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Combining extractive heterogeneous-azeotropic distillation and hydrophilic pervaporation for enhanced separation of non-ideal ternary mixtures

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Frontiers of Chemical Science and Engineering 2020年第5期14卷 913-927页

作者： Eniko Haaz botond Szilagyi Daniel Fozer Andras Jozsef Toth Environmental and Process Engineering Research Group Department of Chemical and Environmental Process EngineeringBudapest University of Technology and EconomicsBudapest H-1111Hungary Institute of Chemistry University of MiskolcMiskolc H-3515Hungary

The separation of non-ideal mixtures using distillation can be an extremely complex process and there continues to be a need to further improve these techniques.A new method which combines extractive heterogeneous-azeotropic distillation(EHAD)and hydrophilic pervapora-tion(HPV)for the separation of non-ideal termary mixtures is *** improved distillation method combines the benefits of heterogeneous-azeotropic and extractive distillations in one column but no added materials are needed as is usually the case with *** separation of water-methanol-ethyl acetate and water-methanol-isopropyl acetate mixtures were investigated to demonstrate the accuracy of the combined EHAD/HPV *** is not currently an established treatment strategy for the separation of the second mixtures in the *** separation processes were rigorously modelled and optimized using a professional *** objective functions were total cost and energy consumption and heat integration was also *** verification of the process modelling was carried out using laboratory-scale *** heterogeneous-distillation combined with methanol dehydration was found to be more efficient than conventional distillation for the separation of these highly non-ideal mixtures.

关键词： hydrophilic pervaporation non-ideal mixture modelling extractive heterogeneous-azeotropic distillation heat integration

Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus

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Neural Regeneration Research 2022年第3期17卷 649-654页

作者： Agnes Magyar Eva Racz Clara Matesz Ervin Wolf Peter Kiss botond Gaal Pediatrics Clinic Faculty of MedicineUniversity of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Division of Oral Anatomy Faculty of DentistryUniversity of DebrecenDebrecenHungary MTA-DE Neuroscience Research Group DebrecenHungary

Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements,posture and vegetative *** a shorter or longer period of time,the vestibular function is partially or completely restored via a series of processes such as modification in the efficacy of synaptic *** the plasticity of adult central nervous system is associated with the alteration of extracellular matrix,including its condensed form,the perineuronal net,we studied the changes of brevican expression in the perineuronal nets of the superior vestibular nucleus after unilateral labyrinth *** results demonstrated that the unilateral labyrinth lesion and subsequent compensation are accompanied by the changing of brevican staining pattern in the perineuronal nets of superior vestibular nucleus of the *** reduction of brevican in the perineuronal nets of superior vestibular nucleus may contribute to the vestibular plasticity by suspending the non-permissive role of brevican in the restoration of perineuronal net *** a transitory decrease,the brevican expression restored to the control level parallel to the partial restoration of impaired vestibular *** bilateral changing in the brevican expression supports the involvement of commissural vestibular fibers in the vestibular *** experimental procedures were approved by the 'University of Debrecen–Committee of Animal Welfare'(approval No.6/2017/DEMAB) and the 'Scientific Ethics Committee of Animal Experimentation'(approval ***/06/éLB/2270-10/2017;approved on June 6,2017).

关键词： brainstem brevican chondroitin sulfate proteoglycan extracellular matrix labyrinth lesion neural plasticity perineuronal net perisynaptic matrix vestibular compensation vestibular system

Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit

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Neural Regeneration Research 2015年第9期10卷 1463-1470页

作者： botond Gaal Einar ?rn Jóhannesson Amit Dattani Agnes Magyar Ildikó Wéber Clara Matesz Department of Anatomy Histology and Embryology Faculty of Medicine and Faculty of Dentistry University of Debrecen Department of Pediatric Surgery Faculty of Medicine Clinical Center University of Debrecen MTA-DE Neuroscience Research Group University of Debrecen

We have previously found that unilateral labyrinthectomy is accompanied by modification of hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of rats and the time course of subsequent reorganization of extracellular matrix assembly correlates to the restoration of impaired vestibular function. The tenascin-R has repelling effect on pathfinding during axonal growth/regrowth, and thus inhibits neural circuit repair. By using immunohistochemical method, we studied the modification of tenascin-R expression in the superior, medial, lateral, and descending vestibular nuclei of the rat following unilateral labyrin- thectomy. On postoperative day 1, tenascin-R reaction in the perineuronal nets disappeared on the side of labyrinthectomy in the superior, lateral, medial, and rostral part of the descending vestibular nuclei. On survival day 3, the staining intensity of tenascin-R reaction in perineuronal nets recovered on the operated side of the medial vestibular nucleus, whereas it was restored by the time of postoperative day 7 in the superior, lateral and rostral part of the descending vestib- ular nuclei. The staining intensity of tenascin-R reaction remained unchanged in the caudal part of the descending vestibular nucleus bilaterally. Regional differences in the modification of tena- scin-R expression presented here may be associated with different roles of individual vestibular nuclei in the compensatory processes. The decreased expression of the tenascin-R may suggest the extracellular facilitation of plastic modifications in the vestibular neural circuit after lesion of the labyrinthine receptors.

关键词： nerve regeneration extracellular matrix brainstem vestibular system vestibular lesion vestibular compensation perineuronal net neural plasticity neural regeneration

Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery

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Bioactive Materials 2022年第8期7卷 152-168页

作者： Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse Frank Witte Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4-614197BerlinGermany Botiss Biomaterials AG Ullsteinstrasse 10812109BerlinGermany Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia CMF Surgery Johannes BLA HospitalMonchengladbachGermany Dental Clinic University of StrasbourgFrance Department of Periodontology Semmelweis UniversityBudapestHungary Xploraytion GmbH Bismarkstrasse 11BerlinGermany Biotrics Bioimplants AG Ullsteinstrasse 10812109BerlinGermany

Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as *** collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second ***,biodegradable GBR membranes made of pure magnesium might be an *** this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological *** implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft *** the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect *** the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier *** the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new *** the membrane had completely resorbed,only healthy tissue *** in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen ***,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment.

关键词： Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing

Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration

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Bioactive Materials 2022年第8期7卷 15-30页

作者： Zeljka Peric Kacarevic Patrick Rider Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David botond Hangyasi Balint Molnar Till Kammerer Bernhard Hesse Emely Bortel Marco Bartosch Frank Witte Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4–614197BerlinGermany Botiss Biomaterials AG Ullsteinstrasse 10812109BerlinGermany CMF Surgery Johannes BLA HospitalMonchengladbachGermany Dental Clinic University of StrasbourgFrance Department of Periodontology Semmelweis UniversityBudapestHungary Xploraytion GmbH Bismarkstrasse 11BerlinGermany University Hospital Munich Department of Dermatology and AllergyFrauenlobstr.9-1180337MunichGermany Biotrics Bioimplants AG Ullsteinstrasse 10812109BerlinGermany

An ideal fixation system for guided bone(GBR)regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation,complete resorption when no longer needed,complete replacement by bone,as well as be biocompatible and have a good clinical *** the first time,a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these *** mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable *** demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of *** of the magnesium fixation screw was demonstrated in several in vitro and in vivo *** of the magnesium screw was investigated in in vitro and in vivo tests,where it was found that the screw is resorbed slowly and completely after 52 weeks,providing adequate fixation in the early critical healing ***,the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration(GBR)surgeries.

关键词： Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing

A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis

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World Journal of Gastroenterology 2005年第7期11卷 990-999页

作者： Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz botond Penke Department of Medical Chemistry First Department of Medicine Department of Genetics and Molecular Biology Institute of Surgical Research Institute of Biophysics Institute of Biochemistry

AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 ***: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of ***: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 *** to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute ***: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis.

关键词： Acute pancreatitis Peptide delivery Penetratin NF-κB inhibition

Efficacy and Safety of Ultrasound Guided Vacuum-Assisted Excision of Fibroadenomas: A Systematic Review

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Open Journal of Radiology 2017年第2期7卷 95-102页

作者： Tajudeen A. Wahab botond K. Szabó Maher Jumah Dalia Elfadl Kasim Behranwala Inga Chen Elm Breast Care Centre Department of Surgery King George Hospital Barking Havering and Redbridge University Hospitals NHS Trust London England Elm Breast Care Centre Department of Radiology King George Hospital Barking Havering and Redbridge University Hospitals NHS Trust London England Department of Surgery Wycombe Hospital High Wycombe England

Background: Ultrasound-guided, vacuum-assisted excision [UGVAE] of fibroadenomas is an emerging minimally invasive procedure. UGVAE is being increasingly employed by breast radiologists and surgeons. It has been approved for this use since 2006 by the National Institute for Health and Clinical Excellence in the UK. The aim of this systematic review is to evaluate the efficacy and safety of this procedure based on the up to date available evidence. Methods: A comprehensive literature search of the Cochrane library, Medline, Embase, PubMed, Google scholar, Trip-database, Internet, and the reference lists of relevant articles was performed. We searched for literature with sizeable cases of therapeutic vacuum-assisted excision of fibroadenomas. All prospective studies with more than 20 study participants were screened. The study quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation [GRADE] approach. All were in English. Results: Of the four case series that fulfilled the inclusion criteria there were 516 patients in which 520 procedures were performed. Overall complete excision rate was 89.4%. In two of the studies, this was 100% when the lesions were less than 1.5 cm but reduced to 61% when between 1.5 and 2 cm. Most common significant complication was bleeding with 2 cases of pneumothorax. None of the studies can be regarded as high quality going by GRADE approach. Conclusion: Within the limit of the current published case series, UGVAE appears to be an effective and safe procedure for excision of small fibroadenomas of less than 15 mm in size. A well designed case control study or randomized controlled trials with a sufficient sample size is needed to further assess its safety, effectiveness and more importantly, patients’ satisfaction especially in larger sized fibroadenomas.

关键词： Ultrasound-Guided Vacuum-Assisted Excision Benign Breast Disease Fibroadenoma