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Influence of biological sex and exercise on murine cardiac metabolism

Journal of Sport and Health Science 2022年第4期11卷 479-494页

作者： Kyle Fulghum Helen E.Collins Steven P.Jones bradford g.hill Diabetes and Obesity Center Department of MedicineDivision of Environmental MedicineChristina Lee Brown Envirome InstituteUniversity of LouisvilleLouisvilleKY 40202USA Department of Physiology University of LouisvilleLouisvilleKY 40202USA

Although the structural and functional effects of exercise on the heart are well established,the metabolic changes that occur in the heart during and after exercise remain *** this study,we used metabolomics to assess time-dependent changes in the murine cardiac metabolome following 1 session of treadmill *** the exercise bout,we also recorded blood lactate,glucose,and ketone body levels and measured cardiac mitochondrial *** both male and female mice,moderate-and high-intensity exercise acutely increased blood lactate *** both sexes,low-and moderate-intensity exercise augmented circulating 3-hydroxybutryrate levels immediately after the exercise bout;however,only in female mice did high-intensity exercise increase 3-hydroxybutyrate levels,with significant increases occurring 1 h after the exercise *** metabolomics analyses of sedentary female and male hearts suggest considerable sex-dependent differences in basal cardiac metabolite levels,with female hearts characterized by higher levels of pantothenate,pyridoxamine,homoarginine,tryptophan,and several glycerophospholipid and sphingomyelin species and lower levels of numerous metabolites,including acetyl coenzyme A,glucuronate,gulonate,hydroxyproline,prolyl-hydroxyproline,carnosine,anserine,and carnitinylated and glycinated species,as compared with male *** after a bout of treadmill exercise,both male and female hearts had higher levels of corticosterone;however,female mice showed more extensive exercise-induced changes in the cardiac metabolome,characterized by significant,time-dependent changes in amino acids(e.g.,serine,alanine,tyrosine,tryptophan,branched-chain amino acids)and the ketone body *** from experiments using isolated cardiac mitochondria suggest that high-intensity treadmill exercise does not acutely affect respiration or mitochondrial coupling;however,female cardiac mitochondria demonstrate generally higher adenosi

关键词： Ketone bodies Metabolomics Mitochondria Physical activity Sex difference

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Health Data Sharing Platforms:Serving Researchers through Provision of Access to High-Quality Data for Reuse

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Health Data Science 2022年第1期2022卷 24-26页

作者： Rebecca Li Nina hill Catherine D’Arcy Amrutha Baskaran Patricia bradford Vivli CambridgeMAUSA Center for Bioethics Harvard Medical SchoolBostonMAUSA hill Scientific and Public Affairs LLCNYNYUSA Antimicrobial Development Specialists LLCNyack NYUSA

*** The objective of health-related data sharing platforms or repositories is to facilitate access to datasets to either researchers or the *** sharing platforms provide a service to researchers worldwide through providing access to high-quality ***,platforms aggregate disparate data sources that are *** the current spectrum of data sharing platforms,there are a variety of implementation models—open,managed access,and *** selected model depends on the data type and governance required.“Open access”or“open data”approaches allow the data to be freely available via download if the user agrees to sign a simple legal data use agreement or terms of use agreement.“Managed access”or“gatekeeper”models require additional elements for data access—these may involve a research proposal,agreeing to data use agreements,and undergoing a review *** or private repositories typically only allow individuals of a single institution or community to access data.

关键词： Access service Open

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Fundamentals of Investments: Valuation and Management 2nd Edition

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丛书名： The Irwin/Mcgraw-hill series in finance,insurance,and real estate

2002年

作者： Charles J. Corrado bradford D. Jordan

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Essentials of corporate finance / 4th ed.

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丛书名： The Mcgraw-hill/Irwin series in finance, insurance, and real estate

2004年

作者： Stephen A. Ross Randolph W. Westerfield bradford

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Fundamentals of corporate finance / 7th ed.

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丛书名： The Mcgraw-hill/Irwin series in finance, insurance, and real estate

2006年

作者： Stephen A. Ross Randolph W. Westerfield bradford

Includes index.

ISBN: (数字)0072991216

ISBN: (纸本)0073134287

Includes index.

关键词： Corporations

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模式法——如何引导初学者进行科学实践

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中国科技教育 2013年第9期 40-44页

作者： bradford hill 韦文潮(翻译)

如果仅仅只专注于概念，而忽略其问的联系，会造成一种很不幸的后果：学生们会形成对科学探究本质的狭隘理解，以及“科学只是一些孤立的事实”这种印象（NRC2012，P．41）。

关键词：科学实践初学者模式法引导科学探究

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Assessing Influence of Ozone in Tomato Seed Dormancy Alleviation

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American Journal of Plant Sciences 2011年第3期2卷 443-448页

作者： N. Sudhakar D. Nagendra-Prasad N. Mohan bradford hill M. gunasekaran K. Murugesan 不详

The study was made on the role of ozone (O3) gas treatment on seeds of Lycopersicon esculentum cv. PKM1 (tomato) to release dormancy in advance. The experimental conditions followed a complete factorial design with 3 independent factors, i.e. A faster start of germination in T2 treatment (98% - 99%) was observed than in other treatments (T1, T3 and T4) compared to control seeds by measuring seedling growth rate on 5th day after treatment. Never the less a too long and high concentration of O3 treatment seemed to be penalizing on germination rate whereas low O3 concentration (T2) for a moderate time interval (20 min) seemed to be most beneficial. The treated seeds were stored, checked 1, 3, 6 months later and found that, the seeds have retained their accelerated germination efficiency. In particular 1T2 (1 month storage), 3T2 (3 month storage) had maximum germination rate among all the stored treated seeds, but 6T2 (6 month storage) didn’t show sustained germination acceleration efficiency. Therefore it was found that when time prolongs, O3 treatment loss its effect steadily and the germination efficiency of all the treatments are more or less same at six months after treatment. It is hypothesized that the application of O3 acts as an important phenomenon in accelerating seed germination by breaking the dormancy in advance which is associated with reduced level of ABA in O3 treated seeds.

关键词： Abscissic Acid germination Ozone Tomato Seed

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Fundamentals of investments Valuation and management

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丛书名： The Irwin/Mcgraw-hill series in finance, insurance, and real estate

2000年

作者： Charles J.Corrado bradford D.Jordan

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Successes, Challenges and Lessons Learned in Accelerating Introduction of Rotavirus Immunisation in Zambia

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World Journal of Vaccines 2015年第1期5卷 43-53页

作者： Roma Chilengi Cheryl Rudd Carolyn Bolton bradford guffey Penelope Kalesha Masumbu Jeffrey Stringer Centre for Infectious Disease Research in Lusaka Lusaka Zambia University of North Carolina at Chapel hill Chapel Hill USA University of Alabama at Birmingham Birmingham USA Ministry of Health Lusaka Zambia

Introduction: Under five mortality in Zambia is unacceptably high and diarrhoea is the third leading contributor. The Programme for Awareness and Elimination of Diarrhoea (PAED) sought to support the government to accelerate the introduction of new vaccines, including the pneumococcal, second dose measles and rotavirus vaccines in Zambia. Here we present our approach, progress and lessons learned in two years of the programme. Stakeholder Engagement: Definite commitment and buy-in and sign off by the MOH were fundamental prerequisites. National and international stakeholders including the Inter Agency Coordinating Committee (ICC), gAVI Alliance, WHO, University Teaching Hospital, Paediatrics Association of Zambia, and UNICEF were engaged for stakeholder buy-in and integration. Progress made: Following successful integration, PAED was officially launched in January 2012. Preparatory work done included: Introduction and acceptance of the PAED agenda in ICC, new vaccines proposal to gAVI, resource mobilisation, Effective Vaccine Management implementation, national cold chain scale-up strategy, vaccine orientation and adapted data collection tools, health worker training, step-wise vaccine introduction to Lusaka province districts and finally national roll-out of the rotavirus vaccine immunisation. Between January 2011 and November 2013, over 270,000 vaccine doses were distributed in Lusaka province. When 94,500 infants were fully immunised, adequate preparations had been made to facilitate national launch of rotavirus immunisations countrywide on 27th November 2013. Discussion: The PAED model was successful at resource mobilization;it has demonstrated how private sector can contribute to new vaccine introduction. Lessons learned from this model can be replicated in other countries with similar need and constraints.

关键词： Zambia Rotavirus Vaccines Introduction Cold Chain

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Fundamentals of corporate finance 7th ed.

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丛书名： The Mcgraw-hill/Irwin series in finance, insurance, and real estate

2008年

作者： Stephen A. Ross Randolph W. Westerfield bradford D. Jordan.

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