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Research 2024年第2期2023卷 541-552页

作者： Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan botao lu Wei Liang Fanli Kong luyi Jing Wei Xu Juntao Liu Mixia Wang Yirong Wu Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Epilepsy severely impairs the cognitive behavior of *** remains unclear whether epilepsy-induced cognitive impairment is associated with neuronal activities in the medial entorhinal cortex(MEC),a region known for its involvement in spatial *** explore this neural mechanism,we recorded the spikes and local field potentials from MEC neurons in lithium-pilocarpine-induced epileptic rats using self-designed microelectrode *** the open field test,we identified spatial cells exhibiting spatially selective firing properties and assessed their spatial representations in relation to the progression of ***,we analyzed theta oscillations and theta modulation in both excitatory and inhibitory ***,we used a novel object recognition test to evaluate changes in spatial cognitive ability of epileptic *** the epilepsy modeling,the spatial tuning of various types of spatial cells had suffered a rapid and pronounced damage during the latent period(1 to 5 d).Subsequently,the firing characteristics and theta oscillations were *** the chronic period(>10 d),the performance in the novel object experiment *** conclusion,our study demonstrates the detrimental effect on spatial representations and electrophysiological properties of MEC neurons in the epileptic latency,suggesting the potential use of these changes as a"functional biomarker"for predicting cognitive impairment caused by epilepsy.

关键词： epilepsy impaired involvement

Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinson’s disease

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Bio-Design and Manufacturing 2024年第4期7卷 439-452页

作者： luyi Jing Zhaojie Xu Penghui Fan botao lu Fan Mo Ruilin Hu Wei Xu Jin Shan Qianli Jia Yuxin Zhu Yiming Duan Mixia Wang Yirong Wu Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep *** microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise *** this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain *** results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned *** addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the ***,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN *** with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned *** may be a cause of sleep and motor disorders associated with ***,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.

关键词： Functional localization Implantable microelectrode arrays Parkinson’s disease Subthalamic nucleus

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Recent advances and research progress on microsystems and bioeffects of terahertz neuromodulation

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Microsystems & Nanoengineering 2023年第6期9卷 25-41页

作者： Meiting Liu Juntao Liu Wei Liang botao lu Penghui Fan Yilin Song Mixia Wang Yirong Wu Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing100049China

Terahertz waves can interact with the nervous system of organisms under certain *** to common optical modulation methods,terahertz waves have the advantages of low photon energy and low risk;therefore,the use of terahertz waves to regulate the nervous system is a promising new method of ***,most of the research has focused on the use of terahertz technology for biodetection,while relatively little research has been carried out on the biological effects of terahertz radiation on the nervous system,and there are almost no review papers on this *** the present article,we begin by reviewing principles and objects of research regarding the biological effects of terahertz radiation and summarizing the current state of related research from a variety of aspects,including the bioeffects of terahertz radiation on neurons in vivo and in vitro,novel regulation and detection methods with terahertz radiation devices and neural microelectrode arrays,and theoretical simulations of neural information encoding and *** addition,we discuss the main problems and their possible causes and give some recommendations on possible future *** paper will provide insight and assistance to researchers in the fields of neuroscience,terahertz technology and biomedicine.

关键词： breakthrough neural microelectrode

Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for the medial entorhinal cortex

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Microsystems & Nanoengineering 2022年第5期8卷 171-181页

作者： Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan Yiding Wang botao lu Jingyu Xie Yuchuan Dai Yilin Song Enhui He Shihong Xu Juntao Liu Mixia Wang Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex(MEC)carry the vital function of serving as a metric for the surrounding *** this mechanism processes only spatial information or involves nonspatial information remains ***,we fabricated an MEC-shaped microelectrode array(MEA)to detect the variation in neural spikes and local field potentials of the MEC when rats forage in a square enclosure with a planar,three-dimensional object and social landmarks in *** results showed that grid cells exhibited rate remapping under social conditions in which spike firing fields closer to the social landmark had a higher firing ***,global remapping showed that hexagonal firing patterns were rotated and scaled when the planar landmark was replaced with object and social *** addition,when grid cells were activated,the local field potentials were dominated by the theta band(5–8 Hz),and spike phase locking was observed at troughs of theta *** results suggest the pattern separation mechanism of grid cells in which the spatial firing structure and firing rate respond to spatial and social information,respectively,which may provide new insights into how the brain creates a cognitive map.

关键词： mapping hexagonal microelectrode

Detection of neuronal defensive discharge information transmission and characteristics in periaqueductal gray double-subregions using PtNP/PEDOT:PSS modified microelectrode arrays

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微系统与纳米工程(英文) 2023年第3期9卷 319-331页

作者： botao lu Penghui Fan Ming Li Yiding Wang Wei Liang Gucheng Yang Fan Mo Zhaojie Xu Jin Shan Yilin Song Juntao Liu Yirong Wu Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Threatened animals respond with appropriate defensive behaviors to *** has been accepted that midbrain periaqueductal gray(PAG)plays an essential role in the circuitry system and organizes defensive behavioral ***,the role and correlation of different PAG subregions in the expression of different defensive behaviors remain largely ***,we designed and manufactured a microelectrode array(MEA)to simultaneously detect the activities of dPAG and vPAG neurons in freely behaving *** improve the detection performance of the MEAs,PtNP/PEDOT:PSS nanocomposites were modified onto the ***,the predator odor was used to induce the rat’s innate fear,and the changes and information transmission in neuronal activities were detected in the dPAG and *** results showed that the dPAG and vPAG participated in innate fear,but the activation degree was distinct in different defense *** flight,neuronal responses were stronger and earlier in the dPAG than the vPAG,while vPAG neurons responded more strongly during *** applying high-performance MEA,it was revealed that neural information spread from the activated dPAG to the weakly activated *** research also revealed that dPAG and vPAG neurons exhibited different defensive discharge characteristics,and dPAG neurons participated in the regulation of defense responses with burst-firing *** slow activation and continuous firing of vPAG neurons cooresponded with the regulation of long-term freezing *** results demonstrated the important role of PAG neuronal activities in controlling different aspects of defensive behaviors and provided novel insights for investigating defense from the electrophysiological perspective.

关键词： microelectrode freezing modified

STRUCTURE OF [Et4N]2[Mo2（CO）8（SCH2C6H4CH2SH）]

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Chinese Journal of Structural Chemistry 1989年第1期8卷 19-22页

作者： Huang Liangren Zhuang botao lu JiaxiFujian Institute of Research on the Structure of Matter, Academia Sinica 中科院福建物质结构所福建福州

Mr =1015.05, P21/c, a= 10.912(4), b= 12.088(3), c= 18.807(8) A.β=103.57(3)° ,V= 2411.4 A3, Z = 2, DC = 1.40 g/cm3.λ(MoKα)= 0.71073 A, μ=7.2 cm-1,F(000)=*** temperature, final R=0.069, Rw=0.091. The geometry around the Mo atom is a distorted octahedron. The equatorial Mo-C distances are shorter than the axial ones. The Mo...Mo distance is 3.949A.

关键词： SCH2C6H4CH2SH STRUCTURE OF Et4N Mo2 SH CO

The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike

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The Crop Journal 2024年第1期12卷 295-300页

作者： Liping Shen Lili Zhang Changbin Yin Xiaowan Xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He Xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi Xuebo Zhao Daxing Xu botao Ye Xuchang Yu Ziying Wang Danni Liu Yuanfeng Hao Fei lu Zifeng Guo Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Crop Sciences Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China University of Chinese Academy of Sciences Beijing 100049China International Maize and Wheat Improvement Center(CIMMYT)China Office c/o CAASBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this *** effects of TaSus1 on grain number per spike(GNS)also are largely *** previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome *** triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type *** 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to *** of the two alleles into a wheat genetic background confirmed their *** alleles differed in geographical distribution among the accessions.

关键词： Domestication selection Fertile spikelet number per spike(FSN) Geographical differentiation Grain number per spike(GNS) TaSus1

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Genetic basis of geographical differentiation,breeding selection,domestication effects,and breeding application for TaJAZ1 in wheat

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Journal of Genetics and Genomics 2024年第6期51卷 665-668页

作者： botao Ye Yangyang Liu Ziying Wang Liping Shen Changbin Yin Kuocheng Shen Jiaqiang Sun Xiaowan Xu Mengjing Sun Jianhui Wu Zhonghu He Xuchang Yu Fei lu Yuanfeng Hao Zifeng Guo Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China China National Botanical Garden Beijing 100093China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F UniversityYanglingShaanxi 712100China International Maize and Wheat Improvement Center China Office c/o CAASBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Common wheat(Triticum aestivum L.,2n=6x=42,AABBDD)is one of the most widely grown crops worldwide,providing about 20%of the daily calories and protein consumed by humans(Shiferaw et al.,2013).The world population is projected to reach 9.8 billion in 2050(https://***/en/desa/world-population-projectedreach-98-billion-2050-and-112-billion-2100);thus,to meet the challenges of global food and nutritional security,wheat yields must continue to be increased through breeding programs and improved agricultural techniques(Hunter et al.,2017).

关键词： breeding crops wheat

CRYSTAL STRUCTUHE OF OXO-BIS[DIETHYLDITHIOCARBAMATO]-MOLYBDENUM(IV)

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结构化学 1986年第2期 124-126页

作者： Huang Liangren Zhuang botao YangYu lu JiaxiFujian Institute of Research on the Structure of Matter, Academia Sinica

INTRODUCTION. The existance of an oxido-reduction cycle in the oxo-molybdenum dithiocarbamates, has attracted much attention. In 1974 Ricardreported the crystal and molecular structure of MoO（Pr2dtc）2, which wereprepared from the reaction of MoO2（Pr2dtc）2 with pph3 in tuluene. Herewe report the structure of the title compound, MoO（Et2dtc）2 （1） obtainedfrom a reaction Mo（CO）6 with Et2NCSSNa in acetonitrile. The structure of1 is very different from the analogue MoO（Pr2dtc）2.

关键词： acetonitrile analogue molybdenum cycle 一彻 Cotton pyramidal 南南 coord Schott

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基于生态文明视角的生态旅游经济发展研究

生态经济 2015年第4期31卷 99-102,160页

作者：刘汀鲁波涛西南交通大学经济管理学院四川成都610031

从生态文明视角出发,分析了当前我国生态旅游发展面临的种种问题,指出了问题产生的直接原因及根本原因,并从注重生态规划、协调各方利益关系、加强生态观念培养以及提高生态旅游科技含量方面对生态旅游发展路径进行了深入思考。

关键词：马克思生态经济思想生态文明生态旅游

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