检索结果-南通市图书馆

Development of radiation countermeasure agents for acute radiation syndromes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2023年第4期6卷 329-336页

作者： bowen guan Deguan Li Aimin Meng National Human Diseases Animal Model Resource Center NHC Key Laboratory of Human Disease Comparative MedicineBeijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesInstitute of Laboratory Animal Sciences Chinese Academy of Medical Sciences(CAMS)Peking Union Medical College(PUMC)National Center of Technology Innovation for Animal ModelBeijingChina Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical SciencePeking Union Medical CollegeTianjinChina

The risk of internal and external exposure to ionizing radiation(IR)has increased alongside the development and implementation of nuclear ***,serious security issues have emerged globally,and there has been an increase in the number of studies focusing on radiological prevention and medical *** drugs are particularly important components of emergency medical preparedness strategies for the clinical management of IR-induced ***,a few drugs have been approved to date to treat such injuries,and the related mechanisms are not entirely ***,the aim of the present review was to provide a brief overview of the World Health Organization's updated list of essential medicines for 2023 for the proper management of national stockpiles and the treatment of radiological *** review also discusses the types of radiation-induced health injuries and the related mechanisms,as well as the development of various radioprotective agents,including Chinese herbal medicines,for which significant survival benefits have been demonstrated in animal models of acute radiation syndrome.

关键词： Chinese herbal medicines essential medicines list ionizing radiation radiation countermeasure agents radiation injury

Hourly energy consumption characteristics of metro rail transit:Train traction versus station operation

在线全文

学校读者我要写书评

暂无评论

Energy and Built Environment 2023年第5期4卷 568-575页

作者： bowen guan Xiaohua Liu Tao Zhang Xinke Wang School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’anShaanxi710054China Department of Building Science Tsinghua UniversityBeijing 100084China

The electricity consumption of the urban metro system can be mainly divided into the following two categories:the electricity consumption for train traction(E_(t))and the electricity consumption for station operation(E_(s)).Although understanding the hourly fluctuation characteristics of E_(t) and E_(s) contributes to renewable energy inte-gration and achieving carbon emission reduction of the metro system,the hourly fluctuation characteristics have been poorly reported in the ***,a typical underground non-transfer metro station of a city’s metro system in the North China Plain is selected in this study,and E_(t) and E_(s) were monitored to portray their hourly fluctuation *** reveal that the hourly E_(t) shows a significant intraday“U”shape on weekdays,indicating two symmetric peaks in morning and evening rush *** the hourly E_(s) shows an intraday“flat”shape,indicating it is nearly free from the effect of rush ***,it is statistically proved that the train frequency is the core influencing factor resulting in the intraday fluctuation of hourly E_(t).In the case study,when the train frequency increases from the mean(20 trains per hour)to maximum(32 trains per hour),the hourly E_(t) will increase by 53.4%.

关键词： Urban rail transit Energy consumption Hourly fluctuation Train traction Station operation Carbon emission reduction

Morphine analgesia in male inbred genetic diversity mice recapitulates the among-individual variance in response to morphine in humans

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2022年第3期5卷 288-296页

作者： Yin Yang bowen guan Qiang Wei Wei Wang Aimin Meng Key Laboratory of Human Disease Comparative Medicine Ministry of HealthBeijing Engineering Research Center for Laboratory Animal Models of Human Critical DiseasesInstitute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC)BeijingChina Department of Physiology and Neurobiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouChina

Morphine is a widely used analgesic, but its use in clinical precision medicine is limited by the variance in response among individuals. Although previous studies have shown that individual differences in morphine can be explained in terms of pharmacodynamics and pharmacokinetics, genetic polymorphisms also play an important role. However, the genetic basis of different sensitivity and tolerance susceptibility to morphine remains ambiguous. Using 15 strains of inbred Genetic Diversity(GD) mice,a new resource with wide genetic and phenotypic variation, we demonstrated great variance in sensitivity to morphine analgesia and susceptibility to morphine tolerance between different GD strains. Among-i ndividual variance in response to morphine analgesia in the population can be modeled in GD mice. Two loci respectively may be associated with the among-i ndividual variance in morphine sensitivity and tolerance,confirming the role of genetic factors in among-i ndividual different responses to morphine. These results indicate that GD mice may be a potential tool for the identification of new biomarkers to improve the clinical administration of morphine.

关键词： inbred genetic diversity mice morphine analgesia morphine tolerance quantitative trait loci mapping

Cost effectiveness of new roadway lighting systems

在线全文

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2015年第3期2卷 158-166页

作者： Yi Jiang Shuo Li bowen guan guangyuan Zhao Department of Building Construction Management Purdue University School of Civil Engineering and Architecture Wuhan Polytechnic University office of Research and Development Indiana Department of Transportation School of Materials Science and Engineering Chang'an University

Appropriate and adequate lighting at select locations on roadways is essential for roadway safety. As the lighting technologies advance, many Wpes of new lighting devices have been developed for roadway lightings. The most promising new lighting technologies for roadway lighting include light emitting diode, induction, plasma, and metal halide lighting systems. A study was conducted to compare the new systems with the conventional high pressure sodium systems that are currently used on the Indiana roadway systems. In this study, the engineering issues, were analyzed such as illuminance, color rendering, power usage, cost effectiveness, and approval procedures for new roadway lighting systems. This paper, however, presents only the study findings related to cost effectiveness of the evaluated roadway lighting systems. Illustrated in this paper are the main features of the roadway lighting systems under evaluations, installations of the new lighting systems, measurements of power consumptions, and life cycle cost analyses of the lighting systems. Through this study, experience and knowledge have been obtained on the installations, power measurements, and cost effectiveness of the new types of the roadway lighting devices. The actual power values of various luminaires were obtained by measuring the electric current with a multi-meter. It was found that the differences between the rated and measured power values could be significant. The results of the life cycle cost analysis indicate that the lower life cycle costs of some of the alternative lighting devices are attributed to their relatively lower electricity usages and longer lamp/emitter replacement cycles.

关键词： Roadway lighting Life cycle cost Luminaire Power consumption

Screening for urinary markers predicting hematopoietic stem cell injury induced by busulfan using genetically diverse mice

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2023年第2期6卷 146-154页

作者： Yuhang Sun bowen guan Xing Liu Lingyan Zhang Xinpei Wang Aimin Meng Ran Gao National Human Diseases Animal Model Resource Center NHC Key Laboratory of Human Disease Comparative MedicineBeijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesInstitute of Laboratory Animal Sciences Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC)National Center of Technology Innovation for Animal ModelBeijingChina

Background:Busulfan(BU)is an alkylating agent used as a conditioning agent prior to hematopoietic stem cell(HSC)transplantation as it is known to be cytotoxic to host hematopoietic stem and progenitor *** susceptibility of HSCs to BU injury plays an important role in the myeloablative efficacy of *** susceptibilities were demonstrated in genetically diverse(GD)mice in our preliminary ***:Three strains of GD mice with different susceptibilities to BU-i nduced HSC injury were used for screening biological markers of HSC injury susceptibility in *** urine proteins were analyzed using liquid chromatography coupled with tandem mass spectrometry to screen for differentially expressed *** for possible biomarkers based on differences in protein expression abundance was validated using enzyme-l inked immunoassay(ELISA).Results:Functional analysis showed that the differential proteins were all involved in a series of biological pathways related to cellular senescence,apoptosis,and angiogenesis;whereas the differential proteins of the high-susceptible strain were enriched for the regulation of bone marrow microenvironment pathways,those of low-susceptible strain were enriched for the proapoptotic effect of GTPase *** on protein abundance differences,several urinary proteins that may be indicative of susceptibility were screened,and ELISA validation results showed that angiotensin-converting enzyme may be a potential biomarker predicting HSC susceptibility for BU ***:This study indicates that urinary protein levels can reflect differences in susceptibility to BU-i nduced HSC *** GD mice to construct genetic difference models will provide preclinical data for screening BU-related biological markers.

关键词： angiotensin I converting enzyme busulfan hematopoietic stem cell injury inbred genetic diversity mice urinary marker

Field evaluation of selected light sources for roadway lighting

在线全文

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2018年第5期5卷 372-385页

作者： Yi Jiang Shuo Li bowen guan guangyuan Zhao Dave Boruff Lalit Garg Prakash Patel Department of Building Construction Management Purdue University West Lafayette IN 47907 USA Division of Research and Development Indiana Department of Transportation West Lafayette IN 47906 USA School of Materials Science and Engineering Chang'an University Xi'an 710064 China Indiana Department of Transportation Indianapolis IN 46204 USA

The development of new lighting sources, such as light emitting diode （LED）, induction, and plasma, presented more possible cost effective ways for roadway lighting. A study was therefore conducted for the Indiana Department of Transportation （INDOT} to evaluate the performance and effectiveness of some selected new lighting devices in roadway lighting. This paper describes the field evaluation process and presents the evaluation results. A number of LEDs, plasma and induction luminaires from various manufacturers were selected to replace the existing high pressure sodium （HPS） lamps in conventional and high mast lightings, llluminance values were measured over a period of 12 months on the existing and new light sources. Light performance metrics, including illuminance level and uniformity ratios, were calculated to make quantitative comparisons of the HPS and new types of light devices. Based on the evaluation in terms of lighting performance and life cycle costs, it was concluded that LED luminaires should be utilized in roadway lighting in place of HPS luminaires. The results of this study will be useful to state highway and city street agencies in making decisions on their lighting policies and developing technical specifications for use of the new lighting technologies in roadway and street lightings. The study provides a basis for manufacturers to improve their luminaire design and integration to better fit the needs of roadway and street lightings.

关键词： Roadway lighting Luminaires Illuminance Field tests LEDHPS

在线全文

学校读者我要写书评

暂无评论

掺天然磁铁矿粉沥青混合料电磁波吸收性能

建筑材料学报 2016年第1期19卷 198-203页

作者：关博文杨涛熊锐王永维长安大学交通铺面材料教育部工程研究中心陕西西安710061

为提高沥青路面电磁波吸收能力,以天然磁铁矿粉为吸收剂制备了沥青混合料试样,采用矩形波导法测试了不同天然磁铁矿粉取代率下试样的电磁参数（复介电常数与复磁导率）,并基于传输线理论计算了掺天然磁铁矿粉沥青路面的反射损耗.结果表... 详细信息

为提高沥青路面电磁波吸收能力,以天然磁铁矿粉为吸收剂制备了沥青混合料试样,采用矩形波导法测试了不同天然磁铁矿粉取代率下试样的电磁参数（复介电常数与复磁导率）,并基于传输线理论计算了掺天然磁铁矿粉沥青路面的反射损耗.结果表明：随天然磁铁矿粉品位与取代率的增加,试样复介电常数实部明显增大,虚部变化不大;试样复磁导率实部与虚部都随天然磁铁矿粉品位与取代率的增加而增大.品位60以上的天然磁铁矿粉均能制备出电磁波反射损耗小于-10dB的沥青混合料.掺天然磁铁矿粉沥青混合料在其厚度为2～11cm时存在3个匹配厚度（3,5,7cm）,结合路面工程要求与经济性,掺天然磁铁矿粉吸波沥青路面上面层设计厚度合理建议值为3cm.路面上面层设计厚度大于3cm时,可适当降低天然磁铁矿粉取代率.

关键词：道路工程沥青混合料天然磁铁矿粉电磁波吸收

复余弦解析映射的广义M集、充满Julia集与其非线性迭代函数系的分形

在线全文

学校读者我要写书评

暂无评论

沈阳建筑大学学报（自然科学版） 2019年第3期35卷 567-576页

作者：陈宁海智刚关博文沈阳建筑大学信息与控制工程学院

目的研究复余弦映射族f(z)=λcos^n(z)的广义M集、充满Julia集与其非线性迭代函数系的构造关系.方法分析复映射的数学特性:在动力平面上的中心周期窗口,考察指定参数下的迭代映射极值点的轨道是否有界,构造参数平面上的广义M集并寻找M... 详细信息

目的研究复余弦映射族f(z)=λcos^n(z)的广义M集、充满Julia集与其非线性迭代函数系的构造关系.方法分析复映射的数学特性:在动力平面上的中心周期窗口,考察指定参数下的迭代映射极值点的轨道是否有界,构造参数平面上的广义M集并寻找M集上周期参数区域的排列规律;在M集的不同周期参数区域挑选参数,构造动力平面上具有高周期吸引轨道的充满Julia集;选用N(N≥2)个广义M集1周期参数,在动力平面上x轴方向的中心周期窗口内构造出N个迭代映射;在N个迭代映射的充满Julia集的公共吸引域上,构造迭代函数系;采用迭代函数系中一个迭代映射的吸引不动点作为初始迭代点,通过随机选取迭代函数系中的迭代映射,跟踪这个吸引不动点在公共吸引域内的迭代轨道,构造出分形.结果采用单参n次复余弦映射族f(z)=λcos^n(z)的广义M集的高周期参数可以构造出在x轴方向具有可数无穷多周期窗口的连续排列的充满Julia集图形;采用N(N≥2)个M集的1周期参数可以构造出在动力平面上的中心周期窗口中充满Julia集的公共吸引域内的有效的非线性迭代函数系.结论提出的构造参数平面上的M集、并在M集上的1周期参数区域选取2个以上的参数构造出相应迭代迭代函数的方法,可以被用于大量构造复映射族f(z)=λcos^n(z)的非线性迭代函数系,随机迭代这种迭代函数系可以大量生成新颖分形.

关键词：分形 IFS 复映射 M集充满Julia集

冻融腐蚀作用下沥青混合料耐久性影响因素的灰熵分析

在线全文

学校读者我要写书评

暂无评论

公路交通科技 2013年第1期30卷 28-32页

作者：熊锐陈拴发关博文长安大学材料科学与工程学院陕西西安710064

针对国内外对冻融腐蚀作用下沥青混合料耐久性能鲜有研究的现状,采用真空饱水冻融劈裂试验,以冻融腐蚀因子评价经不同浓度(2.5%、5%和10%)Na2SO4溶液加速劣化后的沥青混合料性能变化规律;运用灰熵法分析了影响冻融腐蚀作用下沥青混合料... 详细信息

针对国内外对冻融腐蚀作用下沥青混合料耐久性能鲜有研究的现状,采用真空饱水冻融劈裂试验,以冻融腐蚀因子评价经不同浓度(2.5%、5%和10%)Na2SO4溶液加速劣化后的沥青混合料性能变化规律;运用灰熵法分析了影响冻融腐蚀作用下沥青混合料耐久性影响因素——冻融次数、Na2SO4溶液浓度、集料级配、沥青用量和空隙率的显著性。研究结果表明:硫酸盐腐蚀加剧了冻融循环对沥青混合料的破坏作用;集料级配、沥青用量和空隙率对沥青混合料耐久性有较显著影响,可为盐类富集地区沥青混合料的设计和施工提供有益参考。

关键词：道路工程沥青混合料耐久性冻融循环硫酸盐腐蚀灰熵法