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Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping

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Bioactive Materials 2024年第8期38卷 455-471页

作者： Jing-Jun Nie bowen Zhang peng Luo Maoguo Luo Yuwen Luo Jingjing Cao Honggang Wang Jianping Mao Yonggang Xing Weifeng Liu Yuning Cheng Renxian Wang Yajun Liu Xinbao Wu Xieyuan Jiang Xiaoguang Cheng Chi Zhang Da-Fu Chen Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsNational Center for OrthopaedicsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalCapital Medical UniversityBeijingChina Department of Radiology National Center for OrthopaedicsThe Fourth Clinical Medical College of Peking UniversityBeijing Jishuitan HospitalBeijingChina Biological&Medical Engineering Core Facilities School of Life ScienceBeijing Institute of TechnologyBeijingChina Department of Spine Surgery National Center for OrthopaedicsBeijing Jishuitan HospitalCapital Medical UniversityBeijingChina Department of Orthopaedic Oncology Surgery National Center for OrthopaedicsBeijing Jishuitan HospitalCapital Medical UniversityBeijingChina Department of Orthopedic Trauma National Center for OrthopaedicsBeijing Jishuitan HospitalCapital Medical UniversityBeijingChina Department of Orthopedics Peking University International HospitalBeijingChina

Osteosarcoma is the most common malignant bone tumor without efficient management for improving 5-year event-free *** is also limited due to its highly immunosuppressive tumor microenvironment(TME).Pore-forming gasdermins(GSDMs)-mediated pyroptosis has gained increasing concern in reshaping TME,however,the expressions and relationships of GSDMs with osteosarcoma remain ***,gasdermin E(GSDME)expression is found to be positively correlated with the prognosis and immune infiltration of osteosarcoma patients,and low GSDME expression was observed.A vector termed as LPAD contains abundant hydroxyl groups for hydrating layer formation was then prepared to deliver the GSDME gene to upregulate protein expression in osteosarcoma for efficient TME reshaping via enhanced pyroptosis *** molecular dynamics simulations analysis proved that the hydroxyl groups increased LPAD hydration abilities by enhancing coulombic *** upregulated GSDME expression together with cleaved caspase-3 provided impressive pyroptosis *** pyroptosis further initiated proinflammatory cytokines release,increased immune cell infiltration,activated adaptive immune responses and create a favorable immunogenic hot *** study not only confirms the role of GSDME in the immune infiltration and prognosis of osteosarcoma,but also provides a promising strategy for the inhibition of osteosarcoma by pore-forming GSDME gene delivery induced enhanced pyroptosis to reshape the TME of osteosarcoma.

关键词： Osteosarcoma Pyroptosis Gasdermin Gene delivery Immune microenvironment reshaping

Screening A-site ordered quadruple perovskites for alkaline hydrogen evolution reaction via unifying electronic configuration descriptor

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Chinese Physics B 2024年第12期33卷 448-456页

作者： Ning Sun Wenbo Li Yang Qin Zhichuan Zheng bowen Zhang Xiangjiang Dong peng Wei Yixiao Zhang Xian He Xinyu Xie Kai Huang Lailei Wu Ming Lei Huiyang Gou Runze Yu State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and Telecommunications(BUPT)Beijing 100876China Center for High Pressure Science and Technology Advanced Research Beijing 100193China College of Material Science and Engineering Liaoning Technical UniversityFuxin 123000China College of Material Science and Engineering Yanshan UniversityQinhuangdao 066004China

Dynamic adsorption processes of reaction intermediates for alkaline hydrogen evolution(HER)catalysts are still confusing to ***,we report a series of A-site ordered quadruple perovskite ruthenium-based electrocatalysts ACu_(3)Ru_(4)O_(12)(A=Na,Ca,Nd,and La),with the target sample SrCu_(3)Ru_(4)O_(12)exhibiting a very low overpotential(46 mV@10 mA·cm^(-2))and excellent catalytic stability with little decays after 48-h durability *** tuning A-site cations can change the average valence state of Cu and Ru,thus the plot of HER activity versus the average Ru valence number shows a volcano-type *** functional theory indicates that the Ru 4d orbitals of SrCu3Ru4O12possesses the most suitable d-band center position among the five samples,which might be the key parameter to determine the catalytic *** work provides further insight into the discovering advanced,efficient hydrogen evolution catalysts through designing precise descriptor.

关键词： Ru-based electrocatalyst density functional theory descriptor quadruple perovskites hydrogen evolution reaction

The Role of Ras-GTPase Activating Protein SH3Domain Binding Protein in Chilli Veinal Mottle Virus Infected Tobacco

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The Role of Ras-GTPase Activating Protein SH3Domain Binding ...

中国植物病理学会2023年学术年会

作者： peng Qiding CHENG Yongchao YUAN bowen YANG Yiting XI Dehui Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life Sciences Sichuan University

Endogenous messenger RNAs( mRNAs) are exposed to a complex RNA regulatory network, which is a dynamic regulation in plant cells to maintain a delicate balance between active and inactive mRNAs in the development and fluctuating ***-binding proteins(RBPs) are the major regulators in the RNA regulatory network that control RNA processing in the nucleus and regulate gene expression in the cytoplasm at the post-transcriptional ***-GTPase activating protein SH3 domain binding protein( G3 BP) belongs to a family of RBPs and plays role in viral immunity in ***, the role of G3 BP in response to plant virus infection is largely ***, we showed that the expression of NtG3 BP-L could be first up-regulated and then down-regulated in chilli veinal mottle virus( ChiVMV)-infected Nicotiana tabacum *** overexpression of NbG3 BP-L( homologue of NtG3 BP-L) in Nicotiana benthamiana reduced the accumulation of *** result of yeast two-hybrid assay showed that NtG3 BP-L could specifically interact with6 K2 among the 11 proteins encoded by ***, the interaction between NtG3 BP-L and ChiVMV K2 was further confirmed by bimolecular fluorescence complementation(BiFC) and Co-Immunoprecipitation(Co-IP) *** assay showed that NtG3 BP-L and ChiVMV-6 K2 co-localized in cytoplasm and didn’t fuse at the *** localization also showed that more obvious fusion zone of NtG3 BP-L and ChiVMV-6 K2 appeared in cytoplasm under ChiVMV *** addition,*** plants with transgenic overexpression of NtG3 BP-L conferred resistance to ChiVMV infection,whereas the knockout of NtG3 BP-L in *** promoted ChiVMV ***, our results indicate that NtG3 BP-L plays a positive role in tobacco response to ChiVMV infection by interacting with ChiVMV-6 K2 and thereby affecting the infection of ChiVMV, which provide new insights into understanding the antiviral strategies of plants.

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强迫转自然循环一体化压水堆协调控制策略

哈尔滨工程大学学报 2019年第10期40卷 1723-1728页

作者：张博文彭敏俊成守宇哈尔滨工程大学核安全与仿真技术国防重点学科实验室

一体化压水堆系统使用直流蒸汽发生器,通常具有强烈的耦合特性和复杂的非线性,强迫循环转自然循环过程引入大的冷却剂平均温度设定值变化不利于系统控制和反应堆安全。针对以上问题,本文提出一种先进的协调控制策略来实现强迫循环转自... 详细信息

一体化压水堆系统使用直流蒸汽发生器,通常具有强烈的耦合特性和复杂的非线性,强迫循环转自然循环过程引入大的冷却剂平均温度设定值变化不利于系统控制和反应堆安全。针对以上问题,本文提出一种先进的协调控制策略来实现强迫循环转自然循环过程的自动控制,并改善其动态特性。依据模糊逻辑理论,采用协调控制器协调2种底层控制器,分别为模糊控制器和PID控制器,实现反应堆功率控制系统、稳压器压力控制系统和给水控制系统的协调控制。针对强迫循环转自然循环的过渡工况,将常规PID控制策略作为协调控制策略的对比方案。仿真结果表明:本文所提出的协调控制策略优于常规PID控制策略,能够更快速、平稳地实现强迫循环到自然循环的工况转换,有利于提高核动力装置的机动性和灵活性。

关键词：协调控制模糊逻辑模糊控制器 PID控制器强迫循环转自然循环一体化压水堆

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基于间苯三酚的电池热失效自毁机制研究

工程热物理学报 2024年第6期45卷 1663-1670页

作者：侯博文彭勇冯旭宁清华大学车辆与运载学院北京100084

高比能锂离子电池的热失控问题是限制其大规模应用的关键原因。本文从自毁电池的角度出发,以间苯三酚为自毁剂,阻断负极和电解液的反应,避免大量还原性气体的产生,减少气体串扰的反应热释放,最终降低热失控灾害程度。结果表明,间苯三酚... 详细信息

高比能锂离子电池的热失控问题是限制其大规模应用的关键原因。本文从自毁电池的角度出发,以间苯三酚为自毁剂,阻断负极和电解液的反应,避免大量还原性气体的产生,减少气体串扰的反应热释放,最终降低热失控灾害程度。结果表明,间苯三酚的引入使热失控反应提前至120℃,且消除了200℃时的剧烈放热,实现了热失控反应时序的调控和热失控反应焓值的降低,提高了电池的安全性。本文为高安全电池设计提供了新的思路,具有一定的指导意义。

关键词：锂离子电池自毁电池热失控反应时序调控间苯三酚

Magneto-hydrodynamic simulation study of direct current multi-contact circuit breaker for equalizing breaking arc

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Plasma Science and Technology 2023年第2期25卷 207-215页

作者：贾博文武建文李枢吴昊彭向军戴健陈儒盎 Systems Engineering Institute Academy of Military SciencesBeijing 100071People's Republic of China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100083People's Republic of China

This work is based on a direct current(DC)natural current commutation topology,which uses load-carrying branch contacts carrying rated current and multiple sets of series arcing branch contacts in parallel to achieve circuit *** proposed topology can meet the new requirements of higher voltage DC switches in aviation,aerospace,energy and other ***,a magneto-hydrodynamic arc model is built using COMSOL Multiphysics,and the different arc breaking characteristics of the arcing branch contacts in different gas environments are ***,a voltage uniformity coefficient is used to measure the voltage sharing effect in the process of dynamic *** order to solve the dispersion of arcing contact action,a structural control method is adopted to improve the voltage uniformity *** uniform voltage distribution can improve the breaking capacity and electrical life of the series connection structure.

关键词： DC circuit breaker voltage uniformity coefficient MHD modelling uniform-voltage regulation method

The Genomes of the Allohexaploid Echinochloa crus-galli and Its Progenitors Provide Insights into Polyploidization-Driven Adaptation

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Molecular Plant 2020年第9期13卷 1298-1310页

作者： Chu-Yu Ye Dongya Wu Lingfeng Mao Lei Jia Jie Qiu Sangting Lao Meihong Chen bowen Jiang Wei Tang Qiong peng Lang Pan Lifeng Wang Xiaoxiao Feng Longbiao Guo Chulong Zhang Elizabeth A.Kellogg Kenneth M.Olsen Lianyang Bai Longjiang Fan Institute of Crop Sciences&Institute of Bioinformatics Zhejiang UniversityHangzhou 310058China Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200235China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Hunan Weed Science Key Laboratory Hunan Academy of Agriculture ScienceChangsha 410125China Agricultural Experiment Station Zhejiang UniversityHangzhou 310058China lnstitute of Biotechnology Zhejiang UniversityHangzhou 310058China Donald Danforth Plant Science Center St.LouisMO 63132USA Department of Biology Washington University in St.LouisSt.LouisMO 63130USA

The hexaploid species Echinochloa crus-galli is one of the most detrimental weeds in crop fields,especially in rice *** evolutionary history is similar to that of bread wheat,arising through polyploidization after hybridization between a tetraploid and a diploid *** this study,we generated and analyzed high-quality genome sequences of diploid(***),tetraploid(***),and hexaploid(***-galli)Echinochloa *** family analysis showed a significant loss of disease-resistance genes such as those encoding NB-ARC domain-containing proteins during Echinochloa polyploidization,contrary to their significant expansionduring wheat polyploidization,suggesting that natural selection might favor reduced investment in resistance in this weed to maximize its growth and *** contrast to the asymmetric patterns of genome evolution observed in wheat and other crops,no significant differences in selection pressure were detected between the subgenomes in *** and *** addition,distinctive differences in subgenome transcriptome dynamics during hexaploidization were observed between ***-galli and bread ***,our study documents genomic mechanisms underlying the adaptation of a major agricultural weed during *** genomic and transcriptomic resources of three Echinochloa species and new insights into the polyploidization-driven adaptive evolution would be useful for future breeding cereal crops.

关键词： breeding crops ation

Saturated absorption spectrum of cesium micrometric-thin cell with suppressed crossover spectral lines

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Chinese Physics B 2023年第7期32卷 353-360页

作者：韩俊龙王博闻郑俊鹤陈书源肖伟吴腾郭弘彭翔 School of Electronics Peking UniversityBeijing 100871China Center for Quantum Information Technology Peking UniversityBeijing 100871China

Micrometric-thin cells(MCs)with alkali vapor atoms have been valuable for research and applications of hyperfine Zeeman splitting and atomic magnetometers under strong magnetic *** theoretically and experimentally study the saturated absorption spectra using a 100-μm cesium MC,where the pump and probe beams are linearly polarized with mutually perpendicular polarizations,and the magnetic field is along the pump *** of the distinctive thin chamber of the MC,crossover spectral lines in saturated absorption spectra are largely suppressed leading to clear splittings of hyperfine Zeeman transitions in experiments,and the effect of spatial magnetic field gradient is expected to be reduced.A calculation method is proposed to achieve good agreements between theoretical calculations and experimental *** method successfully explains the suppression of crossover lines in MCs,as well as the effects of magnetic field direction,propagation and polarization directions of the pump/probe beam on saturated absorption *** saturated absorption spectrum with suppressed crossover lines is used for laser frequency stabilization,which may provide the potential value of MCs for high spatial resolution strong-field magnetometry with high sensitivity.

关键词： micrometric-thin cells saturated absorption spectrum hyperfine Zeeman splitting crossover spectral lines laser frequency stabilization

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基于生物网络的中医药学原理探索

科学通报 2024年第1期69卷 17-29页

作者：谌攀吴博文张鹏李梢清华大学自动化系清华大学北京市中医药交叉研究所北京信息科学与技术国家研究中心北京100084

中医药生物学基础不清、方剂作用机制不明、缺乏符合中医药整体特点的研究方法学体系是中医药现代化研究面临的关键瓶颈.随着信息学与系统生物学等新兴学科的发展,以生物网络为切入点开展中医药学与人工智能、大数据、信息学等前沿科学... 详细信息

中医药生物学基础不清、方剂作用机制不明、缺乏符合中医药整体特点的研究方法学体系是中医药现代化研究面临的关键瓶颈.随着信息学与系统生物学等新兴学科的发展,以生物网络为切入点开展中医药学与人工智能、大数据、信息学等前沿科学技术的交叉研究,成为探索中医药科学原理、促进中医药现代化的重要途径.基于生物网络的“网络靶标”理论有望突破宏微观内在关联解析的鸿沟,实现还原论和整体论的有机融合,架起传统中医与现代医学研究桥梁,成为探索中医药学原理的突破口之一.“寒、热”等中医药核心诊疗概念、治未病等中医特色理论的科学内涵阐明是解读中医药学原理的重要组成部分.本文基于李梢课题组的研究,综述了基于生物网络的中医药研究理论与技术方法,及其应用于“寒、热”“治未病”等中医特色理论的病证结合科学原理探索所取得的进展,以期为利用现代科学技术解读中医药学原理,促进中医药现代化提供参考.

关键词：中医药学原理生物网络寒热证候治未病网络靶标

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