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Nano Research 2009年第6期2卷 500-508页

作者： Aaron M.Mohs Hongwei Duan brad A.Kairdolf Andrew M.Smith Shuming Nie Departments of Biomedical Engineering and Chemistry Emory University and Georgia Institute of Technology101 Woodruff Circle NESuite 2001AtlantaGeorgia 30322USA

Semiconductor quantum dots(QDs)have shown great promise as fluorescent probes for molecular,cellular and in vivo ***,the fluorescence of traditional polymer-encapsulated QDs is often quenched by proton-induced etching in acidic *** is a major problem for applications of QDs in the gastrointestinal tract because the gastric(stomach)environment is strongly acidic(pH 12).Here we report the use of proton-resistant surface coatings to stabilize QD fl uorescence under acidic *** both hyperbranched polyethylenimine(PEI)and its polyethylene glycol derivative(PEG-grafted PEI),we show that the fl uorescence of coreshell CdSe/CdS/ZnS QDs is effectively protected from quenching in simulated gastric *** comparison,amphiphilic lipid or polymer coatings provide no protection under similarly acidic *** proton-resistant QDs are found to cause moderate membrane damage to cultured epithelial cells,but PEGylation(PEG grafting)can be used to reduce cellular toxicity and to improve nanoparticle stability.

关键词： Nanoparticle quantum dot oral delivery gastrointestinal polyethylenimine(PEI) polyethylene glycol(PEG)

急性肺损伤的肺泡巨噬细胞TNF—α及IL—8免疫组织化学研究

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中华病理学杂志 1996年第1X期26卷 43-44页

作者：梁延杰 Chi.,ey

Physiological Responses to Agonist-Antagonist Superset Resistance Training

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Journal of Science in Sport and Exercise 2021年第4期3卷 355-363页

作者： Julius Fink brad Jon Schoenfeld Mikako Sakamaki-Sunaga Koichi Nakazato Department of Urology Graduate School of MedicineJuntendo University2-1-1HongoBunkyo-kuTokyo 113-8421Japan Department of Health Sciences Lehman CollegeBronxNYUSA Graduate Schools of Health and Sport Science Nippon Sport Science UniversityTokyoJapan

Purpose To investigate the physiological responses to low-load,superset resistance training(two exercises for the agonist and antagonist muscles performed without rest between exercises)to failure using elastic *** Twenty-three athletes were randomized to either a superset group(S,n=12,average age:19.8±1.5 years)or a traditional set group(T,n=11,average age:20.1±1.4 years).Strength,cross-sectional area(CSA)and muscular endurance of the biceps and triceps brachii were assessed before and after 8 *** responses(muscle thickness)were measured during one testing *** Muscle thickness of the biceps significantly increased in both T group(P0.05)or S group(P>0.05).Blood lactate also increased in both groups after one bout of training(T:from 1.3±0.3 to 5.5±2.4 mmol/L,S:from 1.4±0.5 to 5.1±1.5 mmol/L,P<0.05).After 8-week training,both groups showed significant increases in the biceps(T:13.2%±5.0%;S:12.9%±7.3%,P<0.05)and triceps(T:9.5%±9.3%,S:4.8%±4.1%,P<0.05)without differences between *** in one repetition maximum for the bench press(7.8%±6.5%,P<0.05)and maximal voluntary contraction for the arm extensors(9.3%±11.6%,P<0.05)were observed for the T group *** in muscular endurance were observed only in the S group for the bench press(26.0%±19.1%,P<0.05)and the barbell curl(17.2%±16.6%,P<0.05).Conclusions Superset training may enhance muscular endurance while attenuating maximal strength *** does not appear to be a hypertrophic benefit to performing superset training,but it may provide a time-efficient strategy to achieve adaptations in muscle mass.

关键词： Muscle hypertrophy Strength Endurance Thickness Cross-sectional area

The Improvements of the Backhoe-Loader Arms

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Modeling and Numerical Simulation of Material Science 2013年第4期3卷 142-148页

作者： Ahmet Erklig eyüp Yeter Department of Mechanical Engineering Faculty of Engineering University of Gaziantep Gaziantep Turkey

In this study, static structural analysis of backhoe-loader arms has been performed with the finite element method (FEM). The aim of this study is to simulate and strengthen the back and front arms of the backhoe-loader concerning with stress under maximum loading condition and different boundary conditions. According to analysis result, back and front arms of the backhoe-loader are strengthened with the use of reinforcements. As a result of the study, strength of the arms has been increased by nearly 20%.

关键词： Backhoe-Loader Finite Element Simulation ANSYS

Roles of SlETR7,a newly discovered ethylene receptor,in tomato plant and fruit development

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Horticulture Research 2020年第1期7卷 2585-2596页

作者： Yi Chen Guojian Hu Celeste Rodriguez Meiying Liu brad M.Binder Christian Chervin College of Food and Pharmaceutical Sciences Ningbo UniversityNingboChina Genomics and Biotechnology of Fruits University of ToulouseINRAENSAT31326 Castanet-TolosanFrance Department of Biochemistry&Cellular and Molecular Biology University of TennesseeKnoxvilleTNUSA Weifang University Weifang 261041 ShandongChina

Ethylene regulates many aspects of plant growth and *** is perceived by a family of ethylene receptors(ETRs)that have been well ***,a full understanding of ETR function is complicated by functional redundancy between the receptor ***,we characterize a new ETR,SlETR7,that was revealed by tomato genome ***7 expression in tomato fruit pericarp increases when the fruit ripens and its expression is synchronized with the expression of SlETR1,SlETR2,and SlETR5 which occurs later in the ripening phase than the increase observed for SlETR3,SlETR4,and *** uncovered an error in the SlETR7 sequence as documented in the ITAG 3 versions of the tomato genome which has now been corrected in ITAG 4,and we showed that it belongs to sub-family *** also showed that SlETR7 specifically binds ***(OE)of SlETR7 resulted in earlier flowering,shorter plants,and smaller fruit than wild ***-out(KO)mutants of SlETR7 produced more ethylene at breaker(Br)and Br+2 days stages compared to wild type(WT),but there were no other obvious changes in the plant and fruit in these mutant *** observed that expression of the other SlETRs is upregulated in fruit of SlETR7 KO mutants,which may explain the absence of obvious ripening ***,these results show that SlETR7 is a functional ethylene *** work is needed to better understand its specific roles related to the six other tomato ETRs.

关键词： ETR plant fruit

The impact of alloantibodies directed against the second donor on long-term outcomes of repeat liver transplantation

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 246-252页

作者： Qingyong Xu brad Shrum Steve Leckie Anton Skaro Vivian C.McAlister Department of Pathology and Lab Medicine University of Western OntarioLondonONCanada Department of Surgery University of Western OntarioLondonONCanada

Background:Despite reports that associate donor specific antibody(DSA)with rejection after liver transplantation,grafts are still allocated according to blood group(ABO)but not human leukocyte antigen(HLA)compatibility,possibly due to the absence of an easily discernible clinical association between adverse recipient outcome and ***-transplantation provides a test environment where the presence of preformed DSA is prevalent and its effect on outcome should be ***:All patients undergoing a second liver transplantation with available pre-operative serum were included with the exception of ABO incompatible or multiple organ *** sera were tested for anti-HLA antibodies with Luminex-based solid phase ***-HLA antibodies to the second donor(D2SA)were determined using antibodies specificity and HLA typing of 2nd liver ***:Preformed HLA antibodies directed to second liver transplantation(D2SA)were found in 31(39%)of the 79 patients that were included in the *** and re-transplantation characteristics were similar in both subgroups except first graft survival which was significantly shorter in recipients who are negative for *** survival of the second graft was similar in D2SA+and D2SA?cohorts[8.55(range,0.01–24.74)vs.7.56(range,0–23.53)years respectively,P=0.574].Mean patient survival after 2nd liver transplantation was similar in D2SA+and D2SA?cohorts[9.11(range,0.01–24.74)vs.8.10(range,0–23.53)years respectively,P=0.504].Subgroup univariate analysis demonstrated no detrimental effect of class,locus,or strength of D2SA on survival of the second liver *** multivariate cox regression model,neither class I D2DSA(HR=1.101,P=0.92)nor class II D2SA(HR=1.74,P=0.359)were significant risks of graft ***:Presence of D2SA was not found to be associated with inferior outcomes in this retrospective cohort study of liver re-transplantation suggesting that changes to the allocation system are not requ

关键词： Donor-specific antibodies(DSA) human leucocytes antigen(HLA) liver transplantation

Consciousness &Time: A Time-Based Model of the Evolution of Consciousness

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Journal of Behavioral and Brain Science 2017年第1期7卷 9-20页

作者： brad Bowins Centre for Theoretical Research in Psychiatry & Clinical Psychology Toronto Canada

A novel theoretical model is presented maintaining that consciousness evolved on the basis of time distinctions. Various models of time pertain to the existence of future, present and past. It is proposed that the future represents potentialities, the present the actualization of certain potentialities, and the past a record of actualized potentialities. Actualization of potentialities derives from micro quantum wave function collapses with specific constellations corresponding to macro level form. Consciousness provides for an awareness of potentialities being actualized in the present, the time frame of consciousness closely aligning with the time frame of potentialities being actualized in the moment. Evolution of such awareness is highly probable, given the ensuing motivation enabling behavior to be altered in the moment to minimize the actualization of maladaptive potentialities, and maximize the actualization of adaptive potentialities. The model also provides a logical proof for the occurrence of time distinctions.

关键词： Consciousness Evolution of Consciousness Psychological Arrow of Time Time Space-Time Quantum

新生儿骨传导短声听觉脑干电反应重复测试变异

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国际耳鼻咽喉头颈外科杂志 1994年第6期18卷 359-360页

作者： Yang-ey 殷善开

TaARPC5 is required for wheat defense signaling in response to infection by the stripe rust fungus

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The Crop Journal 2022年第1期10卷 88-97页

作者： Jia Guo Huan Peng Tuo Qi Sanding Xu Md Ashraful Islam brad Day Qing Ma Zhensheng Kang Jun Guo State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F UniversityYangling 712100ShaanxiChina Department of Plant Soil and Microbial SciencesMichigan State UniversityEast LansingMI 48824USA

Numerous studies using a combination of confocal microscopic-and pharmacological-based approaches have demonstrated that the actin cytoskeleton dynamically responds to pathogen ***,we observed that phalloidin treatment induced actin nucleation,resulting in enhanced resistance of wheat against the stripe rust pathogen Puccinia striiformis ***(Pst).To define the mechanism underpinning this process,we characterized a family of conserved actin-binding proteins,the actin related protein(ARP)family,which controls actin ***,we identified and characterized a wheat ARPC gene(Ta ARPC5),which encodes a 136-amino acid protein containing a P16-Arc domain,the smallest subunit of the ARP2/3 *** ARPC5 m RNA accumulation was induced following the infection of plants with the avirulent Pst strain,and following the elicitation with flagellin(e.g.,flg22)as *** localization analysis revealed that Ta ARPC5 is primarily localized to the cortical actin cytoskeleton,and its precise cellular localizations suggest the proximity to processes correlated with the actin-organelle *** treatment with virulent Pst,Ta ARPC5-knockdown plants exhibited a significant reduction in the expression of PTI-specific m ***,we observed enhanced induction of reactive oxygen species(ROS)accumulation and a decrease in Ta CAT1 expression following infection with an incompatible Pst *** with yeast complementation assays,the current study demonstrates a role for Ta ARPC5 in resistance signaling in wheat against Pst infection by regulating the host actin cytoskeleton.

关键词： ARPC5 Cytoskeleton Wheat Puccinia striiformis f.sp.tritici Virus-induced gene silencing(VIGS)

Discussions on rockburst and dynamic ground support in deep mines

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 1110-1118页

作者： Charlie C.Li Peter Mikula brad Simser Bruce Hebblewhite William Joughin Xiaowei Feng Nuwen Xu Norwegian University of Science and Technology (NTNU) Trondheim Norway Mikula Geotechnics Pty. Ltd. Kalgoorlie Australia Glencore Company Sudbury Canada The University of New South Wales (UNSW) Sydney Australia SRK Consulting Johannesburg South Africa China University of Mining and Technology Xuzhou China Sichuan University Chengdu China

The paper is a summary of discussions on four topics in rockburst and dynamic ground *** 1 is the mechanisms of *** events are classified into two categories in accordance with the triggering mechanisms,*** burst and fault-slip *** burst occurs on rock surfaces when the tangential stress exceeds the rock strength in hard and brittle ***-slip burst is triggered by fault-slip induced *** 2 is prediction and forecasting of rockburst *** for a rockburst event must tell the location,timing and magnitude of the *** could simply foresee the probability of some of the three *** is extremely challenging to predict rockbursts and large seismic events with current knowledge and technologies,but forecasting is possible,for example the possible locations of strain burst in an underground *** present,the approach using seismic monitoring and numerical modelling is a promising forecasting *** 3 is preconditioning *** current preconditioning methods are blasting,relief-hole drilling and *** fault-slip seismicity is difficult and challenging but has been *** very deep locations(>3000 m),the fracturing could extend from the excavation face to a deep location ahead of the face and therefore preconditioning is usually not *** 4 is dynamic ground support against *** ground support requires that the support system be strong enough to sustain the momentum of the ejecting rock on one hand and tough enough on the other hand to absorb the strain and seismic energies released from the rock *** current dynamic support systems in underground mining are composed of yielding tendons and flexible surface retaining elements like mesh/screen and *** props and engineered timber props are also used for dynamic support.

关键词： Rockburst Seismic event Dynamic ground support Forecasting Preconditioning