Teasing apart socially-induced infertility in non-reproductive female Damaraland mole-rats, Fukomys damarensis (Rodentia:Bathyergidae)

作     者：Nigel C.BENNETT 

作者机构：Department of Zoology and EntomologyUniversity of PretoriaPretoriaSouth Africa and Mammals ChairDepartment ofZoologyKing Saud UniversityRiyadhSaudi Arabia 

出 版 物：《Integrative Zoology》 (整合动物学（英文版）)

年 卷 期：2011年第6卷第4期

页      面：311-320页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：National Research Foundation University of Cape Town University of Pretoria SARChI Chair for Mammal Behavioral Ecology and Physiology 

主　　题：Bathyergidae mole-rat reproduction social suppression 

摘      要：The Damaraland mole-rat is a subterranean mammal exhibiting extreme reproductive skew with a single reproductive female in each colony responsible for ***-reproductive female colony members are physiologically suppressed while in the colony,exhibiting reduced concentrations of plasma luteinizing hormone(LH)and a decreased response of the pituitary,as measured by the release of bioactive LH,to an exogenous dose of gonadotrophin releasing hormone(GnRH).Removal of the reproductive female from the colony results in an elevation of LH and an enhanced response of the pituitary to a GnRH challenge in non-reproductive females comparable to reproductive females,implying control of reproduction in these individuals by the reproductive *** Damaraland mole-rat is an ideal model for investigating the physiological and behavioral mechanisms that regulate the hypothalamo-pituitary-gonadal *** contrast,we know less about the control of reproduction at the level of the *** immunohistochemistry of the GnRH system of both reproductive and non-reproductive female Damaraland mole-rats has revealed no significant differences with respect to morphology,distribution or numbers of immunoreactive GnRH *** examined whether the endogenous opioid peptide beta-endorphin was responsible for the inhibition of the release of the GnRH from the neurons indirectly by measuring LH concentrations in these non-reproductive females following single,hourly and 8 hourly injections of the opioid antagonist *** results imply that the endogenous opioid peptide,beta-endorphin,is not responsible for the inhibition of GnRH release from the perikarya in non-reproductive *** data examining the circulating levels of cortisol also do not support a role for circulating *** possible role of kisspeptin is discussed.