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石油参考资料 1989年第4期 21-26页

作者： bower.,P 李燕

加拿大西部原油和天然气储量增加速度与边际供给...

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四川石油普查 1990年第2期 73-77页

作者： bower.,B 文健

Hepatocellular carcinoma,human immunodeficiency virus and viral hepatitis in the HAART era

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World Journal of Gastroenterology 2008年第11期14卷 1657-1663页

作者： Douglas C Macdonald Mark Nelson Mark bower.Thomas Powles Chelsea and Westminster hospital LondonUnited Kingdom St Bartholomew’s Hospital LondonUnited Kingdom

The incidence of hepatocellular carcinoma(HCC)in patients with human immunodeficiency virus(HIV) is *** in HIV almost invariably occurs in the context of hepatitis C virus(HCV)or hepatitis B virus (HBV)co-infection and,on account of shared modes of transmission,this occurs in more than 33% and 10% of patients with HIV worldwide *** has yet to be clearly established whether HIV directly accelerates HCC pathogenesis or whether the rising incidence is an epiphenomenon of the highly active antiretroviral therapy(HAART)era,wherein the increased longevity of patients with HIV allows long-term complications of viral hepatitis and cirrhosis to *** this question will have implications for HCC surveillance and the timing of HCV/HBV therapy,which in HIV co-infection presents unique *** HCC develops,there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies,including liver transplantation.

关键词： Hepatocellular carcinoma Human immunodeficiency virus hepatitis Hepatitis B virus Hepatitis C virus Co-infection Incidence Transplant Pathogenesis

Graphene for energy harvesting/storage devices and printed electronics

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Particuology 2012年第1期10卷 1-8页

作者： Lorenzo Grande Vishnu Teja Chundi Di Wei Chris bower.Piers Andrew TapaniRyhanen Department of Materials Science and Metallurgy University of Cambridge UK Nokia Research Centre 21 I/Thomson Av. Cambridge CB30FA UK

Graphene-based materials are intriguing from the perspective of fundamental science and technol- ogy because they are non-toxic, chemically and thermally tolerant, and mechanically robust. Graphene exhibits superior electrical conductivity, high surface area and a broad electrochemical window that may be particularly advantageous for their applications in energy storage devices. In addition, graphene can be prepared in the form of a colloidal suspension with adjustable solubility and thus is suitable for printing applications and offers both transparency and good conductivity at the same time. In this review, appli- cations of graphene in solar cells, batteries, supercapacitors and fuel cells are summarized with the latest developments. Furthermore, graphene as a conductive ink for printed electronics is also discussed.

关键词： GrapheneBatterySupercapacitorFuel cellPhotovoltaicsGraphene inkPrintable electronics

Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids

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World Journal of Gastroenterology 2010年第33期16卷 4152-4158页

作者： Matthew R bower.Harini S Aiyer Robert CG Martin Yan Li Division of Surgical Oncology Department of Surgery and James Graham Brown Cancer CenterUniversity of Louisville School of MedicineLouisvilleKY40202United States

AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial ***:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic *** proliferation and viability assays were used to establish an appropriate dose range for *** combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also ***:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell *** acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle *** increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to ***-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 *** addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin ***:Curcumin reverses bile acid suppression of gene expression of *** is also able to inhibit bile acid induction of COX-2 gene expression.

关键词： Esophageal cancer Curcumin Cyclooxy- genase-2 Superoxide dismutase Chemoprevention

Effect of inflammatory bowel disease treatments on patients with diabetes mellitus

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World Journal of Diabetes 2021年第8期12卷 1248-1254页

作者： Joshua Ashley Jack bower.Lauren O'Flynn Rakhi Kakad David Aldulaimi Department of Gastroenterology South Warwickshire Foundation TrustWarwick CV345BWUnited Kingdom Department of Endocrinology South Warwickshire Foundation TrustWarwick CV345BWUnited Kingdom

As medical care progresses and the number of patients with chronic conditions increases there is the inevitable challenge of managing patients with multiple *** bowel disease(IBD)is an umbrella term for are inflammatory conditions affecting the gastrointestinal tract,the two most common forms being Ulcerative Colitis and Crohn’s *** diseases,usually diagnosed in young adults,exhibit a relapsing and remitting course and usually require longterm *** can be treated with a number of topical and systemic *** conducted a review of the current published evidence for the effects these medications can have on diabetes mellitus(DM)and glycaemic *** were conducted on medline and embase with a timeframe from 1947(the date from which studies on embase are recorded)to November *** publications were selected and *** evidence of the impact of aminosalicylates,corticosteroids,thiopurines,and biologic agents was *** there was limited evidence for certain agents,IBD medications have been shown to have an effect of DM and these effects should be considered in managing patients with dual *** effects of steroids on blood sugar control is well documented,but consideration of other agents is also *** patients requiring steroids for Ulcerative Colitis,locally acting steroid agents delivered rectally may be preferred to minimise side effects in those with distal bowel Ulcerative Colitis.A switch to other agents should be considered as soon as possible in people with diabetes to limit the impact on glycaemic control.5-aminosalicylates appear to play a role in the reduction of hemoglobin A1c(HbA1c),although the literature suggests these may be falsely low ***,monitoring of people with diabetes on these agents may require daily monitoring of capillary blood sugars rather than relying simply on HbA1c;for example fructosamine performed 3-6 monthly,although th

关键词： Inflammatory bowel disease Diabetes mellitus Crohn's disease Ulcerative colitis Anti-tumor necrosis factor-α Corticosteroids

Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

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Cell Research 2004年第3期14卷 251-256页

作者： Justin STEBBING,Steve PATTERSON,Simon PORTSMOUTH,Claire THOMAS,Robert GLASSMAN,Adrian WILDFIRE,Frances GOTCH,Mark bower.Mark NELSON,Brian GAZZARD The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Ro

There is increasing recognition of the potential morbidity and mortality associated with HIV-1 and hepatitis C (HCV) co-infection. HIV appears to adversely affect HCV disease while the reciprocal effect of HCV on HIV remains controversial. We therefore studied the effect of co-infection on dendritic cell function versus HIV infection alone, as previous work has shown that HCV impairs dendritic cell (DC) function. HIV-1 positive individuals with HCV were matched for CD4 count, HIV-1 RNA viral load and therapy, to HIV-1 positive patients without HCV. Monocyte-derived DC were generated and mixed leukocyte reactions were performed. We assessed allostimulatory capacity with and without administration of exogenous Thl cytokines, using thymidine uptake and cell division analyses with the vital dye CFSE. We found that monocyte-derived DC from co-infected individuals showed no significant differences in allostimulatory capacity to ex vivo generated DC from HIV-1 infected individuals without HCV. Unlike the situat

关键词： hepatitis C HIV co-infection dendritic cells.

Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin

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Journal of Innovative Optical Health Sciences 2020年第2期13卷 70-80页

作者： Joanne Li Madison N.Wilson Andrew J.bower.Marina Marjanovic Eric J.Chaney Ronit Barkalifa Stephen A.Boppart Department of Bioengineering University of Illinois at Urbana-Champaign Urbana ILU.S.A Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana ILU.S.A Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana ILU.S.A Carle Illinois College of Medicine University of Illinois at Urbana-Champaign Urbana ILU.S.A

To date,numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases,but few have attempted to characterize these cellular events under conditions similar to the native *** address this challenge,a three-dimensional(3D)multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin,which was then utilized to process in vivo wound healing data to demonstrate its *** attention is focused on in vivo biological parameters that are difficult to study with ex vivo analysis,including 3D cell tracking and techniques to connect biological information obtained from different imaging *** results here open new possibilities for evaluating 3D cellular dynamics in vivo,and can potentially provide new tools for characterizing the skin microenvironment and pathologies in the future.

关键词： Cellular dynamics multimodal imaging multiphoton microscopy

Hybrid-Driven Evolution:Genomes Show Complexity of Human-Chimp Split

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当代外语研究 2006年第7期 7-8页

作者： Bruce bower.浦江红

科学家在对比人类与黑猩猩的染色体后发现了一个惊人信息:人类祖先从黑猩猩家族中分化出来后,曾再次和黑猩猩“联姻”了很长一段时间,才最终进化成后期的人类。换言之,现代人类是古人类与黑猩猩结合的后代!

关键词：黑猩猩染色体原始人类科学家现代人类古人类杂交对比分化家族

Coagulopathy reversal in intracerebral haemorrhage

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Stroke & Vascular Neurology 2020年第1期5卷 29-33页

作者： Alexander Jacob Sweidan Navneet Kaur Singh Joseph Luke Conovaloff Matthew bower.Leonid I Groysman Mohammad Shafie Wengui Yu Neurology University of California Irvine Medical CenterOrangeCaliforniaUSA Medicine University of California Irvine Medical CenterOrangeCaliforniaUSA

As intracerebral hemorrahge becomes more frequent as a result of an aging population with greater comorbidities,rapid identification and reversal of precipitators becomes increasingly *** aformentioned population will ever more likely be on some form of anticoagulant *** the mechanisms of these agents and means by which to reverse them early on is critical in managing the acute intracerebral hemorrhage.

关键词： likely mentioned reversal