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Mesoporous silica nanoparticles for drug and gene delivery

Acta Pharmaceutica Sinica B 2018年第2期8卷 165-177页

作者： Yixian Zhou Guilan Quan Qiaoli Wu Xiaoxu Zhang boyi niua Biyuan Wu Ying Huang Xin Pan Chuanbin Wu School of Pharmaceutical Sciences Sun Yat-Sen University Zengcheng District People's Hospital of Guangzhou Qingdao Huanghai University Guangdong Research Center for Drug Delivery Systems

Mesoporous silica nanoparticles(MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume,selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted.

关键词： Mesoporous silica nanoparticles Poorly soluble drug Cancer therapy Multidrug resistance Gene delivery

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Instant formation of nanopores on flexible polymer membranes using intense pulsed light and nanoparticle templates

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International Journal of Smart and Nano Materials 2023年第4期14卷 391-405页

作者： Miaoning Ren Tianyu Li Wenxing Huo Yu Guo Zhiqiang Xia Ya Lia Jing niua M.Serdar Onses Xian Huang Department of Biomedical Engineering Tianjin UniversityTianjinChina ERNAM-Nanotechnology Research and Application Center Department of Materials Science and EngineeringErciyes UniversityKayseriTurkey

The development of simple and high-throughput approaches to yield solid-state nanopores on large surface membranes may facilitate the prevalence of nanopore analysis technology and in-vitro diagnosis using portable ***,solidstate nanopores are typically realized by complex and highend nanofabrication ***,we present a method to achieve nanopores on polymer membranes using,silver nanoparticles(AgNPs)as templates and intense pulsed light(IPL)as a heating *** density and size of nanopores are controllable by adjusting the spin coating rate,the concentration of nanoparticle suspension,and the size of nanoparticles(NPs).The temperature of the AgNPs can rapidly reach 1132 K under instant heating of photothermal effect through light irradiation in 2 ms,resulting in localized melting and decomposition of an underneath polycarbonate(PC)membrane to yield nanopores with sizes ranging from 10 to 270 *** removing the nanoparticle residues,the flexible membrane with nanopores can be integrated into a flow cell to achieve a nanopore sensor that has been used to measure the translocation behaviors of bovine serum albumin(BSA).The results have demonstrated the capability of the sensor in protein denaturation *** low-cost and highthroughput technique to fabricate solid-state nanopores on flexible polymeric membranes may facilitate the development of more nanopore-based flexible sensors that can be integrated with other flexible components for wearable diagnosis.

关键词： Solid-state nanopore intense pulsed light polymer AgNPs flexible membrane

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Dynamic ordering transitions in charged solid

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Fundamental Research 2022年第2期2卷 178-183页

作者： Jian Sun Jiasen Niu Yifan Li Yang Liu LNPfeiffer KWWest Pengjie Wang Xi Lin International Center for Quantum Materials Peking UniversityBejjing 100871China Department of Electrical Engineering Princeton UniversityPrincetonNew Jersey 08544USA Department of Physics Princeton UniversityPrincetonNew Jersey 08544USA Beijing Academy of Quantum Information Sciences Beijing 100193China CAS Center for Exellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

The phenomenon of group motion is common in nature,ranging from the schools of fish,birds and insects,to avalanches,landslides and sand *** we treat objects as collectively moving particles,such phenomena can be studied from a physical point of view,and the research on many-body systems has proved that marvelous effects can arise from the simplest *** motion of numerous individuals presents different dynamic phases related to the ordering of the ***,it is usually difficult to study the dynamic ordering and its transitions through *** bubble states formed in a two-dimensional electron gas,as a type of electron solids,can be driven by an external electric field and provide a platform to study the dynamic collective ***,we demonstrate that the noise spectrum is a powerful method to investigate the dynamics of bubble *** observed not only the phenomena of dynamically ordered and disordered structures,but also unexpected alternations between *** results show that a dissipative system can convert between chaotic structures and ordered structures when tuning global parameters,which is concealed in conventional transport measurements of resistance or ***,charging the objects to study the electrical noise spectrum in collective motions can be an additional approach to revealing dynamic ordering transitions.

关键词： Two-dimensional system Electron solid Dynamic ordering transition Noise spectrum measurement Collective motion

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新型含氮五元杂环E-β-法尼烯类似物的合成及生物活性研究

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有机化学 2008年第4期28卷 617-621页

作者：康铁牛凌云芮昌辉杨新玲范贤林陈馥衡中国农业大学理学院应用化学系北京100094 中国农业科学院植物保护研究所北京100094

为了寻求新型蚜虫防治先导化合物,以蚜虫报警信息素的主要成分E-β-法尼烯(E-β-farnesene,简称EBF)的骨架结构为母体,分别用N-氰基-亚胺基-1,3-噻唑烷、2-噻唑硫酮、2-羰基-1,3-噁唑烷、1-取代-2-硝基亚胺基-1,3-咪唑烷等含氮五元杂环... 详细信息

为了寻求新型蚜虫防治先导化合物,以蚜虫报警信息素的主要成分E-β-法尼烯(E-β-farnesene,简称EBF)的骨架结构为母体,分别用N-氰基-亚胺基-1,3-噻唑烷、2-噻唑硫酮、2-羰基-1,3-噁唑烷、1-取代-2-硝基亚胺基-1,3-咪唑烷等含氮五元杂环取代EBF中的共轭双键,设计合成了8个未见文献报道的EBF类似物,其结构均经1HNMR,IR和元素分析确证,并分析比较了不同类型杂环的化学反应和生物活性差异.初步生物活性试验结果表明,目标化合物对蚜虫具有一定的生物活性,其中4e在5个测试浓度下的活性均优于对照药剂;有意思的现象是,一些在高浓度(1000μg/mL)下活性低于对照药剂噻虫啉的目标物(如4a～4c,4f～4h),在低浓度(如62.5μg/mL)下对蚜虫的生物活性反而高于对照药剂.

关键词：五元杂环 EBF类似物合成生物活性

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A novel field of view zoom scanning protocol for simultaneous time-and spectrum-resolved multifocal multiphoton microscopy

A novel field of view zoom scanning protocol for simultaneou...

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2007亚洲光电子会议保健与生物医学光学分会场

作者： Junle Qua Lixin Liua b Ziyang Lina Lei Wanga Wenqing Liub Hanben niua a Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education Institute of Optoelectronics Shenzhen University Shenzhen 518060 China b Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Anhui 230031 China

We present a simultaneous time- and spectrum-resolved multifocal multiphoton microscopy （MMM） system using a novel field of view （FOV） zoom scanning protocol. The system employs a microlens array for producing discrete excitation spot array, a dispersive prism and a high repetition rate streak camera for simultaneous temporal and spectral resolutions. By combining a pair of galvo mirrors and a sample stage for fine and coarse scanning respectively, the resolution and FOV of the system can be changed without changing any optical elements. The system can be operated not only in low resolution and large FOV, but also in high resolution and small FOV applications, without compromising the performances of the optical elements in the system. By implementing a special system control protocol and image reconstruction algorithm, fluorescence images in different FOVs and resolutions can be obtained. This FOV zoom scanning protocol is demonstrated with two-photon excitation fluorescence imaging of a fluorescence resolution test target.

关键词： zoom scanning field of view multifocal multiphoton microscopy fluorescence microscopy

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Research on LD-Pumped dual wavelength Nd:YAG Laser with high beam quality for machining

Research on LD-Pumped dual wavelength Nd:YAG Laser with high...

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20th Congress of the International Commission for Optics

作者： Jianfeng Cui a b c1 Zhongwei Fana c d Chunhua Zhaoa b c Jing Zhanga b c Gang niua b c Zhaohui Shia b c Bo Peic d Guoxin Zhang c Yan Xue c aChangchun Institute of Optics Fine Mechanics and physics Chinese Academy of Sciences No.16 the Dongnanhu Road Changchun China bAcademy of graduate Chinese Academy of Sciences cBeijing GK Laser Technology Co. Ltd. No.1 the 4thStreet Shangdi Haidian District Beijing China dAcademy of Opto-electronics Chinese Academy of Sciences No.1 the 4thStreet Shangdi Haidian District Beijing China

Considering laser medium thermal lens effect and thermal focal length changes with pumping power, conventionally, lasers are designed to operate in the middle of thermal stable zones, where the fundam

关键词： laser technique self-select mode cavity all solid laser LBO crystal external frequency-doubled

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