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A drug-loaded flexible substrate improves the performance of conformal cortical electrodes

Bio-Design and Manufacturing 2024年第4期7卷 399-412页

作者： Rongrong Qin Tian Li Yifu Tan Fanqi Sun Yuhao Zhou Ronghao Lv Xiaoli You bowen ji Peng Li Wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME)Northwestern Polytechnical UniversityXi’an 710072China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China

Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous ***,the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory reaction risks associated with foreign body ***,inflammation of the wound area can dramatically worsen in response to bacterial *** consequences can not only lead to the failure of cortical electrode implantation but also threaten the lives of ***,we prepared a hydrogel made of bacterial cellulose(BC),a flexible substrate for cortical electrodes,and further loaded antibiotic tetracycline(TC)and the anti-inflammatory drug dexamethasone(DEX)onto *** encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative and Gram-positive ***,therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel and nine-channel serpentine arrays;these were used to record electrocorticography(ECoG)signals in a rat *** to the controlled release of TC and DEX from the BC hydrogel substrate,therapeutic cortical electrodes can alleviate or prevent symptoms associated with the bacterial infection and inflammation of brain *** approach facilitates the development of drug delivery electrodes for resolving complications caused by implantable electrodes.

关键词： Antibacterial Anti-inflammatory Drug loading Cortical electrodes Bacterial cellulose hydrogel

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Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring

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Nanotechnology and Precision Engineering 2024年第1期7卷 18-31页

作者： jiahui Xu Minghao Wang Minyi jin Siyan Shang Chuner Ni Yili Hu Xun Sun Jun Xu bowen ji Le Li Yuhua Cheng Gaofeng Wang School of Electronics&Information MOE Engineering Research Center of Smart Microsensors and MicrosystemsHangzhou Dianzi UniversityHangzhou 310018China Wenzhou Institute of Hangzhou Dianzi University Wenzhou 310018China Key Laboratory of Intelligent Operation and Maintenance Technology&Equipment for Urban Rail Transit of Zhejiang Province College of EngineeringInstitute of Precision Machinery and Smart StructureZhejiang Normal UniversityJinhua 321004China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang 550009China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and ***,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial ***,aﬂexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is *** porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and *** to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aﬂat pressure sensor without a porous MNA ***-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the *** addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode *** importantly,it was found that the sensor could accurately monitor the motion of aﬁnger,wrist joint,arm,face,abdomen,eye,and Adam’s ***,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s ***,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×*** to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer.

关键词： Capacitive pressure sensor Microneedle array Porous PDMS Interdigital electrode

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Progress in Mechanical Modeling of Implantable Flexible Neural Probes

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1205-1231页

作者： Xiaoli You Ruiyu Bai Kai Xue Zimo Zhang Minghao Wang Xuanqi Wang jiahao Wang jinku Guo Qiang Shen Honglong Chang Xu Long bowen ji Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an710072China National Key Laboratory of Unmanned Aerial Vehicle Technology Northwestern Polytechnical UniversityXi’an710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China School of Automobile Chang’an UniversityXi’an710018China MOE Engineering Research Center of Smart Microsensors and Microsystems College of Electronics and InformationHangzhou Dianzi UniversityHangzhou310018China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710129China

Implanted neural probes can detect weak discharges of neurons in the brain by piercing soft brain tissue,thus as important tools for brain science research,as well as diagnosis and treatment of brain ***,the rigid neural probes,such as Utah arrays,Michigan probes,and metal microfilament electrodes,are mechanically unmatched with brain tissue and are prone to rejection and glial scarring after implantation,which leads to a significant degradation in the signal quality with the implantation *** recent years,flexible neural electrodes are rapidly developed with less damage to biological tissues,excellent biocompatibility,and mechanical compliance to alleviate *** them,the mechanical modeling is important for the optimization of the structure and the implantation *** this review,the theoretical calculation of the flexible neural probes is firstly summarized with the processes of buckling,insertion,and relative interaction with soft brain tissue for flexible probes from outside to ***,the corresponding mechanical simulation methods are organized considering multiple impact factors to realize minimally invasive ***,the technical difficulties and future trends of mechanical modeling are discussed for the next-generation flexible neural probes,which is critical to realize low-invasiveness and long-term coexistence in vivo.

关键词： Mechanical modeling flexible neural probes invasive theoretical calculation simulation

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皮层微创脑机接口传感器发展现状与趋势

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信息通信技术与政策 2024年第5期50卷 18-25页

作者：白睿钰王炫棋张梓墨吉博文西北工业大学无人系统技术研究院西安710072 西北工业大学无人飞行器技术全国重点实验室西安710072

脑机接口(Brain-Computer Interface,BCI)传感器作为脑电信号采集与调控的前端器件,是BCI技术的核心基础部件之一。其中,皮层微创BCI传感器贴附在硬脑膜上或硬脑膜下,未进入脑组织,植入安全性高。此类传感器通常用来采集来自大脑皮质区... 详细信息

脑机接口(Brain-Computer Interface,BCI)传感器作为脑电信号采集与调控的前端器件,是BCI技术的核心基础部件之一。其中,皮层微创BCI传感器贴附在硬脑膜上或硬脑膜下,未进入脑组织,植入安全性高。此类传感器通常用来采集来自大脑皮质区域(如运动区、视觉区、语言区)的信号,这为许多其他脑功能和一般BCI应用(如皮质康复)开辟了可能性,已成为近年来科研与临床应用的焦点。因此,聚焦皮层微创BCI传感器在商业及科研领域的发展现状,并对未来技术及应用趋势进行分析和展望,能为BCI学术和产业界提供参考和借鉴。

关键词：脑机接口传感器微创皮层脑电

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脑机接口在无人系统中的应用

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无人系统技术 2024年第4期7卷 16-27页

作者：朱永杰王炫棋张梓墨吉博文西北工业大学无人系统技术研究院西安710072 无人飞行器技术全国重点实验室西安710072 无人飞行器技术集成攻关大平台西安710072 西北工业大学电子信息学院西安710129

对脑机接口在无人系统领域的应用进行了综合评述,并对未来研究进行了展望。首先,系统阐述了脑机接口关键技术的发展脉络,揭示了脑机接口与无人系统结合的内在需求,并针对脑机接口技术的最新发展态势,深入分析了其在无人系统中应用的可... 详细信息

对脑机接口在无人系统领域的应用进行了综合评述,并对未来研究进行了展望。首先,系统阐述了脑机接口关键技术的发展脉络,揭示了脑机接口与无人系统结合的内在需求,并针对脑机接口技术的最新发展态势,深入分析了其在无人系统中应用的可行性及未来潜力。随后,通过对无人系统进行分类和功能解析,探讨了当前脑机接口控制无人系统的策略及其局限性。最后,分析了目前脑机接口技术在无人系统中的典型应用案例及其系统集成方案。综述表明,脑机接口技术能够为无人系统的人机交互控制提供更加实时、可靠与用户友好的人机交互界面,在无人系统领域具有广泛的应用前景。但同时,基于脑机接口的无人系统控制研究仍然面临着高性能脑机接口传感器设计、精确脑波分类识别算法设计与可靠系统集成设计等方面的挑战。

关键词：人机交互脑机接口系统集成无人系统控制策略应用场景

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Recent advances in wireless epicortical and intracortical neuronal recording systems

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Science China(Information Sciences) 2022年第4期65卷 5-22页

作者： bowen ji Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG jingquan LIU Unmanned System Research Institute Northwestern Polytechnical University Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical University Collaborative Innovation Center of Northwestern Polytechnical University NEURACLE TECH (China) Co. Ltd. College of Electronics and Information Hangzhou Dianzi University Defense Innovation Institute Academy of Military Sciences (AMS) Tianjin Artificial Intelligence Innovation Center (TAIIC) National Key Laboratory of Science and Technology on Micro/Nano Fabrication Department of Micro/Nano ElectronicsShanghai Jiao Tong University

An implantable brain-computer interface(BCI) has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders. Using a BCI recording system,we can transform current methods of human interaction with machines and the environment, especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society. However,most reported work has focused on a simple aspect of the whole system, such as electrodes, circuits, or data transmission, and only a very small percentage of systems are wireless. A miniature, lightweight, wireless,implantable microsystem is key to realizing long-term, real-time, and stable monitoring on freely moving animals or humans in their natural conditions. Here, we summarize typical wireless recording systems, from recording electrodes, processing chips and controllers, wireless data transmission, and power supply to the system-level package for either epicortical electrocorticogram(ECo G) or intracortical local field potentials(LFPs)/spike acquisition, developed in recent years. Finally, we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications.

关键词： wireless implant neuronal recording system recording electrodes processing chips wireless data transmission power supply system-level package

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Smart epidermal electrophysiological electrodes:Materials,structures,and algorithms

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Nanotechnology and Precision Engineering 2023年第4期6卷 75-97页

作者： Yuanming Ye Haochao Wang Yanqiu Tian Kunpeng Gao Minghao Wang Xuanqi Wang Zekai Liang Xiaoli You Shan Gao Dian Shao bowen ji Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Queen Mary University of London Engineering School Northwestern Polytechnical UniversityXi’an 710072China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China College of Information Science and Technology Donghua UniversityShanghai 201620China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

Epidermal electrophysiological monitoring has garnered significant attention for its potential in medical diagnosis and healthcare,particularly in continuous signal ***,simultaneously satisfying skin compliance,mechanical properties,environmental adaptation,and biocompatibility to avoid signal attenuation and motion artifacts is challenging,and accurate physiological feature extraction necessitates effective signal-processing *** review presents the latest advancements in smart electrodes for epidermal electrophysiological monitoring,focusing on materials,structures,and ***,smart materials incorporating self-adhesion,self-healing,and self-sensing functions offer promising solutions for long-term ***,smart meso-structures,together with micro/nanostructures endowed the electrodes with self-adaption and ***,intelligent algorithms give smart electrodes a“soul,”facilitating faster and more-accurate identification of required information via automatic processing of collected electrical ***,the existing challenges and future opportunities for developing smart electrodes are *** as a crucial direction for next-generation epidermal electrodes,intelligence holds the potential for extensive,effective,and transformative applications in the future.

关键词： Epidermal electrodes Electrophysiological signal monitoring Smart materials Smart structures Intelligent algorithms

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Stretchable Parylene-C electrodes enabled by serpentine structures on arbitrary elastomers by silicone rubber adhesive

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Journal of Materiomics 2020年第2期6卷 330-338页

作者： bowen ji Zhaoqian Xie Wen Hong Chunpeng jiang Zhejun Guo Longchun Wang Xiaolin Wang Bin Yang jingquan Liu National Key Laboratory of Science and Technology on Micro/Nano Fabrication Department of Micro/Nano ElectronicsShanghai Jiao Tong UniversityShanghai200240China Department of Engineering Mechanics Dalian University of TechnologyDalian116024China

The delicate serpentine structures are widely used in high-performance stretchable electronics over the past *** metal interconnects encapsulated in biocompatible polymer Parylene-C film is a superior choice for long-term implantation in vivo,especially as neural interface to acquire electrophysiological signals or apply electrical *** avoid the physical contact damages from the neural tissues such as the brain or peripheral nerves,serpentine interconnects are utilized as stretchable electrodes and usually bonded to the soft elastomer *** adhesion strength between the serpentine interconnects and the elastomer substrate becomes a considerable issue to ensure reliability and structural *** this paper,the stretchable Parylene-C electrodes can be transfer printed onto arbitrary elastomer substrates by a thin layer of silicone rubber adhesive with low modulus for electrocorticogram(ECoG)*** simulation of serpentine structures consisting of same periodic arcs and different straight segments is investigated by uniaxial ***,the elastic stretchability of serpentine electrodes is further studied by simulation and *** 5000 repetitive stretching cycles,the electrochemical impedance of microelectrodes remains in steady *** results prove that the silicone rubber adhesive facilitates the interfacial bonding in the structure of stretchable electrodes as the compliant and reliable neural interface.

关键词： Stretchable Parylene-C electrodes Serpentine structure Arbitrary elastomers Silicone rubber adhesive

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Melatonin and dopamine alleviate waterlogging stress in apples by recruiting beneficial endophytes to enhance physiological resilience

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Journal of Integrative Agriculture 2024年第7期23卷 2270-2291页

作者： Yang Cao Peihua Du Yuwei Shang jiahao ji Leiqing Tan Xue Zhang jizhong Xu bowen Liang College of Horticulture Hebei Agricultural UniversityBaoding 071001China

Melatonin and dopamine can potentially prevent waterlogging stress in *** current study investigated the mechanism by which melatonin and dopamine alleviate apple waterlogging *** study demonstrated that melatonin and dopamine alleviated waterlogging by removing reactive oxygen species(ROS),and that the nitric oxide(NO)content and nitrate reductase(NR)activity were significantly *** and dopamine were also found to recruit different candidate beneficial endophytes(melatonin:Novosphingobium,Propionivibrio,and Cellvibrio;dopamine:Hydrogenophaga,Simplicispira,Methyloversatilis,Candidatus_Kaiserbacteria,and Humicola),and these endophytes were significantly and positively correlated with plant *** analyses showed that melatonin and dopamine significantly affected the endophytic bacterial and fungal communities under waterlogging *** metabolomic results showed that melatonin and dopamine led to waterlogging resistance by upregulating the abundance of beneficial substances such as amino acids,flavonoids,coumarins,and organic *** addition,melatonin and dopamine regulated the physicochemical properties of the soil,which altered the endophyte community and affected plant *** co-occurrence network demonstrated close and complex relationships among endophytes,metabolites,soil,and the *** results demonstrate that melatonin and dopamine alleviate waterlogging stress in apples by recruiting beneficial endophytes to enhance physiological *** study provides new insights into how melatonin and dopamine alleviate stress and a theoretical basis for synergistic beneficial microbial resistance to waterlogging stress.

关键词： dopamine endophytes Malus hupehensis melatonin metabolomics waterlogging

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Dopamine improves apple replant disease resistance by regulating physiological resilience and rhizosphere microbial community structure

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Journal of Integrative Agriculture 2024年第9期23卷 3025-3044页

作者： Peihua Du Yang Cao Huaite Liu jiahao ji Wei Sun Xueying Zhang jizhong Xu bowen Liang College of Horticulture Hebei Agricultural UniversityBaoding 071001China

Apple replant disease(ARD)is a complex agricultural problem caused by multiple stressors that can lead to increased reactive oxygen species(ROS)levels and limited nutrient utilization in ***,existing countermeasures cannot effectively address this ***,we used Malus hupehensis as a test organism to investigate whether the pleiotropic molecule dopamine can alleviate ARD using pot *** application of 100μmol L-1 dopamine significantly promoted the growth of apple seedlings in the replanted soil,with a relative growth rate increase of 17.44%.Our results revealed two major pathways by which dopamine regulates ARD resistance in apple ***,dopamine effectively reduces the level of ROS and activates the expression of genes related to nitrogen(N)transport and *** those genes,MdNLP5,MdNRT1.1,MdNLP2,MdNRT2.5,MdNLP3,MdNRT2.4,MdNADH-GAGOT,and MdFd-GAGOT were strongly regulated by *** regulatory effects promoted the uptake and utilization of soil N by the ***,dopamine improved the physical and chemical properties,enhanced microbial community diversity,and promoted mutual cooperation between microbial communities in the ***,dopamine altered the microbial structure of rhizosphere soil(upregulating Clostridiales,Gaiellales,Sordariales and Mortierellales;downregulating Micrococcales,Longimicrobiales,Hypocreales and Cystobasidiales).Notably,dopamine significantly upregulated the abundances of Gaiella and Mortierella,both of which were positively correlated with soil urease activity,soil available N content,plant growth and N *** also significantly downregulated the abundance of the plant pathogen Gibberella(by 11.71-fold)in replant *** results provide insights into the mechanisms by which dopamine promotes ARD resistance,and can promote the sustainable development of the apple industry.

关键词： continuous cropping barrier exogenous dopamine Malus hupehensis Rehd. 15N-labeling soil microbiome

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