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Biomarkers of hypoxic-ischemic encephalopathy:a systematic review

World Journal of Pediatrics 2023年第6期19卷 505-548页

作者： Ines Caramelo Margarida Coelho Miguel Rosado Carla M.P.Cardoso Alexandra Dinis Carlos B.Duarte Mario Graos br.no manadas CNC-Center for Neuroscience and Cell Biology University of Coimbra3004‑504 CoimbraPortugal PhD Programme in Experimental Biology and Biomedicine Institute for Interdisciplinary Research(IIIUC)University of CoimbraCasa Costa Alemão3030‑789 CoimbraPortugal Chemistry Department Faculty of Sciences and TechnologyUniversity of Coimbra3004‑535 CoimbraPortugal Stemlab SA 3060‑197 CantanhedePortugal Pediatric Intensive Care Unit Hospital PediátricoCentro Hospitalar E Universitário de Coimbra3000‑075 CoimbraPortugal Department of Life Sciences University of Coimbra3001‑401 CoimbraPortugal Biocant Technology Transfer Association3060‑197 CantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)3030‑789 CoimbraPortugal

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement ***,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROSPERO ID:CRD42021272610).Data sources Searches were performed in PubMed,Web of Science,and Science Direct databases until November *** original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were *** was assessed by the Newcastle–Ottawa *** search and data extraction were verified by two authors *** From 373 papers,30 met the inclusion *** from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal *** addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic ***,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to *** Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy ***,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.

关键词： Biomarker Hypoxic-ischemic encephalopathy Neonatal brain injury Newborn Neuron-specific enolase S100-calcium-binding protein-B

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Pathophysiological subtypes of mild cognitive impairment due to Alzheimer’s disease identified by CSF proteomics

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Translational Neurodegeneration 2024年第1期13卷 837-842页

作者： Daniela Moutinho Vera M.Mendes Alessandro Caula Sara C.Madeira Inês Baldeiras Manuela Guerreiro Sandra Cardoso Johan Gobom Henrik Zetterberg Isabel Santana Alexandre De Mendonça Helena Aidos br.no manadas Faculty of Medicine University of Lisbon1649-028 LisbonPortugal CNC-Center for Neuroscience and Cell Biology University of Coimbra3004-504 CoimbraPortugal CIBB-Centre for Innovative Biomedicine and Biotechnology University of CoimbraCoimbraPortugal LASIGE Faculty of SciencesUniversity of Lisbon1649-028 LisbonPortugal Biocomputing Group Department of Pharmacy and BiotechnologyUniversity of BolognaBolognaItaly Faculty of Medicine University of CoimbraCoimbraPortugal Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgS-43180 MölndalSweden Clinical Neurochemistry Laboratory Sahlgrenska University HospitalS-43180 MölndalSweden Department of Neurodegenerative Disease UCL Institute of NeurologyQueen SquareLondon WC1N 3BGUK Kong Center for Neurodegenerative Diseases Clear Water BayHong KongChina Wisconsin Alzheimer’s Disease Research Center School of Medicine and Public HealthUniversity of WisconsinUniversity of Wisconsin-MadisonMadisonWI 53792USA Department of Neurology Hospital and University Centre of CoimbraCoimbraPortugal UK Dementia Research Institute at UCL London WC1N 3BGUK

The number of patients with Alzheimer’s disease(AD)is increasing worldwide due to extended life expectancy,with AD being the most common cause of *** pathological hallmarks consist of brain depositions of aggregated amyloid beta(Aβ)into neuritic plaques and neurofibrillary tangles of hyperphosphorylated tau,lead-ing to synaptic dysfunction and neuronal loss[1].Prot-eomic studies of cerebrospinal fluid(CSF)have shown that several biological processes are dysregulated in AD,such as the innate immune system,inflammatory response,hemostasis,lipid processing,oxidative stress response and synaptic functioning[2].

关键词： Alzheimer Aβ tau CSF

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A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers

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Translational Neurodegeneration 2020年第2期9卷 118-131页

作者： Sandra I.Anjo Patrícia Valério dos Santos Luiza Rosado Graça Baltazar Inês Baldeiras Diana Pires Andreia Gomes Cristina Januário Miguel Castelo-branco Mário Grãos br.no manadas CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal Faculty of Medicine University of CoimbraCoimbraPortugal Centro de Investigação em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Centro Hospitalar Cova da Beira E.P.ECovilhãPortugal Neurology Department Centro Hospitalar e Universitário de CoimbraCoimbraPortugal Coimbra Institute for Biomedical Imaging and Translational Research(CIBIT) CoimbraPortugal Biocant Biotechnology Transfer AssociationCantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)CoimbraPortugal

Background The identification of circulating biomarkers that closely correlate with Parkinson’s Disease(PD)has failed several times in the ***,in this pilot study,a translational approach was conducted,allowing the evaluation of the plasma levels of two mitochondrial-related proteins,whose combination leads to a robust model with potential diagnostic value to discriminate the PD patients from matched *** The proposed translational approach was initiated by the analysis of secretomes from cells cultured under control or well-defined oxidative stress conditions,followed by the identification of proteins related to PD pathologic mechanisms that were altered between the two *** pipeline was further translated into the analysis of undepleted plasma samples from 28 control and 31 PD *** From the secretome analysis,several mitochondria-related proteins were found to be differentially released between control and stress conditions and to be able to distinguish the two ***,two mitochondrial-related proteins were found to be significantly changed in a PD cohort compared to matched ***,a linear discriminant model with potential diagnostic value to discriminate PD patients was obtained using the combination of these two *** proteins are associated with apoptotic mitochondrial changes,which may correspond to potential indicators of cell ***,one of these proteins,the VPS35 protein,was reported in plasma for the first time,and its quantification was only possible due to its previous identification in the secretome *** In this work,an adaptation of a translational pipeline for biomarker selection was presented and transposed to neurological diseases,in the present case Parkinson’s *** novelty and success of this pilot study may arise from the combination of:i)a translational research pipeline,where plasma samples are interrogated using knowledge previously ob

关键词： Mitochondrial-related proteins SWATH-MS Parkinson's disease Biomarker discovery Blood-biomarker Secretomes Oxidative stress

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