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Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： marco A.Fornazieri bruno m.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard L.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

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Grafting affects yield and phenolic prof ile of Solanum melongena L. landraces

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Journal of Integrative Agriculture 2016年第5期15卷 1017-1024页

作者： L Sabatino G Iapichino A maggio E D’ Anna m bruno F D’ Anna Department of Agricultural and Forest Sciences University of Palermo Department of Biological Chemical and Pharmaceutical Sciences and Technologies University of Palermo Regional Centres for Agricultural Technologies (Ce.R.T.A.) University of Foggia

The influence of grafting on agronomical and qualitative characteristics of four Sicilian eggplant landraces was investigated. Grafted and ungrafted plants were compared in the open field in the northern coast of Sicily. Solanum torvum seedlings were used as rootstock. Regardless of genotypes tested, grafting significantly increased total fruit production, marketable production, and number of marketable fruits, but did not affect weight of marketable fruits and waste production. Landrace 2（Sciacca）, with black epidermal tissue and pyriform fruit shape, when grafted onto S. torvum not only gave a higher yield performance than ungrafted plants, but also showed a higher phenolic antioxidant content. Landrace 4（Sicilia）, with black epidermal tissue and small cylindrical fruits also benefited, when grafted onto S. torvum, from a substantial increase in antioxidant fruit content. As consumers＇ demand for fruits and vegetables rich in compounds important for human health is steadily increasing, these landrace/rootstock combinations should deserve more attention by plant nurseries involved in grafted seedling production and interested in the valorization and conservation of eggplant biodiversity.

关键词： eggplant propagation technique yield polyphenols HPLC analysis

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Association between EGF +61A/G polymorphism and gastric cancer in Caucasians

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World Journal of Gastroenterology 2011年第4期17卷 488-492页

作者： Ana Paula Araújo bruno m Costa Ana L Pinto-Correia maria Fragoso Paula Ferreira mário Dinis-Ribeiro Sandra Costa Rui m Reis Rui medeiros molecular Oncology Group Portuguese Institute of Oncology of Porto Life and Health Sciences Research Institute (ICVS) School of Health Sciences Oncology Department Portuguese Institute of Oncology of Porto Gastroenterology Department Portuguese Institute of Oncology of Porto Portugal Cintesis/Faculty of medicine University of Porto Centro de Estudos em Biomedicina Health Sciences Faculty-Fernando Pessoa University Instituto de Ciencias Biomédicas de Abel Salazar Abel Salazar Institute for the Biomedical Sciences

AIm: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. mETHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.

关键词： Epidermal growth factor polymorphism Epidermal growth factor receptor Gastric cancer

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Circulating cytokeratin-positive cells and tumor budding in colorectal cancer

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World Journal of Clinical Oncology 2016年第6期7卷 433-440页

作者： bruno m?rkl Narjes Wilhelms matthias Anthuber Gerhard Schenkirsch Günter Schlimok Daniel Oruzio Institute of Pathology Klinikum Augsburg Department of Visceral Surgery Klinikum Augsburg Clinical and Population-Based Cancer Registry Augsburg Hematology and Oncology Diakonissen-krankenhaus Augsburg Onkologische Praxis mVZ

AIm To investigate whether circulating cytokeratin-positive(CK^+) cells in the mesenteric blood of resected colorectal specimens are prognostic and correlate with tumor *** Fifty-six colorectal specimens were collected between 9/2007 and 7/*** from the mesenteric vein was drawn immediately after receiving the fresh and unfixed specimens in the pathology *** separation of the mononuclear cells by Ficoll-Hypaquedensity-gradient centrifugation,cytological smears were immunocytochemically stained for *** budding was evaluated on slides stained for *** identification of ≥ 30 buds/1.3 mm2 was defined as high grade *** CK^+ cells and clusters were identified in 29(48%) and 14(25%) of the samples,*** cells were identified in one of three non-malignant *** were found exclusively in malignant *** occurrence of CK^+ cells or clusters was not associated with any of the evaluated clinicopathological factors,including surgical technique and tumor ***,the occurrence of CK^+ cells or clusters had no influence on the cancerspecific survival [75 mo(CI:61;88) vs 83 mo(CI:72;95) and 80 mo(CI:63;98) vs 79 mo(CI:69;89),respectively].CONCLUSION CK^+ cells and showed neither prognostic significance nor an association with tumor *** is very likely that CK18-staining is not specific enough to identify the relevant cells.

关键词： Colorectal cancer Circulating cells Tumor budding Peripheral blood Survival

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Lessons from a methanol poisoning outbreak in Egypt: Six case reports

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World Journal of Critical Care medicine 2020年第3期9卷 54-62页

作者： Ahmed S Gouda Amr m Khattab bruno mégarbane National Egyptian Center of Environmental and Toxicological Research Faculty of MedicineCairo UniversityCairo 11562Egypt Department of Forensic medicine and clinical Toxicology Faculty of MedicineCairo UniversityCairo 11562Egypt Department of medical and Toxicological Critical Care Lariboisière HospitalParis 75010France

BACKGROUND mass methanol poisonings are challenging,especially in regions with no preparedness,management guidelines and available *** SUmmARY Six Ukrainian patients were referred to our emergency department in Cairo,Egypt several hours after drinking an alcoholic beverage made of 70%-ethanol disinfectant bought from a local *** patients presented with severe metabolic acidosis and visual *** were *** was based on the clinical features and chemistry tests due to deficient resources for methanol *** antidote was administered due to fomepizole unavailability and the difficulties expected to obtain ethanol and safely administer it without concentration *** patient died from multiorgan failure,another developed blindness and the four other patients rapidly *** This methanol poisoning outbreak strongly highlights the lack of safety from hazardous pharmaceuticals sold in pharmacies and limitations due to the lack of diagnostic testing,antidote availability and staff training in countries with limited-resources such as Egypt.

关键词： Hemodialysis Limited resources methanol metabolic acidosis Outbreak Poisoning Case report

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Tibetan herbal formula Padma Digestin modulates gastrointestinal motility in vitro

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2013年第1期4卷 9-15页

作者： bruno m Balsiger magali Krayer Andreas Rickenbacher Beatrice Flogerzi Cecile Vennos Juergen m Gschossmann Department of Clinical Research University of Berne 3001 Bern Switzerland Clinic for Gastroenterology Lindenhofspital (Hochhaus) 3001 Bern Switzerland Department of Gastroenterology University of Berne 3001 BernSwitzerland Department of Visceral and Transplant Surgery University of Zürich 8006 Zürich Switzerland Scientific Division Padma Inc. 8340 Hinwil Switzerland Department of Internal medicine Klinikum Forchheim/Friedrich-Alexander Universit t ErlangenNürnberg 91301 Forchheim Germany

AIm:To examine the effects of Padma Digestin on the smooth muscle motility of different gastrointestinal segments in vitro . mETHODS:The effects of the ethanolic extract of Padma Digestin (at 8.16 mg/mL or 81.6mg/mL) on the contractility and susceptibility to acetylcholine (ACh) of muscle strips from the cardia, antrum, pylorus, duodenum, jejunum, ileum and colon of male Wistar rats were ***:Compared with the control treatment, the Padma Digestin extract had a procontractile effect on the antral smooth muscle strips. Padma Digestin decreased ACh sensitivity in cardia muscle strips and increased it in those from the antrum and pylorus. In the intestinal segments, spontaneous contractility was inhibited in both the duodenal and jejunal strips, whereas reactivity to ACh was inhibited in the jejunal strips only. In the colonic samples, Padma Digestin inhibited spontaneous and ACh-stimulated contractility at a low dose but seems to have increasing effects at a high dose. CONCLUSION:Padma Digestin extract has regionspecific effects on the contractility and excitability of gastrointestinal smooth muscle. Our results support the traditional use of Padma Digestin for maldigestion and functional gastrointestinal disorders.

关键词： Tibetan medicine System Herbal Gastrointestinal motility Smooth muscle Padma Digestin

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Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A meV

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Nuclear Science and Techniques 2013年第5期24卷 82-88页

作者： FRANCALANZA L ABBONDANNO U AmORINI F BARLINI S BINI m BOUGAULT R bruno m CARDELLA G CASINI G AGOSTINO m D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAmEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N mAIOLINO C mARINI P mORELLI L OLmI A PAGANO A PAPA m PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L INFN Laboratori Nazionali del Sud-LNS Catania 95123Italy Dipartimento di Fisica Universitàdi Catania I-95129Italy INFN Sezione di Trieste Trieste I-34127Italy Dipartimento di Fisica Universitàdi FirenzeINFN Sezione di Firenze 1-50139Italy LPC Caen IN2P3-CNRS/ENSICAEN and UniversitéF-14050 Caen cedex 5-140France Dipartimento di Fisica Universitàdi Bologna and INFN Sezione di Bologna 4-50121Italy INFN Sezione di Catania I-95129 Italy INFN Sezione di Firenze I-50139 Italy Dipartimento di Fisica Universitàdi Milano and INFN Sezione di Milano1-20126Italy INFN Laboratori Nazionali di Legnaro 1-35020 Italy Centro Siciliano di Fisica Nucleare e Struttura della materia Catania 1-95129Italy UniversitàKore Enna 1-94100Italy

The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A meV,collected by using the CHImERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy *** a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy *** the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been *** main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their *** emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear *** evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport *** approaches have been envisaged(dynamical stochastic BNV calculations + sequential SImON code,QmD,ComD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of ImFs close to the heavy *** deviations from sequential processes were found for those ImFs in the region of masses intermediate between the mass of heavy residues and the mass of light *** simulations are in *** experimental analysis will be enriched also by information obtained inspecting the ImF-ImF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having

关键词：多重碎裂中心碰撞蒸发过程 meV 竞争熔合国际货币基金组织事件分析

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Synthetic Reconstruction of Water Demand Time Series for Real Time Demand Forecasting

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Journal of Water Resource and Protection 2014年第15期6卷 1437-1443页

作者： bruno m.Brentan Lubienska C.L.J.Ribeiro Edevar Luvizotto Jr. Danilo C.mendonca Jose m.Guidi Water Recourses Department School of Civil EngineeringUnicampCampinasBrazil School of Technology UnicampLimeiraBrazil Company of Water Supply of Sao Paulo FrancaBrazil

The forecasting of the demand applied to water supply systems has been an important tool to realize time control. The use of the time series to do the forecasting of the demand is the main way that has been used by researchers. By this way, the need of a complete time demand series increases. This work presents two ways to reconstruct the water demand time series synthetically, using the Average Reconstruction method and Fourier method. Both the methods were considered interesting to do the synthetic reconstruction and able to complete the time series, but the Fourier method showed better results and a better fitness to approximation of the water consumption pattern.

关键词： Water Demand Forecasting Synthetic Reconstruction Water Supply Systems

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Assessment of the performance of the TOPGNSS and ANN-mB antennas for ionospheric measurements using low-cost u-blox GNSS receivers

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Geodesy and Geodynamics 2024年第3期15卷 291-301页

作者： Daniel Okoh Aderonke Obafaye Oluwakemi Dare-Idowu Babatunde Rabiu Anton Kashcheyev Claudio Cesaroni John Bosco Habarulema bruno Nava United Nations African Regional Centre for Space Science and Technology Education-English(UN-ARCSSTE-E) Obafemi Awolowo University CampusIle IfeNigeria National Institute for Geophysics and Volcanology(INGV) 00143 RomeItaly Institute for Space Science and Engineering African University of Science and TechnologyAbujaNigeria University of New Brunswick FrederictonCanada South African National Space Agency(SANSA) P.O Box 32Hermanus 7200South Africa Department of Physics and Electronics Rhodes University6140 MakhandaSouth Africa The Abdus Salam International Centre for Theoretical Physics Strada Costiera11I-34151 TriesteItaly

Low-cost GNSS receivers have recently been gaining reliability as good candidates for ionospheric studies. In line with these gains are genuine concerns about improving the performance of these receivers. In this work, we present a comprehensive investigation of the performances of two antennas(the u-blox ANN-mB and the TOPGNSS TOP-106) used on a low-cost GNSS receiver known as the u-blox ZED-F9P. The two antennas were installed on two identical and co-located u-blox receivers. Data used from both receivers cover the period from January to June 2022. Results from the study indicate that the signal strengths are dominantly greater for the receiver with the TOPGNSS antenna than for the receiver with the ANN-mB antenna, implying that the TOPGNSS antenna is better than the ANN-mB antenna in terms of providing greater signal strengths. Summarily, the TOPGNSS antenna also performed better in minimizing the occurrence of cycle slips on phase TEC measurements. There are no conspicuous differences between the variances(computed as 5-min standard deviations) of phase TEC measurements for the two antennas, except for a period around may-June when the TOPGNSS gave a better performance in terms of minimizing the variances in phase TEC. Remarkably, the ANN-mB antenna gave a better performance than the TOPGNSS antenna in terms of minimizing the variances in pseudorange TEC for some satellite observations. For precise horizontal(North and East) positioning, the receiver with the TOPGNSS antenna gave better results, while the receiver with the ANN-mB antenna gave better vertical(Up) positioning. The errors for the receivers of both antennas are typically within about 5 m(the monthly mean was usually smaller than 1 m) in the horizontal direction and within about 10 m(the monthly mean was usually smaller than 4 m) in the vertical direction.

关键词： GNSS Ionosphere Low-cost Antenna TOPGNSS U-blox

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Within-host models unravelling the dynamics of dengue reinfections

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Infectious Disease modelling 2024年第2期9卷 458-473页

作者： Vizda Anam bruno V.Guerrero Akhil Kumar Srivastav Nico Stollenwerk maíra Aguiar Basque Center for Applied mathematics Basque CountrySpain Department of mathematics and Statistics University of Basque CountryBasque CountrySpain Ikerbasque Basque Foundation for ScienceBasque CountrySpain

Caused by four serotypes,dengue fever is a major public health concern *** modeling efforts have mostly focused on primary and heterologous secondary infections,assuming that lifelong immunity prevents reinfections by the same ***,recent findings challenge this assumption,prompting a reevaluation of dengue immunity *** this study,we develop a within-host modeling framework to explore different scenarios of dengue *** previous studies,we go beyond a deterministic framework,considering individual immunological *** deterministic and stochastic models are calibrated using empirical data on viral load and antibody(Igm and IgG)concentrations for all dengue serotypes,incorporating confidence intervals derived from stochastic *** good agreement between the mean of the stochastic realizations and the mean field solution for each model,our approach not only successfully captures primary and heterologous secondary infection dynamics facilitated by antibody-dependent enhancement(ADE)but also provides,for the first time,insights into homotypic reinfection *** study discusses the relevance of homotypic reinfections in dengue transmission at the population level,highlighting potential implications for disease prevention and control strategies.

关键词： infections immunity prevention

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