检索结果-南通市图书馆

Journal of Innovative Optical Health Sciences 2016年第4期9卷 74-84页

作者： Alla B.Bucharskaya Galina n.Maslyakova Svetlana S.Pakhomy Olga V.Zlobina Irina O.Bugaeva nikita A.navolokin boris n.khlebtsov Vladimir A.Bogatyrev nikolai G.khlebtsov Valery V.Tuchin Saratov State Medical University n.a.V.I.Razumovsky 410012 Saratov Russia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS 410049 Saratov Russia Research-Educational Institute of Optics and Biophotonics Saratov national Research State University 410012 Saratov Russia Institute of Precision Mechanics and Control RAS 410028 Saratov Russia Interdisciplinary Laboratory of Biophotonics Tomsk national Research State University 634050 TomskRussia

Recently gold nanoparticles(GnPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther *** prolonged peroral administration of GnPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory *** this study,GnP's with average diameters of 2 nm,15 nm and 50nm were administered during 30 days,and the reversibility of morphological changes was investigated 14 days after *** the prolonged administration of GnPs,the severity of morphological changes in the liver,kidney,spleen and lymph nodes depended on the nanoparticle ***,50 nm nano-particles caused the most pronounced dystrophic and necrobiotic effects,whereas the smallest 2 nm nanoparticles caused proliferative *** importantly,the development of patho-logical processes was reversible,as evidenced by the gradual restoration of the organ structure at 14 days after the end of GnPs administration.

关键词： Gold nanoparticles prolonged peroral administration morphological changes reversibility.

Alterations of morphology of lymphoid organs and peripheral blood indicators under the influence of gold nanoparticles in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2016年第1期9卷 47-56页

作者： Alla B.Bucharskaya Svetlana S.Pakhomy Olga V.Zlobina Galina n.Maslyakova Olga V.Matveeva Irina O.Bugaeva nikita A.navolokin boris n.khlebtsov Vladimir A.Bogatyrev nikolai G.khlebtsov Valery V.Tuchin Saratov State Medical University 112 B.Kazach'ya str.Saratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS 13 Entuziastov Prospekt.Saratov 410049Russia Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia§Institute of Precise Mechanics and Control of Russian Academy of Sciences 24Rabochaya str.Saratov 410028Russia Interdisciplinary Laboratory of Biophotonics Tomsk State University 36 Lenina str.Tomsk 634050Russia

At present,gold nanoparticles(GnPs)are widely used in biomedical applications such as cancer diagnostics and ***,the potential toxicity hazards of these nanomaterials and human safety concerns are gaining significant ***,we report the effects of prolonged peroral administration of GnPs with different sizes(2,15 and 50 nm)on morphological changes in lymphoid organs and indicators of peripheral blood of laboratory *** experiment was conducted on 24 white mongrel male rats weighing 180–220 g,gold nanospheres sizes 2,15 and 50nm were administered orally for 15 days at a dosage of 190g/kg of animal body *** GnPs were conjugated with polyethylene glycol to increase their biocompatibility and *** size-dependent decrease of the number of neutrophils and lymphocytes was noted in the study of peripheral blood,especially pronounced after administration of GnPs with size of 50 *** stimulation of myelocytic germ of hematopoiesis was recorded at morphological study of the bone *** signs of strengthening of the processes of differentiation and maturation of cellular elements were found in lymph nodes,which were showed as the increasing number of immunoblasts and large *** quantitative changes of cellular component morphology of lymphoid organs due to activation of migration,proliferation and di®erentiation of immune cells indicate the presence of immunostimulation effect of GnPs.

关键词： Gold nanoparticles lymphoid organs morphological changes bone marrow examination

Are population cycles recovering?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第3期19卷 538-547页

作者： Vasily D.YAKUSHOV boris I.SHEFTEL A.n.Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences MoscowRussia

The dynamics of populations of small mammals of Central Siberia was *** studies were carried out at the Yenisei ecological station“Mirnoye”of the *** Institute of Ecology and Evolution,Russian Academy of *** time series analysis was performed by the wavelet transform using the statistical data processing language *** the 20th century,the dynamics of the population of the community and some of its constituent species(Sorex araneus;***;***;***;***;Craseomys rufocanus;Clethrionomys rutilus;Microtus oeconomus;***)were characterized by a 4-year *** type of dynamics changed to noncyclic by the nineties,but by 2022,four species(***,***,***,and ***)and the community as a whole showed a tendency toward recovery of population *** remaining species were characterized by consistently low numbers with irregular low amplitude fluctuations.

关键词： population cycles small mammals time-series analysis wavelet transform

Surface-enhanced Raman scattering inside Au@Ag core/shell nanorods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nano Research 2016年第8期9卷 2303-2318页

作者： boris khlebtsov Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences Saratov 410049 Russia Saratov national Research State University Saratov 410012 Russia

The design and synthesis of plasmonic nanoparticles with Raman-active molecules embedded inside them are of significant interest for sensing and imaging applications. However, direct synthesis of such nanostructures with controllable shape, size, and plasmonic properties remains extremely challenging. Here we report on the preparation of uniform Au@Ag core/sheU nanorods with controllable Ag shells of 1 to 25 nm in thickness. 1,4-Aminothiophenol （4-ATP） molecules, used as the Raman reporters, were located between the Au core and the Ag shell. Successful embedding of reporter molecules inside the core/shell nanoparticles was confirmed by the absence of selective oxidation of the amino groups, as measured by Raman spectroscopy. The dependence of Raman intensity on the location of the reporter molecules in the inside and outside of the nanorods was studied. The molecules in the interior showed strong and uniform Raman intensity, at least an order of magnitude higher than that of the molecules on the nanoparticle surface. In contrast to the usual surface-functionalized Raman tags, aggregation and clustering of nanoparticles with embedded molecules decreased the surface-enhanced Raman scattering （SERS） signal. The findings from this study provide the basis for a novel detection technique of low analyte concentration utilizing the high SERS response of molecules inside the core/shell metal nanostructures. As an example, we show robust SERS detection of thiram fungicide as low as 10-9 M in solutions.

关键词： surface-enhanced Ramanscattering (SERS) Au@Ag nanorods nanocuboids multipole plasmons

SERS-based lateral flow immunoassay of troponin I by using gapenhanced Raman tags

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nano Research 2019年第2期12卷 413-420页

作者： boris n. khlebtsov Daniil n. Bratashov nadezhda A. Byzova boris B. Dzantiev nikolai G. khlebtsov Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences Saratov 410049 Russia Saratov State University Saratov 410012 Russia A. n. Bach Institute of Biochemistry Research Centre of Biotechnology Russian Academy of Sciences Moscow 119071 Russia

The lateral flow immuno assay (LFIA) has emerged as a powerful tool for rapid scree ning owing to its simplicity and flexibility for detection of various biomarkers. However, conventional LFIA strips have several disadvantages, including limits in quantitative analysis and low sensitivity. Here we developed a novel surface-e nhanced Rama n scatteri ng LFIA based on non spherical gap-e nhanced Raman tags (GERTs), with Raman molecules (RMs) embedded in a 1-nm gap between Au nanorod core and Au shell. Such tags have a strong and uniform surface-enhanced Rama n scattering (SERS) resp on se, an order of mag nitude higher than that of other comm on SERS tags such as Au nano rods, nano stars, Au nano shells with surface-adsorbed RMs, or spherical GERTs with embedded RMs. The feasibility of the tags was dem on strated by the semiqua ntitative and sen sitive detecti on of the heart disease biomarker cardiac tropo nin I (cTnI). GERTs were conjugated with mono clonal antibodies and used for LFIA in the same way as ordinary functionalized colloidal gold. The presenee of the target antigen, cTnI, was identified by Raman microscopy mapping of the test zone. With the SERS-based LFIA, the limit of cTnI detection was about 0.1 ng/mL. This value is within the diagnostic range of cTnI in the blood serum of patients with heart infarction and is 30 times lower than that of the colorimetric LFIA test using the same antibodies and either GERTs or colloidal gold as labels.

关键词： surface-enhanced Raman scattering (SERS) lateral flow immunoassay Au core/shell nanorods gap-enhanced Raman tags cardiac troponin I

Two-dimensional anisotropic vortex quantum droplets in dipolar Bose−Einstein condensates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of physics 2024年第2期19卷 205-211页

作者： Guilong Li Xunda Jiang Bin Liu Zhaopin Chen boris A.Malomed Yongyao Li School of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528225China Physics Department and Solid-State Institute TechnionHaifa 32000Israel Department of Physical Electronics School of Electrical EngineeringFaculty of EngineeringTel Aviv UniversityTel Aviv 69978Israel Instituto de Alta Investigación Universidad de TarapacáCasilla 7DAricaChile Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro−nano Optoelectronic Technology Foshan UniversityFoshan 528225China

Creation of stable intrinsically anisotropic self-bound states with embedded vorticity is a challenging ***,no such states in Bose−Einstein condensates(BECs)or other physical settings were *** BEC suggests a unique possibility to predict stable two dimensional anisotropic vortex quantum droplets(2D-AVQDs).We demonstrate that they can be created with the vortex axis oriented perpendicular to the polarization of *** stability area and characteristics of the 2D-AVQDs in the parameter space are revealed by means of analytical and numerical ***,the rotation of the polarizing magnetic field is considered,and the largest angular velocities,up to which spinning 2D-AVQDs can follow the rotation in clockwise and anti-clockwise directions,are *** between moving 2D-AVQDs are studied too,demonstrating formation of bound states with a vortex−antivortex−vortex structure.A stability domain for such stationary bound states is *** dipolar states,that can be readily implemented by means of phase imprinting,quickly transform into robust 2D-AVQDs,which suggests a straightforward possibility for the creation of these states in the experiment.

关键词： dipolar Bose−Einstein condensate anisotropic vortex quantum droplets

Early neoproterozoic Granite-Gneisses of the Junggar Alataw(Southeastern Kazakhstan):Age,Petrogenesis and Tectonic Implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2024年第1期98卷 67-82页

作者： nadezhda KAnYGInA Andrey TRETYAKOV Dmitriy ALEXEIEV Kirill DEGTYAREV Anfisa SKOBLEnKO natalia SOLOSHEnKO boris ERMOLAEV Geological Institute Russian Academy of SciencesMoscow 119017Russia A.n.Zavaritsky Institute of Geology and Geochemistry Ural Branch of the Russian Academy of SciencesYekaterinburg 620016Russia

The combined petrographic,petrological,geochemical and geochronological study of the neoproterozoic gneisses of the Sarychabyn and Baskan complexes of the Junggar Alataw of South Kazakhstan elucidate the Precambrian tectonic evolution of the Aktau–Yili *** is one of the largest Precambrian crustal blocks in the western Central Asian orogenic *** U-Pb single-grain zircon ages indicate that granite-gneisses formed from the same source and crystallised in the early neoproterozoic ca.930–920 *** chemical composition of gneisses corresponds to A2-type *** whole-rock nd isotopic characteristics(εnd(t)=−4.9 to−1.0 and Tnd(DM-2st)=1.9 to 1.7 Ga)indicate the involvement of Paleoproterozoic crustal rocks in magma *** neoproterozoic ca.930–920 Ma A-type granitoids in the Aktau–Yili terrane of South and Central Kazakhstan might reflect within-plate magmatism adjacent to the collisional belt or a local extension setting in back-arc areas of the continental arc.

关键词： granitoid magmatism geochemistry geochronology Sm-nd isotope systematics neoproterozoic Junggar Alataw Kazakhstan Central Asian orogenic belt

Au-nanocluster-loaded human serum albumin nanoparticles with enhanced cellular uptake for fluorescent imaging

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2016年第2期9卷 17-24页

作者： boris khlebtsov Artur Prilepskii Maria Lomova nikolai khlebtsov Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences 13 Prospekt Entuziastov Saratov 410049 Russia Saratov State University 83 Ulitsa Astrakhanskaya Saratov 410012Russia

Protein-directed fluorescent Au nanoclusters have been widely studied owing to their potential applications in sensing,imaging,and drug and gene ***,the use of nanoclusters in drug delivery is limited by low cellular *** this study,human serum albumin-directed Au nanoclusters served as building blocks to obtain protein nanoparticles by *** nanoparticles had a decent quantum yield(QY),high colloidal stability and low cytotoxicity,and they could be readily conjugated with biological *** cellular uptake of the Au nanoclusters and nanocluster-loaded protein nanoparticles were studied by confocal fluorescence *** of the protein-directed Au nanoclusters into 50–150-nm nanoparticles dramatically increased the cellular uptake.

关键词： Au nanoclusters albumin nanoparticles uptake fluorescence

How to fill the biodiversity data gap:Is it better to invest in fieldwork or curation?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2024年第1期46卷 39-48页

作者： Carlos A.Vargas Marius Bottin Tiina Sarkinen James E.Richardson Marcela Celis boris Villanueva Adriana Sanchez Programa de Biología Facultad de Ciencias NaturalesUniversidad del RosarioBogotaD.C.Colombia Subdireccion Científica Jardín Botanico de Bogota“Jose Celestino Mutis”BogotaD.C.Colombia Independent Researcher BogotaD.C.Colombia Tropical Diversity Section Royal Botanic Garden EdinburghUK School of Biological Earth and Environmental SciencesUniversity College CorkCorkIreland Departamento de Química y Biología Universidad del NorteKm.5 Vía Puerto ColombiaArea Metropolitana de Barranquilla 081007Colombia

Data gaps and biases are two important issues that affect the quality of biodiversity information and downstream *** how best to fill existing gaps and account for biases is necessary to improve our current information most *** current main approaches for obtaining and improving data include(1)curation of biological collections,and(2)***,the comparative effectiveness of these approaches in improving biodiversity data remains little *** used the Flora de Bogota project to study the magnitude of change in species richness,spatial coverage,and sample coverage of plant records based on curation versus *** process of curation resulted in a decrease in species richness(synonym and error removal),but it significantly increased the number of records per *** contributed to a slight increase in species richness,via accumulation of new ***,curation led to increases in spatial coverage,species observed by locality,the number of plant records by species,and localities by species compared to ***,curationwas more efficient in producing new information compared to fieldwork,mainly because of the large number of records available in *** recommend intensive curatorial work as the first step in increasing biodiversity data quality and quantity,to identify bias and gaps at the regional scale that can then be targeted with *** stepwise strategy would enable fieldwork to be planned more costeffectively given the limited resources for biodiversity exploration and characterization.

关键词： Colombia Flora de Bogota Sample coverage Species richness Tropical Andes

PACK-CXL *** therapy for bacterial,fungal,and mixed infectious keratitis:a prospective randomized phase 3 trial

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Eye and Vision 2024年第1期10卷 10-20页

作者： Farhad Hafezi Mohammed Hosny Rohit Shetty boris Knyazer Shihao Chen Qinmei Wang Hassan Hashemi Emilio A.Torres‑netto 无 Center for Applied Biotechnology and Molecular Medicine(CABMM) University of ZurichZurichSwitzerland ELZA Institute DietikonSwitzerland. Faculty of Medicine University of GenevaGenevaSwitzerland Department of Ophthalmology Medical University of WenzhouWenzhouChina USC Roski Eye Institute University of Southern California Los AngelesLos AngelesUSA Department of Ophthalmology University of CairoCairoEgypt narayana nethralaya Eye Hospital and the Postgraduate Institute of Ophthal‑mology BangaloreIndia Department of Ophthalmology Soroka University Medical CenterBen-Gurion University of the NegevBeershebaIsrael noor Ophthalmology Research Center Noor Eye HospitalTehranIran University Hospital Zurich ZurichSwitzerland. the PACK-CXL Working Group

Background:Infectious keratitis is a major cause of global *** tested whether standalone photoactivated chromophore corneal cross-linking(PACK-CXL)may be an efective frst-line treatment in early to moderate infectious keratitis,compared with standard antimicrobial ***:This is a randomized,controlled,multinational phase 3 clinical *** in fve centers in Egypt,India,Iran,Israel,and China,aged≥18 years,with infectious keratitis of presumed bacterial,fungal,or mixed origin,were randomly assigned(1:1)to PACK-CXL,or antimicrobial *** measures included healing,defned as time to re-epithelialization of the corneal epithelial defect in the absence of infammatory activity in the anterior chamber and clearance of stromal *** success was defned as the complete resolution of signs of ***:Between July 21,2016,and March 4,2020,participants were randomly assigned to receive PACK-CXL(n=18)or antimicrobial therapy per American Academy of Ophthalmology(AAO)guidelines(n=21).no participants were lost to *** eyes were excluded from the epithelialization time analysis due to treatment failure:two in the antimicrobial therapy group,and two in the PACK-CXL *** rates were 88.9%(16/18 patients)in the PACK-CXL group and 90.5%(19/21 patients)in the medication *** was no signifcant diference in time to complete corneal re-epithelialization(P=0.828)between both treatment ***:PACK-CXL may be an alternative to antimicrobial drugs for frst-line and standalone treatment of early to moderate infectious keratitis of bacterial or fungal origin.

关键词： Photoactivated chromophore Corneal cross-linking Infectious keratitis Corneal melting PACK-CXL