILE and monitor the accompanying histopathological and immunobiochemical changes that occur in an animal model of bronchial asthma using ovalbumin sensitized guinea pigs. Method: Thirty male guinea pigs were divided into five groups of six animals each. Bronchial asthma was simulated in guinea pigs using ovalbumin. Both low dose (300 mg/kg) and high dose extract (900 mg/kg) were administered daily for 42 days. Prednisolone (2.5 mg/kg) was the standard drug used. Results: Guinea pigs in all KILE treated groups maintained the integrity of their airway structures: bronchial folds and walls, alveoli, alveolar ducts and sacs. KILE and prednisolone caused a reduction in immune parameters (p 0.001), extent of bronchoconstriction, bronchial wall thickness and goblet cell accumulation in the sensitized guinea pigs. Conclusion: This study demonstrates the anti-asthmatic potential of KILE during prolonged administration by the oral route.

关键词： Kalanchoe Integra Asthma Bronchoconstriction Goblet Cells Perivascular Oedema

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Incidence of Human Immunodeficiency Virus in Sickle Cell Patients in the Cape Coast Metropolis, Ghana

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World Journal of AIDS 2014年第3期4卷 338-345页

作者： Amaris T. D. Baah daniel E. Azumah Charles Ampiah Johnson Boampong samuel V. Nuvor Central Regional Teaching Hospital Cape Coast Ghana Department of Biolomedical and Forensic Sciences School of Biological Sciences University of Cape Coast Cape Coast Ghana

Context: Human immunodeficiency virus (HIV) is a well-known pathogen that causes acquired immunodeficiency syndrome (AIDS). The course of HIV infection and progression may be influenced by sickle cell traits. Objectives: The aim of this study was to determine the incidence of HIV among sickle cell patients in the Cape Coast metropolis. Methods: A cross sectional study was conducted among patients who visited the Central Regional Hospital, Cape Coast. About 2 ml of blood sample was drawn from each participant for sickle cell test using sodium metabisulphite solution. Sickle cell positive samples were selected and tested for the presence of HIV using Alere DetermineTM?HIV-1/2. Results: A total of 75 patients made up of 25 males and 50 females were enrolled. Their age ranges between 4 to 59 years (27, 1 - 15 years;24, 16 - 30 years;17, 31 - 45 years;7, 46 - 60 years). Fifteen (15) (20%) had received at least a single blood transfusion while the remaining 60 (80%) had never received blood transfusion before the study. Thirty-six patients (48.0%) were married and the other 39 patients (52.0%) were single. Five patients (6.7%) had antibodies to HIV whereas 70 patients (93.3%) were not with the virus. Conclusion: The incidence rate of HIV among sickle cell trait children and the youths of Cape Coast metropolis were found to be 6.7%. This may suggest that sickle cell traits in children and the youth may be associated with HIV transmission.

关键词： HIV Sickle Cell Disease Incidence Prevalence

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Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents

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Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu Carolyn A.Cohen daniel Leung Jaime S.Rosa Duque samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina HKU-Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia Centre for Immunology&Infection C2i Hong KongChina

The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

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Effects of the Orientation of the Mountainside, Altitude and Varieties on the Quality of the Coffee Beverage from the “Matas de Minas” Region, Brazilian Southeast

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American Journal of Plant Sciences 2016年第8期7卷 1291-1303页

作者： Williams P. M. Ferreira daniel M. Queiroz samuel A. Silvac Rafael Simões Tomaz Paulo C. Corrêa National Coffee Research Center Brazilian Corporation of Agricultural Research—EMBRAPA Vicosa Brazil Departament of Agricultural Engineering Federal University of Vicosa—UFV Vicosa Brazil Department of Rural Engineering Federal University of Espirito Santo—UFES Alegre Brazil Department of Agronomy Engineering Faculdade de Ciencias Agrárias e Tecnológicas (FCAT) Sao Paulo State University—UNESP Dracena Brazil

Based upon qualitative parameters experiments, this study aims to investigate how the elements of the environment, where the coffee is produced, contribute to the final quality of the product. For the analyses, it was used approximately one kilogram of coffee cherry samples collected in 14 municipalities previously chosen on the East side of the Minas Gerais State, Brazil. The coffee cherry samples were collected and analyzed for each of the two varieties in four levels of altitude for each exposure side of the mountain in relation to the Sun. The quality of the coffee was evaluated through the analysis of its physical characteristics and sensory analysis, popularly known as "Test of drink or Cupping" carried out by three tasters that belonging to the group of Q-Graders, according to the rules of national and international competitions of the Brazilian Association of Special Coffees (BSCA). Were performed analysis by means descriptive statistics, analysis of variance and multivariate analysis, all of them aiming to study the individual sensory characteristics of quality of the coffee beverage from the “Matas de Minas” region. Path coefficient analysis also was carried out for the partition of the phenotypic correlation coefficients into measures of direct and indirect effects, in order to determine the individual sensory characteristics that played a major role in the beverage final score. The results demonstrate that it is not possible to conclusively establish the differences among coffees evaluated with basis on varieties and environmental factors previously cited. It can be concluded that it is not recommended to associate the quality of coffee only to a specific factor whether from the environment or being it a specific of the culture of coffee. However, the cafes that were evaluated had intrinsic quality, which were derived from the specific characteristics of the “Matas de Minas” region where they were grown.

关键词： Top Quality Coffee Mountain Coffee Coffee Cherry

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