Morphine analgesia in male inbred genetic diversity mice recapitulates the among-individual variance in response to morphine in humans

作     者：Yin Yang Bowen Guan Qiang Wei Wei Wang Aimin Meng Yin Yang;Bowen Guan;Qiang Wei;Wei Wang;Aimin Meng

作者机构：Key Laboratory of Human Disease Comparative MedicineMinistry of HealthBeijing Engineering Research Center for Laboratory Animal Models of Human Critical DiseasesInstitute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC)BeijingChina Department of Physiology and NeurobiologySchool of Basic Medical SciencesZhengzhou UniversityZhengzhouChina 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2022年第5卷第3期

页      面：288-296页

核心收录：

学科分类：10[医学] 

基　　金：supported by the National Key R&D Program of China (2017YFA0105204) National Natural Science Foundation of China (81873963) Fundamental Research Funds of Chinese Academy of Medical Sciences (2016ZX310044) 

主　　题：inbred genetic diversity mice morphine analgesia morphine tolerance quantitative trait loci mapping 

摘      要：Morphine is a widely used analgesic, but its use in clinical precision medicine is limited by the variance in response among individuals. Although previous studies have shown that individual differences in morphine can be explained in terms of pharmacodynamics and pharmacokinetics, genetic polymorphisms also play an important role. However, the genetic basis of different sensitivity and tolerance susceptibility to morphine remains ambiguous. Using 15 strains of inbred Genetic Diversity(GD) mice,a new resource with wide genetic and phenotypic variation, we demonstrated great variance in sensitivity to morphine analgesia and susceptibility to morphine tolerance between different GD strains. Among-i ndividual variance in response to morphine analgesia in the population can be modeled in GD mice. Two loci respectively may be associated with the among-i ndividual variance in morphine sensitivity and tolerance,confirming the role of genetic factors in among-i ndividual different responses to morphine. These results indicate that GD mice may be a potential tool for the identification of new biomarkers to improve the clinical administration of morphine.