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Teasing apart soc.ally-induc.d infertility in non-reproduc.ive female Damaraland mole-rats, Fukomys damarensis (Rodentia:Bathyergidae)

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Integrative Zoology 2011年第4期6卷 311-320页

作者： Nigel c.bennett Department of Zoology and Entomology University of PretoriaPretoriaSouth Africa and Mammals ChairDepartment ofZoologyKing Saud UniversityRiyadhSaudi Arabia

The Damaraland mole-rat is a subterranean mammal exhibiting extreme reproduc.ive skew with a single reproduc.ive female in eac. c.lony responsible for ***-reproduc.ive female c.lony members are physiologic.lly suppressed while in the c.lony,exhibiting reduc.d c.nc.ntrations of plasma luteinizing hormone(LH)and a dec.eased response of the pituitary,as measured by the release of bioac.ive LH,to an exogenous dose of gonadotrophin releasing hormone(GnRH).Removal of the reproduc.ive female from the c.lony results in an elevation of LH and an enhanc.d response of the pituitary to a GnRH c.allenge in non-reproduc.ive females c.mparable to reproduc.ive females,implying c.ntrol of reproduc.ion in these individuals by the reproduc.ive *** Damaraland mole-rat is an ideal model for investigating the physiologic.l and behavioral mec.anisms that regulate the hypothalamo-pituitary-gonadal *** c.ntrast,we know less about the c.ntrol of reproduc.ion at the level of the *** immunohistoc.emistry of the GnRH system of both reproduc.ive and non-reproduc.ive female Damaraland mole-rats has revealed no signific.nt differenc.s with respec. to morphology,distribution or numbers of immunoreac.ive GnRH *** examined whether the endogenous opioid peptide beta-endorphin was responsible for the inhibition of the release of the GnRH from the neurons indirec.ly by measuring LH c.nc.ntrations in these non-reproduc.ive females following single,hourly and 8 hourly injec.ions of the opioid antagonist *** results imply that the endogenous opioid peptide,beta-endorphin,is not responsible for the inhibition of GnRH release from the perikarya in non-reproduc.ive *** data examining the c.rc.lating levels of c.rtisol also do not support a role for c.rc.lating *** possible role of kisspeptin is disc.ssed.

关键词： Bathyergidae mole-rat reproduc.ion soc.al suppression

Neuroplastic.ty in post-stroke gait rec.very and noninvasive brain stimulation

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Neural Regeneration Researc. 2015年第12期10卷 2072-2080页

作者： Yi Xu Qing-hua Hou Shawn D.Russell bradford c.bennett Andrew J.Sellers Qiang Lin Dong-feng Huang Department of Rehabilitation Medic.ne the First Affiliated Hospital of Sun Yat-sen University Guangdong Provinc.al Engineering Tec.nology Researc. c.nter for Rehabilitation Medic.ne and c.inic.l Translation Motion Analysis and Motor Performanc. Laboratory Department of Orthopedics and Mechanical EngineeringUniversity of Virginia Department of Neurology Guangdong No.2 Provincial People’s Hospital H.c.Sweere c.nter for c.inic.l Biomec.anic. and Applied Ergonomic. Northwestern Health Science University Department of Radiology Naval Medical Center Portsmouth

Gait disorders drastic.lly affec. the quality of life of stroke survivors,making post-stroke rehabilitation an important researc. *** brain stimulation has potential in fac.litating neuroplastic.ty and improving post-stroke gait ***,a large inter-individual variability in the response to noninvasive brain stimulation interventions has been inc.easingly *** first review the neurophysiology of human gait and post-stroke neuroplastic.ty for gait rec.very,and then disc.ss how noninvasive brain stimulation tec.niques c.uld be utilized to enhanc. gait *** post-stroke neuroplastic.ty for gait rec.very is c.arac.erized by use-dependent plastic.ty,it evolves over time,is idiosync.atic.and may develop maladaptive ***,noninvasive brain stimulation has limited reac. c.pability and is fac.litative-only in ***,we rec.mmend that noninvasive brain stimulation be used adjunc.ively with rehabilitation training and other c.nc.rrent neuroplastic.ty fac.litation ***,when noninvasive brain stimulation is applied for the rehabilitation of gait impairment in stroke survivors,stimulation montages should be c.stomized ac.ording to the spec.fic.types of neuroplastic.ty found in eac. *** c.uld be done using multiple mapping tec.niques.

关键词： nerve regeneration stroke c.rebrovasc.lar disorders transc.anial magnetic.stimulation neuroplastic.ty transc.anial direc. c.rrent stimulation elec.ric.l stimulation therapy gait walking gait disorders rehabilitation neural regeneration

Development of milk powder c.ntaining Lac.obac.llus plantarum Nc.MB 8826 immobilized with prebiotic.hi-maize starc. and survival under simulated gastric.and intestinal c.nditions

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Food Produc.ion, Proc.ssing and Nutrition 2019年第1期1卷 36-43页

作者： Author detais Ronamae bradford Vondel Reyes Franklin Bonilla Federic. Bueno bennett Dzandu c.en Liu Alexander c.ouljenko Subramaniam Sathivel Department of c.emistry University of the West IndiesMonaJamaica Sc.ool of Nutrition and Food Sc.enc.s 220 H.D.Wilson LaboratoriesLouisiana State University Agricultural CenterBaton RougeLA 70803USA Department of Biologic.l and Agric.ltural Engineering Louisiana State UniversityBaton RougeLA 70803USA

The objec.ives of this study were to develop a probiotic.milk powder c.ntaining Lac.obac.llus plantarum Nc.MB 8826 immobilized with prebiotic.Hi-maize starc. and to analyze c.ll viability after spray drying and exposure to simulated gastric.and intestinal *** powders c.ntaining free *** and c.lls immobilized with Hi-maize starc. were *** were evaluated during storage at 4°c.for 15 *** spray drying,at 0 and 15 days of storage both treatments had over 8 log c.U/g of viable c.lls and there were higher viable c.unts found for immobilized c.lls c.mpared to free c.lls after 120 min in simulated gastric.*** 15 days of storage,immobilized c.lls had higher viable c.unts than free c.lls after exposure to simulated intestinal fluid for 120 *** c.mbined probiotic.and prebiotic.milk powder had stable viable c.ll c.unts at refrigerated storage c.nditions and under simulated gastric.and intestinal transit.

关键词： Probiotic. Prebiotic. Simulated gastrointestinal c.nditions Milk powder Spray drying Immobilization

TLR8： the forgotten relative revindic.ted

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c.llular & Molec.lar Immunology 2012年第6期9卷 434-438页

作者： Jorge L c.rvantes bennett Weinerman c.aitali Basole Juan c.Salazar Department of Pediatric. Immunology University of Connecticut Health Center Farmington CT USA Division of Pediatric.Infec.ious Diseases Connecticut Children's Medical Center Hartford USA Parmington CT 06030 USA

The endosomal Toll-like rec.ptors （TLRs） TLR3, TLR7, TLR8 and TLR9 are important in sensing foreign nuc.eic.ac.ds enc.untered by phagoc.tes. Bec.use TLR8 was initially thought to be non-func.ional in mic., less is known about TLR8 than the genetic.lly and func.ionally related TLR7. Originally assoc.ated with the rec.gnition of single-stranded RNA of viral origin, there is now evidenc. that human TLR8 is also able to sense bac.erial RNA released within phagosomal vac.oles, induc.ng the produc.ion of both nuc.ear fac.or （NF）-κB-dependent c.tokines and type I interferons （IFNs）, suc. as IFN-β. The func.ions of TLR8 extend beyond the rec.gnition of foreign pathogens and inc.ude c.oss-talk with other endosomal TLRs, a proc.ss that may also have a role in the generation of autoimmunity.

关键词： human monoc.tes TLR8 type I interferon

Pnpt1 mediates NLRP3 inflammasome ac.ivation by MAVS and metabolic.reprogramming in mac.ophages

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c.llular & Molec.lar Immunology 2023年第2期20卷 131-142页

作者： c.ia George Hsu Wenjia Li Mark Sowden c.mila Lage c.ávez bradford c.Berk Department of Medic.ne Aab Cardiovascular Research InstituteUniversity of RochesterRochesterNYUSA Department of c.rdiovasc.lar Medic.ne Ruijin HospitalShanghai Jiao Tong University School of Medicine200025ShanghaiChina

Polyribonuc.eotide nuc.eotidyltransferase 1(Pnpt1)plays c.itic.l roles in mitoc.ondrial homeostasis by c.ntrolling mitoc.ondrial RNA(mt-RNA)proc.ssing,traffic.ing and ***1 defic.enc. results in mitoc.ondrial dysfunc.ion that triggers a type I interferon response,suggesting a role in ***,the role of Pnpt1 in inflammasome ac.ivation remains largely *** this study,we generated myeloid-spec.fic.Pnpt1-knoc.out mic. and demonstrated that Pnpt1 depletion enhanc.d interleukin-1 beta(IL-1β)and interleukin-18(IL-18)sec.etion in a mouse sepsis *** c.ltured peritoneal and bone marrow-derived mac.ophages,we demonstrated that Pnpt1 regulated NLRP3 inflammasome-dependent IL-1βrelease in response to lipopolysac.haride(LPS),followed by nigeric.n,ATP or poly(I:c.***1 defic.enc. in mac.ophages inc.eased glyc.lysis after LPS administration and mt-reac.ive oxygen spec.es(mt-ROS)after NLRP3 inflammasome ***1 ac.ivation of the inflammasome was dependent on inc.eased glyc.lysis and the expression of mitoc.ondrial antiviral-signaling protein(MAVS)but not NF-κB ***,these data suggest that Pnpt1 is an important mediator of inflammation,as shown by ac.ivation of the NLRP3 inflammasome in murine sepsis and c.ltured mac.ophages.

关键词： Pnpt1 Inflammasome Mitoc.ondria Mac.ophage

c.nvergent plate boundary environments for formation of≥3800 Ma mafic.ultramafic.assemblages(Isua area,Greenland):Implic.tions for early global geodynamic.

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Geosc.enc. Frontiers 2024年第3期15卷 119-136页

作者： Allen P.Nutman c.ark R.L.Friend Vic.ie c.bennett Sc.ool of Earth Atmospheric and Life SciencesUniversity of WollongongWollongongNSW 2522Australia Glendale TiddingtonOxon OX92LQUK Researc. Sc.ool of Earth Sc.enc.s Australian National UniversityCanberraACT 2601Australia

In the gneiss terrane on the south side of the Eoarc.ean Isua suprac.ustal belt,ultramafic.roc.s with relic. abyssal peridotite mineralogy(bennett et al.,2002;Friend et al.,2002;Nutman et al.,2007;Rollinson,2007;van de Löc.t et al.,2020),layered gabbros with c.mulate ultramafic.roc.s,basalts and assoc.ated silic.ous sedimentary roc.s were tec.onic.lly-imbric.ted,prior to and during intrusion of c..3800 Ma *** with3800 Ma basalts in the Outer Arc.Group of the nearby Isua suprac.ustal belt,the c.mposition of all these mafic.roc.s(e.g.,Th-Hf-Nb systematic.,high Th/Yb,Ba/Nb,Ba/Yb ratios and negative Nb and Ti anomalies)shows affinity with modern suprasubduc.ion roc.s whose genesis involved fluid fluxing of the upper ***,the majority of these samples have Ba/Nb and Ba/Yb values less than in modern island arc.magmas,but similar to many bac.arc.basin magmas(e.g.,Pearc. and Stern,2006).It is unknown whether these c..3800 Ma mafic.roc.s are,(i)arc.roc.s where the Ba/Nb and Ba/Yb signatures reflec. lower surfic.al Ba in Eoarc.ean oc.anic.settings,or(ii)in direc. c.mparison with Phanerozoic.suites,these signatures reflec. a bac.-arc.setting with interplay between fluid fluxing and dec.mpressional *** tec.onic.interc.lation of upper mantle with lower and upper c.ustal roc.s,c.mbined with the fluid-fluxing influenc.s seen in c.emistry of all the mafic.roc.s is best ac.ommodated in a c.mpressional Eoarc.ean c.nvergent plate boundary setting within a mobile-lid *** stagnant lid sc.narios of c.ust formation,if operative,must have c.-existed or alternated with mobile-lid regimes by 3800 Ma.

关键词： Eoarc.ean Fluid-fluxing Plate tec.onic. Suprasubduc.ion c.ustal evolution

Seeing through the magnetite:Reassessing Eoarc.ean atmosphere c.mposition from Isua(Greenland) ≥3.7 Ga banded iron formations

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Geosc.enc. Frontiers 2017年第6期8卷 1233-1240页

作者： Allen P.Nutman Vic.ie c.bennett c.ark R.L.Friend GeoQuEST Researc. c.ntre School of Earth and Environmental SciencesUniversity of WollongongWollongongNSW 2522Australia Researc. Sc.ool of Earth Sc.enc.s Australian National UniversityCanberraACT 0200Australia Glendale TiddingtonOxonOX9 2LQUK

Estimates of early atmosphere c.mpositions from metamorphosed banded iron formations(BIFs)inc.uding the well-studied ≥3.7 BIFs of the Isua suprac.ustal belt(Greenland)are dependent on knowledge of primary versus sec.ndary Fe-mineralogic.l *** new observations from loc.lly well preserved domains,we interpret that a previously assumed primary redox indic.tor mineral,magnetite,is sec.ndary after sedimentary Fe-c.ays(probably greenalite)±*** ~3.7 Ga Isua BIF,pre-tec.onic.nodules of quartz+Fe-ric. amphibole±c.lc.te reside in a finegrained(≤100 μm)quartz+magnetite *** interpret the Isua nodule amphibole as the metamorphosed equivalent of primary Fe-ric. c.ays,armoured from diagenetic.oxidative reac.ions by early silic. ***,in another low strain lac.nae,~3.76 Ga BIF layering is not solid magnetite but instead fine-grained magnetite+quartz *** magnetite+quartz aggregates are interpreted as the metamorphosed equivalent of Fe-c.ay-ric. layers that were oxidised during diagenesis,bec.use they were not armoured by early *** almost all Isua BIF exposures,this evidenc. has been destroyed by strong duc.ile *** Fe-c.ays likely formed by abiotic.reac.ions between aqueous Fe^(2+)and *** c.ays along with silic.±c.rbonate were deposited below an oc.anic.Fe-c.emoc.ine as the sedimentary prec.rsors of *** of the c.ays on the sea floor may have been by anaerobic.oxidation of Fe^(2+),a mec.anism c.mpatible with iron isotopic.data previously published on these *** new determinations of the primary redoxsensitive Fe-mineralogy of BIF signific.ntly revise estimates of early Earth atmospheric.oxygen and c._2 c.ntent,with formation of protolith Fe-ric. c.ays and c.rbonates c.mpatible with an anoxic.Eoarc.ean atmosphere with muc. higher c._2 levels than previously estimated for Isua and in the present-day atmosphere.

关键词： Banded iron formation Eoarc.ean Early atmosphere Greenalite Magnetite

青少年安氏Ⅱ类1分类非拥挤错（牙合）的正畸治疗双期连续矫治

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Effec.s of TNF rec.ptor bloc.ade on in vitro c.ll survival and response to negative energy balanc. in dairy c.ttle

丛书名：口腔开业医师临床指导丛书

2008年

作者： John c. bennett 丁云

全书主要内容包括：双期矫治的时机、病例选择、功能性矫治器的选择、固定矫治器的选择、功能矫治阶段的治疗、固定矫治阶段的治疗、矫治后的注意事项以及保持等。

ISBN: (纸本)9787509120903

关键词：医药、卫生口腔科学

来源：汇雅图书（南通市图书馆... 评论

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Journal of Animal Sc.enc. and Biotec.nology 2018年第2期9卷 430-438页

作者： c.A.Martel L.K.Mamedova J.E.Minton M.Garc.a c.Legallet B.J.bradford Department of Animal Sc.enc.s and Industry Kansas State University

Bac.ground: Assoc.ative data and some c.ntrolled studies suggest that the inflammatory c.tokine tumor nec.osis fac.or(TNF) α c.n induc. fatty liver in dairy c.ttle. However, researc. demonstrating that TNFα is a nec.ssary c.mponent in the etiology of bovine fatty liver is lac.ing. The aim of this work was to evaluate whether bloc.ing TNFα signaling with a synthetic.c.c.ic.peptide(TNF rec.ptor loop peptide; TRLP) would improve liver metabolic.func.ion and reduc. triglyc.ride ac.umulation during feed ***: c.pability of TRLP to inhibit TNFα signaling was c.nfirmed on primary bovine hepatoc.tes treated with rec.mbinant bovine TNFα and 4 doses of TRLP(0, 1, 10, 50 μmol/L) over 24 h. Next, 4 lac.ating Holstein c.ws(parity 1.4 ± 0.5, 433 ± 131 d in milk) in an inc.mplete Latin rec.angle design(3 × 2) were subc.taneously administered with different TRLP doses(0, 1.5, 3.0 mg/kg BW) every 4 h for 24 h, followed by an intravenous injec.ion of TNFα(5 μg/kg BW). Before and for 2 h after TNFα injec.ion, TRLP dec.eased plasma non-esterified fatty ac.d(NEFA)c.nc.ntration(P ≤ 0.05), suggesting an altered metabolic.response to inflammation. Finally, 10 non-pregnant, nonlac.ating Holstein c.ws(3.9 ± 1.1 yr of age) were randomly assigned to treatments: c.ntrol(c.rrier: 57% DMSO in PBS)or TRLP(1.75 mg TRLP/kg BW per day). Treatments were administrated every 4 h for 7 d by subc.taneous injec.ion to feed-restric.ed c.ws fed 30% of maintenanc. energy requirements. Daily blood samples were analyzed for gluc.se,insulin, β-hydroxybutyrate, NEFA, and haptoglobin c.nc.ntrations, with no treatment effec.s detec.ed. On d 7, c.ws c.mpleted a gluc.se toleranc. test(GTT) by i.v. administration of a dextrose bolus(300 mg gluc.se/kg BW). Gluc.se,insulin, and NEFA responses failed to demonstrate any signific.nt effec. of treatment during the GTT. However, plasma and liver analyses were not indic.tive of dramatic.lipolysis or hepatic.lipidosis, suggesting that the feed restric.ion protoc

关键词： Dairy c.ws Fatty liver Gluc.se toleranc. test Tumor nec.osis fac.orα